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GSE49485: Hypoxia transcriptome sequencing of rat brain.

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Results for Irf2_Irf1_Irf8_Irf9_Irf7

Z-value: 1.75

Motif logo

Transcription factors associated with Irf2_Irf1_Irf8_Irf9_Irf7

Gene Symbol Gene ID Gene Info
ENSRNOG00000009824 interferon regulatory factor 2
ENSRNOG00000008144 interferon regulatory factor 1
ENSRNOG00000017869 interferon regulatory factor 8
ENSRNOG00000019478 interferon regulatory factor 9
ENSRNOG00000017414 interferon regulatory factor 7

Activity-expression correlation:

Activity profile of Irf2_Irf1_Irf8_Irf9_Irf7 motif

Sorted Z-values of Irf2_Irf1_Irf8_Irf9_Irf7 motif

Promoter Log-likelihood Transcript Gene Gene Info
chr12_-_47482961 1.81 ENSRNOT00000001600
2'-5' oligoadenylate synthetase-like 2
chr1_-_214252456 1.26 ENSRNOT00000023504
interferon regulatory factor 7
chr2_+_248276709 1.01 ENSRNOT00000068683
guanylate binding protein 2
chr2_-_256915563 0.97 ENSRNOT00000084873
ENSRNOT00000029990
interferon-induced protein 44
chr15_+_60084918 0.88 ENSRNOT00000012632
epithelial stromal interaction 1
chr20_+_3979035 0.82 ENSRNOT00000000529
transporter 1, ATP binding cassette subfamily B member
chr2_+_248178389 0.74 ENSRNOT00000037339
guanylate binding protein 5
chr10_+_34277993 0.73 ENSRNOT00000055872
ENSRNOT00000003343
interferon gamma inducible protein 47
chr4_+_153805993 0.70 ENSRNOT00000056174
ubiquitin specific peptidase 18
chr11_+_38035450 0.68 ENSRNOT00000083067
MX dynamin like GTPase 2
chr1_+_1545134 0.68 ENSRNOT00000044523

chr20_-_3978845 0.64 ENSRNOT00000000532
proteasome subunit beta 9
chr4_-_66899914 0.62 ENSRNOT00000011481
poly (ADP-ribose) polymerase family, member 12
chr9_-_44483655 0.62 ENSRNOT00000024959
microtubule interacting and trafficking domain containing 1
chr11_+_68105369 0.62 ENSRNOT00000046888
poly (ADP-ribose) polymerase family, member 14
chr5_-_173626248 0.61 ENSRNOT00000039263
ISG15 ubiquitin-like modifier
chr8_+_2604962 0.60 ENSRNOT00000009993
caspase 1
chr10_+_64737022 0.59 ENSRNOT00000017071
ENSRNOT00000093232
ENSRNOT00000017042
ENSRNOT00000093244
galectin 9
chr3_-_37445907 0.59 ENSRNOT00000006172
RNA binding motif protein 43
chr10_-_34221928 0.59 ENSRNOT00000045545
immunity-related GTPase M
chr10_+_58860940 0.56 ENSRNOT00000056551
ENSRNOT00000074523
XIAP associated factor-1
chr1_-_198008893 0.55 ENSRNOT00000025950
interleukin 27
chr4_+_179398621 0.54 ENSRNOT00000049474
ENSRNOT00000067506
lymphoid-restricted membrane protein
chr14_+_17210733 0.54 ENSRNOT00000003075
C-X-C motif chemokine ligand 10
chr9_-_44560837 0.52 ENSRNOT00000090870
microtubule interacting and trafficking domain containing 1
chr2_+_216863428 0.48 ENSRNOT00000068413
collagen type XI alpha 1 chain
chr12_+_25497104 0.46 ENSRNOT00000002028
neutrophil cytosolic factor 1
chr17_+_9236249 0.45 ENSRNOT00000015878
TIFA inhibitor
chr15_-_61772516 0.43 ENSRNOT00000015605
ENSRNOT00000093399
WW domain binding protein 4
chr5_-_79570073 0.42 ENSRNOT00000011845
tumor necrosis factor superfamily member 15
chr20_-_3166569 0.42 ENSRNOT00000091390

chr4_-_88649216 0.41 ENSRNOT00000058626
HECT and RLD domain containing E3 ubiquitin protein ligase family member 6
chr8_+_96551245 0.41 ENSRNOT00000039850
BCL2-related protein A1
chr17_-_69827112 0.41 ENSRNOT00000023835
aldo-keto reductase family 1, member C14
chr1_+_142679345 0.41 ENSRNOT00000034267
zinc finger and SCAN domain containing 2
chr11_+_67757928 0.41 ENSRNOT00000039215
deltex E3 ubiquitin ligase 3L
chr4_-_22424862 0.41 ENSRNOT00000082359
ATP binding cassette subfamily B member 1A
chr1_+_252894663 0.41 ENSRNOT00000054757
interferon-induced protein with tetratricopeptide repeats 2
chr1_+_101517714 0.38 ENSRNOT00000028423
pleckstrin homology domain containing A4
chr3_-_171286413 0.38 ENSRNOT00000008365
ENSRNOT00000081036
Z-DNA binding protein 1
chr13_+_44475970 0.37 ENSRNOT00000024602
ENSRNOT00000091645
cyclin T2
chr16_-_19942343 0.37 ENSRNOT00000087162
ENSRNOT00000091906
bone marrow stromal cell antigen 2
chr7_-_36000906 0.37 ENSRNOT00000011178
plexin C1
chr1_-_169463760 0.36 ENSRNOT00000023100
tripartite motif-containing 30C
chr19_-_37912027 0.35 ENSRNOT00000026462
proteasome subunit beta 10
chr18_+_55685613 0.35 ENSRNOT00000040116
similar to cDNA sequence BC023105
chr7_-_117300662 0.35 ENSRNOT00000006376
poly (ADP-ribose) polymerase family, member 10
chr9_-_92616165 0.34 ENSRNOT00000056995
SP110 nuclear body protein
chr16_+_50111306 0.33 ENSRNOT00000019302
cytochrome P450, family 4, subfamily v, polypeptide 3
chr3_+_120726906 0.33 ENSRNOT00000051069
BCL2 like 11
chr17_-_32661865 0.33 ENSRNOT00000022194
serpin family B member 9
chr2_-_207300854 0.33 ENSRNOT00000018061
Mov10 RISC complex RNA helicase
chr13_+_48790767 0.33 ENSRNOT00000087504
ELK4, ETS transcription factor
chr17_-_47653989 0.33 ENSRNOT00000072833
LRRGT00094
chr3_-_29984201 0.31 ENSRNOT00000006350
zinc finger E-box binding homeobox 2
chr5_-_56536772 0.31 ENSRNOT00000060765
DEXD/H-box helicase 58
chr11_+_38035611 0.30 ENSRNOT00000087603
ENSRNOT00000002695
MX dynamin like GTPase 2
chr2_+_248249468 0.30 ENSRNOT00000022648
guanylate binding protein 4
chr10_-_57064600 0.29 ENSRNOT00000032926
C-X-C motif chemokine ligand 16
chr9_-_63641400 0.29 ENSRNOT00000087684
SATB homeobox 2
chr16_-_20383337 0.29 ENSRNOT00000025977
interleukin 12 receptor subunit beta 1
chr3_+_177397892 0.29 ENSRNOT00000078261

