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GSE49485: Hypoxia transcriptome sequencing of rat brain.

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Results for Irx6_Irx2_Irx3

Z-value: 1.20

Motif logo

Transcription factors associated with Irx6_Irx2_Irx3

Gene Symbol Gene ID Gene Info
ENSRNOG00000011037 iroquois homeobox 6
ENSRNOG00000012742 iroquois homeobox 2
ENSRNOG00000011533 iroquois homeobox 3

Activity-expression correlation:

GenePromoterPearson corr. coef.P-valuePlot
Irx2rn6_v1_chr1_-_33275540_33275540-0.622.7e-01Click!
Irx3rn6_v1_chr19_-_15840990_15840990-0.523.7e-01Click!
Irx6rn6_v1_chr19_-_15733412_15733412-0.494.0e-01Click!

Activity profile of Irx6_Irx2_Irx3 motif

Sorted Z-values of Irx6_Irx2_Irx3 motif

Promoter Log-likelihood Transcript Gene Gene Info
chr2_+_71753816 1.04 ENSRNOT00000025809

chr13_-_82129989 0.80 ENSRNOT00000078963

chr4_-_155923079 0.59 ENSRNOT00000013308
C-type lectin domain family 4, member A3
chr5_-_16782647 0.47 ENSRNOT00000072844
ribosomal protein L19-like
chr19_+_26416818 0.43 ENSRNOT00000040473

chr13_-_103080920 0.39 ENSRNOT00000034990

chr16_-_6405117 0.38 ENSRNOT00000047737
calcium voltage-gated channel subunit alpha1 D
chr16_-_6404578 0.37 ENSRNOT00000051371
calcium voltage-gated channel subunit alpha1 D
chr20_+_14578605 0.37 ENSRNOT00000041165
rhabdoid tumor deletion region gene 1
chr15_+_32386816 0.36 ENSRNOT00000060322

chr17_-_51912496 0.35 ENSRNOT00000019272
inhibin beta A subunit
chrX_+_19854836 0.35 ENSRNOT00000075010

chr20_+_8484311 0.35 ENSRNOT00000050041
ribosomal protein S20-like
chr14_+_69800156 0.35 ENSRNOT00000072746
ligand dependent nuclear receptor corepressor-like
chrX_+_18163358 0.32 ENSRNOT00000045517
similar to Spindlin-like protein 2 (SPIN-2)
chr4_-_176026133 0.32 ENSRNOT00000043374
ENSRNOT00000046598
solute carrier organic anion transporter family, member 1a4
chr7_+_27174882 0.32 ENSRNOT00000051181
glycosyltransferase 8 domain containing 2
chrX_-_158288109 0.32 ENSRNOT00000072527
PHD finger protein 6
chrX_+_14019961 0.32 ENSRNOT00000004785
synaptotagmin-like 5
chrX_+_20351486 0.31 ENSRNOT00000093675
ENSRNOT00000047444
WNK lysine deficient protein kinase 3
chr3_-_153246433 0.30 ENSRNOT00000067748
SAM and HD domain containing deoxynucleoside triphosphate triphosphohydrolase 1
chr12_-_13462038 0.30 ENSRNOT00000043110
ribosomal protein L36-like
chrX_-_157628237 0.30 ENSRNOT00000083549
embryonic testis differentiation
chr7_+_142912316 0.29 ENSRNOT00000010171
nuclear receptor subfamily 4, group A, member 1
chr6_-_51498337 0.28 ENSRNOT00000012487
phosphatidylinositol-4,5-bisphosphate 3-kinase, catalytic subunit gamma
chr2_-_208623314 0.27 ENSRNOT00000022731
primary cilia formation
chr19_-_28751584 0.26 ENSRNOT00000079270

chr5_+_10125070 0.26 ENSRNOT00000085321

chr7_-_116063078 0.25 ENSRNOT00000076932
ENSRNOT00000035496
glycosylphosphatidylinositol anchored molecule like
chr1_-_253185533 0.25 ENSRNOT00000067822
pantothenate kinase 1
chr6_+_73358112 0.25 ENSRNOT00000041373
Rho GTPase activating protein 5
chr3_-_161131812 0.24 ENSRNOT00000067008
WAP four-disulfide core domain 11
chr2_-_149444548 0.24 ENSRNOT00000018600
purinergic receptor P2Y12
chr13_-_91776397 0.24 ENSRNOT00000073147
mucosal pentraxin 1
chr17_-_69711689 0.24 ENSRNOT00000041925
aldo-keto reductase family 1, member C12
chrX_-_45284341 0.24 ENSRNOT00000045436
odorant binding protein I f
chr8_+_99713783 0.23 ENSRNOT00000089624
phospholipid scramblase 1
chrX_+_20520034 0.23 ENSRNOT00000093170
family with sequence similarity 120C
chr5_-_164348713 0.23 ENSRNOT00000087044
similar to casein kinase 1, gamma 3 isoform 2
chr2_+_187447501 0.23 ENSRNOT00000038589
IQ motif containing GTPase activating protein 3
chr8_+_2604962 0.23 ENSRNOT00000009993
caspase 1
chr17_-_44815995 0.23 ENSRNOT00000091201
histone H4 variant H4-v.1
chr17_-_21705773 0.23 ENSRNOT00000078010
glucosaminyl (N-acetyl) transferase 2, I-branching enzyme
chr18_+_35121967 0.22 ENSRNOT00000017522
serine peptidase inhibitor, Kazal type 5
chr17_+_53962444 0.21 ENSRNOT00000080101
geranylgeranyl diphosphate synthase 1
chr14_-_23604834 0.21 ENSRNOT00000002760
signal transducing adaptor family member 1
chrX_+_122808605 0.21 ENSRNOT00000017567
zinc finger CCHC-type containing 12
chr19_-_21970103 0.21 ENSRNOT00000074210

