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GSE49485: Hypoxia transcriptome sequencing of rat brain.

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Results for Klf1

Z-value: 0.57

Motif logo

Transcription factors associated with Klf1

Gene Symbol Gene ID Gene Info
ENSRNOG00000003443 Kruppel like factor 1

Activity-expression correlation:

GenePromoterPearson corr. coef.P-valuePlot
Klf1rn6_v1_chr19_+_26016382_260163820.622.7e-01Click!

Activity profile of Klf1 motif

Sorted Z-values of Klf1 motif

Promoter Log-likelihood Transcript Gene Gene Info
chr2_-_77632628 0.37 ENSRNOT00000073915
brain abundant, membrane attached signal protein 1
chr1_+_168964202 0.36 ENSRNOT00000089102
hemoglobin subunit beta-2-like
chr10_-_15590220 0.36 ENSRNOT00000048977
hemoglobin alpha, adult chain 2
chr10_-_56962161 0.32 ENSRNOT00000026038
arachidonate 15-lipoxygenase
chr9_+_82647071 0.31 ENSRNOT00000027135
acid sensing ion channel subunit family member 4
chr10_-_15577977 0.29 ENSRNOT00000052292
hemoglobin alpha, adult chain 3
chr1_+_168945449 0.29 ENSRNOT00000087661
ENSRNOT00000019913
hemoglobin subunit beta-2-like
chr4_-_100883038 0.28 ENSRNOT00000041880
thymosin, beta 10-like
chr4_-_100883275 0.25 ENSRNOT00000022846
thymosin, beta 10-like
chr1_+_198690794 0.25 ENSRNOT00000023999
zinc finger protein 771
chr1_+_168957460 0.25 ENSRNOT00000090745
hemoglobin subunit beta-2
chr1_-_78212350 0.24 ENSRNOT00000071098
InaF-motif containing 1
chr1_-_168972725 0.23 ENSRNOT00000090422
hemoglobin subunit beta
chr10_-_40375605 0.22 ENSRNOT00000014464
annexin A6
chr17_-_9695292 0.21 ENSRNOT00000036162
proline rich 7 (synaptic)
chr11_+_30904733 0.21 ENSRNOT00000036027
melanocortin 2 receptor accessory protein
chr6_+_135856218 0.19 ENSRNOT00000066715
similar to novel protein
chr3_+_154395187 0.18 ENSRNOT00000050810
V-set and transmembrane domain containing 2 like
chr2_-_30127269 0.17 ENSRNOT00000023869
CART prepropeptide
chr1_-_47331412 0.17 ENSRNOT00000046746
ezrin
chr6_-_1942972 0.16 ENSRNOT00000048711
CDC42 effector protein 3
chr5_-_136762986 0.15 ENSRNOT00000026852
artemin
chr12_-_30304036 0.15 ENSRNOT00000001218
nuclear protein 2, transcriptional regulator
chr1_+_80321585 0.15 ENSRNOT00000022895
creatine kinase, M-type
chr20_-_5618254 0.15 ENSRNOT00000092326
ENSRNOT00000000576
BCL2-antagonist/killer 1
chr3_+_11679530 0.15 ENSRNOT00000074562
ENSRNOT00000071801
endoglin
chr10_+_86950557 0.15 ENSRNOT00000014153
insulin-like growth factor binding protein 4
chr20_+_5050327 0.15 ENSRNOT00000083353
dimethylarginine dimethylaminohydrolase 2
chr5_+_157282669 0.14 ENSRNOT00000022827
phospholipase A2 group IIA
chr12_+_22641104 0.14 ENSRNOT00000001916
serpin family E member 1
chr1_-_82610350 0.14 ENSRNOT00000028177
cytochrome P450, family 2, subfamily s, polypeptide 1
chr5_-_72287669 0.14 ENSRNOT00000022255
Kruppel like factor 4
chr5_+_151413382 0.14 ENSRNOT00000012626
CD164 molecule like 2
chr8_+_44847157 0.13 ENSRNOT00000080288
CXADR-like membrane protein
chr18_+_32594958 0.13 ENSRNOT00000018511
sprouty RTK signaling antagonist 4
chr5_-_173222440 0.13 ENSRNOT00000024897
von Willebrand factor A domain containing 1
chr1_+_81230612 0.12 ENSRNOT00000026489
potassium calcium-activated channel subfamily N member 4
chr19_+_56220755 0.12 ENSRNOT00000023452
tubulin, beta 3 class III
chr5_-_152324469 0.12 ENSRNOT00000020688
CD52 molecule
chr6_+_8886591 0.12 ENSRNOT00000091510
ENSRNOT00000089174
SIX homeobox 3
chr3_+_66673246 0.12 ENSRNOT00000081338
protein phosphatase 1, regulatory (inhibitor) subunit 1C
chr1_-_198559568 0.12 ENSRNOT00000023080
quinolinate phosphoribosyltransferase
chr8_+_127144903 0.12 ENSRNOT00000013530
eomesodermin
chr3_-_72289310 0.12 ENSRNOT00000038250
reticulon 4 receptor-like 2
chr2_+_206064394 0.12 ENSRNOT00000077739
synaptotagmin 6
chr3_-_177201525 0.12 ENSRNOT00000022451
regulator of G-protein signaling 19
chr16_-_14300951 0.12 ENSRNOT00000017038
retinal G protein coupled receptor
chr4_-_157439507 0.12 ENSRNOT00000081802
parathymosin
chr10_-_91047177 0.12 ENSRNOT00000003986
complement C1q like 1
chr12_+_24651314 0.11 ENSRNOT00000077016
ENSRNOT00000071569
VPS37D, ESCRT-I subunit
chr2_-_202816562 0.11 ENSRNOT00000020401
family with sequence similarity 46, member C
chr1_+_242572533 0.11 ENSRNOT00000035123
transmembrane protein 252
chr1_-_164307084 0.11 ENSRNOT00000086091
serpin family H member 1
chr4_-_28702559 0.11 ENSRNOT00000013910
ENSRNOT00000013937
calcitonin receptor
chr20_+_5049496 0.11 ENSRNOT00000088251
ENSRNOT00000001118
dimethylarginine dimethylaminohydrolase 2
chr17_+_9653561 0.11 ENSRNOT00000018899
PDZ and LIM domain 7
chr14_-_37770059 0.11 ENSRNOT00000029721
solute carrier family 10, member 4
chr3_-_67668772 0.11 ENSRNOT00000010247
frizzled-related protein
chr13_-_80738634 0.11 ENSRNOT00000081551
flavin containing monooxygenase 1
chr4_+_171250818 0.11 ENSRNOT00000040576
protein tyrosine phosphatase, receptor type, O
chr20_+_5040337 0.10 ENSRNOT00000068435
chloride intracellular channel 1
chr7_+_12974169 0.10 ENSRNOT00000010555
C2 calcium-dependent domain containing 4C
chr1_+_83003841 0.10 ENSRNOT00000057384
carcinoembryonic antigen-related cell adhesion molecule 4
chr11_+_88122271 0.10 ENSRNOT00000002540
stromal cell-derived factor 2-like 1
chr19_+_23389375 0.10 ENSRNOT00000018629
spalt-like transcription factor 1
chr5_+_147714163 0.10 ENSRNOT00000012663
MARCKS-like 1
chr3_-_172537877 0.10 ENSRNOT00000072069
cathepsin Z
chr6_+_29977797 0.10 ENSRNOT00000071784
FK506 binding protein 1B
chr1_+_89215266 0.10 ENSRNOT00000093612
ENSRNOT00000084799
dermokine
chr1_-_101360971 0.10 ENSRNOT00000028164
lin-7 homolog B, crumbs cell polarity complex component
chr1_-_84812486 0.10 ENSRNOT00000078369

chr13_+_110743098 0.10 ENSRNOT00000075086
retinal degeneration 3
chr14_-_82055290 0.10 ENSRNOT00000058062
RGD1560394
chr4_-_14490446 0.10 ENSRNOT00000009132
semaphorin 3C
chr13_-_32427177 0.10 ENSRNOT00000044628
cadherin 19
chr11_+_87549059 0.10 ENSRNOT00000002567
coiled-coil domain containing 74A
chr6_-_46631983 0.10 ENSRNOT00000045963
SRY box 11
chr1_-_89369960 0.09 ENSRNOT00000028545
hepcidin antimicrobial peptide
chr17_+_31441630 0.09 ENSRNOT00000083705
ENSRNOT00000023582
tubulin, beta 2B class IIb
chr9_+_81518584 0.09 ENSRNOT00000084309
actin related protein 2/3 complex, subunit 2
chr1_+_267607416 0.09 ENSRNOT00000087894
ENSRNOT00000076367
ENSRNOT00000016851
glutathione S-transferase omega 2
glutathione S-transferase omega 1
chr19_+_37235001 0.09 ENSRNOT00000020908
nucleolar protein 3
chr3_+_81294275 0.09 ENSRNOT00000009068
similar to RIKEN cDNA 1700029I15
chrX_-_106558366 0.09 ENSRNOT00000042126
brain expressed X-linked 2
chr7_+_142912316 0.09 ENSRNOT00000010171
nuclear receptor subfamily 4, group A, member 1
chr15_+_37790141 0.09 ENSRNOT00000076392
ENSRNOT00000091953
interleukin 17D
chr10_-_14022452 0.09 ENSRNOT00000016554
neuropeptide W
chr20_+_8165307 0.09 ENSRNOT00000000637
Pim-1 proto-oncogene, serine/threonine kinase
chr2_-_195908037 0.09 ENSRNOT00000079776
tuftelin 1
chr1_-_265506046 0.09 ENSRNOT00000023963
nucleophosmin/nucleoplasmin, 3
chr15_-_33193537 0.09 ENSRNOT00000016401
HAUS augmin-like complex, subunit 4
chr1_-_101883744 0.09 ENSRNOT00000028635
synaptogyrin 4
chr7_+_139762614 0.09 ENSRNOT00000031157
coiled-coil domain containing 184
chr7_-_121232741 0.09 ENSRNOT00000023196
platelet derived growth factor subunit B
chr20_+_3178250 0.09 ENSRNOT00000082116
RT1 class Ib, locus S3
chr4_-_114853868 0.09 ENSRNOT00000090828
WD repeat domain 54
chr3_+_147226004 0.09 ENSRNOT00000012765
transmembrane protein 74B
chr1_+_88182585 0.08 ENSRNOT00000044145
Yip1 interacting factor homolog B, membrane trafficking protein
chr1_-_101175570 0.08 ENSRNOT00000073918
golgi-associated, olfactory signaling regulator
chr11_+_33845463 0.08 ENSRNOT00000041838
carbonyl reductase 1
chr3_-_123702732 0.08 ENSRNOT00000028859
similar to RIKEN cDNA 1700037H04
chr1_-_261446570 0.08 ENSRNOT00000020182
secreted frizzled-related protein 5
chr12_-_6703979 0.08 ENSRNOT00000061246
testis expressed 26
chr20_-_14620019 0.08 ENSRNOT00000001779
G protein subunit alpha z
chr10_+_48903540 0.08 ENSRNOT00000004248
transient receptor potential cation channel, subfamily V, member 2
chr1_-_216663720 0.08 ENSRNOT00000078944
ENSRNOT00000077409
cyclin-dependent kinase inhibitor 1C
chr1_+_140602542 0.08 ENSRNOT00000085570
interferon stimulated exonuclease gene 20
chr8_-_13606040 0.08 ENSRNOT00000013577
ENSRNOT00000083395
Pannexin 1
chr4_+_168832910 0.08 ENSRNOT00000011134
G protein-coupled receptor, class C, group 5, member A
chr11_+_33812989 0.08 ENSRNOT00000042283
ENSRNOT00000075985
carbonyl reductase 1
chr1_+_282134981 0.08 ENSRNOT00000036203
nanos C2HC-type zinc finger 1
chr10_-_105668593 0.08 ENSRNOT00000016622
ST6 N-acetylgalactosaminide alpha-2,6-sialyltransferase 2
chr4_+_114854458 0.08 ENSRNOT00000013312
hypothetical gene supported by BC079424
chr1_+_276659542 0.08 ENSRNOT00000019681
transcription factor 7 like 2
chr2_+_22909569 0.08 ENSRNOT00000073871
homer scaffolding protein 1
chr1_-_89473904 0.08 ENSRNOT00000089474
FXYD domain-containing ion transport regulator 5
chr14_+_10692764 0.08 ENSRNOT00000003012
uncharacterized LOC100910270
chr13_-_112005052 0.08 ENSRNOT00000007879
G0/G1switch 2
chr12_-_19599374 0.08 ENSRNOT00000001849
glypican 2
chr13_-_52197205 0.08 ENSRNOT00000009712
shisa family member 4
chr6_+_132246602 0.08 ENSRNOT00000009896
cytochrome P450, family 46, subfamily a, polypeptide 1
chr6_-_135939534 0.08 ENSRNOT00000052237
DIRAS family GTPase 3
chr2_+_211176556 0.08 ENSRNOT00000055880
proline and serine rich coiled-coil 1
chr10_-_108473377 0.08 ENSRNOT00000070934
N-sulfoglucosamine sulfohydrolase
chr1_-_78333321 0.08 ENSRNOT00000020402
SUMO1 activating enzyme subunit 1
chr17_+_15814132 0.08 ENSRNOT00000032997
sushi domain containing 3
chr5_+_147476221 0.08 ENSRNOT00000010730
syncoilin, intermediate filament protein
chr10_+_7041510 0.08 ENSRNOT00000003514
calcium regulated heat stable protein 1
chr9_-_94250809 0.08 ENSRNOT00000026387
endothelin converting enzyme-like 1
chr14_-_107617161 0.08 ENSRNOT00000012286
UDP-GlcNAc:betaGal beta-1,3-N-acetylglucosaminyltransferase 2
chr2_+_189922996 0.08 ENSRNOT00000016499
S100 calcium binding protein A16
chr12_+_47074200 0.08 ENSRNOT00000014910
dynein light chain LC8-type 1
chr1_+_192613372 0.08 ENSRNOT00000016632
calcium voltage-gated channel auxiliary subunit gamma 3
chr20_-_29511382 0.07 ENSRNOT00000085026
DNA-damage-inducible transcript 4
chrX_+_68782872 0.07 ENSRNOT00000075995
StAR-related lipid transfer domain containing 8
chr20_-_14282873 0.07 ENSRNOT00000001759
adenosine A2a receptor
chr8_+_75687100 0.07 ENSRNOT00000038677
annexin A2
