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GSE49485: Hypoxia transcriptome sequencing of rat brain.

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Results for Hoxd11_Cdx1_Hoxc11

Z-value: 0.21

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Transcription factors associated with Hoxd11_Cdx1_Hoxc11

Gene Symbol Gene ID Gene Info
ENSRNOG00000051472 homeobox D11
ENSRNOG00000060334 caudal type homeo box 1
ENSRNOG00000016141 homeobox C11

Activity profile of Hoxd11_Cdx1_Hoxc11 motif

Sorted Z-values of Hoxd11_Cdx1_Hoxc11 motif

Promoter Log-likelihood Transcript Gene Gene Info
chr9_-_52238564 0.20 ENSRNOT00000005073
collagen type V alpha 2 chain
chr2_-_31753528 0.16 ENSRNOT00000075057
phosphoinositide-3-kinase regulatory subunit 1
chr19_-_22194740 0.14 ENSRNOT00000086187
phosphorylase kinase regulatory subunit beta
chr6_+_146784915 0.12 ENSRNOT00000008362
Sp8 transcription factor
chr19_-_19315357 0.10 ENSRNOT00000018888
CYLD lysine 63 deubiquitinase
chr14_+_12218553 0.09 ENSRNOT00000003237
protein kinase, cGMP-dependent, type II
chr13_+_57243877 0.08 ENSRNOT00000083693
potassium sodium-activated channel subfamily T member 2
chr2_+_143895982 0.08 ENSRNOT00000080026
SPT20 homolog, SAGA complex component
chr1_+_8310577 0.07 ENSRNOT00000015131
human immunodeficiency virus type I enhancer binding protein 2
chr15_-_48284548 0.06 ENSRNOT00000038336
homeobox containing 1
chr9_+_118586179 0.06 ENSRNOT00000022351
DLG associated protein 1
chr13_+_90533365 0.06 ENSRNOT00000082469
DDB1 and CUL4 associated factor 8
chr3_-_105663457 0.06 ENSRNOT00000067646
zinc finger protein 770
chr16_+_22361998 0.05 ENSRNOT00000016193
solute carrier family 18 member A1
chr9_+_73529612 0.05 ENSRNOT00000032430
unc-80 homolog, NALCN activator
chr15_-_43542939 0.05 ENSRNOT00000012996
dihydropyrimidinase-like 2
chr7_+_64769089 0.05 ENSRNOT00000088861
glutamate receptor interacting protein 1
chr2_-_96509424 0.05 ENSRNOT00000090866
zinc finger, C2HC-type containing 1A
chr7_-_140437467 0.05 ENSRNOT00000087181
FK506 binding protein 11
chr5_-_154965027 0.04 ENSRNOT00000080881
ENSRNOT00000055992
lysine demethylase 1A
chr11_-_45124423 0.04 ENSRNOT00000046383
filamin A interacting protein 1-like
chr6_-_91250138 0.04 ENSRNOT00000052408
ninein-like
chr1_-_163554839 0.04 ENSRNOT00000081509
EMSY BRCA2-interacting transcriptional repressor
chr4_-_155740193 0.04 ENSRNOT00000043229
LRRGT00188
chr2_-_231409988 0.04 ENSRNOT00000080637
ENSRNOT00000037255
ENSRNOT00000074002
ankyrin 2
chr10_+_77537340 0.04 ENSRNOT00000003297
transmembrane protein 100
chr2_-_173087648 0.04 ENSRNOT00000091079
IQ motif containing J
chr10_+_71546977 0.04 ENSRNOT00000041140
acetyl-CoA carboxylase alpha
chr7_+_122433099 0.04 ENSRNOT00000055447
thymosin, beta 10
chr3_+_47677720 0.04 ENSRNOT00000065340
T-box, brain, 1
chr5_+_167141875 0.04 ENSRNOT00000089314
solute carrier family 2 member 5
chr4_-_108717309 0.03 ENSRNOT00000085062