chr18_-_7081356 0.21 ENSRNOT00000021253
carbohydrate sulfotransferase 9
chr7_-_145338152 0.20 ENSRNOT00000055268
salivary protein 1
chr11_-_1983513 0.20 ENSRNOT00000000907
5-hydroxytryptamine receptor 1F
chr6_-_88917070 0.20 ENSRNOT00000000767
MAM domain containing glycosylphosphatidylinositol anchor 2
chr18_+_29490981 0.19 ENSRNOT00000032316
eukaryotic translation initiation factor 4E binding protein 3
chr2_+_209661244 0.19 ENSRNOT00000091973

chr3_-_71798531 0.19 ENSRNOT00000088170
calcitonin receptor like receptor
chr1_-_116919269 0.19 ENSRNOT00000035149

chr1_+_77967755 0.18 ENSRNOT00000058241
zinc finger protein 541
chrM_+_8599 0.18 ENSRNOT00000049683
mitochondrially encoded cytochrome C oxidase III
chr13_-_67819835 0.18 ENSRNOT00000093666
hemicentin 1
chr19_-_26946044 0.18 ENSRNOT00000090756

chr8_-_17696989 0.18 ENSRNOT00000083752

chr1_+_214183724 0.17 ENSRNOT00000091150
leucine rich repeat containing 56
chr8_-_14157141 0.17 ENSRNOT00000079034
deuterosome assembly protein 1
chr19_+_15081590 0.17 ENSRNOT00000024187
carboxylesterase 1F
chr7_-_24667301 0.17 ENSRNOT00000009154
transmembrane protein 263
chr3_+_86621205 0.16 ENSRNOT00000044595
leucine rich repeat containing 4C
chr7_+_117773948 0.16 ENSRNOT00000021673
leucine rich repeat containing 14
chr3_+_85544827 0.16 ENSRNOT00000051901

chr14_+_39368530 0.16 ENSRNOT00000084367
cytochrome c oxidase subunit 7B2
chr2_-_157035483 0.16 ENSRNOT00000076491
similar to RalA binding protein 1
chr12_+_22965025 0.16 ENSRNOT00000080068
collagen type XXVI alpha 1 chain
chr19_+_26022849 0.16 ENSRNOT00000014887
deoxyribonuclease 2, lysosomal
chr14_-_21709084 0.16 ENSRNOT00000087477
submaxillary gland androgen regulated protein 3B
chr20_-_5166252 0.16 ENSRNOT00000001138
allograft inflammatory factor 1
chr17_+_44794130 0.16 ENSRNOT00000077571
histone cluster 1, H2ac
chr6_-_87427153 0.16 ENSRNOT00000071999

chrX_-_83864150 0.16 ENSRNOT00000073734
odorant binding protein I f
chr14_-_33031282 0.16 ENSRNOT00000043244
60S ribosomal protein L39
chr4_+_152449270 0.15 ENSRNOT00000076733
RAD52 homolog, DNA repair protein
chr15_+_34328851 0.15 ENSRNOT00000026819
testis-specific serine kinase 4
chr1_-_155955173 0.15 ENSRNOT00000079345

chr6_+_127941526 0.15 ENSRNOT00000033897
Ab1-233
chr18_+_25613831 0.15 ENSRNOT00000091040
thymic stromal lymphopoietin
chr1_+_229267916 0.15 ENSRNOT00000073717
ENSRNOT00000082670
ENSRNOT00000076941
serine protease inhibitor Kazal-type 5-like
chr1_-_59732409 0.14 ENSRNOT00000014824
hyaluronan synthase 1
chr9_+_16924520 0.14 ENSRNOT00000025094
solute carrier family 22 member 7
chr2_-_173563273 0.14 ENSRNOT00000081423
zinc finger, B-box domain containing
chr7_-_139731876 0.14 ENSRNOT00000013704
ankyrin repeat and SOCS box-containing 8
chr20_-_5166448 0.14 ENSRNOT00000076331
allograft inflammatory factor 1
chr2_-_235052464 0.14 ENSRNOT00000093512
uncharacterized LOC103691699
chr2_+_195582781 0.14 ENSRNOT00000066020
thioesterase superfamily member 5
chr10_+_34975708 0.14 ENSRNOT00000064984
NHP2 ribonucleoprotein
chr7_+_114724610 0.14 ENSRNOT00000014541
DENN domain containing 3
chr16_+_37177443 0.14 ENSRNOT00000014083
centrosomal protein 44
chr18_+_57727187 0.14 ENSRNOT00000065483
ENSRNOT00000025871
5-hydroxytryptamine receptor 4
chr9_+_61738471 0.14 ENSRNOT00000090305