chr8_+_99977334 0.07 ENSRNOT00000085808
ENSRNOT00000056704
ENSRNOT00000041859
procollagen lysine, 2-oxoglutarate 5-dioxygenase 2
chr5_+_140923914 0.07 ENSRNOT00000020929
hes-related family bHLH transcription factor with YRPW motif-like
chr6_+_137164535 0.07 ENSRNOT00000018225
inverted formin, FH2 and WH2 domain containing
chr1_-_88111293 0.07 ENSRNOT00000077195
sprouty-related, EVH1 domain containing 3
chr5_-_152358643 0.07 ENSRNOT00000021734
SH3 domain binding glutamate-rich protein like 3
chr13_-_91228901 0.07 ENSRNOT00000071728
ENSRNOT00000073643
ENSRNOT00000071897
low affinity immunoglobulin gamma Fc region receptor III-like
chr1_-_226501920 0.07 ENSRNOT00000050716
leucine rich repeat containing 10B
chr12_+_2534212 0.07 ENSRNOT00000001399
cortexin 1
chr7_-_145154131 0.07 ENSRNOT00000055271
protein phosphatase 1, regulatory (inhibitor) subunit 1A
chr7_-_124367630 0.07 ENSRNOT00000055978
tubulin tyrosine ligase like 1
chr10_-_89374516 0.07 ENSRNOT00000028084
vesicle amine transport 1
chr10_-_50402616 0.07 ENSRNOT00000004546
heparan sulfate-glucosamine 3-sulfotransferase 3B1
chr4_-_170763916 0.07 ENSRNOT00000071512
histone cluster 1, H4m
chr8_-_70436028 0.07 ENSRNOT00000077152
solute carrier family 24 member 1
chr3_-_10226286 0.07 ENSRNOT00000093627
far upstream element binding protein 3
chr1_-_214252456 0.07 ENSRNOT00000023504
interferon regulatory factor 7
chr16_-_71809925 0.07 ENSRNOT00000022425
TM2 domain containing 2
chr9_-_43127887 0.07 ENSRNOT00000021685
ankyrin repeat domain 39
chr1_+_85213652 0.07 ENSRNOT00000092044
non-specific cytotoxic cell receptor protein 1 homolog (zebrafish)
chr19_-_6293 0.07 ENSRNOT00000074240
similar to carboxylesterase 2 (intestine, liver)
chr11_+_31428358 0.07 ENSRNOT00000002827
oligodendrocyte transcription factor 1
chr1_+_81208212 0.07 ENSRNOT00000026288
Ly6/Plaur domain containing 5
chr1_-_88686615 0.07 ENSRNOT00000070921
tubulin folding cofactor B
chr3_+_66673071 0.07 ENSRNOT00000034769
protein phosphatase 1, regulatory (inhibitor) subunit 1C
chr3_+_110466790 0.07 ENSRNOT00000089434
p21 (RAC1) activated kinase 6
chr7_-_70348780 0.07 ENSRNOT00000072468
membrane associated ring-CH-type finger 9
chr5_+_152681101 0.07 ENSRNOT00000076052
ENSRNOT00000022574
stathmin 1
chrX_+_15273933 0.07 ENSRNOT00000075082
erythroid transcription factor
chr4_+_55715744 0.07 ENSRNOT00000010429
ADP-ribosylation factor 5
chr17_+_76002275 0.07 ENSRNOT00000092665
ENSRNOT00000086701
enoyl CoA hydratase domain containing 3
chr3_-_170955399 0.07 ENSRNOT00000084990
bone morphogenetic protein 7
chr20_-_4921348 0.07 ENSRNOT00000082497
ENSRNOT00000041151
RT1 class I, locus CE4
chrX_+_65226748 0.07 ENSRNOT00000076181
moesin
chr7_-_18683440 0.07 ENSRNOT00000068323
ribosomal protein S28
chr20_+_5351605 0.07 ENSRNOT00000089306
ENSRNOT00000041590
ENSRNOT00000081240
ENSRNOT00000082538
RT1 class Ia, locus A1
chr10_-_56531483 0.07 ENSRNOT00000022343
eukaryotic translation initiation factor 5A
chr3_-_176144531 0.07 ENSRNOT00000082266
transcription factor like 5
chr10_-_40381886 0.07 ENSRNOT00000050213
nuclease-sensitive element-binding protein 1-like
chr9_-_88357182 0.06 ENSRNOT00000041176
collagen type IV alpha 4 chain
chr10_-_56429748 0.06 ENSRNOT00000020675
ENSRNOT00000092704
spermatid maturation 1
chr7_-_114380613 0.06 ENSRNOT00000011898
argonaute 2, RISC catalytic component
chr6_-_43862131 0.06 ENSRNOT00000089859
cystin 1
chr12_+_17736287 0.06 ENSRNOT00000091476
platelet derived growth factor subunit A
chr10_+_12994683 0.06 ENSRNOT00000004702
host cell factor C1 regulator 1
chr11_+_32211115 0.06 ENSRNOT00000087452
mitochondrial ribosomal protein S6
chr13_+_75111778 0.06 ENSRNOT00000006924
tumor protein p53 inducible protein 3
chr3_+_151285249 0.06 ENSRNOT00000055254
protein C receptor
chr15_+_50891127 0.06 ENSRNOT00000020728
stanniocalcin 1
chr1_+_196942364 0.06 ENSRNOT00000088073
ENSRNOT00000020994
interleukin 4 receptor
chr10_+_85744568 0.06 ENSRNOT00000005522
LIM and SH3 protein 1
chr13_+_85818427 0.06 ENSRNOT00000077227
ENSRNOT00000006117
retinoid X receptor gamma
chr16_-_36161089 0.06 ENSRNOT00000017888
stimulator of chondrogenesis 1
chr3_+_152752091 0.06 ENSRNOT00000037177
DLG associated protein 4
chr13_-_50499060 0.06 ENSRNOT00000065347
ENSRNOT00000076924
ethanolamine kinase 2
chr1_-_142759882 0.06 ENSRNOT00000015218
SEC11 homolog A, signal peptidase complex subunit
chr7_+_11077411 0.06 ENSRNOT00000007117
sphingosine-1-phosphate receptor 4
chr10_-_108196217 0.06 ENSRNOT00000075440
chromobox 4
chr5_-_58113553 0.06 ENSRNOT00000046589
AT-rich interaction domain 3C
chr5_-_155916893 0.06 ENSRNOT00000055947
low density lipoprotein receptor class A domain containing 2
chr14_+_86922223 0.06 ENSRNOT00000086468
receptor activity modifying protein 3
chrX_-_68562301 0.06 ENSRNOT00000076720
oligophrenin 1
chr11_-_61530567 0.06 ENSRNOT00000076277
N(alpha)-acetyltransferase 50, NatE catalytic subunit
chr5_-_153924896 0.06 ENSRNOT00000065247
grainyhead-like transcription factor 3

