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GSE49485: Hypoxia transcriptome sequencing of rat brain.

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Results for Junb_Jund

Z-value: 1.16

Motif logo

Transcription factors associated with Junb_Jund

Gene Symbol Gene ID Gene Info
ENSRNOG00000042838 JunB proto-oncogene, AP-1 transcription factor subunit
ENSRNOG00000019568 JunD proto-oncogene, AP-1 transcription factor subunit

Activity-expression correlation:

GenePromoterPearson corr. coef.P-valuePlot
Jundrn6_v1_chr16_-_20486707_204867070.904.0e-02Click!
Junbrn6_v1_chr19_-_26094756_260947560.838.0e-02Click!

Activity profile of Junb_Jund motif

Sorted Z-values of Junb_Jund motif

Promoter Log-likelihood Transcript Gene Gene Info
chr17_-_9695292 3.36 ENSRNOT00000036162
proline rich 7 (synaptic)
chr7_+_120580743 1.48 ENSRNOT00000017181
MAF bZIP transcription factor F
chr7_-_44121130 0.74 ENSRNOT00000005706
neurotensin
chr10_+_16970626 0.68 ENSRNOT00000005383
dual specificity phosphatase 1
chr16_-_19399851 0.65 ENSRNOT00000089056
ENSRNOT00000021073
tropomyosin 4
chr10_-_85574889 0.65 ENSRNOT00000072274
hypothetical protein LOC691153
chr6_+_146784915 0.60 ENSRNOT00000008362
Sp8 transcription factor
chr17_+_57074525 0.58 ENSRNOT00000020012
ENSRNOT00000074146
cAMP responsive element modulator
chr5_-_152464850 0.58 ENSRNOT00000021937
zinc finger protein 593
chr12_-_13668515 0.56 ENSRNOT00000086847
fascin actin-bundling protein 1
chr2_+_164549455 0.55 ENSRNOT00000017151
myeloid leukemia factor 1
chr8_+_114866768 0.52 ENSRNOT00000076731
WD repeat domain 82
chr1_-_216080287 0.52 ENSRNOT00000027682
tyrosine hydroxylase
chr16_-_20486707 0.51 ENSRNOT00000026470
JunD proto-oncogene, AP-1 transcription factor subunit
chr4_+_83391283 0.50 ENSRNOT00000031365
cAMP responsive element binding protein 5
chr17_+_57075218 0.47 ENSRNOT00000089536
cAMP responsive element modulator
chr9_+_102862890 0.47 ENSRNOT00000050494
ENSRNOT00000080129
family with sequence similarity 174, member A
chr11_+_31389514 0.46 ENSRNOT00000000325
oligodendrocyte lineage transcription factor 2
chr4_+_8256611 0.46 ENSRNOT00000061894

