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GSE49485: Hypoxia transcriptome sequencing of rat brain.

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Results for Klf8

Z-value: 0.26

Motif logo

Transcription factors associated with Klf8

Gene Symbol Gene ID Gene Info
ENSRNOG00000039057 Kruppel-like factor 8

Activity-expression correlation:

GenePromoterPearson corr. coef.P-valuePlot
Klf8rn6_v1_chrX_-_18890090_18890090-0.059.4e-01Click!

Activity profile of Klf8 motif

Sorted Z-values of Klf8 motif

Promoter Log-likelihood Transcript Gene Gene Info
chr1_-_15301998 0.14 ENSRNOT00000016400
solute carrier family 35, member D3
chr10_-_15590220 0.10 ENSRNOT00000048977
hemoglobin alpha, adult chain 2
chr1_-_84812486 0.08 ENSRNOT00000078369

chrX_+_15273933 0.07 ENSRNOT00000075082
erythroid transcription factor
chrX_-_38196060 0.06 ENSRNOT00000006741
ENSRNOT00000006438
SH3 domain-containing kinase-binding protein 1
chr2_-_46544457 0.06 ENSRNOT00000015680
follistatin
chr3_-_5693147 0.05 ENSRNOT00000008660
family with sequence similarity 163, member B
chr4_-_100883275 0.05 ENSRNOT00000022846
thymosin, beta 10-like
chr20_+_4576514 0.05 ENSRNOT00000090125
ENSRNOT00000047370
euchromatic histone lysine methyltransferase 2
chr11_+_32211115 0.05 ENSRNOT00000087452
mitochondrial ribosomal protein S6
chr7_-_121311565 0.04 ENSRNOT00000092252
ribosomal protein L3
chr3_+_110466790 0.04 ENSRNOT00000089434
p21 (RAC1) activated kinase 6
chr12_+_23544287 0.04 ENSRNOT00000001938
ORAI calcium release-activated calcium modulator 2
chr20_+_4576057 0.04 ENSRNOT00000081456
ENSRNOT00000085701
euchromatic histone lysine methyltransferase 2
chr7_+_142877086 0.04 ENSRNOT00000088730
general receptor for phosphoinositides 1 associated scaffold protein
chr14_-_36554580 0.04 ENSRNOT00000002869
RAS-like family 11 member B
chr2_+_251817694 0.03 ENSRNOT00000019964
similar to RIKEN cDNA 2410004B18
chr10_-_48860902 0.03 ENSRNOT00000004127
centromere protein V
chr18_+_47740328 0.03 ENSRNOT00000025119
synuclein, alpha interacting protein
chr2_-_192697800 0.03 ENSRNOT00000066614
small proline rich protein 4
chr13_-_53108713 0.03 ENSRNOT00000035404
similar to hypothetical protein FLJ10901
chr10_-_29450644 0.03 ENSRNOT00000087937
adrenoceptor alpha 1B
chr16_+_9563218 0.03 ENSRNOT00000035915
Rho GTPase activating protein 22
chr6_+_129538982 0.03 ENSRNOT00000083626
ENSRNOT00000082522
adenylate kinase 7
chr12_-_22478752 0.03 ENSRNOT00000089392
ENSRNOT00000086915
acetylcholinesterase
chr2_+_231962517 0.03 ENSRNOT00000014570
neurogenin 2
chr11_-_87236445 0.03 ENSRNOT00000057806
testis-specific serine kinase 2
chr20_-_4943564 0.03 ENSRNOT00000049310
RT1 class I, locus1
chr10_+_109107389 0.03 ENSRNOT00000068437
ENSRNOT00000005687
BAI1-associated protein 2
chr10_-_90999506 0.03 ENSRNOT00000034401
glial fibrillary acidic protein
chr1_-_226657408 0.02 ENSRNOT00000028102
triokinase and FMN cyclase
chr19_-_59502161 0.02 ENSRNOT00000075292
interferon regulatory factor 2 binding protein 2
chr20_-_28814636 0.02 ENSRNOT00000086030
septin 10
chr1_-_80271001 0.02 ENSRNOT00000034266
CD3e molecule associated protein
chr9_+_81672758 0.02 ENSRNOT00000020646
CTD small phosphatase 1
chr10_+_10644572 0.02 ENSRNOT00000004026
periplakin
chr3_+_175982777 0.02 ENSRNOT00000082073
neurotensin receptor 1
chr2_+_23385183 0.02 ENSRNOT00000014860
arylsulfatase B
chr2_+_205160405 0.02 ENSRNOT00000035605
tetraspanin 2
chr3_+_100769839 0.02 ENSRNOT00000077703
brain-derived neurotrophic factor
chr1_-_189911571 0.02 ENSRNOT00000080996
ENSRNOT00000088536
zona pellucida glycoprotein 2
chr3_+_2158995 0.02 ENSRNOT00000010270
zinc finger, MYND-type containing 19
chr8_+_116054465 0.02 ENSRNOT00000040056
cytokine inducible SH2-containing protein
chr1_-_247169693 0.02 ENSRNOT00000079875
adenylate kinase 3
chr3_+_113976687 0.02 ENSRNOT00000022437
eukaryotic translation initiation factor 3, subunit J
chr18_+_70427007 0.02 ENSRNOT00000087959
ENSRNOT00000019512
myosin Vb
chr9_-_82699551 0.02 ENSRNOT00000020673
obscurin-like 1
chr4_-_146839397 0.02 ENSRNOT00000010338
vestigial-like family member 4
chr7_+_145068286 0.02 ENSRNOT00000088956
ENSRNOT00000065753
NCK associated protein 1 like
chr1_-_89488223 0.02 ENSRNOT00000028624
FXYD domain-containing ion transport regulator 1
chr2_-_84437084 0.02 ENSRNOT00000077598
ankyrin repeat domain 33B
chr14_-_78377825 0.02 ENSRNOT00000068104