chr4_+_5644260 0.03 ENSRNOT00000041876
ARP3 actin related protein 3 homolog B
chr14_-_3288017 0.03 ENSRNOT00000080452
hypothetical protein LOC689986
chr17_-_51912496 0.03 ENSRNOT00000019272
inhibin beta A subunit
chr10_-_58771908 0.03 ENSRNOT00000018808
similar to 4933427D14Rik protein
chr15_-_106678918 0.03 ENSRNOT00000034723
serine/threonine kinase 24
chr8_-_49158971 0.03 ENSRNOT00000020573
lysine methyltransferase 2A
chr17_-_18590536 0.03 ENSRNOT00000078992
CAP, adenylate cyclase-associated protein, 2 (yeast)
chr2_+_22910236 0.03 ENSRNOT00000078266
homer scaffolding protein 1
chr3_+_151126591 0.03 ENSRNOT00000025859
myosin heavy chain 7B
chr1_-_48891130 0.03 ENSRNOT00000083884

chrX_-_26376467 0.03 ENSRNOT00000051655
ENSRNOT00000036502
Rho GTPase activating protein 6
chr8_+_118066988 0.03 ENSRNOT00000056161
microtubule-associated protein 4
chr15_-_55209342 0.03 ENSRNOT00000021752
RB transcriptional corepressor 1
chr2_-_231409496 0.03 ENSRNOT00000055615
ENSRNOT00000015386
ENSRNOT00000068415
ankyrin 2
chr14_+_39663421 0.03 ENSRNOT00000003197
gamma-aminobutyric acid type A receptor alpha2 subunit
chr9_-_119818310 0.03 ENSRNOT00000019359
structural maintenance of chromosomes flexible hinge domain containing 1
chr7_-_118332577 0.02 ENSRNOT00000090370
RNA binding protein, fox-1 homolog 2
chr3_-_7796385 0.02 ENSRNOT00000082489
netrin G2
chr1_-_200548317 0.02 ENSRNOT00000088610