chr7_+_123168811 0.45 ENSRNOT00000007091
cold shock domain containing C2
chr5_+_50381244 0.42 ENSRNOT00000012385
glycoprotein hormones, alpha polypeptide
chr1_+_224938801 0.40 ENSRNOT00000073052
RIKEN cDNA 1700092M07 gene
chr17_-_43821536 0.39 ENSRNOT00000072286
histone H4 variant H4-v.1
chr1_+_73719005 0.39 ENSRNOT00000025110
CDC42 effector protein 5
chr2_-_30127269 0.39 ENSRNOT00000023869
CART prepropeptide
chr9_-_78969013 0.37 ENSRNOT00000019772
ENSRNOT00000057585
fibronectin 1
chr9_-_85243001 0.37 ENSRNOT00000020219
secretogranin II
chr16_+_72388880 0.37 ENSRNOT00000072459
similar to Protein C8orf4 (Thyroid cancer protein 1) (TC-1)
chr6_+_98284170 0.36 ENSRNOT00000031979
ras homolog family member J
chr2_-_104461863 0.36 ENSRNOT00000016953
corticotropin releasing hormone
chr13_-_50499060 0.35 ENSRNOT00000065347
ENSRNOT00000076924
ethanolamine kinase 2
chr16_+_72401887 0.35 ENSRNOT00000074449
uncharacterized LOC100910163
chr11_-_36479868 0.34 ENSRNOT00000075762
non-histone chromosomal protein HMG-14-like
chr10_-_85435016 0.34 ENSRNOT00000079921
RIKEN cDNA 4933428G20 gene
chr11_+_88122271 0.33 ENSRNOT00000002540
stromal cell-derived factor 2-like 1
chr3_+_150801289 0.32 ENSRNOT00000035060
microtubule-associated protein 1 light chain 3 alpha
chr20_+_5080070 0.32 ENSRNOT00000086950
ENSRNOT00000077082
abhydrolase domain containing 16A
chrX_-_45522665 0.32 ENSRNOT00000030771
similar to GS2 gene
chr12_-_18531161 0.31 ENSRNOT00000037829
A-kinase anchoring protein 17A
chr19_+_56272162 0.31 ENSRNOT00000030399
AFG3(ATPase family gene 3)-like 1 (S. cerevisiae)
chr5_+_159845774 0.31 ENSRNOT00000012328
Eph receptor A2
chr20_+_4966817 0.30 ENSRNOT00000081527
ENSRNOT00000081265
LSM2 homolog, U6 small nuclear RNA and mRNA degradation associated
chr12_+_52637000 0.30 ENSRNOT00000063905
GTP binding protein 6 (putative)
chr6_+_1657331 0.28 ENSRNOT00000049672
ENSRNOT00000079864
glutaminyl-peptide cyclotransferase
chr17_+_57040023 0.26 ENSRNOT00000020204
cAMP responsive element modulator
chr7_-_58587787 0.25 ENSRNOT00000005814
leucine rich repeat containing G protein coupled receptor 5
chr3_+_3767394 0.25 ENSRNOT00000067840
G-protein signaling modulator 1
chr5_-_151397603 0.24 ENSRNOT00000076866
G protein-coupled receptor 3
chr1_+_86938138 0.24 ENSRNOT00000075601
coiled-coil glutamate-rich protein 2
chr4_+_168832910 0.24 ENSRNOT00000011134
G protein-coupled receptor, class C, group 5, member A
chr5_-_114014277 0.24 ENSRNOT00000011731
Jun proto-oncogene, AP-1 transcription factor subunit
chr17_+_31493107 0.24 ENSRNOT00000023611
ENSRNOT00000086264
tubulin, beta 2A class IIa
chr2_+_124400679 0.24 ENSRNOT00000058495
ENSRNOT00000067034
sprouty RTK signaling antagonist 1
chr7_+_72924799 0.23 ENSRNOT00000008969
lysosomal protein transmembrane 4 beta
chr6_+_26602144 0.23 ENSRNOT00000008037
urocortin
chr12_+_52670898 0.23 ENSRNOT00000056632
putative GTP-binding protein 6-like
chr7_-_2909144 0.23 ENSRNOT00000082518
ENSRNOT00000089074
ENSRNOT00000085644
myosin light chain 6
chr13_+_52553775 0.23 ENSRNOT00000011991
cysteine and glycine-rich protein 1
chr2_+_188784222 0.22 ENSRNOT00000028095
phosphomevalonate kinase
chr14_-_6813945 0.22 ENSRNOT00000002938
integrin-binding sialoprotein
chr16_-_49574314 0.22 ENSRNOT00000017568
ENSRNOT00000085535
ENSRNOT00000017054
PDZ and LIM domain 3
chr1_-_47502952 0.22 ENSRNOT00000025580
T-cell activation RhoGTPase activating protein
chr3_+_176093640 0.22 ENSRNOT00000086541
opioid growth factor receptor
chr4_+_99239115 0.22 ENSRNOT00000009515
CD8a molecule
chr9_+_82556573 0.22 ENSRNOT00000026860
desmin
chr3_+_175930505 0.22 ENSRNOT00000012611
opioid growth factor receptor
chr5_-_153625869 0.22 ENSRNOT00000024464
chloride intracellular channel 4
chr9_+_10535340 0.21 ENSRNOT00000075408
zinc and ring finger 4
chr2_+_187347602 0.21 ENSRNOT00000025384
nestin
chr1_-_80221710 0.21 ENSRNOT00000091687
FosB proto-oncogene, AP-1 transcription factor subunit
chr8_+_48472824 0.21 ENSRNOT00000010463
ENSRNOT00000090780
melanoma cell adhesion molecule
chr5_+_58393603 0.21 ENSRNOT00000080082
DnaJ heat shock protein family (Hsp40) member B5
chr1_-_188190778 0.21 ENSRNOT00000092657
ENSRNOT00000022988
coenzyme Q7, hydroxylase
chr10_-_13542077 0.20 ENSRNOT00000008736
ATPase H+ transporting V0 subunit C
chr20_-_10680283 0.20 ENSRNOT00000001579
salt-inducible kinase 1
chr11_+_88424414 0.20 ENSRNOT00000022328
sperm associated antigen 6-like
chr8_+_64364741 0.20 ENSRNOT00000082840
CUGBP, Elav-like family member 6
chr13_+_104284660 0.20 ENSRNOT00000005400
dual specificity phosphatase 10
chr15_-_6587367 0.20 ENSRNOT00000038449
zinc finger protein 385D
chr16_+_20317446 0.20 ENSRNOT00000025626
coiled-coil domain containing 124
chr1_-_89303968 0.19 ENSRNOT00000056714
free fatty acid receptor 3
chr1_-_209641123 0.19 ENSRNOT00000021702
early B-cell factor 3
chr1_-_64090017 0.19 ENSRNOT00000086622
ENSRNOT00000091654
ribosomal protein S9
chr12_-_2007516 0.19 ENSRNOT00000037564
peroxisomal biogenesis factor 11 gamma
chr19_+_28965583 0.19 ENSRNOT00000049865
similar to spermatogenesis associated glutamate (E)-rich protein 4d
chr20_+_13732198 0.19 ENSRNOT00000008608
macrophage migration inhibitory factor
chr2_-_104133985 0.19 ENSRNOT00000088167
ENSRNOT00000067725
phosphodiesterase 7A
chr9_+_82674202 0.18 ENSRNOT00000027208
transmembrane protein 198
chr15_+_43007908 0.18 ENSRNOT00000084753
ENSRNOT00000091567
ENSRNOT00000087709
stathmin 4
chr5_+_58393233 0.18 ENSRNOT00000000142
DnaJ heat shock protein family (Hsp40) member B5
chr9_-_82673898 0.18 ENSRNOT00000027165
chondroitin polymerizing factor
chr14_-_6900733 0.18 ENSRNOT00000061224
dentin matrix acidic phosphoprotein 1
chr1_+_201429771 0.18 ENSRNOT00000027836
pleckstrin homology domain containing A1
chr1_-_101514974 0.18 ENSRNOT00000044788
protein phosphatase 1, regulatory subunit 15A
chr20_+_29655226 0.17 ENSRNOT00000089059
SPARC/osteonectin, cwcv and kazal like domains proteoglycan 2
chr3_-_7498555 0.17 ENSRNOT00000017725
BarH-like homeobox 1
chr1_-_220467159 0.17 ENSRNOT00000075365
transmembrane protein 151A
chr10_-_66020682 0.17 ENSRNOT00000011019
family with sequence similarity 58, member B
chr10_-_29450644 0.17 ENSRNOT00000087937
adrenoceptor alpha 1B
chr6_-_103313074 0.16 ENSRNOT00000083677
zinc finger protein 36, C3H type-like 1
chr3_-_160922341 0.16 ENSRNOT00000029206
TP53 target 5
chr12_-_18530724 0.16 ENSRNOT00000078999
A-kinase anchoring protein 17A
chr6_-_46631983 0.16 ENSRNOT00000045963
SRY box 11
chr7_+_121311024 0.16 ENSRNOT00000092260
ENSRNOT00000023066
ENSRNOT00000081377
synaptogyrin 1
chr6_-_21600451 0.16 ENSRNOT00000047674
latent transforming growth factor beta binding protein 1
chr15_+_52265557 0.15 ENSRNOT00000015969
nudix hydrolase 18
chr14_-_18531179 0.15 ENSRNOT00000003703
amphiregulin
chr3_+_37545238 0.15 ENSRNOT00000070792
TNF alpha induced protein 6
chr10_+_70884531 0.15 ENSRNOT00000015199
C-C motif chemokine ligand 4
chr1_+_166428761 0.15 ENSRNOT00000085555
StAR-related lipid transfer domain containing 10
chr4_+_27175243 0.15 ENSRNOT00000009985
cytochrome P450, family 51
chr6_+_126434226 0.15 ENSRNOT00000090857
chromogranin A
chr4_-_50312608 0.15 ENSRNOT00000010019
Fez family zinc finger 1
chr2_+_233602732 0.14 ENSRNOT00000044232
paired-like homeodomain 2
chr19_+_55917736 0.14 ENSRNOT00000020635
ribosomal protein L13
chr1_-_198382614 0.14 ENSRNOT00000055016
aspartate beta-hydroxylase domain containing 1
chr14_+_108826831 0.14 ENSRNOT00000083146
ENSRNOT00000009421
B-cell CLL/lymphoma 11A
chr6_+_132702448 0.14 ENSRNOT00000005743
YY1 transcription factor
chr11_+_39482408 0.14 ENSRNOT00000075126
high mobility group nucleosome binding domain 1
chr1_-_64021321 0.14 ENSRNOT00000090819
ribosomal protein S9
chr1_+_201913148 0.14 ENSRNOT00000036128
family with sequence similarity 24, member A
chr1_-_89179825 0.14 ENSRNOT00000028514
transmembrane protein 147
chr8_+_85489553 0.13 ENSRNOT00000082158
ribosomal protein L12, pseudogene 1
chr3_-_120011364 0.13 ENSRNOT00000018922
fumarylacetoacetate hydrolase domain containing 2A
chr1_-_89194602 0.13 ENSRNOT00000028518
glyceraldehyde-3-phosphate dehydrogenase, spermatogenic
chr1_+_221735517 0.13 ENSRNOT00000028628
ENSRNOT00000044866
splicing factor 1
chr17_+_10537365 0.13 ENSRNOT00000023651
clathrin, light chain B
chr11_-_33003021 0.13 ENSRNOT00000084134
runt-related transcription factor 1
chr5_+_147692391 0.13 ENSRNOT00000064855
family with sequence similarity 229, member A
chr2_+_86951776 0.13 ENSRNOT00000087275