chr10_-_38969501 0.28 ENSRNOT00000090691
ENSRNOT00000081309
ENSRNOT00000010029
interleukin 4
chr8_+_48805684 0.28 ENSRNOT00000064041
B-cell CLL/lymphoma 9-like
chr1_-_261446570 0.28 ENSRNOT00000020182
secreted frizzled-related protein 5
chr17_+_36334147 0.28 ENSRNOT00000050261
E2F transcription factor 3
chr18_+_55576239 0.27 ENSRNOT00000050063
interferon-inducible GTPase 1-like
chr4_+_67165883 0.27 ENSRNOT00000012280
RAB19, member RAS oncogene family
chr1_+_226897625 0.27 ENSRNOT00000029443
solute carrier family 15 member 3
chr1_-_218100272 0.27 ENSRNOT00000028411
ENSRNOT00000088588
cyclin D1
chr9_-_54327958 0.26 ENSRNOT00000019465
signal transducer and activator of transcription 1
chr2_+_166475070 0.25 ENSRNOT00000071111

chr11_+_45888221 0.24 ENSRNOT00000071932
ENSRNOT00000066008
ENSRNOT00000060802
leukemia NUP98 fusion partner 1
chr1_+_140601791 0.24 ENSRNOT00000091588
interferon stimulated exonuclease gene 20
chr20_+_22060224 0.24 ENSRNOT00000057992
zinc finger protein 365
chr13_+_48790951 0.24 ENSRNOT00000090233
ELK4, ETS transcription factor
chr12_+_41200718 0.23 ENSRNOT00000038426
ENSRNOT00000048450
ENSRNOT00000067176
2'-5' oligoadenylate synthetase 1A
chr3_+_58164931 0.23 ENSRNOT00000002078
distal-less homeobox 1
chrX_+_11648989 0.23 ENSRNOT00000041003
BCL6 co-repressor
chr7_+_132857628 0.22 ENSRNOT00000005438
leucine-rich repeat kinase 2
chr20_-_4542073 0.22 ENSRNOT00000000477
complement factor B
chr8_-_119889661 0.22 ENSRNOT00000011780
SH3 and cysteine rich domain
chr9_+_60039297 0.22 ENSRNOT00000016262
solute carrier family 39 member 10
chr13_+_93684437 0.20 ENSRNOT00000005005
kynurenine 3-monooxygenase
chr2_+_209097927 0.20 ENSRNOT00000023807
DENN domain containing 2D
chr2_-_98610368 0.20 ENSRNOT00000011641
zinc finger homeobox 4
chr12_-_19254527 0.19 ENSRNOT00000089349

chr20_-_5179217 0.19 ENSRNOT00000065940
ENSRNOT00000092443
leukocyte specific transcript 1
chr2_+_52358097 0.19 ENSRNOT00000037659
transmembrane protein 267
chr8_-_47529689 0.19 ENSRNOT00000012826
out at first homolog
chr6_-_50923510 0.19 ENSRNOT00000010631
B-cell receptor-associated protein 29
chr16_-_19791832 0.19 ENSRNOT00000040393
USH1 protein network component harmonin binding protein 1
chr1_-_205750786 0.19 ENSRNOT00000023946
matrix metallopeptidase 21
chr2_-_34452895 0.19 ENSRNOT00000079385

chr20_-_35450513 0.18 ENSRNOT00000087342
mannosidase, alpha, class 1A, member 1
chr7_-_52404774 0.18 ENSRNOT00000082100
neuron navigator 3
chr5_-_126096068 0.18 ENSRNOT00000036793

chr12_-_44962656 0.18 ENSRNOT00000001499
WD repeat and SOCS box-containing 2
chr3_-_163814799 0.18 ENSRNOT00000055127
zinc finger, NFX1-type containing 1
chrX_-_10031167 0.18 ENSRNOT00000060988
G protein-coupled receptor 34
chr1_-_101236065 0.18 ENSRNOT00000066834
CD37 molecule
chr1_+_265298868 0.17 ENSRNOT00000023278
deleted in primary ciliary dyskinesia
chr14_+_12218553 0.17 ENSRNOT00000003237
protein kinase, cGMP-dependent, type II
chr7_+_116889572 0.17 ENSRNOT00000075917
gasdermin D
chr8_-_63034226 0.17 ENSRNOT00000043434
promyelocytic leukemia
chrX_+_135187468 0.17 ENSRNOT00000006805
BCL6 co-repressor-like 1
chr3_+_114087287 0.16 ENSRNOT00000023017
beta-2 microglobulin
chr13_-_82129989 0.16 ENSRNOT00000078963

chr5_-_158439078 0.16 ENSRNOT00000025517
kelch domain containing 7A
chr17_-_44840131 0.16 ENSRNOT00000083417
histone cluster 1, H3b
chr5_+_27326762 0.16 ENSRNOT00000066191
RUNX1 translocation partner 1
chr20_-_50564987 0.16 ENSRNOT00000034485
ENSRNOT00000064466
lin-28 homolog B
chr10_+_57064482 0.16 ENSRNOT00000046807
zinc finger, MYND-type containing 15
chr5_-_58198782 0.15 ENSRNOT00000023951
C-C motif chemokine ligand 21
chr3_-_48604097 0.15 ENSRNOT00000009620
interferon induced with helicase C domain 1
chr8_-_124399494 0.15 ENSRNOT00000037883
transforming growth factor, beta receptor 2
chr18_+_30581530 0.15 ENSRNOT00000048166
protocadherin beta 20
chr4_+_162934195 0.15 ENSRNOT00000090939
C-type lectin domain family 2, member G
chr3_-_119405300 0.15 ENSRNOT00000015568
signal peptide peptidase-like 2A
chr5_-_133067245 0.15 ENSRNOT00000033163
selection and upkeep of intraepithelial T cells 10
chr10_-_70744315 0.15 ENSRNOT00000014865
C-C motif chemokine ligand 5
chr10_+_28243 0.14 ENSRNOT00000003193
ENSRNOT00000087156
meiosis arrest female protein 1-like
chr15_-_90175802 0.14 ENSRNOT00000013342
sprouty RTK signaling antagonist 2
chr13_+_48644604 0.14 ENSRNOT00000084259
ENSRNOT00000073669
RAB29, member RAS oncogene family
chr1_-_1889236 0.14 ENSRNOT00000087944

chrX_+_14578264 0.14 ENSRNOT00000038994
cytochrome b-245 beta chain
chr6_+_135866739 0.14 ENSRNOT00000013460
exocyst complex component 3-like 4
chr2_+_22950018 0.14 ENSRNOT00000071804
homer scaffolding protein 1
chr14_+_113530470 0.14 ENSRNOT00000004919
polyribonucleotide nucleotidyltransferase 1
chr2_-_149444548 0.14 ENSRNOT00000018600
purinergic receptor P2Y12
chr4_+_22859622 0.14 ENSRNOT00000073501
ENSRNOT00000068410
ADAM metallopeptidase domain 22
chr14_-_6587141 0.14 ENSRNOT00000061664
similar to THO complex subunit 2 (Tho2)
chr1_+_169433539 0.14 ENSRNOT00000055210
tripartite motif-containing 34
chr7_-_122644054 0.14 ENSRNOT00000025941
DnaJ heat shock protein family (Hsp40) member B7
chr8_+_116754178 0.14 ENSRNOT00000068295
ENSRNOT00000084429
ubiquitin-like modifier activating enzyme 7
chr1_+_84009268 0.14 ENSRNOT00000057230
ENSRNOT00000081121
similar to FLJ41131 protein
chr13_+_37400476 0.14 ENSRNOT00000003435
coiled-coil domain containing 93
chr16_+_50016857 0.13 ENSRNOT00000035781
toll-like receptor 3
chr13_-_82607379 0.13 ENSRNOT00000051763
basic leucine zipper nuclear factor 1
chr3_-_95418679 0.13 ENSRNOT00000018074
reticulocalbin 1
chr10_+_89358376 0.13 ENSRNOT00000028067
interferon-induced protein 35
chr18_-_1389929 0.13 ENSRNOT00000051362
Rho-associated coiled-coil containing protein kinase 1
chr16_-_19349080 0.13 ENSRNOT00000038494
hematopoietic SH2 domain containing
chr3_-_163935617 0.13 ENSRNOT00000074023
potassium voltage-gated channel subfamily B member 1
chr1_-_239057732 0.13 ENSRNOT00000024775
guanine deaminase
chr3_+_161519743 0.13 ENSRNOT00000055148
CD40 molecule
chr7_+_118685181 0.13 ENSRNOT00000068221
apolipoprotein L, 3
chr8_+_130366775 0.13 ENSRNOT00000071152
natural killer cell triggering receptor
chr3_+_64190973 0.13 ENSRNOT00000011342

chr1_+_30681681 0.13 ENSRNOT00000015395
R-spondin 3
chr3_+_100788806 0.13 ENSRNOT00000083289
ENSRNOT00000090445
brain-derived neurotrophic factor
chr8_+_103774358 0.13 ENSRNOT00000014481
5'-3' exoribonuclease 1
chr2_-_210550490 0.13 ENSRNOT00000081835
ENSRNOT00000025222
ENSRNOT00000086403
colony stimulating factor 1
chr10_+_89578212 0.13 ENSRNOT00000028178
ADP-ribosylation factor like GTPase 4D
chr5_+_25253010 0.12 ENSRNOT00000061333
RNA binding motif protein 12B
chr10_-_88611105 0.12 ENSRNOT00000024718
DEXH-box helicase 58
chr18_+_56071478 0.12 ENSRNOT00000025344
ENSRNOT00000025354
CD74 molecule
chr5_+_64053946 0.12 ENSRNOT00000011622
inversin
chr13_+_99663150 0.12 ENSRNOT00000036705
cornichon family AMPA receptor auxiliary protein 3
chr15_+_34256071 0.12 ENSRNOT00000025887
proteasome activator subunit 1
chr8_-_76940094 0.12 ENSRNOT00000082709
ENSRNOT00000084313
ring finger protein 111
chr1_-_213818222 0.12 ENSRNOT00000054875
interferon induced transmembrane protein 6
chr8_-_83280888 0.12 ENSRNOT00000052341
GDNF family receptor alpha like
chr2_+_189062443 0.12 ENSRNOT00000028181
adenosine deaminase, RNA-specific
chr8_+_127702534 0.12 ENSRNOT00000075793
CTD small phosphatase like
chr3_-_147809658 0.11 ENSRNOT00000085995
ENSRNOT00000045314
RANBP2-type and C3HC4-type zinc finger containing 1
chr12_+_23514981 0.11 ENSRNOT00000001937
Prkr interacting protein 1 (IL11 inducible)
chr10_-_107424710 0.11 ENSRNOT00000004320
galectin 3 binding protein
chr5_-_142681173 0.11 ENSRNOT00000009882
UTP11, small subunit processome component homolog (S. cerevisiae)
chr11_+_15436269 0.11 ENSRNOT00000002150
ENSRNOT00000084928
ubiquitin specific peptidase 25
chr5_+_25725683 0.11 ENSRNOT00000087602
similar to swan
chrX_-_74968405 0.11 ENSRNOT00000035653
similar to KIAA2022 protein
chr3_-_107760550 0.11 ENSRNOT00000077091
ENSRNOT00000051638
Meis homeobox 2
chr15_+_27933211 0.11 ENSRNOT00000013619
ribonuclease A family member 10
chr10_-_15928169 0.11 ENSRNOT00000028069
neuron specific gene family member 2
chr14_+_8080275 0.11 ENSRNOT00000065965
ENSRNOT00000092542
mitogen activated protein kinase 10
chr2_+_2456735 0.11 ENSRNOT00000032974
elongation factor for RNA polymerase II 2
chr19_-_31942180 0.11 ENSRNOT00000024924
OTU deubiquitinase 4
chr16_-_32439421 0.11 ENSRNOT00000043100
NIMA-related kinase 1
chr15_+_36809361 0.11 ENSRNOT00000076667
poly (ADP-ribose) polymerase family, member 4
chr10_+_76343847 0.11 ENSRNOT00000055674
tripartite motif-containing 25
chr2_-_149432106 0.11 ENSRNOT00000051027
purinergic receptor P2Y13
chr20_-_19479325 0.11 ENSRNOT00000051491
family with sequence similarity 13, member C
chr4_-_163214678 0.11 ENSRNOT00000091602
C-type lectin domain family 1, member A
chr1_-_197886759 0.11 ENSRNOT00000074274
SH2B adaptor protein 1
chr3_-_2474913 0.11 ENSRNOT00000014445
NADPH dependent diflavin oxidoreductase 1
chr10_-_104155717 0.10 ENSRNOT00000089894
golgi associated, gamma adaptin ear containing, ARF binding protein 3
chr9_+_65534704 0.10 ENSRNOT00000016730
CASP8 and FADD-like apoptosis regulator
chr10_+_108527740 0.10 ENSRNOT00000044983
ring finger protein 213
chr1_-_101131413 0.10 ENSRNOT00000093729
fms-related tyrosine kinase 3 ligand
chr13_-_82005741 0.10 ENSRNOT00000076404
methyltransferase like 11B
chr7_+_23403891 0.10 ENSRNOT00000037918
synapsin III
chr7_-_118933812 0.10 ENSRNOT00000031951
apolipoprotein L 9a
chr1_-_141579871 0.10 ENSRNOT00000020002
alanyl aminopeptidase, membrane
chr5_+_79382096 0.10 ENSRNOT00000085461
transmembrane protein 268
chr8_+_21663325 0.10 ENSRNOT00000027749
ubiquitin-like 5
chr1_+_64046377 0.10 ENSRNOT00000085010
transmembrane channel-like 4
chr5_+_68717519 0.10 ENSRNOT00000066226
structural maintenance of chromosomes 2
chr19_-_49510901 0.10 ENSRNOT00000082929
ENSRNOT00000079969
hypothetical protein LOC687399
chr3_+_80555196 0.10 ENSRNOT00000067318
Rho GTPase activating protein 1

Network of associatons between targets according to the STRING database.

