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GSE49485: Hypoxia transcriptome sequencing of rat brain.
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Results for Klf1
Z-value: 0.57
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Transcription factors associated with Klf1
Activity-expression correlation:
| Gene | Promoter | Pearson corr. coef. | P-value | Plot |
|---|---|---|---|---|
| Klf1 | rn6_v1_chr19_+_26016382_26016382 | 0.62 | 2.7e-01 | Click! |
| Promoter | Log-likelihood | Transcript | Gene | Gene Info |
|---|---|---|---|---|
| chr2_-_77632628 Show fit | 0.37 |
ENSRNOT00000073915
|
brain abundant, membrane attached signal protein 1 |
|
| chr1_+_168964202 Show fit | 0.36 |
ENSRNOT00000089102
|
hemoglobin subunit beta-2-like |
|
| chr10_-_15590220 Show fit | 0.36 |
ENSRNOT00000048977
|
hemoglobin alpha, adult chain 2 |
|
| chr10_-_56962161 Show fit | 0.32 |
ENSRNOT00000026038
|
arachidonate 15-lipoxygenase |
|
| chr9_+_82647071 Show fit | 0.31 |
ENSRNOT00000027135
|
acid sensing ion channel subunit family member 4 |
|
| chr10_-_15577977 Show fit | 0.29 |
ENSRNOT00000052292
|
hemoglobin alpha, adult chain 3 |
|
| chr1_+_168945449 Show fit | 0.29 |
ENSRNOT00000087661
ENSRNOT00000019913 |
hemoglobin subunit beta-2-like |
|
| chr4_-_100883038 Show fit | 0.28 |
ENSRNOT00000041880
|
thymosin, beta 10-like |
|
| chr4_-_100883275 Show fit | 0.25 |
ENSRNOT00000022846
|
thymosin, beta 10-like |
|
| chr1_+_198690794 Show fit | 0.25 |
ENSRNOT00000023999
|
zinc finger protein 771 |
Network of associatons between targets according to the STRING database.
First level regulatory network of Klf1
Gene Ontology Analysis
Gene overrepresentation in biological process category:
| Log-likelihood per target | Total log-likelihood | Term | Description |
|---|---|---|---|
| 0.2 | 1.8 | GO:0015671 | oxygen transport(GO:0015671) |
| 0.0 | 0.5 | GO:0061318 | renal filtration cell differentiation(GO:0061318) glomerular visceral epithelial cell differentiation(GO:0072112) glomerular epithelial cell differentiation(GO:0072311) |
| 0.1 | 0.3 | GO:0051121 | hepoxilin metabolic process(GO:0051121) hepoxilin biosynthetic process(GO:0051122) |
| 0.0 | 0.3 | GO:0006527 | arginine catabolic process(GO:0006527) |
| 0.1 | 0.2 | GO:1901662 | phylloquinone metabolic process(GO:0042374) phylloquinone catabolic process(GO:0042376) quinone catabolic process(GO:1901662) |
| 0.1 | 0.2 | GO:0070366 | regulation of hepatocyte differentiation(GO:0070366) |
| 0.0 | 0.2 | GO:0070093 | negative regulation of glucagon secretion(GO:0070093) |
| 0.0 | 0.2 | GO:2000814 | positive regulation of barbed-end actin filament capping(GO:2000814) |
| 0.0 | 0.2 | GO:1902896 | terminal web assembly(GO:1902896) |
| 0.0 | 0.2 | GO:1903575 | cornified envelope assembly(GO:1903575) |
Gene overrepresentation in cellular component category:
| Log-likelihood per target | Total log-likelihood | Term | Description |
|---|---|---|---|
