ISMARA results: Irf2_Irf1_Irf8_Irf9

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GSE49485: Hypoxia transcriptome sequencing of rat brain.

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Results for Irf2_Irf1_Irf8_Irf9_Irf7

Z-value: 1.75

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Transcription factors associated with Irf2_Irf1_Irf8_Irf9_Irf7

Gene Symbol	Gene ID	Gene Info
Irf2 NCBI RGD Ensembl	ENSRNOG00000009824	interferon regulatory factor 2
Irf1 NCBI RGD Ensembl	ENSRNOG00000008144	interferon regulatory factor 1
Irf8 NCBI RGD Ensembl	ENSRNOG00000017869	interferon regulatory factor 8
Irf9 NCBI RGD Ensembl	ENSRNOG00000019478	interferon regulatory factor 9
Irf7 NCBI RGD Ensembl	ENSRNOG00000017414	interferon regulatory factor 7

Activity-expression correlation:

Gene	Promoter	Pearson corr. coef.	P-value	Plot
Irf7	rn6_v1_chr1_-_214252456_214252456	0.71	1.8e-01	Click!
Irf2	rn6_v1_chr16_-_48732932_48732932	0.67	2.1e-01	Click!
Irf9	rn6_v1_chr15_+_34282936_34282936	0.53	3.6e-01	Click!
Irf1	rn6_v1_chr10_+_39109522_39109522	-0.15	8.1e-01	Click!
Irf8	rn6_v1_chr19_+_54314865_54314865	-0.10	8.7e-01	Click!

Activity profile of Irf2_Irf1_Irf8_Irf9_Irf7 motif

Sorted Z-values of Irf2_Irf1_Irf8_Irf9_Irf7 motif

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Promoter	Log-likelihood	Transcript	Gene	Gene Info
chr12_-_47482961 Show fit	1.81	ENSRNOT00000001600	Oasl2 NCBI RGD Ensembl Show fit	2'-5' oligoadenylate synthetase-like 2
chr1_-_214252456 Show fit	1.26	ENSRNOT00000023504	Irf7 NCBI RGD Ensembl Show fit	interferon regulatory factor 7
chr2_+_248276709 Show fit	1.01	ENSRNOT00000068683	Gbp2 NCBI RGD Ensembl Show fit	guanylate binding protein 2
chr2_-_256915563 Show fit	0.97	ENSRNOT00000084873 ENSRNOT00000029990	Ifi44 NCBI RGD Ensembl Show fit	interferon-induced protein 44
chr15_+_60084918 Show fit	0.88	ENSRNOT00000012632	Epsti1 NCBI RGD Ensembl Show fit	epithelial stromal interaction 1
chr20_+_3979035 Show fit	0.82	ENSRNOT00000000529	Tap1 NCBI RGD Ensembl Show fit	transporter 1, ATP binding cassette subfamily B member
chr2_+_248178389 Show fit	0.74	ENSRNOT00000037339	Gbp5 NCBI RGD Ensembl Show fit	guanylate binding protein 5
chr10_+_34277993 Show fit	0.73	ENSRNOT00000055872 ENSRNOT00000003343	Ifi47 NCBI RGD Ensembl Show fit	interferon gamma inducible protein 47
chr4_+_153805993 Show fit	0.70	ENSRNOT00000056174	Usp18 NCBI RGD Ensembl Show fit	ubiquitin specific peptidase 18
chr11_+_38035450 Show fit	0.68	ENSRNOT00000083067	Mx2 NCBI RGD Ensembl Show fit	MX dynamin like GTPase 2

Showing 1 to 10 of 200 entries

Network of associatons between targets according to the STRING database.

First level regulatory network of Irf2_Irf1_Irf8_Irf9_Irf7

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Gene Ontology Analysis

Gene overrepresentation in biological process category:

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Log-likelihood per target	Total log-likelihood	Term	Description
0.1	3.7	GO:0035458	cellular response to interferon-beta(GO:0035458)
0.2	1.3	GO:0034124	regulation of MyD88-dependent toll-like receptor signaling pathway(GO:0034124)
0.1	1.1	GO:0071985	multivesicular body sorting pathway(GO:0071985)
0.1	0.9	GO:0003374	dynamin polymerization involved in membrane fission(GO:0003373) dynamin polymerization involved in mitochondrial fission(GO:0003374)
0.2	0.8	GO:0032020	ISG15-protein conjugation(GO:0032020)
0.2	0.7	GO:0046967	cytosol to ER transport(GO:0046967) peptide antigen transport(GO:0046968)
0.1	0.7	GO:2000563	positive regulation of CD4-positive, alpha-beta T cell proliferation(GO:2000563)
0.1	0.7	GO:0032621	interleukin-18 production(GO:0032621)
0.2	0.6	GO:1901423	response to benzene(GO:1901423)
0.1	0.6	GO:0050717	positive regulation of interleukin-1 alpha secretion(GO:0050717)

Showing 1 to 10 of 146 entries

Gene overrepresentation in cellular component category:

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Log-likelihood per target	Total log-likelihood	Term	Description
0.3	1.3	GO:0020005	symbiont-containing vacuole membrane(GO:0020005)
0.0	1.1	GO:0031902	late endosome membrane(GO:0031902)
0.2	1.0	GO:1990111	spermatoproteasome complex(GO:1990111)
0.1	0.8	GO:0072559	NLRP3 inflammasome complex(GO:0072559)
0.1	0.7	GO:0042825	TAP complex(GO:0042825)
0.0	0.6	GO:0001891	phagocytic cup(GO:0001891)
0.2	0.5	GO:0005592	collagen type XI trimer(GO:0005592)
0.0	0.4	GO:0008024	cyclin/CDK positive transcription elongation factor complex(GO:0008024)
0.0	0.4	GO:0046581	intercellular canaliculus(GO:0046581)
0.0	0.3	GO:0097136	Bcl-2 family protein complex(GO:0097136)