chr17_-_35037076 0.02 ENSRNOT00000090946
dual specificity phosphatase 22
chr9_+_99998275 0.02 ENSRNOT00000074395
glypican 1
chr1_-_167347662 0.02 ENSRNOT00000027641
ENSRNOT00000076592
ras homolog family member G
chr1_-_242083484 0.02 ENSRNOT00000065921
tight junction protein 2
chr6_-_38228379 0.01 ENSRNOT00000084924
v-myc avian myelocytomatosis viral oncogene neuroblastoma derived homolog
chr10_+_69434941 0.01 ENSRNOT00000009756
C-C motif chemokine ligand 11
chr2_+_85377318 0.01 ENSRNOT00000016506
ENSRNOT00000085094
semaphorin 5A
chr1_-_229601032 0.01 ENSRNOT00000016690
ciliary neurotrophic factor
chr1_+_84304228 0.01 ENSRNOT00000024771
periaxin
chr19_+_37127508 0.01 ENSRNOT00000019656
core-binding factor, beta subunit
chr20_+_11863082 0.01 ENSRNOT00000001640
family with sequence similarity 207, member A
chr10_+_55169282 0.01 ENSRNOT00000005423
coiled-coil domain containing 42
chr11_-_34598102 0.01 ENSRNOT00000068743
phosphatidylinositol glycan anchor biosynthesis, class P
chr13_+_79378733 0.01 ENSRNOT00000039221
tumor necrosis factor superfamily member 18
chr16_+_10554136 0.01 ENSRNOT00000079030
synaptotagmin 15
chr11_-_84047497 0.01 ENSRNOT00000088821
ENSRNOT00000058092
adaptor-related protein complex 2, mu 1 subunit
chr15_+_34431357 0.01 ENSRNOT00000027604
NOP9 nucleolar protein
chrX_-_142248369 0.01 ENSRNOT00000091330
fibroblast growth factor 13
chr10_+_56237755 0.01 ENSRNOT00000016163
FMR1 autosomal homolog 2
chr1_-_53087474 0.01 ENSRNOT00000017302
C-C motif chemokine receptor 6
chrM_-_14061 0.01 ENSRNOT00000051268
mitochondrially encoded NADH dehydrogenase 6
chr4_-_45332420 0.01 ENSRNOT00000083039
wingless-type MMTV integration site family member 2
chr6_-_102353403 0.01 ENSRNOT00000090407
vesicle transport through interaction with t-SNAREs 1B
chr8_+_32018560 0.01 ENSRNOT00000007358
ADAM metallopeptidase with thrombospondin type 1 motif, 8
chr14_+_19319299 0.01 ENSRNOT00000086542
ankyrin repeat domain 17
chr3_-_176706896 0.01 ENSRNOT00000017337
protein tyrosine kinase 6
chr18_+_48132414 0.01 ENSRNOT00000050631
sorting nexin 2
chr7_+_92234597 0.01 ENSRNOT00000067491
ENSRNOT00000089991
mediator complex subunit 30
chr20_+_27129291 0.01 ENSRNOT00000031053