chr19_+_27404712 0.13 ENSRNOT00000023657
myosin light chain kinase 3
chr14_-_108284619 0.13 ENSRNOT00000078814
hypothetical protein LOC690352
chr5_-_146446227 0.13 ENSRNOT00000044868
high-mobility group box 4
chr14_-_86739335 0.12 ENSRNOT00000078282
purine rich element binding protein B
chr19_+_27835890 0.12 ENSRNOT00000042150
disks large homolog 5-like
chr4_-_184096806 0.12 ENSRNOT00000055433
mKIAA1238 protein-like
chr3_+_163552166 0.12 ENSRNOT00000049082
TP53 regulating kinase
chr15_-_70399924 0.12 ENSRNOT00000087940
diaphanous-related formin 3
chr9_+_17817721 0.12 ENSRNOT00000086986
ENSRNOT00000026920
heat shock protein 90 alpha family class B member 1
chr1_-_80544825 0.12 ENSRNOT00000057802
ENSRNOT00000040060
ENSRNOT00000067049
ENSRNOT00000052387
ENSRNOT00000073352
RELB proto-oncogene, NF-kB subunit
chr1_+_100473643 0.12 ENSRNOT00000026379
Josephin domain containing 2
chr3_+_150910398 0.12 ENSRNOT00000055310
tumor protein p53 inducible nuclear protein 2
chr3_+_79918969 0.12 ENSRNOT00000016306
Spi-1 proto-oncogene
chr1_-_101514547 0.12 ENSRNOT00000079633
protein phosphatase 1, regulatory subunit 15A
chr1_+_191344979 0.12 ENSRNOT00000023773
heparan sulfate-glucosamine 3-sulfotransferase 2
chr4_+_157453069 0.12 ENSRNOT00000088622
myeloid leukemia factor 2
chr13_+_49003803 0.12 ENSRNOT00000080556
LEM domain containing 1
chr10_-_57064600 0.12 ENSRNOT00000032926
C-X-C motif chemokine ligand 16
chr4_+_157452607 0.12 ENSRNOT00000022467
myeloid leukemia factor 2
chr4_-_181477281 0.12 ENSRNOT00000055463
MANSC domain containing 4
chr20_-_3299420 0.12 ENSRNOT00000090999
G protein nucleolar 1
chr1_-_52495582 0.12 ENSRNOT00000067142
phosphodiesterase 10A
chr1_+_84304228 0.11 ENSRNOT00000024771
periaxin
chr3_+_125428260 0.11 ENSRNOT00000028892
chromogranin B
chr9_-_16406338 0.11 ENSRNOT00000073079
tubulin folding cofactor C
chr7_+_141054494 0.11 ENSRNOT00000088176
transmembrane BAX inhibitor motif containing 6
chr12_+_2170630 0.11 ENSRNOT00000071928
PET100 homolog
chrX_-_139329975 0.11 ENSRNOT00000086405
high mobility group protein B4-like
chr19_-_36157924 0.11 ENSRNOT00000072022