chr10_-_88060561 0.02 ENSRNOT00000019133
keratin 19
chr1_+_44311513 0.02 ENSRNOT00000065386
T-cell lymphoma invasion and metastasis 2
chr3_+_54253949 0.02 ENSRNOT00000010018
Beta-1,3-galactosyltransferase 1
chr7_+_34533543 0.02 ENSRNOT00000007412
ENSRNOT00000084185
netrin 4
chr7_-_52404774 0.02 ENSRNOT00000082100
neuron navigator 3
chrX_+_78042859 0.02 ENSRNOT00000003286
lysophosphatidic acid receptor 4
chr15_+_56666012 0.02 ENSRNOT00000013408
5-hydroxytryptamine receptor 2A
chr2_+_206064179 0.02 ENSRNOT00000025953
synaptotagmin 6
chr12_+_51960262 0.02 ENSRNOT00000084214
E1A binding protein p400
chr6_+_83421882 0.02 ENSRNOT00000084258
leucine rich repeat and fibronectin type III domain containing 5
chr7_+_130042947 0.02 ENSRNOT00000089707
pannexin 2
chr8_-_63750531 0.02 ENSRNOT00000009496
neogenin 1
chr3_+_48096954 0.02 ENSRNOT00000068238
ENSRNOT00000064344
ENSRNOT00000044638
solute carrier family 4 member 10
chr7_-_122329443 0.02 ENSRNOT00000032232
megakaryoblastic leukemia (translocation) 1
chrX_-_10031167 0.02 ENSRNOT00000060988
G protein-coupled receptor 34
chr6_+_107603580 0.02 ENSRNOT00000036430
dynein, axonemal, light chain 1
chr7_+_142575672 0.02 ENSRNOT00000080923
ENSRNOT00000008160
sodium voltage-gated channel alpha subunit 8
chr5_-_50221095 0.02 ENSRNOT00000012164
similar to hypothetical protein
chr4_-_178441547 0.02 ENSRNOT00000087434
ENSRNOT00000055542
SRY box 5
chr3_+_43255567 0.02 ENSRNOT00000044419
glycerol-3-phosphate dehydrogenase 2
chr10_-_37311625 0.02 ENSRNOT00000043343
jade family PHD finger 2
chr5_+_25725683 0.02 ENSRNOT00000087602
similar to swan
chr6_-_8344574 0.02 ENSRNOT00000009660
prolyl endopeptidase-like
chr6_+_25076147 0.02 ENSRNOT00000010419
EH-domain containing 3
chr16_-_32421005 0.01 ENSRNOT00000082712
NIMA-related kinase 1
chr13_-_37697569 0.01 ENSRNOT00000045263
similar to NADH-ubiquinone oxidoreductase B9 subunit (Complex I-B9) (CI-B9)
chr13_-_72744295 0.01 ENSRNOT00000093366
ENSRNOT00000077157
immediate early response 5
chr13_+_77485113 0.01 ENSRNOT00000080254
tenascin R
chr3_-_7795758 0.01 ENSRNOT00000045919
netrin G2
chr4_+_158243086 0.01 ENSRNOT00000032112
anoctamin 2
chr5_+_25253010 0.01 ENSRNOT00000061333
RNA binding motif protein 12B
chrX_+_71528988 0.01 ENSRNOT00000075963
O-linked N-acetylglucosamine (GlcNAc) transferase
chr7_-_2961873 0.01 ENSRNOT00000067441
ribosomal protein S15, pseudogene 2
chr8_+_82037977 0.01 ENSRNOT00000082288
myosin VA
chr11_-_46369577 0.01 ENSRNOT00000049859
ENSRNOT00000047817
ENSRNOT00000002220
ENSRNOT00000002223
ENSRNOT00000063864
ENSRNOT00000070871
ENSRNOT00000072140
ABI family member 3 binding protein
chr9_+_16737642 0.01 ENSRNOT00000061430
serum response factor
chr6_-_42002819 0.01 ENSRNOT00000032417
growth regulation by estrogen in breast cancer 1
chr10_-_87248572 0.01 ENSRNOT00000066637
ENSRNOT00000085677
keratin 26
chr7_-_59547174 0.01 ENSRNOT00000085836
CCR4-NOT transcription complex, subunit 2
chr19_+_9895121 0.01 ENSRNOT00000033953
protease, serine, 54
chr5_-_6186329 0.01 ENSRNOT00000012610
sulfatase 1
chr3_-_121882726 0.01 ENSRNOT00000006308
interleukin 1 beta
chr8_+_103938520 0.01 ENSRNOT00000067835
glycerol kinase 5 (putative)
chr1_+_198682230 0.01 ENSRNOT00000023995
zinc finger protein 48
chr1_+_282134981 0.01 ENSRNOT00000036203
nanos C2HC-type zinc finger 1
chr4_+_6559545 0.01 ENSRNOT00000067183
protein kinase AMP-activated non-catalytic subunit gamma 2
chr2_+_41467064 0.01 ENSRNOT00000073231

