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GSE49485: Hypoxia transcriptome sequencing of rat brain.
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Results for Junb_Jund
Z-value: 1.16
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Transcription factors associated with Junb_Jund
Activity-expression correlation:
| Gene | Promoter | Pearson corr. coef. | P-value | Plot |
|---|---|---|---|---|
| Jund | rn6_v1_chr16_-_20486707_20486707 | 0.90 | 4.0e-02 | Click! |
| Junb | rn6_v1_chr19_-_26094756_26094756 | 0.83 | 8.0e-02 | Click! |
| Promoter | Log-likelihood | Transcript | Gene | Gene Info |
|---|---|---|---|---|
| chr17_-_9695292 Show fit | 3.36 |
ENSRNOT00000036162
|
proline rich 7 (synaptic) |
|
| chr7_+_120580743 Show fit | 1.48 |
ENSRNOT00000017181
|
MAF bZIP transcription factor F |
|
| chr7_-_44121130 Show fit | 0.74 |
ENSRNOT00000005706
|
neurotensin |
|
| chr10_+_16970626 Show fit | 0.68 |
ENSRNOT00000005383
|
dual specificity phosphatase 1 |
|
| chr16_-_19399851 Show fit | 0.65 |
ENSRNOT00000089056
ENSRNOT00000021073 |
tropomyosin 4 |
|
| chr10_-_85574889 Show fit | 0.65 |
ENSRNOT00000072274
|
hypothetical protein LOC691153 |
|
| chr6_+_146784915 Show fit | 0.60 |
ENSRNOT00000008362
|
Sp8 transcription factor |
|
| chr17_+_57074525 Show fit | 0.58 |
ENSRNOT00000020012
ENSRNOT00000074146 |
cAMP responsive element modulator |
|
| chr5_-_152464850 Show fit | 0.58 |
ENSRNOT00000021937
|
zinc finger protein 593 |
|
| chr12_-_13668515 Show fit | 0.56 |
ENSRNOT00000086847
|
fascin actin-bundling protein 1 |
Network of associatons between targets according to the STRING database.
First level regulatory network of Junb_Jund
Gene Ontology Analysis
Gene overrepresentation in biological process category:
| Log-likelihood per target | Total log-likelihood | Term | Description |
|---|---|---|---|
| 0.0 | 1.4 | GO:0048384 | retinoic acid receptor signaling pathway(GO:0048384) |
| 0.0 | 1.4 | GO:0045604 | regulation of epidermal cell differentiation(GO:0045604) |
| 0.2 | 0.7 | GO:0070093 | negative regulation of glucagon secretion(GO:0070093) |
| 0.1 | 0.7 | GO:0097332 | response to antipsychotic drug(GO:0097332) |
| 0.0 | 0.7 | GO:0090266 | regulation of spindle checkpoint(GO:0090231) regulation of mitotic cell cycle spindle assembly checkpoint(GO:0090266) regulation of mitotic spindle checkpoint(GO:1903504) |
| 0.1 | 0.6 | GO:0071460 | cellular response to cell-matrix adhesion(GO:0071460) |
| 0.1 | 0.6 | GO:1903026 | negative regulation of RNA polymerase II regulatory region sequence-specific DNA binding(GO:1903026) |
| 0.0 | 0.6 | GO:0031274 | positive regulation of pseudopodium assembly(GO:0031274) |
| 0.0 | 0.6 | GO:0061299 | retina vasculature morphogenesis in camera-type eye(GO:0061299) |
| 0.2 | 0.5 | GO:0021530 | spinal cord oligodendrocyte cell differentiation(GO:0021529) spinal cord oligodendrocyte cell fate specification(GO:0021530) |
Gene overrepresentation in cellular component category:
| Log-likelihood per target | Total log-likelihood | Term | Description |
|---|---|---|---|
| 0.2 | 0.8 | GO:0035976 | AP1 complex(GO:0035976) |
| 0.1 | 0.7 | GO:0005862 | muscle thin filament tropomyosin(GO:0005862) |
| 0.1 | 0.6 | GO:0044393 | microspike(GO:0044393) |
| 0.0 | 0.6 | GO:0043196 | varicosity(GO:0043196) |
| 0.1 | 0.5 | GO:0045009 | melanosome membrane(GO:0033162) chitosome(GO:0045009) |
