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GSE49485: Hypoxia transcriptome sequencing of rat brain.
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Results for Klf4_Sp3
Z-value: 2.34
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Transcription factors associated with Klf4_Sp3
Activity-expression correlation:
| Gene | Promoter | Pearson corr. coef. | P-value | Plot |
|---|---|---|---|---|
| Sp3 | rn6_v1_chr3_-_59688692_59688692 | -0.84 | 7.5e-02 | Click! |
| Klf4 | rn6_v1_chr5_-_72287669_72287669 | 0.56 | 3.3e-01 | Click! |
| Promoter | Log-likelihood | Transcript | Gene | Gene Info |
|---|---|---|---|---|
| chr19_+_20607507 Show fit | 5.52 |
ENSRNOT00000000011
|
cerebellin 1 precursor |
|
| chr7_-_70842405 Show fit | 3.64 |
ENSRNOT00000047449
|
neurexophilin 4 |
|
| chr16_-_8685529 Show fit | 3.31 |
ENSRNOT00000092751
|
solute carrier family 18 member A3 |
|
| chr1_-_78212350 Show fit | 2.99 |
ENSRNOT00000071098
|
InaF-motif containing 1 |
|
| chr1_-_216663720 Show fit | 2.70 |
ENSRNOT00000078944
ENSRNOT00000077409 |
cyclin-dependent kinase inhibitor 1C |
|
| chr7_+_120580743 Show fit | 2.64 |
ENSRNOT00000017181
|
MAF bZIP transcription factor F |
|
| chr19_+_16415636 Show fit | 2.07 |
ENSRNOT00000089975
|
iroquois homeobox 5 |
|
| chr6_+_33885495 Show fit | 2.02 |
ENSRNOT00000086633
|
syndecan 1 |
|
| chr1_+_166893734 Show fit | 1.87 |
ENSRNOT00000026702
|
paired-like homeobox 2a |
|
| chr20_-_14282873 Show fit | 1.81 |
ENSRNOT00000001759
|
adenosine A2a receptor |
Network of associatons between targets according to the STRING database.
First level regulatory network of Klf4_Sp3
Gene Ontology Analysis
Gene overrepresentation in biological process category:
| Log-likelihood per target | Total log-likelihood | Term | Description |
|---|---|---|---|
| 0.5 | 5.9 | GO:1901374 | acetate ester transport(GO:1901374) |
| 0.3 | 4.5 | GO:0021707 | cerebellar granular layer formation(GO:0021684) cerebellar granule cell differentiation(GO:0021707) |
| 0.4 | 3.9 | GO:0015671 | oxygen transport(GO:0015671) |
| 0.1 | 3.0 | GO:0031146 | SCF-dependent proteasomal ubiquitin-dependent protein catabolic process(GO:0031146) |
| 0.7 | 2.9 | GO:0051944 | positive regulation of neurotransmitter uptake(GO:0051582) positive regulation of dopamine uptake involved in synaptic transmission(GO:0051586) positive regulation of catecholamine uptake involved in synaptic transmission(GO:0051944) |
| 0.1 | 2.9 | GO:1900027 | regulation of ruffle assembly(GO:1900027) |
| 0.7 | 2.7 | GO:0000379 | tRNA-type intron splice site recognition and cleavage(GO:0000379) |
| 0.2 | 2.7 | GO:0044829 | positive regulation by host of viral genome replication(GO:0044829) |
| 0.1 | 2.6 | GO:0006749 | glutathione metabolic process(GO:0006749) |
| 0.1 | 2.5 | GO:0034723 | DNA replication-dependent nucleosome assembly(GO:0006335) DNA replication-dependent nucleosome organization(GO:0034723) |
Gene overrepresentation in cellular component category:
| Log-likelihood per target | Total log-likelihood | Term | Description |
|---|---|---|---|
| 0.0 | 49.7 | GO:0070062 | extracellular exosome(GO:0070062) |
| 0.0 | 15.5 | GO:0005576 | extracellular region(GO:0005576) |
| 0.0 | 7.4 | GO:0005743 | mitochondrial inner membrane(GO:0005743) |
| 0.0 | 6.6 | GO:0043209 | myelin sheath(GO:0043209) |
| 0.1 | 6.3 | GO:0070469 | respiratory chain(GO:0070469) |
| 0.1 | 5.6 | GO:0022626 | cytosolic ribosome(GO:0022626) |
| 0.1 | 5.3 | GO:0022627 | cytosolic small ribosomal subunit(GO:0022627) |
| 0.1 | 4.6 | GO:0000118 | histone deacetylase complex(GO:0000118) |
| 0.4 | 4.3 | GO:0030891 | VCB complex(GO:0030891) |
| 1.0 | 4.2 | GO:0030121 | AP-1 adaptor complex(GO:0030121) |