chr7_-_134722215 0.01 ENSRNOT00000036750
prickle planar cell polarity protein 1
chr5_+_71742911 0.01 ENSRNOT00000047225
zinc finger protein 462
chr7_+_80750725 0.01 ENSRNOT00000079962
oxidation resistance 1
chr3_-_60166013 0.01 ENSRNOT00000024922
WAS/WASL interacting protein family, member 1
chr3_+_113918629 0.01 ENSRNOT00000078978
ENSRNOT00000037168
CTD small phosphatase like 2
chr7_+_64768742 0.01 ENSRNOT00000005545
glutamate receptor interacting protein 1
chr9_+_92681078 0.01 ENSRNOT00000034152
SP100 nuclear antigen
chr8_-_22086095 0.01 ENSRNOT00000068598
zinc finger, GATA-like protein 1
chr10_-_16731898 0.01 ENSRNOT00000028186
CREB3 regulatory factor
chr3_+_9366053 0.01 ENSRNOT00000073999
fibrinogen C domain containing 1-like 1
chr3_+_154910626 0.01 ENSRNOT00000079515
Ral GTPase activating protein non-catalytic beta subunit
chr6_-_26680284 0.01 ENSRNOT00000039709
carbamoyl-phosphate synthetase 2, aspartate transcarbamylase, and dihydroorotase
chr2_+_8732932 0.01 ENSRNOT00000072849
arrestin domain containing 3
chr10_+_45322248 0.01 ENSRNOT00000047268
tripartite motif-containing 11
chr9_+_100489852 0.01 ENSRNOT00000022854
protein phosphatase 1, regulatory subunit 7
chr9_+_66888393 0.01 ENSRNOT00000023536
calcium responsive transcription factor
chr2_-_120316357 0.01 ENSRNOT00000065469
coiled-coil domain containing 39
chr15_-_34693034 0.01 ENSRNOT00000083314
mast cell protease 8
chr6_+_73358112 0.01 ENSRNOT00000041373
Rho GTPase activating protein 5
chr18_+_17403407 0.01 ENSRNOT00000045150
similar to KIAA1328 protein
chr5_+_128083118 0.01 ENSRNOT00000079161
zinc finger CCHC-type containing 11
chr5_+_64566804 0.01 ENSRNOT00000073192
TGF-beta receptor type-1-like
chr10_-_109802739 0.01 ENSRNOT00000054951
sirtuin 7
chr1_+_167522895 0.01 ENSRNOT00000092987
stromal interaction molecule 1
chr12_-_11175917 0.01 ENSRNOT00000079573
zinc finger with KRAB and SCAN domains 5
chr1_+_266844480 0.01 ENSRNOT00000027482
TATA-box binding protein associated factor 5
chrX_+_65040775 0.01 ENSRNOT00000081354
zinc finger CCCH-type containing 12B
chrX_+_33884499 0.01 ENSRNOT00000090041
RALBP1 associated Eps domain containing protein 2
chr9_-_11027506 0.01 ENSRNOT00000071107
chromatin assembly factor 1 subunit A
chr1_+_64928503 0.01 ENSRNOT00000086274
vomeronasal 2 receptor, 80
chr4_-_173640684 0.01 ENSRNOT00000010728
RERG like
chr1_+_42169501 0.01 ENSRNOT00000025477
ENSRNOT00000092791
vasoactive intestinal peptide
chr1_-_126211439 0.01 ENSRNOT00000014988
tight junction protein 1
chr15_-_100303807 0.01 ENSRNOT00000041344
40S ribosomal protein S16-like
chr14_-_20920286 0.01 ENSRNOT00000004391
solute carrier family 4 member 4
chr7_+_66742987 0.01 ENSRNOT00000045130
MON2 homolog, regulator of endosome-to-Golgi trafficking
chr8_-_52828134 0.01 ENSRNOT00000007736
RNA binding motif protein 7
chr15_+_4240203 0.01 ENSRNOT00000010178
MSS51 mitochondrial translational activator
chr6_+_8218696 0.01 ENSRNOT00000083470
protein phosphatase, Mg2+/Mn2+ dependent, 1B
chr7_+_140829076 0.01 ENSRNOT00000086179
spermatogenesis associated, serine-rich 2
chr5_+_167142182 0.00 ENSRNOT00000024054
solute carrier family 2 member 5
chr13_-_94289333 0.00 ENSRNOT00000078195
phospholipase D family, member 5
chr3_-_14643897 0.00 ENSRNOT00000082008
ENSRNOT00000025983
glycoprotein, alpha-galactosyltransferase 1
chr17_-_43770561 0.00 ENSRNOT00000088408
histone H4 variant H4-v.1
chr4_+_158088505 0.00 ENSRNOT00000026643
von Willebrand factor
chr9_-_7891514 0.00 ENSRNOT00000072684
protection of telomeres 1B