chr1_-_67284864 0.14 ENSRNOT00000082908
similar to zinc finger and SCAN domain containing 4
chr10_-_17415251 0.13 ENSRNOT00000005509
EF-hand calcium binding domain 9
chr4_+_33890349 0.13 ENSRNOT00000078680
core 1 synthase, glycoprotein-N-acetylgalactosamine 3-beta-galactosyltransferase, 1
chr19_+_25946979 0.13 ENSRNOT00000004027
GADD45G interacting protein 1
chr10_-_109840047 0.13 ENSRNOT00000054947
NOTUM, palmitoleoyl-protein carboxylesterase
chr17_-_44793927 0.13 ENSRNOT00000086309
histone cluster 1 H2B family member o
chr1_-_183763664 0.13 ENSRNOT00000044231
similar to 6.8 kDa mitochondrial proteolipid
chr2_+_192538899 0.13 ENSRNOT00000045691
ENSRNOT00000085931
small proline-rich protein 2I-like
chr10_+_49259194 0.13 ENSRNOT00000091100
ENSRNOT00000004390
F-box and WD repeat domain containing 10
chr16_-_6404957 0.13 ENSRNOT00000048459
calcium voltage-gated channel subunit alpha1 D
chr7_-_107223047 0.13 ENSRNOT00000007250
ENSRNOT00000084875
leucine rich repeat containing 6
chr3_-_46601409 0.12 ENSRNOT00000079261
phospholipase A2 receptor 1
chr10_-_70744315 0.12 ENSRNOT00000014865
C-C motif chemokine ligand 5
chr10_-_107114271 0.12 ENSRNOT00000004035
dynein, axonemal, heavy chain 17
chr16_-_47208110 0.12 ENSRNOT00000017670
dCMP deaminase
chr1_-_227506822 0.12 ENSRNOT00000091506
membrane spanning 4-domains A7
chr7_-_80457816 0.12 ENSRNOT00000039430

chr3_-_173944396 0.12 ENSRNOT00000079019
synaptonemal complex protein 2
chr3_+_152226070 0.12 ENSRNOT00000073201

chr2_+_222792999 0.12 ENSRNOT00000036228

chr4_+_14039977 0.12 ENSRNOT00000091249
ENSRNOT00000075878
CD36 molecule
chr14_+_17534412 0.12 ENSRNOT00000079304
ENSRNOT00000046771
cyclin dependent kinase like 2
chr10_-_74360937 0.12 ENSRNOT00000088182
glycerophosphodiester phosphodiesterase domain containing 1
chr12_-_30491102 0.12 ENSRNOT00000001224
sulfatase modifying factor 2
chr4_-_164123974 0.11 ENSRNOT00000082447
similar to immunoreceptor Ly49si1
chr7_-_68512397 0.11 ENSRNOT00000058036
solute carrier family 16 member 7
chr10_+_68588789 0.11 ENSRNOT00000049614

chr19_+_50045020 0.11 ENSRNOT00000090165
phospholipase C, gamma 2
chr16_+_22979444 0.11 ENSRNOT00000017822
chondroitin sulfate N-acetylgalactosaminyltransferase 1
chr6_+_64649194 0.11 ENSRNOT00000039776

chr14_-_113968268 0.11 ENSRNOT00000005872
ribosomal protein S27a
chr9_+_8349033 0.11 ENSRNOT00000073775
hypothetical protein LOC100360856
chrX_+_16050780 0.11 ENSRNOT00000079054
chloride voltage-gated channel 5
chr17_+_42302540 0.11 ENSRNOT00000025389
geminin, DNA replication inhibitor
chrX_-_82986051 0.11 ENSRNOT00000077587
highly divergent homeobox
chr10_+_81592114 0.11 ENSRNOT00000072783
mbt domain containing 1
chr1_-_62681471 0.11 ENSRNOT00000042466
vomeronasal 2 receptor, 15
chr16_-_7412150 0.11 ENSRNOT00000047252
similar to ribosomal protein S24
chr10_+_62981297 0.11 ENSRNOT00000031618
EF-hand calcium binding domain 5
chr4_-_120559078 0.11 ENSRNOT00000085730
ENSRNOT00000079575
kelch repeat and BTB domain containing 12
chr14_-_6284145 0.11 ENSRNOT00000044065
zinc finger protein 951
chr14_-_6358720 0.11 ENSRNOT00000048419
zinc finger protein 951
chr2_+_242634399 0.10 ENSRNOT00000035700
endomucin
chr15_+_87704340 0.10 ENSRNOT00000034987
sciellin
chr8_+_29714285 0.10 ENSRNOT00000042890
opioid binding protein/cell adhesion molecule-like
chr1_+_82089922 0.10 ENSRNOT00000071251
zinc finger protein 526
chr13_+_85818427 0.10 ENSRNOT00000077227
ENSRNOT00000006117
retinoid X receptor gamma
chr1_-_227441442 0.10 ENSRNOT00000028433
membrane spanning 4-domains A1
chrM_+_14136 0.10 ENSRNOT00000042098
mitochondrially encoded cytochrome b
chr1_+_42170583 0.10 ENSRNOT00000093104
vasoactive intestinal peptide
chr15_+_38069320 0.10 ENSRNOT00000014397
Sin3-associated polypeptide 18
chr10_+_29067102 0.10 ENSRNOT00000005161
C1q and tumor necrosis factor related protein 2
chr9_+_24066303 0.10 ENSRNOT00000018163
cysteine-rich secretory protein 3
chr4_+_163358009 0.10 ENSRNOT00000082064
killer cell lectin like receptor D1
chr1_+_147713892 0.10 ENSRNOT00000092985
ENSRNOT00000054742
ENSRNOT00000074103
cytochrome P450, family 2, subfamily C, polypeptide 6, variant 1
chrM_-_14061 0.10 ENSRNOT00000051268
mitochondrially encoded NADH dehydrogenase 6
chr9_+_77320726 0.10 ENSRNOT00000068450
sperm associated antigen 16
chr16_+_20657099 0.10 ENSRNOT00000027053
KxDL motif containing 1
chr5_-_29682005 0.10 ENSRNOT00000012394
oxidative stress induced growth inhibitor family member 2
chr1_-_167911961 0.10 ENSRNOT00000025097
olfactory receptor 59
chr3_-_10153554 0.10 ENSRNOT00000093246
exosome component 2
chr9_-_24383679 0.10 ENSRNOT00000040542
cysteine-rich secretory protein 1
chr10_-_93679974 0.10 ENSRNOT00000009316
membrane associated ring-CH-type finger 10
chr5_-_79899054 0.09 ENSRNOT00000074379