chr9_+_93080615 0.01 ENSRNOT00000024306
proteasome 26S subunit, non-ATPase 1
chr2_-_24923128 0.01 ENSRNOT00000044087
phosphodiesterase 8B
chr1_+_221872220 0.01 ENSRNOT00000028651
neurexin 2
chr5_-_139933764 0.01 ENSRNOT00000015278
similar to ribosomal protein L10a
chr1_+_192025710 0.01 ENSRNOT00000077457
ubiquitin family domain containing 1
chr1_-_84168044 0.01 ENSRNOT00000084586
ENSRNOT00000028348
Sh3kbp1 binding protein 1
chr5_-_168004724 0.01 ENSRNOT00000024711
Parkinsonism associated deglycase
chr9_+_113699170 0.01 ENSRNOT00000017915
twisted gastrulation BMP signaling modulator 1
chr6_-_76079664 0.01 ENSRNOT00000033533
protein phosphatase 2, regulatory subunit B'', gamma
chr1_-_73753128 0.01 ENSRNOT00000068459
tweety family member 1
chr15_+_24267323 0.01 ENSRNOT00000015778
F-box protein 34
chr8_-_117797427 0.01 ENSRNOT00000033719
three prime repair exonuclease 1
chr1_-_4653210 0.01 ENSRNOT00000019121
RAB32, member RAS oncogene family
chr1_-_274106502 0.01 ENSRNOT00000020539
survival motor neuron domain containing 1
chr1_-_225014538 0.01 ENSRNOT00000026376
tetratricopeptide repeat domain 9C
chr8_-_123371257 0.01 ENSRNOT00000017243
STT3B, catalytic subunit of the oligosaccharyltransferase complex
chr7_+_10937599 0.01 ENSRNOT00000008758
sirtuin 6
chr5_+_59348639 0.01 ENSRNOT00000084031
ENSRNOT00000060264
reversion-inducing-cysteine-rich protein with kazal motifs
chrX_-_33665821 0.01 ENSRNOT00000066676
RB binding protein 7, chromatin remodeling factor
chr2_-_252359798 0.01 ENSRNOT00000021063
spermatogenesis associated 1
chr7_-_105592804 0.01 ENSRNOT00000006789
adenylate cyclase 8
chr12_-_6956914 0.01 ENSRNOT00000072129
ENSRNOT00000001210
ubiquitin specific peptidase like 1
chr2_-_192027225 0.01 ENSRNOT00000016430
proline rich 9
chr18_+_28594892 0.01 ENSRNOT00000067702
ubiquitin-conjugating enzyme E2D 2
chr6_-_76079283 0.01 ENSRNOT00000082198
protein phosphatase 2, regulatory subunit B'', gamma
chr8_-_67232298 0.01 ENSRNOT00000049441
sperm equatorial segment protein 1
chr12_-_47588335 0.00 ENSRNOT00000001595
ankyrin repeat domain 13a
chr10_-_15235740 0.00 ENSRNOT00000027170
MAPK regulated co-repressor interacting protein 2
chr3_-_12029877 0.00 ENSRNOT00000022327
solute carrier family 2 member 8
chr6_+_26517840 0.00 ENSRNOT00000031842
protein phosphatase, Mg2+/Mn2+ dependent, 1G
chr20_-_3728844 0.00 ENSRNOT00000074958
psoriasis susceptibility 1 candidate 2
chr2_+_24024791 0.00 ENSRNOT00000089599
ENSRNOT00000066302
adaptor-related protein complex 3, beta 1 subunit
chr11_+_34598492 0.00 ENSRNOT00000065600
tetratricopeptide repeat domain 3
chr12_-_39882030 0.00 ENSRNOT00000078761
ENSRNOT00000048851
protein phosphatase 1 catalytic subunit gamma
chr10_-_13075864 0.00 ENSRNOT00000005220
progestin and adipoQ receptor family member 4
chr12_+_13716596 0.00 ENSRNOT00000080216
actin, beta
chr10_-_45798715 0.00 ENSRNOT00000028948
synaptosomal-associated protein, 47
chr7_-_144960527 0.00 ENSRNOT00000086554
zinc finger protein 385A
chr1_+_63964155 0.00 ENSRNOT00000078512

