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GSE49485: Hypoxia transcriptome sequencing of rat brain.
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Results for Hsf4
Z-value: 0.61
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Transcription factors associated with Hsf4
Activity-expression correlation:
| Gene | Promoter | Pearson corr. coef. | P-value | Plot |
|---|---|---|---|---|
| Hsf4 | rn6_v1_chr19_+_37229120_37229120 | 0.86 | 6.5e-02 | Click! |
| Promoter | Log-likelihood | Transcript | Gene | Gene Info |
|---|---|---|---|---|
| chr1_-_12952906 Show fit | 0.36 |
ENSRNOT00000078193
|
hypothetical protein LOC100360362 |
|
| chr5_-_153924896 Show fit | 0.34 |
ENSRNOT00000065247
|
grainyhead-like transcription factor 3 |
|
| chr1_+_83003841 Show fit | 0.31 |
ENSRNOT00000057384
|
carcinoembryonic antigen-related cell adhesion molecule 4 |
|
| chr16_-_19942343 Show fit | 0.30 |
ENSRNOT00000087162
ENSRNOT00000091906 |
bone marrow stromal cell antigen 2 |
|
| chr4_-_482645 Show fit | 0.30 |
ENSRNOT00000062073
ENSRNOT00000071713 |
canopy FGF signaling regulator 1 |
|
| chr20_-_9855443 Show fit | 0.30 |
ENSRNOT00000090275
ENSRNOT00000066266 |
trefoil factor 3 |
|
| chr12_-_23841049 Show fit | 0.29 |
ENSRNOT00000031555
|
heat shock protein family B (small) member 1 |
|
| chr1_+_80135391 Show fit | 0.25 |
ENSRNOT00000021893
|
G protein-coupled receptor 4 |
|
| chr2_-_187668677 Show fit | 0.24 |
ENSRNOT00000056898
ENSRNOT00000092563 |
TSSK6 activating co-chaperone |
|
| chr8_+_55178289 Show fit | 0.24 |
ENSRNOT00000059127
|
crystallin, alpha B |
Network of associatons between targets according to the STRING database.
First level regulatory network of Hsf4
Gene Ontology Analysis
Gene overrepresentation in biological process category:
| Log-likelihood per target | Total log-likelihood | Term | Description |
|---|---|---|---|
| 0.0 | 0.4 | GO:1990173 | protein localization to nuclear body(GO:1903405) protein localization to Cajal body(GO:1904867) regulation of protein localization to Cajal body(GO:1904869) positive regulation of protein localization to Cajal body(GO:1904871) protein localization to nucleoplasm(GO:1990173) |
| 0.1 | 0.3 | GO:1901252 | negative regulation of dendritic cell cytokine production(GO:0002731) regulation of intracellular transport of viral material(GO:1901252) |
| 0.1 | 0.3 | GO:1903544 | cellular response to interleukin-11(GO:0071348) response to butyrate(GO:1903544) |
| 0.1 | 0.3 | GO:0097032 | respiratory chain complex II assembly(GO:0034552) mitochondrial respiratory chain complex II assembly(GO:0034553) mitochondrial respiratory chain complex II biogenesis(GO:0097032) |
| 0.1 | 0.3 | GO:0072144 | glomerular mesangial cell development(GO:0072144) |
| 0.0 | 0.3 | GO:0061029 | eyelid development in camera-type eye(GO:0061029) |
| 0.0 | 0.3 | GO:0031115 | negative regulation of microtubule polymerization(GO:0031115) |
| 0.1 | 0.2 | GO:0017185 | peptidyl-lysine hydroxylation(GO:0017185) |
| 0.0 | 0.2 | GO:0034486 | vacuolar transmembrane transport(GO:0034486) chaperone-mediated protein transport involved in chaperone-mediated autophagy(GO:0061741) |
| 0.0 | 0.2 | GO:0070318 | positive regulation of G0 to G1 transition(GO:0070318) |
Gene overrepresentation in cellular component category:
| Log-likelihood per target | Total log-likelihood | Term | Description |
|---|---|---|---|
| 0.1 | 0.5 | GO:0097512 | cardiac myofibril(GO:0097512) |
| 0.0 | 0.4 | GO:0002199 | zona pellucida receptor complex(GO:0002199) |
| 0.0 | 0.2 | GO:0061617 | MICOS complex(GO:0061617) |
| 0.0 | 0.2 | GO:0042105 | alpha-beta T cell receptor complex(GO:0042105) |
| 0.0 | 0.2 | GO:0042612 | MHC class I protein complex(GO:0042612) |
| 0.0 | 0.1 | GO:1990826 | nucleoplasmic periphery of the nuclear pore complex(GO:1990826) |
| 0.0 | 0.1 | GO:0070110 | ciliary neurotrophic factor receptor complex(GO:0070110) |
| 0.0 | 0.1 | GO:0005784 | Sec61 translocon complex(GO:0005784) translocon complex(GO:0071256) |
| 0.0 | 0.1 | GO:0031415 | NatA complex(GO:0031415) |
| 0.0 | 0.1 | GO:0000220 | vacuolar proton-transporting V-type ATPase, V0 domain(GO:0000220) |
Gene overrepresentation in molecular function category:
| Log-likelihood per target | Total log-likelihood | Term | Description |
|---|---|---|---|
| 0.0 | 0.7 | GO:0044183 | protein binding involved in protein folding(GO:0044183) |
| 0.0 | 0.4 | GO:0031492 | nucleosomal DNA binding(GO:0031492) |
| 0.0 | 0.3 | GO:0008191 | metalloendopeptidase inhibitor activity(GO:0008191) |
| 0.0 | 0.3 | GO:0005212 | structural constituent of eye lens(GO:0005212) |
| 0.1 | 0.2 | GO:0070815 | peptidyl-lysine 5-dioxygenase activity(GO:0070815) |
| 0.0 | 0.2 | GO:0032767 | copper-dependent protein binding(GO:0032767) |
| 0.0 | 0.2 | GO:0030911 | TPR domain binding(GO:0030911) |
| 0.0 | 0.2 | GO:0000774 | adenyl-nucleotide exchange factor activity(GO:0000774) |
| 0.0 | 0.2 | GO:0004806 | triglyceride lipase activity(GO:0004806) |
| 0.0 | 0.1 | GO:0046592 | polyamine oxidase activity(GO:0046592) |
Gene overrepresentation in curated gene sets: canonical pathways category:
| Log-likelihood per target | Total log-likelihood | Term | Description |
|---|---|---|---|
| 0.0 | 0.3 | PID P38 MK2 PATHWAY | p38 signaling mediated by MAPKAP kinases |
Gene overrepresentation in curated gene sets: REACTOME pathways category:
| Log-likelihood per target | Total log-likelihood | Term | Description |
|---|---|---|---|
| 0.0 | 0.4 | REACTOME FORMATION OF TUBULIN FOLDING INTERMEDIATES BY CCT TRIC | Genes involved in Formation of tubulin folding intermediates by CCT/TriC |
| 0.0 | 0.1 | REACTOME REGULATION OF ORNITHINE DECARBOXYLASE ODC | Genes involved in Regulation of ornithine decarboxylase (ODC) |
| 0.0 | 0.1 | REACTOME APOBEC3G MEDIATED RESISTANCE TO HIV1 INFECTION | Genes involved in APOBEC3G mediated resistance to HIV-1 infection |
| 0.0 | 0.1 | REACTOME TRANSLOCATION OF ZAP 70 TO IMMUNOLOGICAL SYNAPSE | Genes involved in Translocation of ZAP-70 to Immunological synapse |