chr10_-_68926264 0.09 ENSRNOT00000008661
prohibitin, pseudogene 1
chr13_+_89597138 0.09 ENSRNOT00000004662
apolipoprotein A2
chr3_+_100373439 0.09 ENSRNOT00000085176
kinesin family member 18A
chr1_+_42170281 0.09 ENSRNOT00000092879
vasoactive intestinal peptide
chr10_-_95431312 0.09 ENSRNOT00000085552

chr3_-_104502471 0.09 ENSRNOT00000040306
ryanodine receptor 3
chr16_+_69003868 0.09 ENSRNOT00000016907
adrenoceptor beta 3
chr4_+_98337367 0.09 ENSRNOT00000042165

chrX_+_31984612 0.09 ENSRNOT00000005181
BMX non-receptor tyrosine kinase
chr16_+_22250470 0.09 ENSRNOT00000015799
leucine zipper tumor suppressor 1
chrX_+_83926513 0.09 ENSRNOT00000035274
similar to RIKEN cDNA 2010106E10
chr4_+_156051915 0.09 ENSRNOT00000087933
ENSRNOT00000077840
C-type lectin domain family 4, member A
chr2_-_209537087 0.09 ENSRNOT00000024344
Cd53 molecule
chr17_-_2278613 0.09 ENSRNOT00000046525
contactin associated protein-like 3B
chr18_-_60835739 0.09 ENSRNOT00000039569
similar to glyceraldehyde-3-phosphate dehydrogenase
chr10_-_88152064 0.09 ENSRNOT00000019477
keratin 16
chr12_-_13133219 0.09 ENSRNOT00000092292
diacylglycerol lipase, beta
chr4_-_164453171 0.09 ENSRNOT00000077539
ENSRNOT00000083610
ENSRNOT00000079975
Ly49 stimulatory receptor 6
chr18_+_29999290 0.09 ENSRNOT00000027372
protocadherin alpha 4
chr18_+_35574002 0.09 ENSRNOT00000093442
ENSRNOT00000070817
ENSRNOT00000093356
myotilin
chr4_+_69386698 0.09 ENSRNOT00000091655
T cell receptor beta, variable 13-2
chr5_-_9094616 0.09 ENSRNOT00000072210
serum/glucocorticoid regulated kinase family, member 3
chr18_+_29993361 0.09 ENSRNOT00000075810
protocadherin alpha 4
chr1_-_176983045 0.09 ENSRNOT00000022301
dickkopf WNT signaling pathway inhibitor 3
chr9_+_15313523 0.09 ENSRNOT00000070805
translocase of outer mitochondrial membrane 6
chr14_-_100184192 0.09 ENSRNOT00000007044
pleckstrin
chr10_-_64550145 0.08 ENSRNOT00000050232
nucleoredoxin
chr1_+_1545134 0.08 ENSRNOT00000044523

chr16_+_2278701 0.08 ENSRNOT00000016233
DENN domain containing 6A
chr4_-_165541314 0.08 ENSRNOT00000013833
serine/threonine/tyrosine kinase 1
chr17_-_77261731 0.08 ENSRNOT00000066850
upper zone of growth plate and cartilage matrix associated
chr17_+_10065947 0.08 ENSRNOT00000022703
ubiquitin interaction motif containing 1
chr15_+_104026601 0.08 ENSRNOT00000013520
ENSRNOT00000083269
ENSRNOT00000093403
claudin 10
chr10_-_18506337 0.08 ENSRNOT00000043036
gamma-aminobutyric acid type A receptor pi subunit
chr10_+_84669914 0.08 ENSRNOT00000011665
chromobox 1
chr20_-_821332 0.08 ENSRNOT00000040957
olfactory receptor 1692
chr20_+_47596575 0.08 ENSRNOT00000087230
ENSRNOT00000064905
sex comb on midleg-like 4 (Drosophila)
chr4_-_28437676 0.08 ENSRNOT00000012995
HEPACAM family member 2
chr9_+_37727942 0.08 ENSRNOT00000016511
ENSRNOT00000074276
myotilin-like
chr16_+_39909270 0.08 ENSRNOT00000081994
WD repeat domain 17

Network of associatons between targets according to the STRING database.

