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GSE49485: Hypoxia transcriptome sequencing of rat brain.

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Results for Hoxb5

Z-value: 0.45

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Transcription factors associated with Hoxb5

Gene Symbol Gene ID Gene Info
ENSRNOG00000008010 homeo box B5

Activity-expression correlation:

GenePromoterPearson corr. coef.P-valuePlot
Hoxb5rn6_v1_chr10_+_84152152_841521520.395.1e-01Click!

Activity profile of Hoxb5 motif

Sorted Z-values of Hoxb5 motif

Promoter Log-likelihood Transcript Gene Gene Info
chr14_-_6679878 0.58 ENSRNOT00000075989
ENSRNOT00000067875
secreted phosphoprotein 1
chr2_+_164549455 0.22 ENSRNOT00000017151
myeloid leukemia factor 1
chr20_+_5067330 0.15 ENSRNOT00000037482
lymphocyte antigen 6 complex, locus G6E
chr5_-_38923095 0.13 ENSRNOT00000009146

chr12_-_38782010 0.12 ENSRNOT00000001813
WD repeat domain 66
chr4_+_7173961 0.11 ENSRNOT00000017854
gastrulation brain homeobox 1
chr10_-_13115294 0.11 ENSRNOT00000005899
FLYWCH family member 2
chr12_+_2170630 0.10 ENSRNOT00000071928
PET100 homolog
chr10_-_83898527 0.10 ENSRNOT00000009815
ATP synthase, H+ transporting, mitochondrial Fo complex, subunit C1 (subunit 9)
chr2_+_187740531 0.10 ENSRNOT00000092653
progestin and adipoQ receptor family member 6
chr18_+_25163561 0.10 ENSRNOT00000042287
ENSRNOT00000049898
ENSRNOT00000017573
bridging integrator 1
chr1_-_107385257 0.09 ENSRNOT00000074296
coiled-coil domain containing 179
chr11_-_74866451 0.08 ENSRNOT00000002330
interleukin 13 receptor subunit alpha 1
chrX_+_15049462 0.08 ENSRNOT00000007015
emopamil binding protein (sterol isomerase)
chr11_+_87374690 0.08 ENSRNOT00000086117
apoptosis inducing factor, mitochondria associated 3
chr9_+_9842585 0.08 ENSRNOT00000070806
Cd70 molecule
chr2_+_174203693 0.08 ENSRNOT00000073540
uncharacterized LOC108350036
chr3_-_176465162 0.08 ENSRNOT00000048807
Sodium/potassium transporting ATPase interacting 4
chr1_+_216191886 0.07 ENSRNOT00000054863
tetraspanin 32
chr13_-_109997092 0.07 ENSRNOT00000005190
neudesin neurotrophic factor
chr13_-_99101208 0.07 ENSRNOT00000004329
H3 histone family member 3A
chr11_+_70056624 0.07 ENSRNOT00000002447