First level regulatory network of Irf2_Irf1_Irf8_Irf9_Irf7

PNG image of the network

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Gene Ontology Analysis

Gene overrepresentation in biological process category:

Log-likelihood per target  Total log-likelihood Term Description
0.2 0.7 GO:0046967 cytosol to ER transport(GO:0046967) peptide antigen transport(GO:0046968)
0.2 1.3 GO:0034124 regulation of MyD88-dependent toll-like receptor signaling pathway(GO:0034124)
0.2 0.6 GO:1901423 response to benzene(GO:1901423)
0.2 0.5 GO:0070946 neutrophil mediated killing of gram-positive bacterium(GO:0070946)
0.2 0.8 GO:0032020 ISG15-protein conjugation(GO:0032020)
0.1 0.6 GO:0050717 positive regulation of interleukin-1 alpha secretion(GO:0050717)
0.1 0.4 GO:0007356 thorax and anterior abdomen determination(GO:0007356)
0.1 0.7 GO:2000563 positive regulation of CD4-positive, alpha-beta T cell proliferation(GO:2000563)
0.1 0.4 GO:1901252 regulation of intracellular transport of viral material(GO:1901252)
0.1 0.4 GO:1902748 positive regulation of lens fiber cell differentiation(GO:1902748)
0.1 0.4 GO:0019086 late viral transcription(GO:0019086)
0.1 0.3 GO:0010847 regulation of chromatin assembly(GO:0010847) protein poly-ADP-ribosylation(GO:0070212)
0.1 1.1 GO:0071985 multivesicular body sorting pathway(GO:0071985)
0.1 0.5 GO:1901509 regulation of endothelial tube morphogenesis(GO:1901509)
0.1 3.7 GO:0035458 cellular response to interferon-beta(GO:0035458)
0.1 0.9 GO:0003374 dynamin polymerization involved in membrane fission(GO:0003373) dynamin polymerization involved in mitochondrial fission(GO:0003374)
0.1 0.3 GO:0000738 DNA catabolic process, exonucleolytic(GO:0000738)
0.1 0.4 GO:1990963 carbohydrate export(GO:0033231) daunorubicin transport(GO:0043215) response to borneol(GO:1905230) cellular response to borneol(GO:1905231) response to codeine(GO:1905233) response to quercetin(GO:1905235) drug transport across blood-brain barrier(GO:1990962) establishment of blood-retinal barrier(GO:1990963)
0.1 0.3 GO:0071349 interleukin-12-mediated signaling pathway(GO:0035722) cellular response to interleukin-12(GO:0071349)
0.1 0.3 GO:2000422 T-helper 1 cell lineage commitment(GO:0002296) negative regulation of complement-dependent cytotoxicity(GO:1903660) regulation of eosinophil chemotaxis(GO:2000422) positive regulation of eosinophil chemotaxis(GO:2000424)
0.1 0.3 GO:2000041 Wnt signaling pathway involved in digestive tract morphogenesis(GO:0044333) regulation of planar cell polarity pathway involved in axis elongation(GO:2000040) negative regulation of planar cell polarity pathway involved in axis elongation(GO:2000041)
0.1 0.3 GO:1904139 microglial cell migration(GO:1904124) regulation of microglial cell migration(GO:1904139)
0.1 0.3 GO:1902263 apoptotic process involved in embryonic digit morphogenesis(GO:1902263)
0.1 0.7 GO:0032621 interleukin-18 production(GO:0032621)
0.1 0.2 GO:0033566 gamma-tubulin complex localization(GO:0033566)
0.1 0.3 GO:0009597 detection of virus(GO:0009597)
0.1 0.2 GO:0021882 regulation of transcription from RNA polymerase II promoter involved in forebrain neuron fate commitment(GO:0021882) commitment of multipotent stem cells to neuronal lineage in forebrain(GO:0021898)
0.1 0.2 GO:0065001 specification of axis polarity(GO:0065001)
0.1 0.2 GO:1902499 positive regulation of protein autoubiquitination(GO:1902499) regulation of peroxidase activity(GO:2000468)
0.1 0.4 GO:0042270 protection from natural killer cell mediated cytotoxicity(GO:0042270)
0.1 0.3 GO:0098795 mRNA cleavage involved in gene silencing by miRNA(GO:0035279) mRNA cleavage involved in gene silencing(GO:0098795)
0.1 0.6 GO:0035989 tendon development(GO:0035989)
0.1 0.6 GO:0045078 positive regulation of interferon-gamma biosynthetic process(GO:0045078)
0.1 0.3 GO:0019805 quinolinate biosynthetic process(GO:0019805)
0.1 0.2 GO:0030886 negative regulation of myeloid dendritic cell activation(GO:0030886)
0.1 0.2 GO:0021678 third ventricle development(GO:0021678)
0.1 0.2 GO:2001226 negative regulation of chloride transport(GO:2001226)
0.1 0.2 GO:0097026 dendritic cell dendrite assembly(GO:0097026)
0.1 0.2 GO:0050713 negative regulation of interleukin-1 beta secretion(GO:0050713)
0.1 0.2 GO:0071283 cellular response to iron(III) ion(GO:0071283)
0.1 0.4 GO:0060340 positive regulation of type I interferon-mediated signaling pathway(GO:0060340)
0.1 0.3 GO:0035672 oligopeptide transmembrane transport(GO:0035672)
0.0 0.1 GO:0042531 CD8-positive, alpha-beta T cell extravasation(GO:0035697) regulation of tyrosine phosphorylation of STAT protein(GO:0042509) positive regulation of tyrosine phosphorylation of STAT protein(GO:0042531)
0.0 0.1 GO:1904845 response to L-glutamine(GO:1904844) cellular response to L-glutamine(GO:1904845)
0.0 0.1 GO:1990478 response to ultrasound(GO:1990478)
0.0 0.3 GO:0000320 re-entry into mitotic cell cycle(GO:0000320)
0.0 0.1 GO:0006480 N-terminal protein amino acid methylation(GO:0006480)
0.0 0.1 GO:1900245 positive regulation of MDA-5 signaling pathway(GO:1900245)
0.0 0.4 GO:0035457 cellular response to interferon-alpha(GO:0035457)
0.0 0.0 GO:0090648 response to environmental enrichment(GO:0090648)
0.0 0.1 GO:0019626 short-chain fatty acid catabolic process(GO:0019626)
0.0 0.1 GO:1900368 miRNA loading onto RISC involved in gene silencing by miRNA(GO:0035280) regulation of RNA interference(GO:1900368)
0.0 0.1 GO:0002462 tolerance induction to nonself antigen(GO:0002462)
0.0 0.2 GO:0070973 protein localization to endoplasmic reticulum exit site(GO:0070973)
0.0 0.5 GO:0002903 negative regulation of B cell apoptotic process(GO:0002903)
0.0 0.4 GO:0010818 T cell chemotaxis(GO:0010818)
0.0 0.1 GO:1903943 regulation of hepatocyte apoptotic process(GO:1903943) negative regulation of hepatocyte apoptotic process(GO:1903944)
0.0 0.2 GO:0070269 pyroptosis(GO:0070269)
0.0 0.2 GO:0010587 miRNA catabolic process(GO:0010587)
0.0 0.3 GO:0070345 negative regulation of fat cell proliferation(GO:0070345)
0.0 0.1 GO:0045341 MHC class I biosynthetic process(GO:0045341) regulation of MHC class I biosynthetic process(GO:0045343) positive regulation of MHC class I biosynthetic process(GO:0045345)
0.0 0.1 GO:0002232 leukocyte chemotaxis involved in inflammatory response(GO:0002232)
0.0 0.1 GO:0060971 embryonic heart tube left/right pattern formation(GO:0060971)
0.0 0.1 GO:0042501 serine phosphorylation of STAT protein(GO:0042501)
0.0 0.3 GO:0021902 commitment of neuronal cell to specific neuron type in forebrain(GO:0021902)
0.0 0.1 GO:0051387 negative regulation of neurotrophin TRK receptor signaling pathway(GO:0051387)
0.0 0.1 GO:0045080 positive regulation of chemokine biosynthetic process(GO:0045080)
0.0 0.1 GO:0044778 meiotic DNA integrity checkpoint(GO:0044778)
0.0 0.3 GO:0006957 complement activation, alternative pathway(GO:0006957)
