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GSE49485: Hypoxia transcriptome sequencing of rat brain.
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Results for Irf3
Z-value: 0.53
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Transcription factors associated with Irf3
Activity-expression correlation:
| Gene | Promoter | Pearson corr. coef. | P-value | Plot |
|---|---|---|---|---|
| Irf3 | rn6_v1_chr1_+_100992405_100992405 | -0.02 | 9.7e-01 | Click! |
| Promoter | Log-likelihood | Transcript | Gene | Gene Info |
|---|---|---|---|---|
| chr10_-_70744315 Show fit | 0.24 |
ENSRNOT00000014865
|
C-C motif chemokine ligand 5 |
|
| chr1_-_214252456 Show fit | 0.17 |
ENSRNOT00000023504
|
interferon regulatory factor 7 |
|
| chr1_-_198008893 Show fit | 0.16 |
ENSRNOT00000025950
|
interleukin 27 |
|
| chr2_-_256915563 Show fit | 0.14 |
ENSRNOT00000084873
ENSRNOT00000029990 |
interferon-induced protein 44 |
|
| chr20_+_3979035 Show fit | 0.13 |
ENSRNOT00000000529
|
transporter 1, ATP binding cassette subfamily B member |
|
| chr6_-_127337791 Show fit | 0.13 |
ENSRNOT00000032015
|
interferon, alpha-inducible protein 27 like 2B |
|
| chr12_+_41200718 Show fit | 0.13 |
ENSRNOT00000038426
ENSRNOT00000048450 ENSRNOT00000067176 |
2'-5' oligoadenylate synthetase 1A |
|
| chr5_-_173626248 Show fit | 0.11 |
ENSRNOT00000039263
|
ISG15 ubiquitin-like modifier |
|
| chr7_-_28040510 Show fit | 0.11 |
ENSRNOT00000005674
|
achaete-scute family bHLH transcription factor 1 |
|
| chr16_-_19942343 Show fit | 0.09 |
ENSRNOT00000087162
ENSRNOT00000091906 |
bone marrow stromal cell antigen 2 |
Network of associatons between targets according to the STRING database.
First level regulatory network of Irf3
Gene Ontology Analysis
Gene overrepresentation in biological process category:
| Log-likelihood per target | Total log-likelihood | Term | Description |
|---|---|---|---|
| 0.1 | 0.2 | GO:0042509 | CD8-positive, alpha-beta T cell extravasation(GO:0035697) regulation of tyrosine phosphorylation of STAT protein(GO:0042509) positive regulation of tyrosine phosphorylation of STAT protein(GO:0042531) |
| 0.0 | 0.2 | GO:0034124 | regulation of MyD88-dependent toll-like receptor signaling pathway(GO:0034124) |
| 0.0 | 0.2 | GO:0045625 | regulation of T-helper 1 cell differentiation(GO:0045625) |
| 0.0 | 0.1 | GO:0046968 | cytosol to ER transport(GO:0046967) peptide antigen transport(GO:0046968) |
| 0.0 | 0.1 | GO:0021550 | neuroblast differentiation(GO:0014016) spinal cord oligodendrocyte cell differentiation(GO:0021529) spinal cord oligodendrocyte cell fate specification(GO:0021530) medulla oblongata development(GO:0021550) musculoskeletal movement, spinal reflex action(GO:0050883) olfactory pit development(GO:0060166) |
| 0.0 | 0.1 | GO:0002731 | negative regulation of dendritic cell cytokine production(GO:0002731) |
| 0.0 | 0.1 | GO:0002477 | antigen processing and presentation of exogenous peptide antigen via MHC class Ib(GO:0002477) antigen processing and presentation of exogenous protein antigen via MHC class Ib, TAP-dependent(GO:0002481) |
| 0.0 | 0.1 | GO:0032020 | ISG15-protein conjugation(GO:0032020) |
| 0.0 | 0.1 | GO:1900245 | positive regulation of MDA-5 signaling pathway(GO:1900245) |
| 0.0 | 0.1 | GO:1901423 | response to benzene(GO:1901423) |
Gene overrepresentation in cellular component category:
| Log-likelihood per target | Total log-likelihood | Term | Description |
|---|---|---|---|
| 0.0 | 0.2 | GO:1990111 | spermatoproteasome complex(GO:1990111) |
| 0.0 | 0.1 | GO:0008537 | proteasome activator complex(GO:0008537) |
| 0.0 | 0.1 | GO:0020005 | symbiont-containing vacuole membrane(GO:0020005) |
| 0.0 | 0.1 | GO:0042825 | TAP complex(GO:0042825) |
Gene overrepresentation in molecular function category:
| Log-likelihood per target | Total log-likelihood | Term | Description |
|---|---|---|---|
| 0.0 | 0.2 | GO:0031726 | CCR1 chemokine receptor binding(GO:0031726) receptor antagonist activity(GO:0048019) |
| 0.0 | 0.1 | GO:0046980 | peptide antigen-transporting ATPase activity(GO:0015433) tapasin binding(GO:0046980) |
| 0.0 | 0.1 | GO:0008670 | 2,4-dienoyl-CoA reductase (NADPH) activity(GO:0008670) trans-2-enoyl-CoA reductase (NADPH) activity(GO:0019166) |
| 0.0 | 0.1 | GO:0061133 | endopeptidase activator activity(GO:0061133) |
| 0.0 | 0.1 | GO:0031386 | protein tag(GO:0031386) |
| 0.0 | 0.1 | GO:0001730 | 2'-5'-oligoadenylate synthetase activity(GO:0001730) |
Gene overrepresentation in curated gene sets: REACTOME pathways category:
| Log-likelihood per target | Total log-likelihood | Term | Description |
|---|---|---|---|
| 0.0 | 0.2 | REACTOME TRAF6 MEDIATED IRF7 ACTIVATION IN TLR7 8 OR 9 SIGNALING | Genes involved in TRAF6 mediated IRF7 activation in TLR7/8 or 9 signaling |
| 0.0 | 0.1 | REACTOME ENDOSOMAL VACUOLAR PATHWAY | Genes involved in Endosomal/Vacuolar pathway |