chr1_-_229639187 0.00 ENSRNOT00000016804
zinc finger protein 91
chr1_+_41323194 0.00 ENSRNOT00000026350
estrogen receptor 1
chr1_-_73682247 0.00 ENSRNOT00000079498
leukocyte immunoglobulin-like receptor, subfamily A (with TM domain), member 5
chr7_-_139254551 0.00 ENSRNOT00000083182
Rap guanine nucleotide exchange factor 3
chr14_-_83062302 0.00 ENSRNOT00000086769
ENSRNOT00000085735
tyrosine 3-monooxygenase/tryptophan 5-monooxygenase activation protein, eta
chr6_-_23581052 0.00 ENSRNOT00000006190
protein phosphatase 1 catalytic subunit beta
chr10_-_89454681 0.00 ENSRNOT00000028109
BRCA1, DNA repair associated
chr10_-_109827143 0.00 ENSRNOT00000054948
myeloid-associated differentiation marker-like 2
chr16_-_6404957 0.00 ENSRNOT00000048459
calcium voltage-gated channel subunit alpha1 D
chr1_-_72461547 0.00 ENSRNOT00000022480
scavenger receptor cysteine rich family member with 5 domains
chr4_-_184096806 0.00 ENSRNOT00000055433
mKIAA1238 protein-like
chr19_+_38669230 0.00 ENSRNOT00000027273
cadherin 3
chr10_+_12980674 0.00 ENSRNOT00000004638
BICD family like cargo adaptor 2
chr5_-_145418992 0.00 ENSRNOT00000037128
gap junction protein, beta 4

Network of associatons between targets according to the STRING database.

First level regulatory network of Klf8

PNG image of the network

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Gene Ontology Analysis

Gene overrepresentation in biological process category:

Log-likelihood per target  Total log-likelihood Term Description
0.0 0.1 GO:0010424 DNA methylation on cytosine within a CG sequence(GO:0010424) phenotypic switching(GO:0036166)
0.0 0.1 GO:0030221 basophil differentiation(GO:0030221)
0.0 0.1 GO:0070863 positive regulation of protein exit from endoplasmic reticulum(GO:0070863)
0.0 0.0 GO:0001982 baroreceptor response to decreased systemic arterial blood pressure(GO:0001982) positive regulation of glycogen catabolic process(GO:0045819)

Gene overrepresentation in cellular component category:

Log-likelihood per target  Total log-likelihood Term Description
0.0 0.1 GO:0031838 haptoglobin-hemoglobin complex(GO:0031838)

Gene overrepresentation in molecular function category:

Log-likelihood per target  Total log-likelihood Term Description
0.0 0.1 GO:0031720 haptoglobin binding(GO:0031720)
0.0 0.1 GO:0046976 histone methyltransferase activity (H3-K27 specific)(GO:0046976)
0.0 0.0 GO:0004937 alpha1-adrenergic receptor activity(GO:0004937)