0.0 0.1 GO:0080154 regulation of fertilization(GO:0080154) positive regulation of sperm motility(GO:1902093)
0.0 0.2 GO:0061193 taste bud development(GO:0061193)
0.0 0.1 GO:0014908 myotube differentiation involved in skeletal muscle regeneration(GO:0014908)
0.0 0.4 GO:0007250 activation of NF-kappaB-inducing kinase activity(GO:0007250)
0.0 0.1 GO:0000189 MAPK import into nucleus(GO:0000189)
0.0 0.1 GO:0046098 guanine metabolic process(GO:0046098)
0.0 0.1 GO:1903336 negative regulation of vacuolar transport(GO:1903336)
0.0 0.1 GO:0060830 ciliary receptor clustering involved in smoothened signaling pathway(GO:0060830)
0.0 0.0 GO:1901492 positive regulation of lymphangiogenesis(GO:1901492)
0.0 0.1 GO:0071529 cementum mineralization(GO:0071529)
0.0 0.0 GO:0097029 mature conventional dendritic cell differentiation(GO:0097029)
0.0 0.1 GO:0002148 hypochlorous acid metabolic process(GO:0002148) hypochlorous acid biosynthetic process(GO:0002149)
0.0 0.0 GO:0003104 positive regulation of glomerular filtration(GO:0003104)
0.0 0.2 GO:0071787 endoplasmic reticulum tubular network assembly(GO:0071787)
0.0 0.1 GO:0006059 hexitol metabolic process(GO:0006059)
0.0 0.1 GO:0042276 error-prone translesion synthesis(GO:0042276)
0.0 0.1 GO:1903347 negative regulation of bicellular tight junction assembly(GO:1903347)
0.0 0.1 GO:0010701 positive regulation of norepinephrine secretion(GO:0010701)
0.0 0.1 GO:0071409 cellular response to cycloheximide(GO:0071409)
0.0 0.1 GO:0032916 positive regulation of transforming growth factor beta3 production(GO:0032916)
0.0 0.1 GO:2000298 regulation of Rho-dependent protein serine/threonine kinase activity(GO:2000298)
0.0 0.1 GO:0002397 MHC class I protein complex assembly(GO:0002397)
0.0 0.4 GO:0045292 mRNA cis splicing, via spliceosome(GO:0045292)
0.0 0.1 GO:1901098 positive regulation of autophagosome maturation(GO:1901098)
0.0 0.0 GO:2000830 vacuolar phosphate transport(GO:0007037) positive regulation of parathyroid hormone secretion(GO:2000830)
0.0 0.1 GO:0010032 meiotic chromosome condensation(GO:0010032)
0.0 0.1 GO:0072262 metanephric glomerular mesangial cell proliferation involved in metanephros development(GO:0072262)
0.0 0.1 GO:1903463 regulation of mitotic cell cycle DNA replication(GO:1903463)
0.0 0.1 GO:1904158 axonemal central apparatus assembly(GO:1904158)
0.0 0.1 GO:0035627 ceramide transport(GO:0035627)
0.0 0.1 GO:0050925 negative regulation of negative chemotaxis(GO:0050925)
0.0 0.5 GO:0070932 histone H3 deacetylation(GO:0070932)
0.0 0.1 GO:0090037 positive regulation of protein kinase C signaling(GO:0090037)
0.0 0.1 GO:0002343 positive regulation of type I hypersensitivity(GO:0001812) peripheral B cell selection(GO:0002343) B cell affinity maturation(GO:0002344) cellular response to molecule of fungal origin(GO:0071226)
0.0 0.1 GO:0032727 positive regulation of interferon-alpha production(GO:0032727)
0.0 0.2 GO:0015760 hexose phosphate transport(GO:0015712) glucose-6-phosphate transport(GO:0015760)
0.0 0.1 GO:2000051 negative regulation of non-canonical Wnt signaling pathway(GO:2000051)
0.0 0.1 GO:0019343 cysteine biosynthetic process via cystathionine(GO:0019343)
0.0 0.1 GO:0030579 ubiquitin-dependent SMAD protein catabolic process(GO:0030579)
0.0 0.4 GO:0010390 histone monoubiquitination(GO:0010390)
0.0 0.0 GO:0044565 dendritic cell proliferation(GO:0044565)
0.0 0.1 GO:1903300 negative regulation of glucokinase activity(GO:0033132) negative regulation of hexokinase activity(GO:1903300)
0.0 0.1 GO:0050862 positive regulation of T cell receptor signaling pathway(GO:0050862) protein localization to ciliary membrane(GO:1903441)
0.0 0.0 GO:0070640 calcitriol biosynthetic process from calciol(GO:0036378) vitamin D3 metabolic process(GO:0070640)
0.0 0.2 GO:0007258 JUN phosphorylation(GO:0007258)
0.0 0.0 GO:0097298 regulation of nucleus size(GO:0097298)
0.0 0.0 GO:1902310 positive regulation of peptidyl-serine dephosphorylation(GO:1902310)
0.0 0.0 GO:0010637 negative regulation of mitochondrial fusion(GO:0010637)
0.0 0.1 GO:1902683 regulation of receptor localization to synapse(GO:1902683)
0.0 0.2 GO:0046548 retinal rod cell development(GO:0046548)
0.0 0.2 GO:0060546 negative regulation of necroptotic process(GO:0060546)
0.0 0.1 GO:0042795 snRNA transcription from RNA polymerase II promoter(GO:0042795)
0.0 0.1 GO:0010990 regulation of SMAD protein complex assembly(GO:0010990) negative regulation of SMAD protein complex assembly(GO:0010991)
0.0 0.1 GO:0071360 cellular response to exogenous dsRNA(GO:0071360)
0.0 0.1 GO:0042339 keratan sulfate metabolic process(GO:0042339)
0.0 0.0 GO:0007066 female meiosis sister chromatid cohesion(GO:0007066)
0.0 0.0 GO:1901317 regulation of sperm motility(GO:1901317)
0.0 0.1 GO:0044336 canonical Wnt signaling pathway involved in negative regulation of apoptotic process(GO:0044336)
0.0 0.0 GO:0045357 interferon-alpha biosynthetic process(GO:0045349) interferon-beta biosynthetic process(GO:0045350) regulation of interferon-alpha biosynthetic process(GO:0045354) regulation of interferon-beta biosynthetic process(GO:0045357)
0.0 0.0 GO:0071332 cellular response to fructose stimulus(GO:0071332)
0.0 0.0 GO:1902202 regulation of hepatocyte growth factor receptor signaling pathway(GO:1902202)
0.0 0.1 GO:1900165 negative regulation of interleukin-6 secretion(GO:1900165)
0.0 0.1 GO:1903599 positive regulation of mitophagy(GO:1903599)
0.0 0.0 GO:2000503 positive regulation of natural killer cell chemotaxis(GO:2000503)
0.0 0.0 GO:0002581 negative regulation of antigen processing and presentation of peptide or polysaccharide antigen via MHC class II(GO:0002581)
0.0 0.1 GO:0010808 positive regulation of synaptic vesicle priming(GO:0010808)
0.0 0.0 GO:0010533 regulation of activation of Janus kinase activity(GO:0010533)
0.0 0.1 GO:0035634 response to stilbenoid(GO:0035634)
0.0 0.1 GO:2001256 regulation of store-operated calcium entry(GO:2001256)
0.0 0.0 GO:0006045 N-acetylglucosamine biosynthetic process(GO:0006045) N-acetylneuraminate biosynthetic process(GO:0046380)
0.0 0.0 GO:0031296 B cell costimulation(GO:0031296)
0.0 0.0 GO:0070560 protein secretion by platelet(GO:0070560)
0.0 0.0 GO:2001245 regulation of phosphatidylcholine biosynthetic process(GO:2001245)
0.0 0.0 GO:1902998 regulation of neuronal signal transduction(GO:1902847) positive regulation of tau-protein kinase activity(GO:1902949) neurofibrillary tangle assembly(GO:1902988) regulation of neurofibrillary tangle assembly(GO:1902996) positive regulation of neurofibrillary tangle assembly(GO:1902998)
0.0 0.1 GO:0070092 regulation of glucagon secretion(GO:0070092)
0.0 0.1 GO:0042148 strand invasion(GO:0042148)
0.0 0.1 GO:2000327 positive regulation of ligand-dependent nuclear receptor transcription coactivator activity(GO:2000327)