Showing 1 to 10 of 49 entries

Gene overrepresentation in molecular function category:

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Log-likelihood per target	Total log-likelihood	Term	Description
0.0	5.0	GO:0003924	GTPase activity(GO:0003924)
0.2	2.2	GO:0001730	2'-5'-oligoadenylate synthetase activity(GO:0001730)
0.1	1.6	GO:0003950	NAD+ ADP-ribosyltransferase activity(GO:0003950)
0.0	1.3	GO:0000979	RNA polymerase II core promoter sequence-specific DNA binding(GO:0000979)
0.0	0.9	GO:0003725	double-stranded RNA binding(GO:0003725)
0.1	0.8	GO:0097200	cysteine-type endopeptidase activity involved in execution phase of apoptosis(GO:0097200)
0.0	0.8	GO:0004298	threonine-type endopeptidase activity(GO:0004298) threonine-type peptidase activity(GO:0070003)
0.2	0.7	GO:0015433	peptide antigen-transporting ATPase activity(GO:0015433) tapasin binding(GO:0046980)
0.1	0.7	GO:0031386	protein tag(GO:0031386)
0.0	0.7	GO:0070064	proline-rich region binding(GO:0070064)

Showing 1 to 10 of 76 entries

Gene overrepresentation in curated gene sets: canonical pathways category:

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Total log-likelihood	Term	Description
1.7	PID P53 DOWNSTREAM PATHWAY	Direct p53 effectors
1.3	PID SMAD2 3NUCLEAR PATHWAY	Regulation of nuclear SMAD2/3 signaling
0.8	PID IL27 PATHWAY	IL27-mediated signaling events
0.7	PID ANTHRAX PATHWAY	Cellular roles of Anthrax toxin
0.7	PID SYNDECAN 1 PATHWAY	Syndecan-1-mediated signaling events
0.6	PID CD40 PATHWAY	CD40/CD40L signaling
0.6	PID CXCR3 PATHWAY	CXCR3-mediated signaling events
0.6	PID IL4 2PATHWAY	IL4-mediated signaling events
0.5	PID P38 ALPHA BETA DOWNSTREAM PATHWAY	Signaling mediated by p38-alpha and p38-beta
0.4	ST GA12 PATHWAY	G alpha 12 Pathway

Showing 1 to 10 of 17 entries

Gene overrepresentation in curated gene sets: REACTOME pathways category:

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Log-likelihood per target	Total log-likelihood	Term	Description
0.1	5.0	REACTOME INTERFERON ALPHA BETA SIGNALING	Genes involved in Interferon alpha/beta signaling
0.0	1.4	REACTOME CHEMOKINE RECEPTORS BIND CHEMOKINES	Genes involved in Chemokine receptors bind chemokines
0.1	1.3	REACTOME TRAF6 MEDIATED IRF7 ACTIVATION IN TLR7 8 OR 9 SIGNALING	Genes involved in TRAF6 mediated IRF7 activation in TLR7/8 or 9 signaling
0.0	1.3	REACTOME INTERFERON GAMMA SIGNALING	Genes involved in Interferon gamma signaling
0.0	1.1	REACTOME CROSS PRESENTATION OF SOLUBLE EXOGENOUS ANTIGENS ENDOSOMES	Genes involved in Cross-presentation of soluble exogenous antigens (endosomes)
0.0	0.9	REACTOME PRE NOTCH TRANSCRIPTION AND TRANSLATION	Genes involved in Pre-NOTCH Transcription and Translation
0.1	0.7	REACTOME NFKB ACTIVATION THROUGH FADD RIP1 PATHWAY MEDIATED BY CASPASE 8 AND10	Genes involved in NF-kB activation through FADD/RIP-1 pathway mediated by caspase-8 and -10
0.0	0.6	REACTOME THE NLRP3 INFLAMMASOME	Genes involved in The NLRP3 inflammasome
0.0	0.6	REACTOME ANTIGEN PRESENTATION FOLDING ASSEMBLY AND PEPTIDE LOADING OF CLASS I MHC	Genes involved in Antigen Presentation: Folding, assembly and peptide loading of class I MHC
0.0	0.5	REACTOME RIP MEDIATED NFKB ACTIVATION VIA DAI	Genes involved in RIP-mediated NFkB activation via DAI

Showing 1 to 10 of 24 entries

Results for Irf2_Irf1_Irf8_Irf9_Irf7

Z-value: 1.75

Motif logo

Transcription factors associated with Irf2_Irf1_Irf8_Irf9_Irf7

Activity-expression correlation:

Activity profile of Irf2_Irf1_Irf8_Irf9_Irf7 motif

Sorted Z-values of Irf2_Irf1_Irf8_Irf9_Irf7 motif

Top targets:

Network of associatons between targets according to the STRING database.

First level regulatory network of Irf2_Irf1_Irf8_Irf9_Irf7

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Gene Ontology Analysis

Gene overrepresentation in biological process category:

Gene overrepresentation in cellular component category:

Gene overrepresentation in molecular function category:

Gene overrepresentation in curated gene sets: canonical pathways category:

Gene overrepresentation in curated gene sets: REACTOME pathways category: