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GSE49485: Hypoxia transcriptome sequencing of rat brain.
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Results for Irx6_Irx2_Irx3
Z-value: 1.20
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Transcription factors associated with Irx6_Irx2_Irx3
Activity-expression correlation:
| Gene | Promoter | Pearson corr. coef. | P-value | Plot |
|---|---|---|---|---|
| Irx2 | rn6_v1_chr1_-_33275540_33275540 | -0.62 | 2.7e-01 | Click! |
| Irx3 | rn6_v1_chr19_-_15840990_15840990 | -0.52 | 3.7e-01 | Click! |
| Irx6 | rn6_v1_chr19_-_15733412_15733412 | -0.49 | 4.0e-01 | Click! |
| Promoter | Log-likelihood | Transcript | Gene | Gene Info |
|---|---|---|---|---|
| chr2_+_71753816 Show fit | 1.04 |
ENSRNOT00000025809
|
|
|
| chr13_-_82129989 Show fit | 0.80 |
ENSRNOT00000078963
|
|
|
| chr4_-_155923079 Show fit | 0.59 |
ENSRNOT00000013308
|
C-type lectin domain family 4, member A3 |
|
| chr5_-_16782647 Show fit | 0.47 |
ENSRNOT00000072844
|
ribosomal protein L19-like |
|
| chr19_+_26416818 Show fit | 0.43 |
ENSRNOT00000040473
|
|
|
| chr13_-_103080920 Show fit | 0.39 |
ENSRNOT00000034990
|
|
|
| chr16_-_6405117 Show fit | 0.38 |
ENSRNOT00000047737
|
calcium voltage-gated channel subunit alpha1 D |
|
| chr16_-_6404578 Show fit | 0.37 |
ENSRNOT00000051371
|
calcium voltage-gated channel subunit alpha1 D |
|
| chr20_+_14578605 Show fit | 0.37 |
ENSRNOT00000041165
|
rhabdoid tumor deletion region gene 1 |
|
| chr15_+_32386816 Show fit | 0.36 |
ENSRNOT00000060322
|
|
Network of associatons between targets according to the STRING database.
First level regulatory network of Irx6_Irx2_Irx3
Gene Ontology Analysis
Gene overrepresentation in biological process category:
| Log-likelihood per target | Total log-likelihood | Term | Description |
|---|---|---|---|
| 0.1 | 0.9 | GO:0086046 | membrane depolarization during SA node cell action potential(GO:0086046) |
| 0.2 | 0.5 | GO:0032197 | transposition, RNA-mediated(GO:0032197) |
| 0.2 | 0.5 | GO:1904124 | microglial cell migration(GO:1904124) regulation of microglial cell migration(GO:1904139) |
| 0.0 | 0.5 | GO:0043252 | sodium-independent organic anion transport(GO:0043252) |
| 0.1 | 0.4 | GO:0060279 | positive regulation of ovulation(GO:0060279) |
| 0.1 | 0.3 | GO:2000682 | positive regulation of rubidium ion transport(GO:2000682) positive regulation of rubidium ion transmembrane transporter activity(GO:2000688) |
| 0.1 | 0.3 | GO:0014739 | positive regulation of muscle hyperplasia(GO:0014739) |
| 0.1 | 0.3 | GO:0046061 | dATP catabolic process(GO:0046061) |
| 0.0 | 0.3 | GO:0071376 | response to corticotropin-releasing hormone(GO:0043435) cellular response to corticotropin-releasing hormone stimulus(GO:0071376) |
| 0.0 | 0.3 | GO:2000371 | regulation of DNA topoisomerase (ATP-hydrolyzing) activity(GO:2000371) positive regulation of DNA topoisomerase (ATP-hydrolyzing) activity(GO:2000373) |
Gene overrepresentation in cellular component category:
| Log-likelihood per target | Total log-likelihood | Term | Description |
|---|---|---|---|
| 0.1 | 0.9 | GO:1990454 | L-type voltage-gated calcium channel complex(GO:1990454) |
| 0.1 | 0.4 | GO:0043511 | inhibin complex(GO:0043511) |