chr17_+_53956203 0.07 ENSRNOT00000022483
geranylgeranyl diphosphate synthase 1
chr5_-_126221916 0.07 ENSRNOT00000052130
lymphocyte expansion molecule
chr1_+_94718402 0.07 ENSRNOT00000046035
ubiquinol-cytochrome c reductase binding protein
chr3_-_102826379 0.06 ENSRNOT00000073423
olfactory receptor 769
chr10_-_48038647 0.06 ENSRNOT00000078448
phosphoribosyl pyrophosphate synthetase-associated protein 2
chrX_-_14220662 0.06 ENSRNOT00000045753
sushi-repeat-containing protein, X-linked
chr9_-_16612136 0.06 ENSRNOT00000023495
male-enhanced antigen 1
chr16_+_21275311 0.06 ENSRNOT00000027980
NADH dehydrogenase [ubiquinone] 1 alpha subcomplex subunit 13-like
chr17_+_23116661 0.06 ENSRNOT00000067374
neural precursor cell expressed, developmentally down-regulated 9
chr14_-_60964324 0.06 ENSRNOT00000005155
superoxide dismutase 3, extracellular
chr1_+_100939740 0.06 ENSRNOT00000049584
testis-specific serine kinase substrate
chr5_-_155258392 0.06 ENSRNOT00000017065
complement C1q C chain
chr1_-_48825364 0.05 ENSRNOT00000024213
1-acylglycerol-3-phosphate O-acyltransferase 4
chr14_-_106393670 0.05 ENSRNOT00000011429
malate dehydrogenase 1
chr6_-_127653124 0.05 ENSRNOT00000047324
serpin family A member 11
chr7_-_29233392 0.05 ENSRNOT00000064241
Spi-C transcription factor
chr12_+_41463922 0.05 ENSRNOT00000089378
cilia and flagella associated protein 73
chr9_-_15410943 0.05 ENSRNOT00000074217
cyclin D3
chr3_+_95233874 0.04 ENSRNOT00000079743
hypothetical protein LOC691083
chrX_+_28593405 0.04 ENSRNOT00000071708
thymosin beta 4, X-linked
chr1_+_101012822 0.04 ENSRNOT00000027809
related RAS viral (r-ras) oncogene homolog
chr6_-_102372611 0.04 ENSRNOT00000085927
retinol dehydrogenase 11 (all-trans/9-cis/11-cis)
chr15_-_12889102 0.04 ENSRNOT00000061214
ENSRNOT00000084687
similar to HT021
chr18_-_52017734 0.04 ENSRNOT00000081020
membrane associated ring-CH-type finger 3
chr3_-_15376767 0.04 ENSRNOT00000044885
NADH:ubiquinone oxidoreductase subunit A8
chr20_+_1749716 0.03 ENSRNOT00000048856
olfactory receptor 1735
chr16_-_2048292 0.03 ENSRNOT00000061883
zinc finger CCHC-type containing 24
chrX_-_1718637 0.03 ENSRNOT00000064309
cyclin-dependent kinase 16
chr16_+_81089292 0.03 ENSRNOT00000087192
ENSRNOT00000026150
transcription factor Dp-1
chrM_+_5323 0.03 ENSRNOT00000050156
mitochondrially encoded cytochrome c oxidase 1
chr2_-_178612470 0.03 ENSRNOT00000013499
transmembrane protein 144
chr1_+_227892956 0.03 ENSRNOT00000028483

chr8_+_85355766 0.03 ENSRNOT00000010583
glial cells missing homolog 1
chr1_+_89202527 0.03 ENSRNOT00000028526
suprabasin
chr7_-_29282039 0.03 ENSRNOT00000067777
similar to ribosomal protein S12
chr6_+_135866739 0.03 ENSRNOT00000013460
exocyst complex component 3-like 4
chr20_+_10123651 0.03 ENSRNOT00000001559
phosphodiesterase 9A
chr2_-_27287605 0.03 ENSRNOT00000034041
ankyrin repeat and death domain containing 1B
chrX_+_124894466 0.03 ENSRNOT00000080894
MCTS1, re-initiation and release factor
chr19_+_45946236 0.02 ENSRNOT00000045250
synaptonemal complex central element protein 1-like
chr8_-_79715284 0.02 ENSRNOT00000088562
phosphatidylinositol glycan anchor biosynthesis, class B
chr5_+_28395296 0.02 ENSRNOT00000009375
transmembrane protein 55A
chr1_+_167944448 0.02 ENSRNOT00000087667
olfactory receptor 56
chrX_+_105537602 0.02 ENSRNOT00000029833
armadillo repeat containing, X-linked 1
chr1_+_84304228 0.02 ENSRNOT00000024771
periaxin
chr1_-_82279145 0.02 ENSRNOT00000057433
C-X-C motif chemokine ligand 17
chr16_-_21274688 0.02 ENSRNOT00000027953
testis-specific serine kinase 6
chr5_+_104362971 0.02 ENSRNOT00000058520
ADAMTS-like 1
chr15_-_33656089 0.02 ENSRNOT00000024186
myosin heavy chain 7
chr1_-_164307084 0.02 ENSRNOT00000086091
serpin family H member 1
chr9_+_12633990 0.02 ENSRNOT00000066517
ENSRNOT00000077532
deleted in azoospermia-like
chr5_+_144308611 0.02 ENSRNOT00000014388
collagen type VIII alpha 2 chain
chr4_+_88584242 0.02 ENSRNOT00000008973
PIGY upstream reading frame
chrX_-_30831483 0.02 ENSRNOT00000004443
glycine receptor, alpha 2
chr5_-_144779212 0.02 ENSRNOT00000016230
neurochondrin
chr12_-_52124779 0.02 ENSRNOT00000088839
polypeptide N-acetylgalactosaminyltransferase 9
chr4_+_175431904 0.02 ENSRNOT00000032843
phosphodiesterase 3A
chr1_+_22364551 0.02 ENSRNOT00000043157
trace amine-associated receptor 8a
chr4_-_70659252 0.02 ENSRNOT00000048049
trypsin 10
chr7_+_107467260 0.01 ENSRNOT00000009240
ENSRNOT00000077382
thyroglobulin
chr14_+_106393959 0.01 ENSRNOT00000092168
WD repeat containing planar cell polarity effector
chr1_-_100537377 0.01 ENSRNOT00000026599
Spi-B transcription factor
chr7_+_1206648 0.01 ENSRNOT00000073689
protein S (alpha)
chr12_+_37702404 0.01 ENSRNOT00000049985
M-phase phosphoprotein 9
chr9_+_16612433 0.01 ENSRNOT00000023979
kelch domain containing 3
chr20_+_12052693 0.01 ENSRNOT00000083851
adenosine deaminase, RNA-specific, B1
chr11_-_69223158 0.01 ENSRNOT00000067060
myosin light chain kinase
chr12_-_31629881 0.01 ENSRNOT00000001238
piwi-like RNA-mediated gene silencing 1
chr19_+_56136904 0.01 ENSRNOT00000022823
spire-type actin nucleation factor 2
chr10_+_103349172 0.01 ENSRNOT00000035963
G protein-coupled receptor 142
chr4_+_180291389 0.01 ENSRNOT00000002465
sarcospan
chr14_+_85113578 0.01 ENSRNOT00000011158
nipsnap homolog 1
chr16_-_69961162 0.01 ENSRNOT00000074955
proline rich and Gla domain 3
chr11_+_58624198 0.01 ENSRNOT00000002091
growth associated protein 43
chr5_+_144779681 0.01 ENSRNOT00000016493
dyslexia susceptibility 2-like
chr1_-_82580007 0.01 ENSRNOT00000078668
Axl receptor tyrosine kinase
chr10_-_45480999 0.00 ENSRNOT00000078353
ENSRNOT00000084697
ENSRNOT00000087926
obscurin, cytoskeletal calmodulin and titin-interacting RhoGEF
chr15_+_42653148 0.00 ENSRNOT00000022095
clusterin
chr5_-_28349927 0.00 ENSRNOT00000008725
OTU domain containing 6B
chr9_+_38544398 0.00 ENSRNOT00000016828
primase (DNA) subunit 2
chr1_-_256914260 0.00 ENSRNOT00000020620
FRA10A associated CGG repeat 1
chr3_-_4405194 0.00 ENSRNOT00000072025