Network of associatons between targets according to the STRING database.

First level regulatory network of Klf1

PNG image of the network

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Gene Ontology Analysis

Gene overrepresentation in biological process category:

Log-likelihood per target  Total log-likelihood Term Description
0.2 1.8 GO:0015671 oxygen transport(GO:0015671)
0.1 0.3 GO:0051121 hepoxilin metabolic process(GO:0051121) hepoxilin biosynthetic process(GO:0051122)
0.1 0.2 GO:1901662 phylloquinone metabolic process(GO:0042374) phylloquinone catabolic process(GO:0042376) quinone catabolic process(GO:1901662)
0.1 0.2 GO:0070366 regulation of hepatocyte differentiation(GO:0070366)
0.0 0.1 GO:1905072 cardiac jelly development(GO:1905072)
0.0 0.1 GO:1904638 response to resveratrol(GO:1904638)
0.0 0.2 GO:0070093 negative regulation of glucagon secretion(GO:0070093)
0.0 0.1 GO:2000342 negative regulation of chemokine (C-X-C motif) ligand 2 production(GO:2000342)
0.0 0.2 GO:2000814 positive regulation of barbed-end actin filament capping(GO:2000814)
0.0 0.2 GO:1902896 terminal web assembly(GO:1902896)
0.0 0.0 GO:0021539 subthalamus development(GO:0021539)
0.0 0.1 GO:0014016 neuroblast differentiation(GO:0014016)
0.0 0.1 GO:0060478 acrosomal vesicle exocytosis(GO:0060478)
0.0 0.1 GO:0045819 positive regulation of glycogen catabolic process(GO:0045819)
0.0 0.2 GO:1903575 cornified envelope assembly(GO:1903575)
0.0 0.2 GO:0010512 negative regulation of phosphatidylinositol biosynthetic process(GO:0010512)
0.0 0.0 GO:0097214 regulation of lysosomal membrane permeability(GO:0097213) positive regulation of lysosomal membrane permeability(GO:0097214)
0.0 0.1 GO:2000384 regulation of ectoderm development(GO:2000383) negative regulation of ectoderm development(GO:2000384)
0.0 0.1 GO:0090194 negative regulation of glomerular mesangial cell proliferation(GO:0072125) negative regulation of glomerulus development(GO:0090194)
0.0 0.1 GO:0003350 pulmonary myocardium development(GO:0003350)
0.0 0.1 GO:0003357 noradrenergic neuron differentiation(GO:0003357)
0.0 0.1 GO:0014736 negative regulation of muscle atrophy(GO:0014736)
0.0 0.1 GO:0061146 Peyer's patch morphogenesis(GO:0061146)
0.0 0.1 GO:0032639 TRAIL production(GO:0032639) regulation of TRAIL production(GO:0032679) positive regulation of TRAIL production(GO:0032759)
0.0 0.2 GO:0048597 B cell selection(GO:0002339) post-embryonic camera-type eye morphogenesis(GO:0048597)
0.0 0.2 GO:0060315 negative regulation of ryanodine-sensitive calcium-release channel activity(GO:0060315)
0.0 0.1 GO:0044333 Wnt signaling pathway involved in digestive tract morphogenesis(GO:0044333) regulation of planar cell polarity pathway involved in axis elongation(GO:2000040) negative regulation of planar cell polarity pathway involved in axis elongation(GO:2000041)
0.0 0.1 GO:0000738 DNA catabolic process, exonucleolytic(GO:0000738)
0.0 0.1 GO:0098749 cerebellar neuron development(GO:0098749)
0.0 0.1 GO:0010908 regulation of heparan sulfate proteoglycan biosynthetic process(GO:0010908) positive regulation of heparan sulfate proteoglycan biosynthetic process(GO:0010909) embryonic hindgut morphogenesis(GO:0048619)
0.0 0.1 GO:0070494 regulation of thrombin receptor signaling pathway(GO:0070494) negative regulation of thrombin receptor signaling pathway(GO:0070495)
0.0 0.1 GO:0030200 heparan sulfate proteoglycan catabolic process(GO:0030200)
0.0 0.1 GO:2000645 negative regulation of receptor catabolic process(GO:2000645)
0.0 0.1 GO:0046946 hydroxylysine metabolic process(GO:0046946) hydroxylysine biosynthetic process(GO:0046947)
0.0 0.1 GO:0034756 regulation of iron ion transport(GO:0034756) regulation of iron ion transmembrane transport(GO:0034759)
0.0 0.3 GO:0006527 arginine catabolic process(GO:0006527)
0.0 0.1 GO:0061743 motor learning(GO:0061743)
0.0 0.0 GO:0030167 proteoglycan catabolic process(GO:0030167)
0.0 0.1 GO:0030221 basophil differentiation(GO:0030221)