Gene overrepresentation in cellular component category:

Log-likelihood per target  Total log-likelihood Term Description
0.3 1.3 GO:0020005 symbiont-containing vacuole membrane(GO:0020005)
0.2 0.5 GO:0005592 collagen type XI trimer(GO:0005592)
0.2 1.0 GO:1990111 spermatoproteasome complex(GO:1990111)
0.1 0.1 GO:0020003 symbiont-containing vacuole(GO:0020003)
0.1 0.8 GO:0072559 NLRP3 inflammasome complex(GO:0072559)
0.1 0.7 GO:0042825 TAP complex(GO:0042825)
0.1 0.2 GO:0008537 proteasome activator complex(GO:0008537)
0.1 0.2 GO:0097487 multivesicular body, internal vesicle(GO:0097487)
0.1 0.2 GO:0070022 transforming growth factor beta receptor homodimeric complex(GO:0070022)
0.0 0.3 GO:0097136 Bcl-2 family protein complex(GO:0097136)
0.0 0.1 GO:0045025 mitochondrial degradosome(GO:0045025)
0.0 0.1 GO:1990682 CSF1-CSF1R complex(GO:1990682)
0.0 0.4 GO:0008024 cyclin/CDK positive transcription elongation factor complex(GO:0008024)
0.0 0.1 GO:0035692 macrophage migration inhibitory factor receptor complex(GO:0035692)
0.0 0.1 GO:0097543 ciliary inversin compartment(GO:0097543)
0.0 0.4 GO:0046581 intercellular canaliculus(GO:0046581)
0.0 0.2 GO:0031265 CD95 death-inducing signaling complex(GO:0031265)
0.0 0.1 GO:1990589 ATF4-CREB1 transcription factor complex(GO:1990589)
0.0 0.1 GO:0005668 RNA polymerase transcription factor SL1 complex(GO:0005668)
0.0 0.3 GO:0043020 NADPH oxidase complex(GO:0043020)
0.0 0.1 GO:0097444 spine apparatus(GO:0097444)
0.0 0.1 GO:1990037 Lewy body core(GO:1990037)
0.0 0.1 GO:0042406 extrinsic component of endoplasmic reticulum membrane(GO:0042406)
0.0 0.1 GO:1990712 HFE-transferrin receptor complex(GO:1990712)
0.0 0.1 GO:0065010 extracellular membrane-bounded organelle(GO:0065010)
0.0 0.1 GO:0044530 supraspliceosomal complex(GO:0044530)
0.0 0.1 GO:0016035 zeta DNA polymerase complex(GO:0016035)
0.0 0.6 GO:0001891 phagocytic cup(GO:0001891)
0.0 0.1 GO:0033185 dolichol-phosphate-mannose synthase complex(GO:0033185)
0.0 0.1 GO:0097209 epidermal lamellar body(GO:0097209)
0.0 0.1 GO:0071797 LUBAC complex(GO:0071797)
0.0 0.1 GO:0097443 sorting endosome(GO:0097443)
0.0 0.1 GO:0097454 Schwann cell microvillus(GO:0097454)
0.0 1.1 GO:0031902 late endosome membrane(GO:0031902)
0.0 0.1 GO:0032059 bleb(GO:0032059)
0.0 0.1 GO:0009330 DNA topoisomerase complex (ATP-hydrolyzing)(GO:0009330)
0.0 0.2 GO:0035631 CD40 receptor complex(GO:0035631)
0.0 0.1 GO:0000445 THO complex(GO:0000347) THO complex part of transcription export complex(GO:0000445)
0.0 0.2 GO:0030061 mitochondrial crista(GO:0030061)
0.0 0.0 GO:0000814 ESCRT II complex(GO:0000814)
0.0 0.1 GO:0031262 Ndc80 complex(GO:0031262)
0.0 0.3 GO:0005771 multivesicular body(GO:0005771)
0.0 0.1 GO:0000796 condensin complex(GO:0000796)
0.0 0.2 GO:0000930 gamma-tubulin complex(GO:0000930)
0.0 0.1 GO:0030896 checkpoint clamp complex(GO:0030896)
0.0 0.1 GO:0070847 core mediator complex(GO:0070847)
0.0 0.1 GO:0005832 chaperonin-containing T-complex(GO:0005832)
0.0 0.1 GO:0030991 intraciliary transport particle A(GO:0030991)
0.0 0.1 GO:0031983 vesicle lumen(GO:0031983)