chr2_+_188745503 0.00 ENSRNOT00000056652
SHC adaptor protein 1
chr2_-_35104963 0.00 ENSRNOT00000018058
regulator of G-protein signaling 7-binding protein
chr4_+_127164453 0.00 ENSRNOT00000017889
kelch repeat and BTB domain containing 8
chr4_-_6978073 0.00 ENSRNOT00000045311
negative regulator of ubiquitin-like proteins 1
chr1_+_277355619 0.00 ENSRNOT00000022788
NHL repeat containing 2
chrX_+_104734082 0.00 ENSRNOT00000005020
sushi-repeat-containing protein, X-linked 2
chr7_+_58814805 0.00 ENSRNOT00000005909
tetraspanin 8
chr15_-_93748742 0.00 ENSRNOT00000093370
MYC binding protein 2, E3 ubiquitin protein ligase
chr4_-_157486844 0.00 ENSRNOT00000038281
ENSRNOT00000022874
COP9 signalosome subunit 7A
chr2_-_188745144 0.00 ENSRNOT00000055533
CDC28 protein kinase regulatory subunit 1B
chr10_-_107386072 0.00 ENSRNOT00000004290
TIMP metallopeptidase inhibitor 2
chr7_+_132378273 0.00 ENSRNOT00000010990
hypothetical protein LOC690142
chr2_+_54466280 0.00 ENSRNOT00000033112
complement C6
chr6_+_52459946 0.00 ENSRNOT00000073277
ENSRNOT00000013474
ataxin 7-like 1
chr18_+_29999290 0.00 ENSRNOT00000027372
protocadherin alpha 4
chr14_-_115391652 0.00 ENSRNOT00000002094
ChaC cation transport regulator 2
chr6_+_37144787 0.00 ENSRNOT00000075503
RAD51 associated protein 2
chr2_+_200572502 0.00 ENSRNOT00000074666
zinc finger protein 697
chr3_+_154905141 0.00 ENSRNOT00000088748
ENSRNOT00000020556
Ral GTPase activating protein non-catalytic beta subunit
chrX_+_106306795 0.00 ENSRNOT00000073661
G protein-coupled receptor associated sorting protein 1
chr2_-_79078258 0.00 ENSRNOT00000031170
F-box and leucine-rich repeat protein 7
chr1_-_198652674 0.00 ENSRNOT00000023706
TBC1 domain family, member 10b
chr2_-_140334912 0.00 ENSRNOT00000015067
E74-like factor 2
chr9_+_52023295 0.00 ENSRNOT00000004956
collagen type III alpha 1 chain
chr12_-_40590361 0.00 ENSRNOT00000067503
transmembrane protein 116
chr17_+_2690062 0.00 ENSRNOT00000024937
olfactory receptor 1653
chr15_-_39705208 0.00 ENSRNOT00000015412
PHD finger protein 11
chr16_+_50152008 0.00 ENSRNOT00000019237
kallikrein B1
chr6_-_26314844 0.00 ENSRNOT00000006658
zinc finger protein 512
chr4_+_56981283 0.00 ENSRNOT00000010989
tetraspanin 33
chr2_+_206064394 0.00 ENSRNOT00000077739
synaptotagmin 6
chr11_-_4397361 0.00 ENSRNOT00000046370
cell adhesion molecule 2
chr8_+_1459526 0.00 ENSRNOT00000034503
kelch repeat and BTB domain containing 3
chr8_+_106816152 0.00 ENSRNOT00000047613
Fas apoptotic inhibitory molecule
chr3_+_44025300 0.00 ENSRNOT00000006319
polypeptide N-acetylgalactosaminyltransferase 5
chr12_+_13715843 0.00 ENSRNOT00000042459
actin, beta
chr10_-_84920886 0.00 ENSRNOT00000068083
Sp2 transcription factor
chr8_-_60570058 0.00 ENSRNOT00000009169
S-phase cyclin A-associated protein in the ER
chr10_-_70337532 0.00 ENSRNOT00000055963
schlafen family member 13
chr4_+_182483194 0.00 ENSRNOT00000002528
fatty acyl CoA reductase 2
chr2_+_52431601 0.00 ENSRNOT00000023554
3-hydroxy-3-methylglutaryl-CoA synthase 1
chr14_-_66978499 0.00 ENSRNOT00000081601
slit guidance ligand 2
chr3_+_67538289 0.00 ENSRNOT00000009839
DnaJ heat shock protein family (Hsp40) member C10
chr14_-_21553949 0.00 ENSRNOT00000031642
submaxillary gland androgen regulated protein 3B
chr17_+_78876111 0.00 ENSRNOT00000057895
ribosomal protein L34, pseudogene 1
chr9_+_81689802 0.00 ENSRNOT00000021432
villin 1
chr2_-_250805445 0.00 ENSRNOT00000055362
chloride channel calcium activated 4-like
chr8_+_130581062 0.00 ENSRNOT00000014323
family with sequence similarity 198, member A