Network of associatons between targets according to the STRING database.

First level regulatory network of Hoxb5

PNG image of the network

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Gene Ontology Analysis

Gene overrepresentation in biological process category:

Log-likelihood per target  Total log-likelihood Term Description
0.2 0.6 GO:0006710 androgen catabolic process(GO:0006710)
0.0 0.1 GO:0060988 lipid tube assembly(GO:0060988)
0.0 0.1 GO:0097374 proprioception(GO:0019230) sensory neuron axon guidance(GO:0097374)
0.0 0.1 GO:0030886 negative regulation of myeloid dendritic cell activation(GO:0030886)
0.0 0.1 GO:0033386 geranylgeranyl diphosphate metabolic process(GO:0033385) geranylgeranyl diphosphate biosynthetic process(GO:0033386)
0.0 0.2 GO:0002318 myeloid progenitor cell differentiation(GO:0002318)
0.0 0.1 GO:0035772 interleukin-13-mediated signaling pathway(GO:0035772)
0.0 0.1 GO:0031508 pericentric heterochromatin assembly(GO:0031508) regulation of chromosome condensation(GO:0060623)
0.0 0.1 GO:0045039 protein import into mitochondrial inner membrane(GO:0045039)
0.0 0.1 GO:0060244 negative regulation of cell proliferation involved in contact inhibition(GO:0060244)

Gene overrepresentation in cellular component category:

Log-likelihood per target  Total log-likelihood Term Description
0.0 0.1 GO:0002189 ribose phosphate diphosphokinase complex(GO:0002189)

Gene overrepresentation in molecular function category:

Log-likelihood per target  Total log-likelihood Term Description
0.0 0.1 GO:0004337 dimethylallyltranstransferase activity(GO:0004161) geranyltranstransferase activity(GO:0004337)
0.0 0.1 GO:0030060 L-malate dehydrogenase activity(GO:0030060)
0.0 0.1 GO:0016721 superoxide dismutase activity(GO:0004784) oxidoreductase activity, acting on superoxide radicals as acceptor(GO:0016721)

Gene overrepresentation in curated gene sets: canonical pathways category:

Log-likelihood per target  Total log-likelihood Term Description
0.0 0.6 PID INTEGRIN A9B1 PATHWAY Alpha9 beta1 integrin signaling events
0.0 0.1 ST IL 13 PATHWAY Interleukin 13 (IL-13) Pathway