Gene overrepresentation in molecular function category:

Log-likelihood per target  Total log-likelihood Term Description
0.2 2.2 GO:0001730 2'-5'-oligoadenylate synthetase activity(GO:0001730)
0.2 0.7 GO:0015433 peptide antigen-transporting ATPase activity(GO:0015433) tapasin binding(GO:0046980)
0.1 0.4 GO:0047023 androsterone dehydrogenase activity(GO:0047023)
0.1 0.6 GO:0048248 CXCR3 chemokine receptor binding(GO:0048248)
0.1 0.5 GO:0003726 double-stranded RNA adenosine deaminase activity(GO:0003726)
0.1 0.3 GO:0035673 oligopeptide transmembrane transporter activity(GO:0035673)
0.1 0.7 GO:0031386 protein tag(GO:0031386)
0.1 0.4 GO:0090555 phosphatidylethanolamine-translocating ATPase activity(GO:0090555)
0.1 0.5 GO:0016936 galactoside binding(GO:0016936)
0.1 0.2 GO:0034211 GTP-dependent protein kinase activity(GO:0034211)
0.1 1.6 GO:0003950 NAD+ ADP-ribosyltransferase activity(GO:0003950)
0.1 0.3 GO:0005136 interleukin-4 receptor binding(GO:0005136)
0.1 0.8 GO:0097200 cysteine-type endopeptidase activity involved in execution phase of apoptosis(GO:0097200)
0.1 0.3 GO:0008310 single-stranded DNA 3'-5' exodeoxyribonuclease activity(GO:0008310)
0.1 0.4 GO:0097322 7SK snRNA binding(GO:0097322)
0.0 0.5 GO:0016176 superoxide-generating NADPH oxidase activator activity(GO:0016176)
0.0 0.1 GO:0005157 macrophage colony-stimulating factor receptor binding(GO:0005157)
0.0 0.1 GO:0071885 N-terminal protein N-methyltransferase activity(GO:0071885)
0.0 0.5 GO:0031730 CCR5 chemokine receptor binding(GO:0031730)
0.0 0.2 GO:0005143 interleukin-12 receptor binding(GO:0005143)
0.0 0.3 GO:0016174 NAD(P)H oxidase activity(GO:0016174)
0.0 0.1 GO:0031735 CCR10 chemokine receptor binding(GO:0031735)
0.0 0.2 GO:0004690 cyclic nucleotide-dependent protein kinase activity(GO:0004690)
0.0 0.4 GO:0008191 metalloendopeptidase inhibitor activity(GO:0008191)
0.0 0.2 GO:0034714 type III transforming growth factor beta receptor binding(GO:0034714)
0.0 0.8 GO:0004298 threonine-type endopeptidase activity(GO:0004298) threonine-type peptidase activity(GO:0070003)
0.0 0.1 GO:0004771 sterol esterase activity(GO:0004771)
0.0 0.2 GO:0034046 poly(G) binding(GO:0034046)
0.0 0.1 GO:0070976 TIR domain binding(GO:0070976)
0.0 0.1 GO:0031802 type 5 metabotropic glutamate receptor binding(GO:0031802)
0.0 0.1 GO:0008502 melatonin receptor activity(GO:0008502)
0.0 0.4 GO:0005123 death receptor binding(GO:0005123)
0.0 0.2 GO:0005169 neurotrophin TRKB receptor binding(GO:0005169)
0.0 0.2 GO:0061133 endopeptidase activator activity(GO:0061133)
0.0 0.4 GO:0017154 semaphorin receptor activity(GO:0017154)
0.0 0.4 GO:0051400 BH domain binding(GO:0051400)
0.0 0.1 GO:0034191 apolipoprotein A-I receptor binding(GO:0034191)
0.0 0.2 GO:0061513 hexose phosphate transmembrane transporter activity(GO:0015119) organophosphate:inorganic phosphate antiporter activity(GO:0015315) hexose-phosphate:inorganic phosphate antiporter activity(GO:0015526) glucose 6-phosphate:inorganic phosphate antiporter activity(GO:0061513)
0.0 0.2 GO:1901611 phosphatidylglycerol binding(GO:1901611) cardiolipin binding(GO:1901612)
0.0 0.1 GO:0001609 G-protein coupled adenosine receptor activity(GO:0001609)
0.0 0.7 GO:0070064 proline-rich region binding(GO:0070064)
0.0 0.5 GO:0008009 chemokine activity(GO:0008009)
0.0 0.1 GO:0002151 G-quadruplex RNA binding(GO:0002151)
0.0 0.1 GO:1990763 arrestin family protein binding(GO:1990763)
0.0 0.1 GO:0004582 dolichyl-phosphate beta-D-mannosyltransferase activity(GO:0004582)
0.0 0.1 GO:0042289 MHC class II protein binding(GO:0042289)
0.0 0.1 GO:0004473 malic enzyme activity(GO:0004470) malate dehydrogenase (decarboxylating) (NAD+) activity(GO:0004471) malate dehydrogenase (decarboxylating) (NADP+) activity(GO:0004473)
0.0 0.1 GO:0004977 melanocortin receptor activity(GO:0004977)
0.0 0.1 GO:0005017 platelet-derived growth factor-activated receptor activity(GO:0005017)
0.0 0.1 GO:0030881 beta-2-microglobulin binding(GO:0030881)
0.0 0.1 GO:0048403 brain-derived neurotrophic factor binding(GO:0048403)
0.0 0.1 GO:0002046 opsin binding(GO:0002046)
0.0 0.2 GO:0004571 mannosyl-oligosaccharide 1,2-alpha-mannosidase activity(GO:0004571)
0.0 0.1 GO:0048019 receptor antagonist activity(GO:0048019)
0.0 0.5 GO:0070840 dynein complex binding(GO:0070840)
0.0 0.2 GO:0016909 JUN kinase activity(GO:0004705) SAP kinase activity(GO:0016909)
0.0 5.0 GO:0003924 GTPase activity(GO:0003924)
0.0 0.1 GO:0046976 histone methyltransferase activity (H3-K27 specific)(GO:0046976)
0.0 1.3 GO:0000979 RNA polymerase II core promoter sequence-specific DNA binding(GO:0000979)
0.0 0.4 GO:0032183 SUMO binding(GO:0032183)
0.0 0.2 GO:0030306 ADP-ribosylation factor binding(GO:0030306)
0.0 0.0 GO:0004647 phosphoserine phosphatase activity(GO:0004647)
0.0 0.4 GO:0070412 R-SMAD binding(GO:0070412)
0.0 0.9 GO:0003725 double-stranded RNA binding(GO:0003725)
0.0 0.1 GO:0003958 NADPH-hemoprotein reductase activity(GO:0003958)
0.0 0.0 GO:0004995 tachykinin receptor activity(GO:0004995)
0.0 0.0 GO:0042610 CD8 receptor binding(GO:0042610)
0.0 0.1 GO:0000150 recombinase activity(GO:0000150)
0.0 0.0 GO:0008265 Mo-molybdopterin cofactor sulfurase activity(GO:0008265)
0.0 0.1 GO:0004875 complement receptor activity(GO:0004875)
0.0 0.0 GO:0070699 type II activin receptor binding(GO:0070699)
0.0 0.1 GO:0032558 adenyl deoxyribonucleotide binding(GO:0032558)
0.0 0.1 GO:0005078 MAP-kinase scaffold activity(GO:0005078)
0.0 0.0 GO:0000179 rRNA (adenine-N6,N6-)-dimethyltransferase activity(GO:0000179)
0.0 0.1 GO:1904264 ubiquitin protein ligase activity involved in ERAD pathway(GO:1904264)
0.0 0.0 GO:0009384 N-acylmannosamine kinase activity(GO:0009384)