| 0.2 | 1.8 | GO:0005833 | hemoglobin complex(GO:0005833) |
| 0.0 | 0.6 | GO:0008180 | COP9 signalosome(GO:0008180) |
| 0.0 | 0.2 | GO:0036398 | TCR signalosome(GO:0036398) microspike(GO:0044393) |
| 0.0 | 0.2 | GO:0034663 | endoplasmic reticulum chaperone complex(GO:0034663) |
| 0.0 | 0.2 | GO:0042612 | MHC class I protein complex(GO:0042612) |
| 0.0 | 0.1 | GO:0032398 | MHC class Ib protein complex(GO:0032398) |
| 0.0 | 0.1 | GO:1990907 | beta-catenin-TCF complex(GO:1990907) |
| 0.0 | 0.1 | GO:0031510 | SUMO activating enzyme complex(GO:0031510) |
| 0.0 | 0.1 | GO:0042571 | immunoglobulin complex, circulating(GO:0042571) |
| 0.0 | 0.1 | GO:0044301 | climbing fiber(GO:0044301) |
Gene overrepresentation in molecular function category:
| Log-likelihood per target | Total log-likelihood | Term | Description |
|---|---|---|---|
| 0.1 | 1.2 | GO:0005344 | oxygen transporter activity(GO:0005344) |
| 0.2 | 0.6 | GO:0031720 | haptoglobin binding(GO:0031720) |
| 0.1 | 0.3 | GO:0004052 | arachidonate 12-lipoxygenase activity(GO:0004052) |
| 0.1 | 0.3 | GO:0016403 | dimethylargininase activity(GO:0016403) |
| 0.0 | 0.3 | GO:0004865 | protein serine/threonine phosphatase inhibitor activity(GO:0004865) |
| 0.0 | 0.3 | GO:0044548 | S100 protein binding(GO:0044548) |
| 0.1 | 0.2 | GO:0031780 | corticotropin hormone receptor binding(GO:0031780) type 5 melanocortin receptor binding(GO:0031783) |
| 0.0 | 0.2 | GO:0031802 | type 5 metabotropic glutamate receptor binding(GO:0031802) |
| 0.0 | 0.2 | GO:0004090 | carbonyl reductase (NADPH) activity(GO:0004090) |
| 0.0 | 0.2 | GO:0004111 | creatine kinase activity(GO:0004111) |
Gene overrepresentation in curated gene sets: canonical pathways category:
| Log-likelihood per target | Total log-likelihood | Term | Description |
|---|---|---|---|
| 0.0 | 0.2 | ST INTERFERON GAMMA PATHWAY | Interferon gamma pathway. |
| 0.0 | 0.2 | PID P38 GAMMA DELTA PATHWAY | Signaling mediated by p38-gamma and p38-delta |
| 0.0 | 0.1 | ST IL 13 PATHWAY | Interleukin 13 (IL-13) Pathway |
Gene overrepresentation in curated gene sets: REACTOME pathways category:
| Log-likelihood per target | Total log-likelihood | Term | Description |
|---|---|---|---|
| 0.0 | 0.4 | REACTOME POST CHAPERONIN TUBULIN FOLDING PATHWAY | Genes involved in Post-chaperonin tubulin folding pathway |
| 0.0 | 0.2 | REACTOME SYNTHESIS SECRETION AND DEACYLATION OF GHRELIN | Genes involved in Synthesis, Secretion, and Deacylation of Ghrelin |
| 0.0 | 0.1 | REACTOME ENDOSOMAL VACUOLAR PATHWAY | Genes involved in Endosomal/Vacuolar pathway |
| 0.0 | 0.1 | REACTOME OPSINS | Genes involved in Opsins |
| 0.0 | 0.1 | REACTOME MEMBRANE BINDING AND TARGETTING OF GAG PROTEINS | Genes involved in Membrane binding and targetting of GAG proteins |
| 0.0 | 0.1 | REACTOME OLFACTORY SIGNALING PATHWAY | Genes involved in Olfactory Signaling Pathway |
| 0.0 | 0.0 | REACTOME FRS2 MEDIATED CASCADE | Genes involved in FRS2-mediated cascade |