| 0.1 | 0.3 | GO:0005944 | phosphatidylinositol 3-kinase complex, class IB(GO:0005944) |
| 0.0 | 0.3 | GO:0001891 | phagocytic cup(GO:0001891) |
| 0.1 | 0.2 | GO:0097209 | epidermal lamellar body(GO:0097209) |
| 0.0 | 0.2 | GO:0072557 | IPAF inflammasome complex(GO:0072557) NLRP1 inflammasome complex(GO:0072558) AIM2 inflammasome complex(GO:0097169) |
| 0.0 | 0.2 | GO:0098536 | deuterosome(GO:0098536) |
| 0.0 | 0.2 | GO:0031083 | BLOC-1 complex(GO:0031083) |
| 0.0 | 0.1 | GO:0061574 | ASAP complex(GO:0061574) |
| 0.0 | 0.1 | GO:0019815 | B cell receptor complex(GO:0019815) |
Gene overrepresentation in molecular function category:
| Log-likelihood per target | Total log-likelihood | Term | Description |
|---|---|---|---|
| 0.1 | 0.9 | GO:0086059 | voltage-gated calcium channel activity involved SA node cell action potential(GO:0086059) |
| 0.0 | 0.5 | GO:0005549 | odorant binding(GO:0005549) |
| 0.1 | 0.4 | GO:0070699 | type II activin receptor binding(GO:0070699) |
| 0.0 | 0.4 | GO:0035259 | glucocorticoid receptor binding(GO:0035259) |
| 0.1 | 0.3 | GO:0032027 | myosin light chain binding(GO:0032027) |
| 0.0 | 0.3 | GO:0032554 | purine deoxyribonucleotide binding(GO:0032554) |
| 0.0 | 0.3 | GO:0019869 | chloride channel inhibitor activity(GO:0019869) |
| 0.0 | 0.3 | GO:0015125 | bile acid transmembrane transporter activity(GO:0015125) |
| 0.0 | 0.3 | GO:0016303 | 1-phosphatidylinositol-3-kinase activity(GO:0016303) |
| 0.0 | 0.3 | GO:0032183 | SUMO binding(GO:0032183) |
Gene overrepresentation in curated gene sets: canonical pathways category:
| Log-likelihood per target | Total log-likelihood | Term | Description |
|---|---|---|---|
| 0.0 | 0.4 | PID RXR VDR PATHWAY | RXR and RAR heterodimerization with other nuclear receptor |
| 0.0 | 0.3 | PID ALK1 PATHWAY | ALK1 signaling events |
| 0.0 | 0.3 | PID IL8 CXCR1 PATHWAY | IL8- and CXCR1-mediated signaling events |
| 0.0 | 0.2 | PID ANTHRAX PATHWAY | Cellular roles of Anthrax toxin |
Gene overrepresentation in curated gene sets: REACTOME pathways category:
| Log-likelihood per target | Total log-likelihood | Term | Description |
|---|---|---|---|
| 0.0 | 0.3 | REACTOME GLYCOPROTEIN HORMONES | Genes involved in Glycoprotein hormones |
| 0.0 | 0.3 | REACTOME P2Y RECEPTORS | Genes involved in P2Y receptors |
| 0.0 | 0.3 | REACTOME SEROTONIN RECEPTORS | Genes involved in Serotonin receptors |
| 0.0 | 0.3 | REACTOME RNA POL I PROMOTER OPENING | Genes involved in RNA Polymerase I Promoter Opening |
| 0.0 | 0.3 | REACTOME CHONDROITIN SULFATE BIOSYNTHESIS | Genes involved in Chondroitin sulfate biosynthesis |
| 0.0 | 0.3 | REACTOME ASSOCIATION OF LICENSING FACTORS WITH THE PRE REPLICATIVE COMPLEX | Genes involved in Association of licensing factors with the pre-replicative complex |
| 0.0 | 0.2 | REACTOME VITAMIN B5 PANTOTHENATE METABOLISM | Genes involved in Vitamin B5 (pantothenate) metabolism |
| 0.0 | 0.2 | REACTOME THE NLRP3 INFLAMMASOME | Genes involved in The NLRP3 inflammasome |
| 0.0 | 0.2 | REACTOME BILE SALT AND ORGANIC ANION SLC TRANSPORTERS | Genes involved in Bile salt and organic anion SLC transporters |
| 0.0 | 0.1 | REACTOME ORGANIC CATION ANION ZWITTERION TRANSPORT | Genes involved in Organic cation/anion/zwitterion transport |