0.0 0.1 GO:0002462 tolerance induction to nonself antigen(GO:0002462)
0.0 0.0 GO:2000049 positive regulation of cell-cell adhesion mediated by cadherin(GO:2000049)
0.0 0.5 GO:0061318 renal filtration cell differentiation(GO:0061318) glomerular visceral epithelial cell differentiation(GO:0072112) glomerular epithelial cell differentiation(GO:0072311)
0.0 0.1 GO:0046874 quinolinate metabolic process(GO:0046874)
0.0 0.1 GO:0097168 mesenchymal stem cell proliferation(GO:0097168)
0.0 0.1 GO:1903334 positive regulation of protein folding(GO:1903334)
0.0 0.1 GO:0050717 positive regulation of interleukin-1 alpha secretion(GO:0050717)
0.0 0.2 GO:0001714 endodermal cell fate specification(GO:0001714)
0.0 0.1 GO:1900195 positive regulation of oocyte maturation(GO:1900195) positive regulation of proteasomal ubiquitin-dependent protein catabolic process involved in cellular response to hypoxia(GO:2000777)
0.0 0.1 GO:0003340 negative regulation of mesenchymal to epithelial transition involved in metanephros morphogenesis(GO:0003340)
0.0 0.0 GO:0060424 foregut regionalization(GO:0060423) lung field specification(GO:0060424) lung induction(GO:0060492)
0.0 0.1 GO:0014057 positive regulation of acetylcholine secretion, neurotransmission(GO:0014057)
0.0 0.1 GO:2000853 negative regulation of corticosterone secretion(GO:2000853)
0.0 0.1 GO:1903002 regulation of lipid transport across blood brain barrier(GO:1903000) positive regulation of lipid transport across blood brain barrier(GO:1903002)
0.0 0.1 GO:1900039 positive regulation of cellular response to hypoxia(GO:1900039)
0.0 0.1 GO:0002380 immunoglobulin secretion involved in immune response(GO:0002380)
0.0 0.0 GO:0032805 positive regulation of low-density lipoprotein particle receptor catabolic process(GO:0032805)
0.0 0.1 GO:0001810 regulation of type I hypersensitivity(GO:0001810) type I hypersensitivity(GO:0016068)
0.0 0.1 GO:0010757 negative regulation of plasminogen activation(GO:0010757)
0.0 0.1 GO:1902965 regulation of protein localization to early endosome(GO:1902965) positive regulation of protein localization to early endosome(GO:1902966)
0.0 0.2 GO:0050862 positive regulation of T cell receptor signaling pathway(GO:0050862)
0.0 0.1 GO:1903361 protein localization to basolateral plasma membrane(GO:1903361)
0.0 0.1 GO:1902746 regulation of lens fiber cell differentiation(GO:1902746)
0.0 0.0 GO:0042339 keratan sulfate metabolic process(GO:0042339)
0.0 0.1 GO:0035087 siRNA loading onto RISC involved in RNA interference(GO:0035087)
0.0 0.1 GO:0045626 negative regulation of T-helper 1 cell differentiation(GO:0045626)
0.0 0.0 GO:0060468 negative regulation of fertilization(GO:0060467) prevention of polyspermy(GO:0060468)
0.0 0.0 GO:0030886 negative regulation of myeloid dendritic cell activation(GO:0030886)
0.0 0.0 GO:0060399 positive regulation of growth hormone receptor signaling pathway(GO:0060399)
0.0 0.1 GO:0070934 CRD-mediated mRNA stabilization(GO:0070934)
0.0 0.0 GO:1904170 regulation of bleb assembly(GO:1904170)
0.0 0.1 GO:0030309 poly-N-acetyllactosamine metabolic process(GO:0030309) poly-N-acetyllactosamine biosynthetic process(GO:0030311)
0.0 0.0 GO:0031438 negative regulation of mRNA cleavage(GO:0031438) negative regulation of mRNA endonucleolytic cleavage involved in unfolded protein response(GO:1904721)
0.0 0.1 GO:0043435 response to corticotropin-releasing hormone(GO:0043435) cellular response to corticotropin-releasing hormone stimulus(GO:0071376)
0.0 0.1 GO:0003433 chondrocyte development involved in endochondral bone morphogenesis(GO:0003433)
0.0 0.1 GO:0006477 protein sulfation(GO:0006477)
0.0 0.1 GO:0045901 positive regulation of translational elongation(GO:0045901)
0.0 0.0 GO:0035995 detection of muscle stretch(GO:0035995)
0.0 0.1 GO:0031659 positive regulation of cyclin-dependent protein serine/threonine kinase activity involved in G1/S transition of mitotic cell cycle(GO:0031659)