| 0.0 | 0.5 | GO:0030687 | preribosome, large subunit precursor(GO:0030687) |
| 0.0 | 0.4 | GO:0005577 | fibrinogen complex(GO:0005577) |
| 0.0 | 0.4 | GO:0000788 | nuclear nucleosome(GO:0000788) |
| 0.1 | 0.3 | GO:0005745 | m-AAA complex(GO:0005745) |
| 0.0 | 0.3 | GO:0034663 | endoplasmic reticulum chaperone complex(GO:0034663) |
Gene overrepresentation in molecular function category:
| Log-likelihood per target | Total log-likelihood | Term | Description |
|---|---|---|---|
| 0.0 | 1.1 | GO:0005184 | neuropeptide hormone activity(GO:0005184) |
| 0.0 | 1.0 | GO:0008307 | structural constituent of muscle(GO:0008307) |
| 0.3 | 0.8 | GO:0008330 | protein tyrosine/threonine phosphatase activity(GO:0008330) |
| 0.0 | 0.8 | GO:0071837 | HMG box domain binding(GO:0071837) |
| 0.2 | 0.6 | GO:0031177 | phosphopantetheine binding(GO:0031177) |
| 0.1 | 0.6 | GO:0051431 | corticotropin-releasing hormone receptor 2 binding(GO:0051431) |
| 0.1 | 0.5 | GO:0016714 | oxidoreductase activity, acting on paired donors, with incorporation or reduction of molecular oxygen, reduced pteridine as one donor, and incorporation of one atom of oxygen(GO:0016714) |
| 0.0 | 0.5 | GO:0017049 | GTP-Rho binding(GO:0017049) |
| 0.0 | 0.5 | GO:0031492 | nucleosomal DNA binding(GO:0031492) |
| 0.1 | 0.4 | GO:0045340 | mercury ion binding(GO:0045340) |
Gene overrepresentation in curated gene sets: canonical pathways category:
| Log-likelihood per target | Total log-likelihood | Term | Description |
|---|---|---|---|
| 0.0 | 3.0 | PID AP1 PATHWAY | AP-1 transcription factor network |
| 0.0 | 1.3 | PID TCR CALCIUM PATHWAY | Calcium signaling in the CD4+ TCR pathway |
| 0.0 | 0.7 | ST P38 MAPK PATHWAY | p38 MAPK Pathway |
| 0.0 | 0.6 | PID IL12 2PATHWAY | IL12-mediated signaling events |
| 0.0 | 0.4 | PID INTEGRIN5 PATHWAY | Beta5 beta6 beta7 and beta8 integrin cell surface interactions |
| 0.0 | 0.3 | PID EPHA2 FWD PATHWAY | EPHA2 forward signaling |
| 0.0 | 0.1 | PID S1P S1P2 PATHWAY | S1P2 pathway |
Gene overrepresentation in curated gene sets: REACTOME pathways category:
| Log-likelihood per target | Total log-likelihood | Term | Description |
|---|---|---|---|
| 0.1 | 1.0 | REACTOME AMINE DERIVED HORMONES | Genes involved in Amine-derived hormones |
| 0.0 | 1.0 | REACTOME SMOOTH MUSCLE CONTRACTION | Genes involved in Smooth Muscle Contraction |
| 0.0 | 0.4 | REACTOME POST CHAPERONIN TUBULIN FOLDING PATHWAY | Genes involved in Post-chaperonin tubulin folding pathway |
| 0.0 | 0.3 | REACTOME SYNTHESIS OF PE | Genes involved in Synthesis of PE |
| 0.0 | 0.3 | REACTOME P130CAS LINKAGE TO MAPK SIGNALING FOR INTEGRINS | Genes involved in p130Cas linkage to MAPK signaling for integrins |
| 0.0 | 0.3 | REACTOME DOWNREGULATION OF TGF BETA RECEPTOR SIGNALING | Genes involved in Downregulation of TGF-beta receptor signaling |
| 0.0 | 0.3 | REACTOME CHOLESTEROL BIOSYNTHESIS | Genes involved in Cholesterol biosynthesis |
| 0.0 | 0.1 | REACTOME GAP JUNCTION DEGRADATION | Genes involved in Gap junction degradation |
| 0.0 | 0.1 | REACTOME FORMATION OF TUBULIN FOLDING INTERMEDIATES BY CCT TRIC | Genes involved in Formation of tubulin folding intermediates by CCT/TriC |
| 0.0 | 0.1 | REACTOME SIGNALLING TO P38 VIA RIT AND RIN | Genes involved in Signalling to p38 via RIT and RIN |