Network of associatons between targets according to the STRING database.

First level regulatory network of Hoxd11_Cdx1_Hoxc11

PNG image of the network

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Gene Ontology Analysis

Gene overrepresentation in biological process category:

Log-likelihood per target  Total log-likelihood Term Description
0.0 0.2 GO:1903225 negative regulation of endodermal cell differentiation(GO:1903225)
0.0 0.1 GO:1990108 protein linear deubiquitination(GO:1990108)
0.0 0.1 GO:2001226 negative regulation of chloride transport(GO:2001226)
0.0 0.1 GO:0036371 protein localization to M-band(GO:0036309) protein localization to T-tubule(GO:0036371)
0.0 0.0 GO:0010725 regulation of primitive erythrocyte differentiation(GO:0010725)
0.0 0.2 GO:0010459 negative regulation of heart rate(GO:0010459)
0.0 0.1 GO:0035948 positive regulation of gluconeogenesis by positive regulation of transcription from RNA polymerase II promoter(GO:0035948)
0.0 0.1 GO:0051611 negative regulation of neurotransmitter uptake(GO:0051581) regulation of serotonin uptake(GO:0051611) negative regulation of serotonin uptake(GO:0051612)
0.0 0.0 GO:1901674 histone H3-K27 acetylation(GO:0043974) regulation of histone H3-K27 acetylation(GO:1901674) regulation of cellular response to drug(GO:2001038)

Gene overrepresentation in cellular component category:

Log-likelihood per target  Total log-likelihood Term Description
0.1 0.2 GO:0005943 phosphatidylinositol 3-kinase complex, class IA(GO:0005943)
0.0 0.2 GO:0005588 collagen type V trimer(GO:0005588)
0.0 0.1 GO:0005964 phosphorylase kinase complex(GO:0005964)
0.0 0.0 GO:0043511 inhibin complex(GO:0043511)

Gene overrepresentation in molecular function category:

Log-likelihood per target  Total log-likelihood Term Description
0.0 0.2 GO:0046935 1-phosphatidylinositol-3-kinase regulator activity(GO:0046935)
0.0 0.1 GO:0004690 cyclic nucleotide-dependent protein kinase activity(GO:0004690)
0.0 0.1 GO:0015222 serotonin transmembrane transporter activity(GO:0015222)
0.0 0.1 GO:0004689 phosphorylase kinase activity(GO:0004689)
0.0 0.1 GO:0061578 Lys63-specific deubiquitinase activity(GO:0061578)

Gene overrepresentation in curated gene sets: REACTOME pathways category:

Log-likelihood per target  Total log-likelihood Term Description
0.0 0.2 REACTOME IL 7 SIGNALING Genes involved in Interleukin-7 signaling