Gene overrepresentation in molecular function category:
| Log-likelihood per target | Total log-likelihood | Term | Description |
|---|---|---|---|
| 0.1 | 14.0 | GO:0003735 | structural constituent of ribosome(GO:0003735) |
| 0.0 | 6.4 | GO:0005525 | GTP binding(GO:0005525) |
| 0.1 | 5.0 | GO:0005179 | hormone activity(GO:0005179) |
| 0.1 | 3.9 | GO:0004129 | cytochrome-c oxidase activity(GO:0004129) heme-copper terminal oxidase activity(GO:0015002) oxidoreductase activity, acting on a heme group of donors, oxygen as acceptor(GO:0016676) |
| 0.0 | 3.6 | GO:0008236 | serine-type peptidase activity(GO:0008236) |
| 0.2 | 3.5 | GO:0004861 | cyclin-dependent protein serine/threonine kinase inhibitor activity(GO:0004861) |
| 1.1 | 3.3 | GO:0005277 | acetylcholine transmembrane transporter activity(GO:0005277) acetate ester transmembrane transporter activity(GO:1901375) |
| 0.1 | 3.3 | GO:0008157 | protein phosphatase 1 binding(GO:0008157) |
| 0.0 | 3.3 | GO:0004867 | serine-type endopeptidase inhibitor activity(GO:0004867) |
| 0.1 | 3.0 | GO:0043014 | alpha-tubulin binding(GO:0043014) |
Gene overrepresentation in curated gene sets: canonical pathways category:
| Log-likelihood per target | Total log-likelihood | Term | Description |
|---|---|---|---|
| 0.0 | 12.8 | NABA SECRETED FACTORS | Genes encoding secreted soluble factors |
| 0.1 | 5.5 | PID HDAC CLASSI PATHWAY | Signaling events mediated by HDAC Class I |
| 0.1 | 4.3 | PID HIF2PATHWAY | HIF-2-alpha transcription factor network |
| 0.1 | 4.3 | PID HIF1 TFPATHWAY | HIF-1-alpha transcription factor network |
| 0.0 | 4.0 | NABA ECM GLYCOPROTEINS | Genes encoding structural ECM glycoproteins |
| 0.1 | 3.6 | PID INSULIN GLUCOSE PATHWAY | Insulin-mediated glucose transport |
| 0.1 | 3.1 | PID HNF3B PATHWAY | FOXA2 and FOXA3 transcription factor networks |
| 0.0 | 3.0 | NABA ECM REGULATORS | Genes encoding enzymes and their regulators involved in the remodeling of the extracellular matrix |
| 0.1 | 2.3 | PID SYNDECAN 4 PATHWAY | Syndecan-4-mediated signaling events |
| 0.1 | 2.2 | PID FRA PATHWAY | Validated transcriptional targets of AP1 family members Fra1 and Fra2 |
Gene overrepresentation in curated gene sets: REACTOME pathways category:
| Log-likelihood per target | Total log-likelihood | Term | Description |
|---|---|---|---|
| 0.1 | 8.4 | REACTOME INFLUENZA VIRAL RNA TRANSCRIPTION AND REPLICATION | Genes involved in Influenza Viral RNA Transcription and Replication |
| 0.1 | 6.6 | REACTOME RESPIRATORY ELECTRON TRANSPORT ATP SYNTHESIS BY CHEMIOSMOTIC COUPLING AND HEAT PRODUCTION BY UNCOUPLING PROTEINS | Genes involved in Respiratory electron transport, ATP synthesis by chemiosmotic coupling, and heat production by uncoupling proteins. |
| 0.0 | 5.7 | REACTOME METABOLISM OF AMINO ACIDS AND DERIVATIVES | Genes involved in Metabolism of amino acids and derivatives |
| 0.0 | 5.3 | REACTOME PEPTIDE LIGAND BINDING RECEPTORS | Genes involved in Peptide ligand-binding receptors |
| 0.1 | 4.9 | REACTOME REGULATION OF ORNITHINE DECARBOXYLASE ODC | Genes involved in Regulation of ornithine decarboxylase (ODC) |
| 0.1 | 4.4 | REACTOME RESPONSE TO ELEVATED PLATELET CYTOSOLIC CA2 | Genes involved in Response to elevated platelet cytosolic Ca2+ |
| 0.2 | 3.6 | REACTOME POST CHAPERONIN TUBULIN FOLDING PATHWAY | Genes involved in Post-chaperonin tubulin folding pathway |
| 0.2 | 3.5 | REACTOME CHYLOMICRON MEDIATED LIPID TRANSPORT | Genes involved in Chylomicron-mediated lipid transport |
| 0.1 | 3.3 | REACTOME TIGHT JUNCTION INTERACTIONS | Genes involved in Tight junction interactions |
| 0.1 | 3.2 | REACTOME GLUCONEOGENESIS | Genes involved in Gluconeogenesis |