0.0 0.0 GO:2000157 regulation of protein K48-linked deubiquitination(GO:1903093) negative regulation of protein K48-linked deubiquitination(GO:1903094) negative regulation of ubiquitin-specific protease activity(GO:2000157)
0.0 0.1 GO:0010637 negative regulation of mitochondrial fusion(GO:0010637)
0.0 0.1 GO:0070560 protein secretion by platelet(GO:0070560)
0.0 0.1 GO:1903238 positive regulation of leukocyte tethering or rolling(GO:1903238)
0.0 0.0 GO:0036166 phenotypic switching(GO:0036166)
0.0 0.1 GO:1902109 negative regulation of mitochondrial membrane permeability involved in apoptotic process(GO:1902109)
0.0 0.1 GO:1902866 regulation of retina development in camera-type eye(GO:1902866)
0.0 0.1 GO:1903298 regulation of hypoxia-induced intrinsic apoptotic signaling pathway(GO:1903297) negative regulation of hypoxia-induced intrinsic apoptotic signaling pathway(GO:1903298)
0.0 0.1 GO:1902951 negative regulation of dendritic spine maintenance(GO:1902951)
0.0 0.0 GO:0019375 galactosylceramide biosynthetic process(GO:0006682) galactolipid biosynthetic process(GO:0019375)
0.0 0.0 GO:0090669 telomerase RNA stabilization(GO:0090669)
0.0 0.1 GO:0051586 glial cell-derived neurotrophic factor secretion(GO:0044467) positive regulation of neurotransmitter uptake(GO:0051582) positive regulation of dopamine uptake involved in synaptic transmission(GO:0051586) positive regulation of catecholamine uptake involved in synaptic transmission(GO:0051944) negative regulation of dopamine receptor signaling pathway(GO:0060160) regulation of glial cell-derived neurotrophic factor secretion(GO:1900166) positive regulation of glial cell-derived neurotrophic factor secretion(GO:1900168)
0.0 0.0 GO:0032701 negative regulation of interleukin-18 production(GO:0032701)
0.0 0.0 GO:0016476 regulation of embryonic cell shape(GO:0016476)
0.0 0.1 GO:0000320 re-entry into mitotic cell cycle(GO:0000320)
0.0 0.1 GO:2000630 positive regulation of miRNA metabolic process(GO:2000630)
0.0 0.0 GO:0055129 L-proline biosynthetic process(GO:0055129)
0.0 0.0 GO:1990790 response to glial cell derived neurotrophic factor(GO:1990790) cellular response to glial cell derived neurotrophic factor(GO:1990792)
0.0 0.1 GO:0033277 abortive mitotic cell cycle(GO:0033277)
0.0 0.0 GO:0014738 regulation of muscle hyperplasia(GO:0014738) muscle hyperplasia(GO:0014900)
0.0 0.2 GO:2001256 regulation of store-operated calcium entry(GO:2001256)
0.0 0.0 GO:0010273 detoxification of copper ion(GO:0010273) stress response to copper ion(GO:1990169)
0.0 0.0 GO:0015746 citrate transport(GO:0015746)
0.0 0.1 GO:2000823 regulation of androgen receptor activity(GO:2000823)
0.0 0.1 GO:0009405 pathogenesis(GO:0009405)
0.0 0.0 GO:1900738 positive regulation of phospholipase C-activating G-protein coupled receptor signaling pathway(GO:1900738)
0.0 0.0 GO:1904059 regulation of locomotor rhythm(GO:1904059)
0.0 0.0 GO:0035965 cardiolipin acyl-chain remodeling(GO:0035965)
0.0 0.0 GO:0061738 late endosomal microautophagy(GO:0061738)
0.0 0.0 GO:0036112 medium-chain fatty-acyl-CoA metabolic process(GO:0036112) fatty-acyl-CoA catabolic process(GO:0036115)
0.0 0.1 GO:0005981 regulation of glycogen catabolic process(GO:0005981)
0.0 0.1 GO:0006707 cholesterol catabolic process(GO:0006707) sterol catabolic process(GO:0016127)
0.0 0.1 GO:0019373 epoxygenase P450 pathway(GO:0019373)
0.0 0.2 GO:0021892 cerebral cortex GABAergic interneuron differentiation(GO:0021892)
0.0 0.0 GO:1901873 regulation of post-translational protein modification(GO:1901873)
0.0 0.1 GO:0036016 response to interleukin-3(GO:0036015) cellular response to interleukin-3(GO:0036016)
0.0 0.0 GO:0034971 histone H3-R17 methylation(GO:0034971)
0.0 0.0 GO:0019287 isopentenyl diphosphate biosynthetic process, mevalonate pathway(GO:0019287)
0.0 0.0 GO:2000820 negative regulation of transcription from RNA polymerase II promoter involved in smooth muscle cell differentiation(GO:2000820)
0.0 0.0 GO:0098886 modification of dendritic spine(GO:0098886)