chr8_+_48094673 0.11 ENSRNOT00000008614
nectin cell adhesion molecule 1
chr4_-_120559078 0.11 ENSRNOT00000085730
ENSRNOT00000079575
kelch repeat and BTB domain containing 12
chr19_-_56731372 0.11 ENSRNOT00000024182
nucleoporin 133
chr2_+_233615739 0.11 ENSRNOT00000051009
paired-like homeodomain 2
chr6_+_136279496 0.11 ENSRNOT00000091946
apoptogenic 1, mitochondrial
chr6_+_136185487 0.10 ENSRNOT00000015373
apoptogenic 1, mitochondrial
chr8_+_23113048 0.10 ENSRNOT00000029577
calponin 1
chr10_-_102269272 0.10 ENSRNOT00000048264
CDC42 effector protein 4
chr14_+_107767392 0.10 ENSRNOT00000012847
chaperonin containing TCP1 subunit 4
chr18_-_14016713 0.10 ENSRNOT00000041125
nucleolar protein 4
chr14_-_86868598 0.10 ENSRNOT00000087212
NAC alpha domain containing
chr1_-_81295442 0.10 ENSRNOT00000030900
immunity related GTPase cinema
chr8_+_22021213 0.10 ENSRNOT00000049706
mitochondrial ribosomal protein L4
chr20_-_3299580 0.10 ENSRNOT00000050373
G protein nucleolar 1
chr1_-_100501437 0.10 ENSRNOT00000026445
ER membrane protein complex subunit 10
chr5_+_78428669 0.10 ENSRNOT00000080744
regulator of G-protein signaling 3
chr10_+_89376530 0.10 ENSRNOT00000028089
Rho family GTPase 2
chr14_-_83741969 0.10 ENSRNOT00000026293
inositol polyphosphate-5-phosphatase J
chr4_-_157252565 0.09 ENSRNOT00000079947
protein tyrosine phosphatase, non-receptor type 6
chrX_-_1346181 0.09 ENSRNOT00000042736
60S ribosomal protein L12-like
chr2_+_45104305 0.09 ENSRNOT00000014559
endothelial cell-specific molecule 1
chr12_-_18526250 0.09 ENSRNOT00000001791
acetylserotonin O-methyltransferase
chr1_+_100501676 0.09 ENSRNOT00000043724
family with sequence similarity 71, member E1
chr19_-_54245855 0.09 ENSRNOT00000023855
ER membrane protein complex subunit 8
chr4_+_84854386 0.09 ENSRNOT00000013620
maturin, neural progenitor differentiation regulator homolog
chr10_+_89578212 0.09 ENSRNOT00000028178
ADP-ribosylation factor like GTPase 4D
chr17_+_10463303 0.09 ENSRNOT00000060822
ring finger protein 44
chr7_-_18612118 0.09 ENSRNOT00000078122
ENSRNOT00000010197
RAB11B, member RAS oncogene family
chr7_-_12085226 0.09 ENSRNOT00000088669
ENSRNOT00000079925
one cut domain, family member 3
chr12_+_37984790 0.09 ENSRNOT00000001445
VPS37B, ESCRT-I subunit
chr2_-_66608324 0.09 ENSRNOT00000077597
ceroid-lipofuscinosis, neuronal 5
chr7_-_120518653 0.09 ENSRNOT00000016362
BAI1-associated protein 2-like 2
chr10_+_37594824 0.09 ENSRNOT00000085463
S-phase kinase-associated protein 1
chr20_+_3299730 0.09 ENSRNOT00000078538
proline rich 3
chr1_+_78015722 0.09 ENSRNOT00000002043
kaptin (actin binding protein)
chr6_+_72891725 0.09 ENSRNOT00000038074
nucleotide binding protein-like
chr7_+_10962330 0.09 ENSRNOT00000008360
transducin-like enhancer of split 6
chr1_-_198267093 0.09 ENSRNOT00000047477
similar to RIKEN cDNA 4930451I11
chr6_+_26387877 0.09 ENSRNOT00000076105

chr16_-_20873344 0.08 ENSRNOT00000027381
coatomer protein complex, subunit epsilon
chr2_+_189423559 0.08 ENSRNOT00000029076
tropomyosin 3

Network of associatons between targets according to the STRING database.

First level regulatory network of Junb_Jund

PNG image of the network

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Gene Ontology Analysis

Gene overrepresentation in biological process category:

Log-likelihood per target  Total log-likelihood Term Description
0.2 0.7 GO:0070093 negative regulation of glucagon secretion(GO:0070093)
0.2 0.5 GO:0021530 spinal cord oligodendrocyte cell differentiation(GO:0021529) spinal cord oligodendrocyte cell fate specification(GO:0021530)
0.1 0.7 GO:0097332 response to antipsychotic drug(GO:0097332)
0.1 0.5 GO:0052314 phytoalexin metabolic process(GO:0052314)
0.1 0.4 GO:0007161 calcium-independent cell-matrix adhesion(GO:0007161) interaction with other organism via secreted substance involved in symbiotic interaction(GO:0052047) regulation of transforming growth factor-beta secretion(GO:2001201)
0.1 0.3 GO:0021539 subthalamus development(GO:0021539)
0.1 0.3 GO:0060734 regulation of endoplasmic reticulum stress-induced eIF2 alpha phosphorylation(GO:0060734) response to methyl methanesulfonate(GO:0072702) cellular response to methyl methanesulfonate(GO:0072703) response to environmental enrichment(GO:0090648) positive regulation of peptidyl-serine dephosphorylation(GO:1902310)
0.1 0.3 GO:0018199 peptidyl-glutamine modification(GO:0018199)
0.1 0.6 GO:0071460 cellular response to cell-matrix adhesion(GO:0071460)
0.1 0.3 GO:0002877 regulation of acute inflammatory response to non-antigenic stimulus(GO:0002877)
0.1 0.3 GO:0048319 axial mesoderm morphogenesis(GO:0048319)
0.1 0.3 GO:0045903 positive regulation of translational fidelity(GO:0045903)
0.1 0.3 GO:0046462 monoacylglycerol metabolic process(GO:0046462) monoacylglycerol catabolic process(GO:0052651)
0.1 0.2 GO:0060935 cardiac fibroblast cell differentiation(GO:0060935) cardiac fibroblast cell development(GO:0060936) epicardium-derived cardiac fibroblast cell differentiation(GO:0060938) epicardium-derived cardiac fibroblast cell development(GO:0060939)
0.1 0.6 GO:1903026 negative regulation of RNA polymerase II regulatory region sequence-specific DNA binding(GO:1903026)
0.1 0.2 GO:0019287 isopentenyl diphosphate biosynthetic process, mevalonate pathway(GO:0019287)
0.1 0.2 GO:0045065 cytotoxic T cell differentiation(GO:0045065)
0.1 0.2 GO:0001306 age-dependent response to oxidative stress(GO:0001306) age-dependent general metabolic decline(GO:0007571)
0.1 0.2 GO:0044375 regulation of peroxisome size(GO:0044375)
0.1 0.2 GO:2001013 epithelial cell proliferation involved in renal tubule morphogenesis(GO:2001013)
0.1 0.2 GO:0070173 regulation of enamel mineralization(GO:0070173)
0.1 0.1 GO:0010980 regulation of vitamin D 24-hydroxylase activity(GO:0010979) positive regulation of vitamin D 24-hydroxylase activity(GO:0010980)
0.1 0.2 GO:1903367 positive regulation of fear response(GO:1903367) positive regulation of behavioral fear response(GO:2000987)
0.1 0.2 GO:0045819 baroreceptor response to decreased systemic arterial blood pressure(GO:0001982) positive regulation of glycogen catabolic process(GO:0045819)
0.1 0.2 GO:0003342 proepicardium development(GO:0003342) septum transversum development(GO:0003343) mesendoderm development(GO:0048382)
0.1 0.2 GO:0045105 intermediate filament polymerization or depolymerization(GO:0045105)
0.1 0.2 GO:0003357 noradrenergic neuron differentiation(GO:0003357)
0.1 0.2 GO:0046066 purine deoxyribonucleoside diphosphate metabolic process(GO:0009182) dGDP metabolic process(GO:0046066)
0.1 0.2 GO:2000503 positive regulation of natural killer cell chemotaxis(GO:2000503)
0.1 0.4 GO:1990441 negative regulation of transcription from RNA polymerase II promoter in response to endoplasmic reticulum stress(GO:1990441)
0.0 0.2 GO:0060266 negative regulation of respiratory burst involved in inflammatory response(GO:0060266)
0.0 0.1 GO:1900738 positive regulation of phospholipase C-activating G-protein coupled receptor signaling pathway(GO:1900738)
0.0 0.3 GO:1900019 regulation of protein kinase C activity(GO:1900019) positive regulation of protein kinase C activity(GO:1900020)
0.0 0.7 GO:0090266 regulation of spindle checkpoint(GO:0090231) regulation of mitotic cell cycle spindle assembly checkpoint(GO:0090266) regulation of mitotic spindle checkpoint(GO:1903504)
0.0 0.1 GO:1903860 negative regulation of dendrite extension(GO:1903860)
0.0 0.1 GO:0000720 pyrimidine dimer repair by nucleotide-excision repair(GO:0000720)
0.0 0.1 GO:2000872 positive regulation of progesterone secretion(GO:2000872)
0.0 0.6 GO:0031274 positive regulation of pseudopodium assembly(GO:0031274)
0.0 0.1 GO:1903660 negative regulation of complement-dependent cytotoxicity(GO:1903660)
0.0 0.6 GO:0061299 retina vasculature morphogenesis in camera-type eye(GO:0061299)
0.0 0.3 GO:0007042 lysosomal lumen acidification(GO:0007042)
0.0 0.1 GO:0021797 forebrain anterior/posterior pattern specification(GO:0021797)
0.0 0.1 GO:0034696 response to prostaglandin F(GO:0034696)
0.0 1.4 GO:0048384 retinoic acid receptor signaling pathway(GO:0048384)
0.0 0.2 GO:0032792 negative regulation of CREB transcription factor activity(GO:0032792)
0.0 0.1 GO:0003330 regulation of extracellular matrix constituent secretion(GO:0003330) positive regulation of extracellular matrix constituent secretion(GO:0003331)
0.0 0.0 GO:1901421 positive regulation of response to alcohol(GO:1901421)
0.0 0.5 GO:0006590 thyroid hormone generation(GO:0006590)
0.0 0.1 GO:0060298 positive regulation of sarcomere organization(GO:0060298)
0.0 1.4 GO:0045604 regulation of epidermal cell differentiation(GO:0045604)
0.0 0.1 GO:0030186 melatonin metabolic process(GO:0030186)
0.0 0.2 GO:0042695 thelarche(GO:0042695) mammary gland branching involved in thelarche(GO:0060744)
0.0 0.1 GO:0045054 constitutive secretory pathway(GO:0045054)