First level regulatory network of Irx6_Irx2_Irx3

PNG image of the network

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Gene Ontology Analysis

Gene overrepresentation in biological process category:

Log-likelihood per target  Total log-likelihood Term Description
0.2 0.5 GO:0032197 transposition, RNA-mediated(GO:0032197)
0.2 0.5 GO:1904124 microglial cell migration(GO:1904124) regulation of microglial cell migration(GO:1904139)
0.1 0.3 GO:2000682 positive regulation of rubidium ion transport(GO:2000682) positive regulation of rubidium ion transmembrane transporter activity(GO:2000688)
0.1 0.3 GO:0014739 positive regulation of muscle hyperplasia(GO:0014739)
0.1 0.9 GO:0086046 membrane depolarization during SA node cell action potential(GO:0086046)
0.1 0.4 GO:0060279 positive regulation of ovulation(GO:0060279)
0.1 0.3 GO:0046061 dATP catabolic process(GO:0046061)
0.1 0.2 GO:0033386 geranylgeranyl diphosphate metabolic process(GO:0033385) geranylgeranyl diphosphate biosynthetic process(GO:0033386)
0.1 0.2 GO:0010897 negative regulation of triglyceride catabolic process(GO:0010897)
0.1 0.2 GO:0050717 positive regulation of interleukin-1 alpha secretion(GO:0050717)
0.0 0.3 GO:0071376 response to corticotropin-releasing hormone(GO:0043435) cellular response to corticotropin-releasing hormone stimulus(GO:0071376)
0.0 0.1 GO:1900135 positive regulation of renin secretion into blood stream(GO:1900135)
0.0 0.1 GO:0010903 negative regulation of very-low-density lipoprotein particle remodeling(GO:0010903)
0.0 0.1 GO:0016267 O-glycan processing, core 1(GO:0016267)
0.0 0.3 GO:2000371 regulation of DNA topoisomerase (ATP-hydrolyzing) activity(GO:2000371) positive regulation of DNA topoisomerase (ATP-hydrolyzing) activity(GO:2000373)
0.0 0.2 GO:1903251 multi-ciliated epithelial cell differentiation(GO:1903251)
0.0 0.2 GO:2000327 positive regulation of ligand-dependent nuclear receptor transcription coactivator activity(GO:2000327)
0.0 0.1 GO:0042531 CD8-positive, alpha-beta T cell extravasation(GO:0035697) regulation of tyrosine phosphorylation of STAT protein(GO:0042509) positive regulation of tyrosine phosphorylation of STAT protein(GO:0042531)
0.0 0.1 GO:0010070 zygote asymmetric cell division(GO:0010070)
0.0 0.1 GO:0019276 UDP-N-acetylgalactosamine metabolic process(GO:0019276)
0.0 0.2 GO:0036438 maintenance of lens transparency(GO:0036438)
0.0 0.1 GO:0071163 DNA replication preinitiation complex assembly(GO:0071163)
0.0 0.1 GO:0045226 extracellular polysaccharide biosynthetic process(GO:0045226) extracellular polysaccharide metabolic process(GO:0046379)
0.0 0.2 GO:0002784 antimicrobial peptide production(GO:0002775) antibacterial peptide production(GO:0002778) regulation of antimicrobial peptide production(GO:0002784) regulation of antibacterial peptide production(GO:0002786) negative regulation of defense response to bacterium(GO:1900425)
0.0 0.1 GO:0002554 serotonin secretion by platelet(GO:0002554)
0.0 0.1 GO:0002025 vasodilation by norepinephrine-epinephrine involved in regulation of systemic arterial blood pressure(GO:0002025)
0.0 0.1 GO:0035965 cardiolipin acyl-chain remodeling(GO:0035965)
0.0 0.5 GO:0043252 sodium-independent organic anion transport(GO:0043252)
0.0 0.1 GO:0051012 microtubule sliding(GO:0051012)
0.0 0.1 GO:0071049 nuclear mRNA surveillance of mRNA 3'-end processing(GO:0071031) nuclear polyadenylation-dependent tRNA catabolic process(GO:0071038) nuclear retention of pre-mRNA with aberrant 3'-ends at the site of transcription(GO:0071049)
0.0 0.1 GO:0090238 positive regulation of arachidonic acid secretion(GO:0090238)
0.0 0.2 GO:1901475 pyruvate transmembrane transport(GO:1901475)
0.0 0.1 GO:0032632 interleukin-3 production(GO:0032632)
0.0 0.1 GO:2000049 positive regulation of cell-cell adhesion mediated by cadherin(GO:2000049)
0.0 0.1 GO:0000454 snoRNA guided rRNA pseudouridine synthesis(GO:0000454)
0.0 0.1 GO:0000738 DNA catabolic process, exonucleolytic(GO:0000738)
0.0 0.1 GO:0065001 specification of axis polarity(GO:0065001)
0.0 0.1 GO:0032218 riboflavin transport(GO:0032218)
0.0 0.1 GO:2000978 gastrin-induced gastric acid secretion(GO:0001698) positive regulation of actin filament-based movement(GO:1903116) negative regulation of forebrain neuron differentiation(GO:2000978)