Gene overrepresentation in cellular component category:

Log-likelihood per target  Total log-likelihood Term Description
0.2 1.8 GO:0005833 hemoglobin complex(GO:0005833)
0.0 0.2 GO:0036398 TCR signalosome(GO:0036398) microspike(GO:0044393)
0.0 0.1 GO:0032398 MHC class Ib protein complex(GO:0032398)
0.0 0.1 GO:1990907 beta-catenin-TCF complex(GO:1990907)
0.0 0.1 GO:0031510 SUMO activating enzyme complex(GO:0031510)
0.0 0.1 GO:0042571 immunoglobulin complex, circulating(GO:0042571)
0.0 0.1 GO:0044301 climbing fiber(GO:0044301)
0.0 0.1 GO:0036488 CHOP-C/EBP complex(GO:0036488)
0.0 0.1 GO:0036195 muscle cell projection(GO:0036194) muscle cell projection membrane(GO:0036195)
0.0 0.2 GO:0034663 endoplasmic reticulum chaperone complex(GO:0034663)
0.0 0.1 GO:0005607 laminin-2 complex(GO:0005607)
0.0 0.1 GO:0045179 apical cortex(GO:0045179)
0.0 0.6 GO:0008180 COP9 signalosome(GO:0008180)
0.0 0.0 GO:0044317 rod spherule(GO:0044317)
0.0 0.1 GO:0032059 bleb(GO:0032059)
0.0 0.0 GO:0097444 spine apparatus(GO:0097444)
0.0 0.0 GO:0031205 endoplasmic reticulum Sec complex(GO:0031205)
0.0 0.1 GO:0005642 annulate lamellae(GO:0005642)
0.0 0.2 GO:0042612 MHC class I protein complex(GO:0042612)
0.0 0.1 GO:0005787 signal peptidase complex(GO:0005787)
0.0 0.1 GO:0005862 muscle thin filament tropomyosin(GO:0005862)
0.0 0.0 GO:0097125 cyclin B1-CDK1 complex(GO:0097125)
0.0 0.1 GO:0071204 histone pre-mRNA 3'end processing complex(GO:0071204)
0.0 0.0 GO:0030906 retromer, cargo-selective complex(GO:0030906)
0.0 0.1 GO:0090543 Flemming body(GO:0090543)
0.0 0.0 GO:0031095 platelet dense tubular network membrane(GO:0031095)
0.0 0.1 GO:0034365 discoidal high-density lipoprotein particle(GO:0034365)
0.0 0.1 GO:0000220 vacuolar proton-transporting V-type ATPase, V0 domain(GO:0000220)
0.0 0.0 GO:0020016 ciliary pocket(GO:0020016) ciliary pocket membrane(GO:0020018)
0.0 0.1 GO:0000813 ESCRT I complex(GO:0000813)

Gene overrepresentation in molecular function category:

Log-likelihood per target  Total log-likelihood Term Description
0.2 0.6 GO:0031720 haptoglobin binding(GO:0031720)
0.1 1.2 GO:0005344 oxygen transporter activity(GO:0005344)
0.1 0.3 GO:0004052 arachidonate 12-lipoxygenase activity(GO:0004052)
0.1 0.3 GO:0016403 dimethylargininase activity(GO:0016403)
0.1 0.2 GO:0031780 corticotropin hormone receptor binding(GO:0031780) type 5 melanocortin receptor binding(GO:0031783)
0.0 0.3 GO:0004865 protein serine/threonine phosphatase inhibitor activity(GO:0004865)
0.0 0.1 GO:0005534 galactose binding(GO:0005534)
0.0 0.2 GO:0031802 type 5 metabotropic glutamate receptor binding(GO:0031802)
0.0 0.1 GO:0001010 transcription factor activity, sequence-specific DNA binding transcription factor recruiting(GO:0001010)
0.0 0.2 GO:0004090 carbonyl reductase (NADPH) activity(GO:0004090)
0.0 0.1 GO:0035939 microsatellite binding(GO:0035939)
0.0 0.1 GO:0004948 calcitonin receptor activity(GO:0004948)
0.0 0.1 GO:0008508 bile acid:sodium symporter activity(GO:0008508)
0.0 0.1 GO:0004514 nicotinate-nucleotide diphosphorylase (carboxylating) activity(GO:0004514)
0.0 0.1 GO:0008475 procollagen-lysine 5-dioxygenase activity(GO:0008475) procollagen glucosyltransferase activity(GO:0033823)
0.0 0.2 GO:0004111 creatine kinase activity(GO:0004111)
0.0 0.1 GO:0030613 oxidoreductase activity, acting on a sulfur group of donors, quinone or similar compound as acceptor(GO:0016672) oxidoreductase activity, acting on phosphorus or arsenic in donors(GO:0030613) oxidoreductase activity, acting on phosphorus or arsenic in donors, disulfide as acceptor(GO:0030614) glutathione dehydrogenase (ascorbate) activity(GO:0045174) methylarsonate reductase activity(GO:0050610)
0.0 0.1 GO:0035877 death effector domain binding(GO:0035877)
0.0 0.2 GO:0030881 beta-2-microglobulin binding(GO:0030881)
0.0 0.1 GO:0035650 AP-1 adaptor complex binding(GO:0035650)
0.0 0.1 GO:0004169 dolichyl-phosphate-mannose-protein mannosyltransferase activity(GO:0004169)
0.0 0.1 GO:0055077 gap junction hemi-channel activity(GO:0055077)
0.0 0.1 GO:0004937 alpha1-adrenergic receptor activity(GO:0004937)
0.0 0.1 GO:0008532 N-acetyllactosaminide beta-1,3-N-acetylglucosaminyltransferase activity(GO:0008532)
0.0 0.1 GO:0042903 tubulin deacetylase activity(GO:0042903)
0.0 0.3 GO:0044548 S100 protein binding(GO:0044548)
0.0 0.1 GO:0046911 metal chelating activity(GO:0046911)
0.0 0.1 GO:0016286 small conductance calcium-activated potassium channel activity(GO:0016286)
0.0 0.1 GO:0034618 arginine binding(GO:0034618)
0.0 0.1 GO:0005173 stem cell factor receptor binding(GO:0005173)
0.0 0.1 GO:0004505 phenylalanine 4-monooxygenase activity(GO:0004505)
0.0 0.2 GO:0030215 semaphorin receptor binding(GO:0030215)
0.0 0.1 GO:0031995 insulin-like growth factor II binding(GO:0031995)
0.0 0.1 GO:0008310 single-stranded DNA 3'-5' exodeoxyribonuclease activity(GO:0008310)
0.0 0.1 GO:0008467 [heparan sulfate]-glucosamine 3-sulfotransferase 1 activity(GO:0008467)
0.0 0.0 GO:0016422 mRNA (2'-O-methyladenosine-N6-)-methyltransferase activity(GO:0016422)
0.0 0.1 GO:0001591 dopamine neurotransmitter receptor activity, coupled via Gi/Go(GO:0001591)
0.0 0.1 GO:0022841 potassium ion leak channel activity(GO:0022841)
0.0 0.1 GO:0051870 methotrexate binding(GO:0051870)
0.0 0.0 GO:0015137 citrate transmembrane transporter activity(GO:0015137)
0.0 0.0 GO:0042610 CD8 receptor binding(GO:0042610)
0.0 0.1 GO:0004103 choline kinase activity(GO:0004103)
0.0 0.0 GO:0031893 vasopressin receptor binding(GO:0031893)
0.0 0.0 GO:0044378 non-sequence-specific DNA binding, bending(GO:0044378)
0.0 0.1 GO:0019864 IgG binding(GO:0019864)
0.0 0.1 GO:0005176 ErbB-2 class receptor binding(GO:0005176)
0.0 0.1 GO:0030235 nitric-oxide synthase regulator activity(GO:0030235)
0.0 0.0 GO:0047619 acylcarnitine hydrolase activity(GO:0047619)
0.0 0.0 GO:0060698 endoribonuclease inhibitor activity(GO:0060698)
0.0 0.1 GO:0019855 calcium channel inhibitor activity(GO:0019855)
0.0 0.1 GO:0044388 small protein activating enzyme binding(GO:0044388)
0.0 0.1 GO:0008392 arachidonic acid epoxygenase activity(GO:0008392)
0.0 0.1 GO:0004499 N,N-dimethylaniline monooxygenase activity(GO:0004499)
0.0 0.1 GO:0004920 interleukin-10 receptor activity(GO:0004920)
0.0 0.0 GO:0034211 GTP-dependent protein kinase activity(GO:0034211)
0.0 0.1 GO:0003960 NADPH:quinone reductase activity(GO:0003960)
0.0 0.1 GO:0004886 9-cis retinoic acid receptor activity(GO:0004886)
0.0 0.2 GO:0017049 GTP-Rho binding(GO:0017049)
0.0 0.1 GO:0031014 troponin T binding(GO:0031014)
0.0 0.0 GO:0001733 galactosylceramide sulfotransferase activity(GO:0001733)
0.0 0.1 GO:0008273 calcium, potassium:sodium antiporter activity(GO:0008273)

Gene overrepresentation in curated gene sets: canonical pathways category:

Log-likelihood per target  Total log-likelihood Term Description
0.0 0.2 ST INTERFERON GAMMA PATHWAY Interferon gamma pathway.
0.0 0.2 PID P38 GAMMA DELTA PATHWAY Signaling mediated by p38-gamma and p38-delta
0.0 0.1 ST IL 13 PATHWAY Interleukin 13 (IL-13) Pathway

Gene overrepresentation in curated gene sets: REACTOME pathways category:

Log-likelihood per target  Total log-likelihood Term Description
0.0 0.4 REACTOME POST CHAPERONIN TUBULIN FOLDING PATHWAY Genes involved in Post-chaperonin tubulin folding pathway
0.0 0.1 REACTOME ENDOSOMAL VACUOLAR PATHWAY Genes involved in Endosomal/Vacuolar pathway
0.0 0.2 REACTOME SYNTHESIS SECRETION AND DEACYLATION OF GHRELIN Genes involved in Synthesis, Secretion, and Deacylation of Ghrelin
0.0 0.1 REACTOME OPSINS Genes involved in Opsins
0.0 0.1 REACTOME MEMBRANE BINDING AND TARGETTING OF GAG PROTEINS Genes involved in Membrane binding and targetting of GAG proteins
0.0 0.0 REACTOME FRS2 MEDIATED CASCADE Genes involved in FRS2-mediated cascade
0.0 0.1 REACTOME OLFACTORY SIGNALING PATHWAY Genes involved in Olfactory Signaling Pathway