0.0 0.1 GO:1903774 positive regulation of viral budding via host ESCRT complex(GO:1903774)
0.0 0.1 GO:0090164 asymmetric Golgi ribbon formation(GO:0090164)
0.0 0.4 GO:0048245 eosinophil chemotaxis(GO:0048245)
0.0 0.3 GO:0034982 mitochondrial protein processing(GO:0034982)
0.0 0.1 GO:0061084 negative regulation of protein refolding(GO:0061084)
0.0 0.1 GO:0048294 negative regulation of isotype switching to IgE isotypes(GO:0048294)
0.0 0.3 GO:0071712 ER-associated misfolded protein catabolic process(GO:0071712)
0.0 0.0 GO:0009240 isopentenyl diphosphate biosynthetic process(GO:0009240) isopentenyl diphosphate metabolic process(GO:0046490)
0.0 0.1 GO:0046604 positive regulation of mitotic centrosome separation(GO:0046604)
0.0 0.4 GO:0045653 negative regulation of megakaryocyte differentiation(GO:0045653)
0.0 0.1 GO:0090666 scaRNA localization to Cajal body(GO:0090666)
0.0 0.2 GO:0035360 positive regulation of peroxisome proliferator activated receptor signaling pathway(GO:0035360)
0.0 0.5 GO:0002076 osteoblast development(GO:0002076)
0.0 0.1 GO:0060370 susceptibility to T cell mediated cytotoxicity(GO:0060370)
0.0 0.1 GO:0045347 negative regulation of MHC class II biosynthetic process(GO:0045347)
0.0 0.1 GO:1904685 positive regulation of skeletal muscle cell proliferation(GO:0014858) positive regulation of metalloendopeptidase activity(GO:1904685)
0.0 0.2 GO:0034393 positive regulation of smooth muscle cell apoptotic process(GO:0034393)
0.0 0.1 GO:1902202 regulation of hepatocyte growth factor receptor signaling pathway(GO:1902202)
0.0 0.1 GO:2000767 positive regulation of cytoplasmic translation(GO:2000767)
0.0 0.3 GO:0006646 phosphatidylethanolamine biosynthetic process(GO:0006646)
0.0 0.2 GO:0007175 negative regulation of epidermal growth factor-activated receptor activity(GO:0007175)
0.0 0.3 GO:0010040 response to iron(II) ion(GO:0010040)
0.0 0.2 GO:0019800 peptide cross-linking via chondroitin 4-sulfate glycosaminoglycan(GO:0019800)
0.0 0.1 GO:0021593 rhombomere morphogenesis(GO:0021593)
0.0 0.2 GO:0061042 vascular wound healing(GO:0061042)
0.0 0.1 GO:0035063 nuclear speck organization(GO:0035063)
0.0 0.1 GO:2000328 regulation of T-helper 17 cell lineage commitment(GO:2000328)
0.0 0.1 GO:0060279 positive regulation of ovulation(GO:0060279)
0.0 0.1 GO:0042822 pyridoxal phosphate metabolic process(GO:0042822)
0.0 0.2 GO:0070525 tRNA threonylcarbamoyladenosine metabolic process(GO:0070525)
0.0 0.1 GO:1903576 response to L-arginine(GO:1903576)
0.0 0.1 GO:0016185 synaptic vesicle budding from presynaptic endocytic zone membrane(GO:0016185)
0.0 0.0 GO:0030167 proteoglycan catabolic process(GO:0030167) heparan sulfate proteoglycan catabolic process(GO:0030200) positive regulation of skeletal muscle cell differentiation(GO:2001016)
0.0 0.1 GO:1903659 complement-dependent cytotoxicity(GO:0097278) regulation of complement-dependent cytotoxicity(GO:1903659)
0.0 0.3 GO:0033327 Leydig cell differentiation(GO:0033327)
0.0 0.1 GO:0001915 negative regulation of T cell mediated cytotoxicity(GO:0001915)
0.0 0.1 GO:0032707 negative regulation of interleukin-23 production(GO:0032707)
0.0 0.1 GO:0003419 growth plate cartilage chondrocyte proliferation(GO:0003419)
0.0 0.1 GO:0007021 tubulin complex assembly(GO:0007021)
0.0 0.3 GO:0009954 proximal/distal pattern formation(GO:0009954)
0.0 0.1 GO:1902414 protein localization to cell junction(GO:1902414)
0.0 0.1 GO:1904781 positive regulation of protein localization to centrosome(GO:1904781)
0.0 0.1 GO:1902162 regulation of DNA damage response, signal transduction by p53 class mediator resulting in transcription of p21 class mediator(GO:1902162)
0.0 0.0 GO:0009216 purine deoxyribonucleotide biosynthetic process(GO:0009153) purine deoxyribonucleoside triphosphate biosynthetic process(GO:0009216)
0.0 0.2 GO:0030206 chondroitin sulfate biosynthetic process(GO:0030206)
0.0 0.1 GO:0002318 myeloid progenitor cell differentiation(GO:0002318)
0.0 0.1 GO:1903300 negative regulation of glucokinase activity(GO:0033132) negative regulation of hexokinase activity(GO:1903300)
0.0 0.2 GO:1901409 positive regulation of phosphorylation of RNA polymerase II C-terminal domain(GO:1901409)
0.0 0.2 GO:0007288 sperm axoneme assembly(GO:0007288)
0.0 0.0 GO:0017055 negative regulation of RNA polymerase II transcriptional preinitiation complex assembly(GO:0017055)
0.0 0.1 GO:0050859 negative regulation of B cell receptor signaling pathway(GO:0050859)
0.0 0.0 GO:0030886 negative regulation of myeloid dendritic cell activation(GO:0030886)
0.0 0.1 GO:0006369 termination of RNA polymerase II transcription(GO:0006369)
0.0 0.2 GO:0071374 cellular response to parathyroid hormone stimulus(GO:0071374)
0.0 0.1 GO:0006824 cobalt ion transport(GO:0006824)
0.0 0.0 GO:0010157 response to chlorate(GO:0010157)
0.0 0.1 GO:0032287 peripheral nervous system myelin maintenance(GO:0032287)
0.0 0.1 GO:0098914 membrane repolarization during atrial cardiac muscle cell action potential(GO:0098914)
0.0 0.1 GO:0046070 dGTP metabolic process(GO:0046070)
0.0 0.1 GO:0035726 common myeloid progenitor cell proliferation(GO:0035726)
0.0 0.1 GO:0097577 intracellular sequestering of iron ion(GO:0006880) sequestering of iron ion(GO:0097577)
0.0 0.1 GO:1903142 positive regulation of endothelial cell development(GO:1901552) positive regulation of establishment of endothelial barrier(GO:1903142)
0.0 0.0 GO:0090370 negative regulation of cholesterol efflux(GO:0090370)
0.0 0.0 GO:1902869 regulation of amacrine cell differentiation(GO:1902869)
0.0 0.2 GO:0035518 histone H2A monoubiquitination(GO:0035518)
0.0 0.1 GO:0035617 stress granule disassembly(GO:0035617)