0.0 0.1 GO:0006574 valine catabolic process(GO:0006574)
0.0 0.1 GO:1903566 positive regulation of protein localization to cilium(GO:1903566)
0.0 0.1 GO:0045041 protein import into mitochondrial intermembrane space(GO:0045041)
0.0 0.1 GO:1990918 double-strand break repair involved in meiotic recombination(GO:1990918)
0.0 0.2 GO:2000819 regulation of nucleotide-excision repair(GO:2000819)
0.0 0.2 GO:0070459 prolactin secretion(GO:0070459)
0.0 0.1 GO:0070560 protein secretion by platelet(GO:0070560)
0.0 0.1 GO:0070537 histone H2A K63-linked deubiquitination(GO:0070537)
0.0 0.3 GO:0033601 positive regulation of mammary gland epithelial cell proliferation(GO:0033601)
0.0 0.1 GO:0080154 regulation of fertilization(GO:0080154)
0.0 0.1 GO:0048808 male genitalia morphogenesis(GO:0048808) male anatomical structure morphogenesis(GO:0090598)
0.0 0.0 GO:0061732 mitochondrial acetyl-CoA biosynthetic process from pyruvate(GO:0061732)
0.0 0.1 GO:0016098 monoterpenoid metabolic process(GO:0016098)
0.0 0.1 GO:0072564 blood microparticle formation(GO:0072564) regulation of blood microparticle formation(GO:2000332) positive regulation of blood microparticle formation(GO:2000334)
0.0 0.1 GO:0001905 activation of membrane attack complex(GO:0001905) regulation of activation of membrane attack complex(GO:0001969)
0.0 0.1 GO:0090172 microtubule cytoskeleton organization involved in homologous chromosome segregation(GO:0090172)
0.0 0.1 GO:0036515 serotonergic neuron axon guidance(GO:0036515)
0.0 0.1 GO:0007403 glial cell fate determination(GO:0007403)
0.0 0.0 GO:1902299 pre-replicative complex assembly involved in nuclear cell cycle DNA replication(GO:0006267) pre-replicative complex assembly(GO:0036388) pre-replicative complex assembly involved in cell cycle DNA replication(GO:1902299)
0.0 0.2 GO:0060287 epithelial cilium movement involved in determination of left/right asymmetry(GO:0060287)
0.0 0.1 GO:0032345 negative regulation of aldosterone metabolic process(GO:0032345) negative regulation of aldosterone biosynthetic process(GO:0032348) negative regulation of cortisol biosynthetic process(GO:2000065)
0.0 0.1 GO:2000230 negative regulation of pancreatic stellate cell proliferation(GO:2000230)
0.0 0.0 GO:0002589 regulation of antigen processing and presentation of peptide antigen via MHC class I(GO:0002589)
0.0 0.0 GO:0002331 pre-B cell allelic exclusion(GO:0002331)
0.0 0.0 GO:0009794 regulation of mitotic cell cycle, embryonic(GO:0009794) mitotic cell cycle, embryonic(GO:0045448)
0.0 0.0 GO:1903378 positive regulation of oxidative stress-induced neuron intrinsic apoptotic signaling pathway(GO:1903378)
0.0 0.0 GO:0048003 antigen processing and presentation of lipid antigen via MHC class Ib(GO:0048003) antigen processing and presentation, exogenous lipid antigen via MHC class Ib(GO:0048007)
0.0 0.2 GO:0045653 negative regulation of megakaryocyte differentiation(GO:0045653)
0.0 0.1 GO:1903862 positive regulation of oxidative phosphorylation(GO:1903862)
0.0 0.1 GO:0033590 response to cobalamin(GO:0033590)
0.0 0.2 GO:0006309 apoptotic DNA fragmentation(GO:0006309)
0.0 0.1 GO:0015747 urate transport(GO:0015747)
0.0 0.0 GO:2000158 positive regulation of ubiquitin-specific protease activity(GO:2000158)
0.0 0.2 GO:0009744 response to sucrose(GO:0009744) response to disaccharide(GO:0034285)
0.0 0.1 GO:0015811 L-cystine transport(GO:0015811)
0.0 0.1 GO:0042138 meiotic DNA double-strand break formation(GO:0042138)
0.0 0.1 GO:0001865 NK T cell differentiation(GO:0001865)
0.0 0.0 GO:1901750 leukotriene D4 metabolic process(GO:1901748) leukotriene D4 biosynthetic process(GO:1901750)
0.0 0.1 GO:0042159 lipoprotein catabolic process(GO:0042159)
0.0 0.1 GO:0045650 negative regulation of macrophage differentiation(GO:0045650)
0.0 0.1 GO:0045084 positive regulation of interleukin-12 biosynthetic process(GO:0045084)
0.0 0.1 GO:0032959 inositol trisphosphate biosynthetic process(GO:0032959)
0.0 0.0 GO:0034421 post-translational protein acetylation(GO:0034421)
0.0 0.1 GO:0052697 xenobiotic glucuronidation(GO:0052697)
0.0 0.2 GO:0015937 coenzyme A biosynthetic process(GO:0015937)
0.0 0.0 GO:0060369 positive regulation of Fc receptor mediated stimulatory signaling pathway(GO:0060369)
0.0 0.2 GO:0032793 positive regulation of CREB transcription factor activity(GO:0032793)

Gene overrepresentation in cellular component category:

Log-likelihood per target  Total log-likelihood Term Description
0.1 0.4 GO:0043511 inhibin complex(GO:0043511)
0.1 0.3 GO:0005944 phosphatidylinositol 3-kinase complex, class IB(GO:0005944)
0.1 0.9 GO:1990454 L-type voltage-gated calcium channel complex(GO:1990454)
0.1 0.2 GO:0097209 epidermal lamellar body(GO:0097209)
0.0 0.2 GO:0072557 IPAF inflammasome complex(GO:0072557) NLRP1 inflammasome complex(GO:0072558) AIM2 inflammasome complex(GO:0097169)
0.0 0.2 GO:0098536 deuterosome(GO:0098536)
0.0 0.1 GO:0061574 ASAP complex(GO:0061574)
0.0 0.1 GO:0019815 B cell receptor complex(GO:0019815)
0.0 0.1 GO:0090661 box H/ACA telomerase RNP complex(GO:0090661)
0.0 0.1 GO:0070821 tertiary granule membrane(GO:0070821)
0.0 0.1 GO:1990716 axonemal central apparatus(GO:1990716)
0.0 0.1 GO:0009279 cell outer membrane(GO:0009279) external encapsulating structure(GO:0030312) cell envelope(GO:0030313) external encapsulating structure part(GO:0044462)
0.0 0.0 GO:0016935 glycine-gated chloride channel complex(GO:0016935) GABA-ergic synapse(GO:0098982)
0.0 0.1 GO:1990769 proximal neuron projection(GO:1990769)
0.0 0.1 GO:0035061 interchromatin granule(GO:0035061)
0.0 0.0 GO:0036387 nuclear pre-replicative complex(GO:0005656) pre-replicative complex(GO:0036387)
0.0 0.3 GO:0001891 phagocytic cup(GO:0001891)
0.0 0.1 GO:0002081 outer acrosomal membrane(GO:0002081)
0.0 0.1 GO:0034366 spherical high-density lipoprotein particle(GO:0034366)
0.0 0.1 GO:0005828 kinetochore microtubule(GO:0005828)
0.0 0.1 GO:0030314 junctional membrane complex(GO:0030314)
0.0 0.2 GO:0031083 BLOC-1 complex(GO:0031083)

Gene overrepresentation in molecular function category:

Log-likelihood per target  Total log-likelihood Term Description
0.1 0.9 GO:0086059 voltage-gated calcium channel activity involved SA node cell action potential(GO:0086059)
0.1 0.4 GO:0070699 type II activin receptor binding(GO:0070699)
0.1 0.2 GO:0005157 macrophage colony-stimulating factor receptor binding(GO:0005157)
0.1 0.2 GO:0001605 adrenomedullin receptor activity(GO:0001605)
0.1 0.2 GO:0004594 pantothenate kinase activity(GO:0004594)
0.1 0.2 GO:0008109 N-acetyllactosaminide beta-1,6-N-acetylglucosaminyltransferase activity(GO:0008109)
0.1 0.3 GO:0032027 myosin light chain binding(GO:0032027)
0.0 0.1 GO:0016263 glycoprotein-N-acetylgalactosamine 3-beta-galactosyltransferase activity(GO:0016263)
0.0 0.2 GO:0004161 dimethylallyltranstransferase activity(GO:0004161) geranyltranstransferase activity(GO:0004337)
0.0 0.3 GO:0032554 purine deoxyribonucleotide binding(GO:0032554)
0.0 0.1 GO:0047237 glucuronylgalactosylproteoglycan 4-beta-N-acetylgalactosaminyltransferase activity(GO:0047237)
0.0 0.1 GO:0004939 beta-adrenergic receptor activity(GO:0004939)
0.0 0.2 GO:0001609 G-protein coupled adenosine receptor activity(GO:0001609)
0.0 0.2 GO:0001537 N-acetylgalactosamine 4-O-sulfotransferase activity(GO:0001537)
0.0 0.1 GO:0023025 MHC class Ib protein complex binding(GO:0023025) MHC class Ib protein binding, via antigen binding groove(GO:0023030)
0.0 0.1 GO:0070653 high-density lipoprotein particle receptor binding(GO:0070653)
0.0 0.2 GO:0050833 pyruvate transmembrane transporter activity(GO:0050833)
0.0 0.1 GO:0050501 hyaluronan synthase activity(GO:0050501)
0.0 0.1 GO:0001594 trace-amine receptor activity(GO:0001594)
0.0 0.3 GO:0019869 chloride channel inhibitor activity(GO:0019869)
0.0 0.1 GO:0032217 riboflavin transporter activity(GO:0032217)
0.0 0.1 GO:0102390 mycophenolic acid acyl-glucuronide esterase activity(GO:0102390)
0.0 0.1 GO:0070892 lipoteichoic acid receptor activity(GO:0070892)
0.0 0.5 GO:0005549 odorant binding(GO:0005549)
0.0 0.3 GO:0015125 bile acid transmembrane transporter activity(GO:0015125)
0.0 0.1 GO:0048019 CCR1 chemokine receptor binding(GO:0031726) receptor antagonist activity(GO:0048019)
0.0 0.3 GO:0016303 1-phosphatidylinositol-3-kinase activity(GO:0016303)
0.0 0.1 GO:0016716 oxidoreductase activity, acting on paired donors, with incorporation or reduction of molecular oxygen, another compound as one donor, and incorporation of one atom of oxygen(GO:0016716)
0.0 0.2 GO:0097200 cysteine-type endopeptidase activity involved in execution phase of apoptosis(GO:0097200)
0.0 0.1 GO:0004886 9-cis retinoic acid receptor activity(GO:0004886)
0.0 0.2 GO:0042609 CD4 receptor binding(GO:0042609)
0.0 0.2 GO:0008190 eukaryotic initiation factor 4E binding(GO:0008190)
0.0 0.1 GO:0034513 box H/ACA snoRNA binding(GO:0034513)
0.0 0.2 GO:0016889 endodeoxyribonuclease activity, producing 3'-phosphomonoesters(GO:0016889)
0.0 0.0 GO:0022852 glycine-gated chloride ion channel activity(GO:0022852)
0.0 0.1 GO:0017081 chloride channel regulator activity(GO:0017081)
0.0 0.1 GO:0019237 centromeric DNA binding(GO:0019237)
0.0 0.1 GO:1990226 histone methyltransferase binding(GO:1990226)
0.0 0.4 GO:0035259 glucocorticoid receptor binding(GO:0035259)
0.0 0.1 GO:1901702 urate transmembrane transporter activity(GO:0015143) salt transmembrane transporter activity(GO:1901702)
0.0 0.0 GO:0050309 glucose-6-phosphatase activity(GO:0004346) sugar-terminal-phosphatase activity(GO:0050309)
0.0 0.1 GO:0030881 beta-2-microglobulin binding(GO:0030881)
0.0 0.0 GO:0035800 deubiquitinase activator activity(GO:0035800)
0.0 0.0 GO:0016422 mRNA (2'-O-methyladenosine-N6-)-methyltransferase activity(GO:0016422)
0.0 0.1 GO:0015184 L-cystine transmembrane transporter activity(GO:0015184)
0.0 0.0 GO:0005219 ryanodine-sensitive calcium-release channel activity(GO:0005219)
0.0 0.0 GO:0004185 serine-type carboxypeptidase activity(GO:0004185)
0.0 0.1 GO:0009008 DNA-methyltransferase activity(GO:0009008)
0.0 0.1 GO:0015347 sodium-independent organic anion transmembrane transporter activity(GO:0015347)
0.0 0.1 GO:0016290 palmitoyl-CoA hydrolase activity(GO:0016290)
0.0 0.1 GO:0004616 phosphogluconate dehydrogenase (decarboxylating) activity(GO:0004616)
0.0 0.3 GO:0032183 SUMO binding(GO:0032183)
0.0 0.2 GO:0051378 serotonin binding(GO:0051378)
0.0 0.0 GO:0003839 gamma-glutamylcyclotransferase activity(GO:0003839)
0.0 0.1 GO:0004957 prostaglandin E receptor activity(GO:0004957)
0.0 0.1 GO:0050692 DBD domain binding(GO:0050692)

Gene overrepresentation in curated gene sets: canonical pathways category:

Log-likelihood per target  Total log-likelihood Term Description
0.0 0.2 PID ANTHRAX PATHWAY Cellular roles of Anthrax toxin
0.0 0.3 PID ALK1 PATHWAY ALK1 signaling events
0.0 0.3 PID IL8 CXCR1 PATHWAY IL8- and CXCR1-mediated signaling events
0.0 0.4 PID RXR VDR PATHWAY RXR and RAR heterodimerization with other nuclear receptor

Gene overrepresentation in curated gene sets: REACTOME pathways category:

Log-likelihood per target  Total log-likelihood Term Description
0.0 0.3 REACTOME GLYCOPROTEIN HORMONES Genes involved in Glycoprotein hormones
0.0 0.3 REACTOME P2Y RECEPTORS Genes involved in P2Y receptors
0.0 0.3 REACTOME SEROTONIN RECEPTORS Genes involved in Serotonin receptors
0.0 0.2 REACTOME VITAMIN B5 PANTOTHENATE METABOLISM Genes involved in Vitamin B5 (pantothenate) metabolism
0.0 0.2 REACTOME THE NLRP3 INFLAMMASOME Genes involved in The NLRP3 inflammasome
0.0 0.3 REACTOME RNA POL I PROMOTER OPENING Genes involved in RNA Polymerase I Promoter Opening
0.0 0.3 REACTOME CHONDROITIN SULFATE BIOSYNTHESIS Genes involved in Chondroitin sulfate biosynthesis
0.0 0.1 REACTOME ORGANIC CATION ANION ZWITTERION TRANSPORT Genes involved in Organic cation/anion/zwitterion transport
0.0 0.3 REACTOME ASSOCIATION OF LICENSING FACTORS WITH THE PRE REPLICATIVE COMPLEX Genes involved in Association of licensing factors with the pre-replicative complex
0.0 0.2 REACTOME BILE SALT AND ORGANIC ANION SLC TRANSPORTERS Genes involved in Bile salt and organic anion SLC transporters
0.0 0.1 REACTOME THE ACTIVATION OF ARYLSULFATASES Genes involved in The activation of arylsulfatases