Gene overrepresentation in curated gene sets: canonical pathways category:

Log-likelihood per target  Total log-likelihood Term Description
0.0 0.8 PID IL27 PATHWAY IL27-mediated signaling events
0.0 0.7 PID ANTHRAX PATHWAY Cellular roles of Anthrax toxin
0.0 0.3 SA PROGRAMMED CELL DEATH Programmed cell death, or apoptosis, eliminates damaged or unneeded cells.
0.0 0.2 PID P38 GAMMA DELTA PATHWAY Signaling mediated by p38-gamma and p38-delta
0.0 0.2 SA FAS SIGNALING The TNF-type receptor Fas induces apoptosis on ligand binding.
0.0 0.6 PID CD40 PATHWAY CD40/CD40L signaling
0.0 0.4 ST GA12 PATHWAY G alpha 12 Pathway
0.0 0.6 PID CXCR3 PATHWAY CXCR3-mediated signaling events
0.0 0.7 PID SYNDECAN 1 PATHWAY Syndecan-1-mediated signaling events
0.0 0.1 PID THROMBIN PAR4 PATHWAY PAR4-mediated thrombin signaling events
0.0 1.3 PID SMAD2 3NUCLEAR PATHWAY Regulation of nuclear SMAD2/3 signaling
0.0 0.5 PID P38 ALPHA BETA DOWNSTREAM PATHWAY Signaling mediated by p38-alpha and p38-beta
0.0 0.1 SA G2 AND M PHASES Cdc25 activates the cdc2/cyclin B complex to induce the G2/M transition.
0.0 0.2 SA MMP CYTOKINE CONNECTION Cytokines can induce activation of matrix metalloproteinases, which degrade extracellular matrix.
0.0 1.7 PID P53 DOWNSTREAM PATHWAY Direct p53 effectors
0.0 0.6 PID IL4 2PATHWAY IL4-mediated signaling events
0.0 0.2 PID TOLL ENDOGENOUS PATHWAY Endogenous TLR signaling

Gene overrepresentation in curated gene sets: REACTOME pathways category:

Log-likelihood per target  Total log-likelihood Term Description
0.1 1.3 REACTOME TRAF6 MEDIATED IRF7 ACTIVATION IN TLR7 8 OR 9 SIGNALING Genes involved in TRAF6 mediated IRF7 activation in TLR7/8 or 9 signaling
0.1 5.0 REACTOME INTERFERON ALPHA BETA SIGNALING Genes involved in Interferon alpha/beta signaling
0.1 0.7 REACTOME NFKB ACTIVATION THROUGH FADD RIP1 PATHWAY MEDIATED BY CASPASE 8 AND10 Genes involved in NF-kB activation through FADD/RIP-1 pathway mediated by caspase-8 and -10
0.1 0.2 REACTOME ENDOSOMAL VACUOLAR PATHWAY Genes involved in Endosomal/Vacuolar pathway
0.0 0.6 REACTOME THE NLRP3 INFLAMMASOME Genes involved in The NLRP3 inflammasome
0.0 0.5 REACTOME RIP MEDIATED NFKB ACTIVATION VIA DAI Genes involved in RIP-mediated NFkB activation via DAI
0.0 1.3 REACTOME INTERFERON GAMMA SIGNALING Genes involved in Interferon gamma signaling
0.0 0.6 REACTOME ANTIGEN PRESENTATION FOLDING ASSEMBLY AND PEPTIDE LOADING OF CLASS I MHC Genes involved in Antigen Presentation: Folding, assembly and peptide loading of class I MHC
0.0 0.9 REACTOME PRE NOTCH TRANSCRIPTION AND TRANSLATION Genes involved in Pre-NOTCH Transcription and Translation
0.0 1.4 REACTOME CHEMOKINE RECEPTORS BIND CHEMOKINES Genes involved in Chemokine receptors bind chemokines
0.0 0.0 REACTOME TRAF6 MEDIATED NFKB ACTIVATION Genes involved in TRAF6 mediated NF-kB activation
0.0 1.1 REACTOME CROSS PRESENTATION OF SOLUBLE EXOGENOUS ANTIGENS ENDOSOMES Genes involved in Cross-presentation of soluble exogenous antigens (endosomes)
0.0 0.3 REACTOME ACTIVATION OF BH3 ONLY PROTEINS Genes involved in Activation of BH3-only proteins
0.0 0.3 REACTOME REGULATION OF COMPLEMENT CASCADE Genes involved in Regulation of Complement cascade
0.0 0.4 REACTOME OTHER SEMAPHORIN INTERACTIONS Genes involved in Other semaphorin interactions
0.0 0.2 REACTOME ACTIVATION OF THE AP1 FAMILY OF TRANSCRIPTION FACTORS Genes involved in Activation of the AP-1 family of transcription factors
0.0 0.2 REACTOME TETRAHYDROBIOPTERIN BH4 SYNTHESIS RECYCLING SALVAGE AND REGULATION Genes involved in Tetrahydrobiopterin (BH4) synthesis, recycling, salvage and regulation
0.0 0.1 REACTOME P53 INDEPENDENT G1 S DNA DAMAGE CHECKPOINT Genes involved in p53-Independent G1/S DNA damage checkpoint
0.0 0.4 REACTOME ELONGATION ARREST AND RECOVERY Genes involved in Elongation arrest and recovery
0.0 0.1 REACTOME PURINE CATABOLISM Genes involved in Purine catabolism
0.0 0.2 REACTOME SPRY REGULATION OF FGF SIGNALING Genes involved in Spry regulation of FGF signaling
0.0 0.1 REACTOME G2 M CHECKPOINTS Genes involved in G2/M Checkpoints
0.0 0.3 REACTOME ADP SIGNALLING THROUGH P2RY12 Genes involved in ADP signalling through P2Y purinoceptor 12
0.0 0.2 REACTOME ZINC TRANSPORTERS Genes involved in Zinc transporters