Gene overrepresentation in cellular component category:

Log-likelihood per target  Total log-likelihood Term Description
0.2 0.8 GO:0035976 AP1 complex(GO:0035976)
0.1 0.6 GO:0044393 microspike(GO:0044393)
0.1 0.7 GO:0005862 muscle thin filament tropomyosin(GO:0005862)
0.1 0.3 GO:0005745 m-AAA complex(GO:0005745)
0.1 0.5 GO:0045009 melanosome membrane(GO:0033162) chitosome(GO:0045009)
0.0 0.4 GO:0005577 fibrinogen complex(GO:0005577)
0.0 0.2 GO:0045098 type III intermediate filament(GO:0045098)
0.0 0.2 GO:0000220 vacuolar proton-transporting V-type ATPase, V0 domain(GO:0000220)
0.0 0.2 GO:1990716 axonemal central apparatus(GO:1990716)
0.0 0.1 GO:0005971 ribonucleoside-diphosphate reductase complex(GO:0005971)
0.0 0.1 GO:0000408 EKC/KEOPS complex(GO:0000408)
0.0 0.3 GO:0034663 endoplasmic reticulum chaperone complex(GO:0034663)
0.0 0.2 GO:0031314 extrinsic component of mitochondrial inner membrane(GO:0031314)
0.0 0.3 GO:0016461 unconventional myosin complex(GO:0016461)
0.0 0.6 GO:0043196 varicosity(GO:0043196)
0.0 0.2 GO:0031467 Cul7-RING ubiquitin ligase complex(GO:0031467)
0.0 0.1 GO:0034751 aryl hydrocarbon receptor complex(GO:0034751)
0.0 0.1 GO:0046691 intracellular canaliculus(GO:0046691)
0.0 0.3 GO:0044754 autolysosome(GO:0044754)
0.0 0.2 GO:0072546 ER membrane protein complex(GO:0072546)
0.0 0.1 GO:0000839 Hrd1p ubiquitin ligase ERAD-L complex(GO:0000839)
0.0 0.3 GO:0000164 protein phosphatase type 1 complex(GO:0000164)
0.0 0.5 GO:0030687 preribosome, large subunit precursor(GO:0030687)
0.0 0.2 GO:0031045 dense core granule(GO:0031045)
0.0 0.1 GO:0033256 I-kappaB/NF-kappaB complex(GO:0033256)
0.0 0.4 GO:0000788 nuclear nucleosome(GO:0000788)
0.0 0.1 GO:0045252 mitochondrial alpha-ketoglutarate dehydrogenase complex(GO:0005947) oxoglutarate dehydrogenase complex(GO:0045252)
0.0 0.1 GO:0042583 chromaffin granule(GO:0042583)
0.0 0.1 GO:0072357 PTW/PP1 phosphatase complex(GO:0072357)
0.0 0.1 GO:0000322 storage vacuole(GO:0000322)
0.0 0.1 GO:0099571 postsynaptic actin cytoskeleton(GO:0098871) postsynaptic cytoskeleton(GO:0099571)
0.0 0.2 GO:0001527 microfibril(GO:0001527) fibril(GO:0043205)
0.0 0.0 GO:0031515 tRNA (m1A) methyltransferase complex(GO:0031515)
0.0 0.0 GO:0045257 mitochondrial respiratory chain complex II, succinate dehydrogenase complex (ubiquinone)(GO:0005749) succinate dehydrogenase complex (ubiquinone)(GO:0045257) fumarate reductase complex(GO:0045283)
0.0 0.1 GO:0042105 alpha-beta T cell receptor complex(GO:0042105)
0.0 0.2 GO:0031011 Ino80 complex(GO:0031011) DNA helicase complex(GO:0033202)
0.0 0.2 GO:0046581 intercellular canaliculus(GO:0046581)
0.0 0.1 GO:0089701 U2AF(GO:0089701)
0.0 0.0 GO:0030689 Noc complex(GO:0030689)
0.0 0.1 GO:0071439 clathrin complex(GO:0071439)
0.0 0.1 GO:0042788 polysomal ribosome(GO:0042788)
0.0 0.1 GO:0030130 clathrin coat of trans-Golgi network vesicle(GO:0030130)

Gene overrepresentation in molecular function category:

Log-likelihood per target  Total log-likelihood Term Description
0.3 0.8 GO:0008330 protein tyrosine/threonine phosphatase activity(GO:0008330)
0.2 0.6 GO:0031177 phosphopantetheine binding(GO:0031177)
0.1 0.6 GO:0051431 corticotropin-releasing hormone receptor 2 binding(GO:0051431)
0.1 0.3 GO:0050253 retinyl-palmitate esterase activity(GO:0050253)
0.1 0.5 GO:0016714 oxidoreductase activity, acting on paired donors, with incorporation or reduction of molecular oxygen, reduced pteridine as one donor, and incorporation of one atom of oxygen(GO:0016714)
0.1 0.3 GO:0004103 choline kinase activity(GO:0004103)
0.1 0.3 GO:0004169 dolichyl-phosphate-mannose-protein mannosyltransferase activity(GO:0004169)
0.1 0.3 GO:1990932 5.8S rRNA binding(GO:1990932)
0.1 0.2 GO:0004167 dopachrome isomerase activity(GO:0004167)
0.1 0.2 GO:0004937 alpha1-adrenergic receptor activity(GO:0004937)
0.1 0.4 GO:0045340 mercury ion binding(GO:0045340)
0.1 0.2 GO:0044715 8-oxo-dGDP phosphatase activity(GO:0044715)
0.0 1.1 GO:0005184 neuropeptide hormone activity(GO:0005184)
0.0 0.1 GO:0032422 purine-rich negative regulatory element binding(GO:0032422)
0.0 0.1 GO:0072590 N-acetyl-L-aspartate-L-glutamate ligase activity(GO:0072590)
0.0 0.1 GO:0017098 UTP binding(GO:0002134) sulfonylurea receptor binding(GO:0017098) pyrimidine ribonucleoside binding(GO:0032551)
0.0 0.2 GO:0043891 glyceraldehyde-3-phosphate dehydrogenase (NAD+) (phosphorylating) activity(GO:0004365) glyceraldehyde-3-phosphate dehydrogenase (NAD(P)+) (phosphorylating) activity(GO:0043891)
0.0 0.4 GO:0031730 CCR5 chemokine receptor binding(GO:0031730)
0.0 0.3 GO:0008429 phosphatidylethanolamine binding(GO:0008429)
0.0 0.1 GO:0052743 phosphatidylinositol-3,4,5-trisphosphate 5-phosphatase activity(GO:0034485) inositol tetrakisphosphate phosphatase activity(GO:0052743)
0.0 0.1 GO:0004687 myosin light chain kinase activity(GO:0004687)
0.0 0.1 GO:0005171 hepatocyte growth factor receptor binding(GO:0005171)
0.0 0.8 GO:0071837 HMG box domain binding(GO:0071837)
0.0 0.1 GO:0097677 STAT family protein binding(GO:0097677)
0.0 0.3 GO:0047372 acylglycerol lipase activity(GO:0047372)
0.0 0.5 GO:0017049 GTP-Rho binding(GO:0017049)
0.0 1.0 GO:0008307 structural constituent of muscle(GO:0008307)
0.0 0.3 GO:0005092 GDP-dissociation inhibitor activity(GO:0005092)
0.0 0.1 GO:0016728 ribonucleoside-diphosphate reductase activity, thioredoxin disulfide as acceptor(GO:0004748) oxidoreductase activity, acting on CH or CH2 groups, disulfide as acceptor(GO:0016728) ribonucleoside-diphosphate reductase activity(GO:0061731)
0.0 0.1 GO:0030060 L-malate dehydrogenase activity(GO:0030060)
0.0 0.2 GO:0008140 cAMP response element binding protein binding(GO:0008140)
0.0 0.1 GO:0008467 [heparan sulfate]-glucosamine 3-sulfotransferase 1 activity(GO:0008467)
0.0 0.1 GO:0032427 GBD domain binding(GO:0032427)
0.0 0.1 GO:0004118 cGMP-stimulated cyclic-nucleotide phosphodiesterase activity(GO:0004118)
0.0 0.1 GO:0004459 L-lactate dehydrogenase activity(GO:0004459)
0.0 0.1 GO:0015087 cobalt ion transmembrane transporter activity(GO:0015087)
0.0 0.1 GO:0032564 dATP binding(GO:0032564)
0.0 0.1 GO:0086089 voltage-gated potassium channel activity involved in atrial cardiac muscle cell action potential repolarization(GO:0086089)
0.0 0.1 GO:0019136 deoxynucleoside kinase activity(GO:0019136)
0.0 0.2 GO:0017017 MAP kinase tyrosine/serine/threonine phosphatase activity(GO:0017017)
0.0 0.3 GO:0005003 ephrin receptor activity(GO:0005003)
0.0 0.1 GO:0005001 transmembrane receptor protein tyrosine phosphatase activity(GO:0005001) transmembrane receptor protein phosphatase activity(GO:0019198)
0.0 0.4 GO:0005112 Notch binding(GO:0005112)
0.0 0.1 GO:0046790 virion binding(GO:0046790)
0.0 0.3 GO:0016755 transferase activity, transferring amino-acyl groups(GO:0016755)
0.0 0.1 GO:0051525 NFAT protein binding(GO:0051525)
0.0 0.4 GO:0042056 chemoattractant activity(GO:0042056)
0.0 0.1 GO:0005105 type 1 fibroblast growth factor receptor binding(GO:0005105)
0.0 0.5 GO:0031492 nucleosomal DNA binding(GO:0031492)
0.0 0.1 GO:0032050 clathrin heavy chain binding(GO:0032050)
0.0 0.3 GO:0016922 ligand-dependent nuclear receptor binding(GO:0016922)
0.0 0.0 GO:0016429 tRNA (adenine-N1-)-methyltransferase activity(GO:0016429)
0.0 0.1 GO:0050733 RS domain binding(GO:0050733)
0.0 0.1 GO:0051022 Rho GDP-dissociation inhibitor binding(GO:0051022)
0.0 0.1 GO:0016863 intramolecular oxidoreductase activity, transposing C=C bonds(GO:0016863)
0.0 0.0 GO:0008177 succinate dehydrogenase (ubiquinone) activity(GO:0008177) 3 iron, 4 sulfur cluster binding(GO:0051538)
0.0 0.1 GO:0004720 protein-lysine 6-oxidase activity(GO:0004720)
0.0 0.3 GO:0008157 protein phosphatase 1 binding(GO:0008157)
0.0 0.1 GO:1990715 mRNA CDS binding(GO:1990715)
0.0 0.0 GO:0097108 hedgehog family protein binding(GO:0097108)
0.0 0.0 GO:0051373 FATZ binding(GO:0051373)
0.0 0.1 GO:0044323 retinoic acid-responsive element binding(GO:0044323)
0.0 0.0 GO:0060698 endoribonuclease inhibitor activity(GO:0060698)
0.0 0.4 GO:0016709 oxidoreductase activity, acting on paired donors, with incorporation or reduction of molecular oxygen, NAD(P)H as one donor, and incorporation of one atom of oxygen(GO:0016709)
0.0 0.1 GO:0016681 ubiquinol-cytochrome-c reductase activity(GO:0008121) oxidoreductase activity, acting on diphenols and related substances as donors(GO:0016679) oxidoreductase activity, acting on diphenols and related substances as donors, cytochrome as acceptor(GO:0016681)

Gene overrepresentation in curated gene sets: canonical pathways category:

Log-likelihood per target  Total log-likelihood Term Description
0.0 3.0 PID AP1 PATHWAY AP-1 transcription factor network
0.0 1.3 PID TCR CALCIUM PATHWAY Calcium signaling in the CD4+ TCR pathway
0.0 0.1 PID S1P S1P2 PATHWAY S1P2 pathway
0.0 0.4 PID INTEGRIN5 PATHWAY Beta5 beta6 beta7 and beta8 integrin cell surface interactions
0.0 0.7 ST P38 MAPK PATHWAY p38 MAPK Pathway
0.0 0.6 PID IL12 2PATHWAY IL12-mediated signaling events
0.0 0.3 PID EPHA2 FWD PATHWAY EPHA2 forward signaling

Gene overrepresentation in curated gene sets: REACTOME pathways category:

Log-likelihood per target  Total log-likelihood Term Description
0.1 1.0 REACTOME AMINE DERIVED HORMONES Genes involved in Amine-derived hormones
0.0 1.0 REACTOME SMOOTH MUSCLE CONTRACTION Genes involved in Smooth Muscle Contraction
0.0 0.3 REACTOME SYNTHESIS OF PE Genes involved in Synthesis of PE
0.0 0.3 REACTOME P130CAS LINKAGE TO MAPK SIGNALING FOR INTEGRINS Genes involved in p130Cas linkage to MAPK signaling for integrins
0.0 0.4 REACTOME POST CHAPERONIN TUBULIN FOLDING PATHWAY Genes involved in Post-chaperonin tubulin folding pathway
0.0 0.1 REACTOME GAP JUNCTION DEGRADATION Genes involved in Gap junction degradation
0.0 0.1 REACTOME FORMATION OF TUBULIN FOLDING INTERMEDIATES BY CCT TRIC Genes involved in Formation of tubulin folding intermediates by CCT/TriC
0.0 0.3 REACTOME DOWNREGULATION OF TGF BETA RECEPTOR SIGNALING Genes involved in Downregulation of TGF-beta receptor signaling
0.0 0.3 REACTOME CHOLESTEROL BIOSYNTHESIS Genes involved in Cholesterol biosynthesis
0.0 0.1 REACTOME SIGNALLING TO P38 VIA RIT AND RIN Genes involved in Signalling to p38 via RIT and RIN