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GSE49485: Hypoxia transcriptome sequencing of rat brain.

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Results for Hoxa7_Hoxc8

Z-value: 0.47

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Transcription factors associated with Hoxa7_Hoxc8

Gene Symbol Gene ID Gene Info
ENSRNOG00000049858 homeobox A7
ENSRNOG00000028619 homeobox C8

Activity-expression correlation:

GenePromoterPearson corr. coef.P-valuePlot
Hoxa7rn6_v1_chr4_-_82271893_822718930.573.2e-01Click!
Hoxc8rn6_v1_chr7_+_144605058_144605058-0.474.3e-01Click!

Activity profile of Hoxa7_Hoxc8 motif

Sorted Z-values of Hoxa7_Hoxc8 motif

Promoter Log-likelihood Transcript Gene Gene Info
chr18_+_14757679 0.22 ENSRNOT00000071364
microtubule-associated protein, RP/EB family, member 2
chr1_+_141767940 0.21 ENSRNOT00000064034
zinc finger protein 710
chr2_-_33025271 0.14 ENSRNOT00000074941
microtubule associated serine/threonine kinase family member 4
chr10_+_61685645 0.13 ENSRNOT00000003933
MAX network transcriptional repressor
chr6_+_64789940 0.13 ENSRNOT00000085979
ENSRNOT00000059739
ENSRNOT00000051908
ENSRNOT00000082793
ENSRNOT00000078583
ENSRNOT00000091677
ENSRNOT00000093241
neuronal cell adhesion molecule
chr5_+_25725683 0.13 ENSRNOT00000087602
similar to swan
chr15_+_62406873 0.13 ENSRNOT00000047572
olfactomedin 4
chr1_+_99505677 0.12 ENSRNOT00000024645
zinc finger protein 719
chr1_+_217345545 0.12 ENSRNOT00000071741
SH3 and multiple ankyrin repeat domains 2
chr9_+_67234303 0.11 ENSRNOT00000050179
abl-interactor 2
chr1_-_43638161 0.11 ENSRNOT00000024460
interaction protein for cytohesin exchange factors 1
chr15_-_30147793 0.11 ENSRNOT00000060399

chr8_-_128754514 0.11 ENSRNOT00000025019
C-X3-C motif chemokine receptor 1
chr5_+_25253010 0.10 ENSRNOT00000061333
RNA binding motif protein 12B
chr6_+_106052212 0.10 ENSRNOT00000010626
signal-induced proliferation-associated 1 like 1
chr1_-_236729412 0.10 ENSRNOT00000054794
prune homolog 2
chr4_-_18396035 0.10 ENSRNOT00000034692
semaphorin 3A
chr10_-_87286387 0.09 ENSRNOT00000044206
keratin 28
chr3_+_148654668 0.08 ENSRNOT00000081370
transmembrane 9 superfamily member 4
chr1_-_66212418 0.08 ENSRNOT00000026074
hypothetical protein LOC691722
chr10_-_74679858 0.08 ENSRNOT00000003859
protein phosphatase, Mg2+/Mn2+ dependent, 1E
chr3_-_141411170 0.08 ENSRNOT00000017364
NK2 homeobox 2
chr9_+_71915421 0.08 ENSRNOT00000020447
phosphoinositide kinase, FYVE-type zinc finger containing
chr12_-_52658275 0.08 ENSRNOT00000041981
zinc finger protein 605
chr12_-_45801842 0.07 ENSRNOT00000078837

chr17_+_11683862 0.07 ENSRNOT00000024766
msh homeobox 2
chr9_+_73378057 0.07 ENSRNOT00000043627
ENSRNOT00000045766
ENSRNOT00000092445
ENSRNOT00000037974
microtubule-associated protein 2
chr11_-_61287914 0.07 ENSRNOT00000086286
spindle and centriole associated protein 1
chr8_+_71591360 0.07 ENSRNOT00000090096
casein kinase 1, gamma 1
chr8_-_69508024 0.07 ENSRNOT00000083564

chr15_-_55209342 0.06 ENSRNOT00000021752
RB transcriptional corepressor 1
chr2_+_72006099 0.06 ENSRNOT00000034044
cadherin 12
chr3_+_48096954 0.06 ENSRNOT00000068238
ENSRNOT00000064344
ENSRNOT00000044638
solute carrier family 4 member 10
chr5_-_133959447 0.06 ENSRNOT00000011985
cytochrome P450, family 4, subfamily x, polypeptide 1
chr8_+_33239139 0.06 ENSRNOT00000011589
Rho GTPase activating protein 32
chr10_-_62184874 0.06 ENSRNOT00000004229
replication protein A1
chr3_-_15278645 0.06 ENSRNOT00000032204
tubulin tyrosine ligase like11
chr2_+_145174876 0.06 ENSRNOT00000040631
mab-21 like 1
chr9_+_84203072 0.06 ENSRNOT00000018882
sphingosine-1-phosphate phosphatase 2
chr4_+_94696965 0.05 ENSRNOT00000064696
glutamate ionotropic receptor delta type subunit 2
chr9_+_73418607 0.05 ENSRNOT00000092547
microtubule-associated protein 2
chr4_+_148208260 0.05 ENSRNOT00000015742
zinc finger AN1-type containing 4
chr10_-_46172166 0.05 ENSRNOT00000091052
ENSRNOT00000004412
folliculin
chr4_+_157524423 0.05 ENSRNOT00000036654
zinc finger protein 384
chr8_-_7426611 0.05 ENSRNOT00000031492
Rho GTPase activating protein 42
chr18_+_30880020 0.05 ENSRNOT00000060468
protocadherin gamma subfamily B, 5
chr5_+_6373583 0.05 ENSRNOT00000084749

chr2_-_185852759 0.04 ENSRNOT00000049461
mab-21 like 2
chr14_+_39964588 0.04 ENSRNOT00000003240
gamma-aminobutyric acid type A receptor gamma 1 subunit
chr8_-_39460844 0.04 ENSRNOT00000048875
PBX/knotted 1 homeobox 2
chr1_-_241046249 0.04 ENSRNOT00000067796
ENSRNOT00000081866
structural maintenance of chromosomes 5
chr3_-_90751055 0.04 ENSRNOT00000040741
LRRGT00091
chr18_+_30820321 0.04 ENSRNOT00000060472
protocadherin gamma subfamily A, 3
chr20_-_29184185 0.04 ENSRNOT00000090771
mitochondrial calcium uniporter
chr4_-_150485781 0.04 ENSRNOT00000008763
zinc finger protein 248
chr12_+_25430464 0.04 ENSRNOT00000002020
general transcription factor II I
chrM_+_9870 0.03 ENSRNOT00000044582
mitochondrially encoded NADH 4L dehydrogenase
chrX_-_69218526 0.03 ENSRNOT00000092321
ENSRNOT00000074071
ENSRNOT00000092571
praja ring finger ubiquitin ligase 1
chr5_+_58661049 0.03 ENSRNOT00000078274
unc-13 homolog B
chr1_+_101599018 0.03 ENSRNOT00000028494
fucosyltransferase 1
chr1_+_101603222 0.03 ENSRNOT00000033278
izumo sperm-egg fusion 1
chr18_+_30592794 0.03 ENSRNOT00000027133
protocadherin beta 22
chrX_+_84064427 0.03 ENSRNOT00000046364
zinc finger protein 711
chr2_-_35870578 0.03 ENSRNOT00000066069
ring finger protein 180
chr3_-_72081079 0.03 ENSRNOT00000007914
thioredoxin-related transmembrane protein 2
chr8_+_82038967 0.03 ENSRNOT00000079535
myosin VA
chr6_+_2216623 0.03 ENSRNOT00000008045
regulator of microtubule dynamics 2
chr1_-_266428239 0.03 ENSRNOT00000027160
cytochrome P450, family 17, subfamily a, polypeptide 1
chr5_+_22392732 0.03 ENSRNOT00000087182
clavesin 1
chr3_-_52447622 0.02 ENSRNOT00000083552
sodium voltage-gated channel alpha subunit 1
chr8_+_32188617 0.02 ENSRNOT00000081145
zinc finger and BTB domain containing 44
chr2_-_57935334 0.02 ENSRNOT00000022319
ENSRNOT00000085599
ENSRNOT00000077790
ENSRNOT00000035821
solute carrier family 1 member 3
chr2_+_220432037 0.02 ENSRNOT00000021988
ferric-chelate reductase 1
chr18_-_74059533 0.02 ENSRNOT00000038767
similar to hypothetical protein
chr1_+_166141954 0.02 ENSRNOT00000042524
FCH and double SH3 domains 2
chr2_+_248398917 0.02 ENSRNOT00000045855
guanylate binding protein 1
chr18_+_59748444 0.02 ENSRNOT00000024752
ST8 alpha-N-acetyl-neuraminide alpha-2,8-sialyltransferase 3
chr3_-_64095120 0.02 ENSRNOT00000016837
SEC14 and spectrin domain containing 1
chr13_-_89545182 0.02 ENSRNOT00000078402
Purkinje cell protein 4-like 1
chr3_+_15560712 0.02 ENSRNOT00000010218
prostaglandin-endoperoxide synthase 1
chr18_+_79773608 0.02 ENSRNOT00000088484
zinc finger protein 516
chr20_+_3155652 0.02 ENSRNOT00000042882
RT1 class Ib, locus S2
chr5_+_58995249 0.01 ENSRNOT00000023411
coiled-coil domain containing 107
chr1_+_69841998 0.01 ENSRNOT00000072231
zinc finger protein 773, pseudogene 1
chr3_-_160561741 0.01 ENSRNOT00000018364
potassium voltage-gated channel, modifier subfamily S, member 1
chr6_+_44225233 0.01 ENSRNOT00000066593
kinase D-interacting substrate 220
chr3_-_45169118 0.01 ENSRNOT00000086371
coiled-coil domain containing 148
chr18_-_26656879 0.01 ENSRNOT00000086729
erythrocyte membrane protein band 4.1 like 4A
chrX_-_36884748 0.01 ENSRNOT00000065678
phosphorylase kinase, alpha 2
chr1_+_255579474 0.01 ENSRNOT00000024465
B-TFIID TATA-box binding protein associated factor 1
chr11_-_29710849 0.01 ENSRNOT00000029345
keratin associated protein 11-1
chr3_-_7498555 0.01 ENSRNOT00000017725
BarH-like homeobox 1
chr3_-_148057523 0.01 ENSRNOT00000055408
defensin beta 24
chr17_+_34704616 0.01 ENSRNOT00000090706
ENSRNOT00000083674
ENSRNOT00000077110
exocyst complex component 2
chrX_+_9956370 0.01 ENSRNOT00000082316
peripheral plasma membrane protein CASK-like
chr11_-_82893845 0.01 ENSRNOT00000075306
eukaryotic translation initiation factor 4 gamma 1-like
chrX_-_32095867 0.01 ENSRNOT00000049947
ENSRNOT00000080730
angiotensin I converting enzyme 2
chr10_+_76320041 0.01 ENSRNOT00000037693
coilin
chr1_+_201337416 0.01 ENSRNOT00000067742
BTB domain containing 16
chr16_+_24978527 0.01 ENSRNOT00000019363
translation machinery associated 16 homolog
chr8_+_36850324 0.01 ENSRNOT00000060448
prostate and testis expressed 2
chr1_-_23556241 0.00 ENSRNOT00000072943
syntaxin-7-like
chr9_+_71247781 0.00 ENSRNOT00000049654
cAMP responsive element binding protein 1
chr4_+_68608137 0.00 ENSRNOT00000036398
WEE1 homolog 2
chr10_-_71441389 0.00 ENSRNOT00000003699
transcriptional adaptor 2A
chr8_+_81863619 0.00 ENSRNOT00000080608
family with sequence similarity 214, member A
chr3_-_166994286 0.00 ENSRNOT00000081593
zinc finger protein 217
chr10_+_95770154 0.00 ENSRNOT00000030300
helicase with zinc finger
chr16_+_50022998 0.00 ENSRNOT00000087986
toll-like receptor 3
chr2_-_60657712 0.00 ENSRNOT00000040348
retinoic acid induced 14
chr19_-_37528011 0.00 ENSRNOT00000059628
agouti related neuropeptide
chr20_+_3830164 0.00 ENSRNOT00000045533
ENSRNOT00000084117
collagen type XI alpha 2 chain
chr2_+_196462554 0.00 ENSRNOT00000056380
family with sequence similarity 63, member A

Network of associatons between targets according to the STRING database.

First level regulatory network of Hoxa7_Hoxc8

PNG image of the network

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Gene Ontology Analysis

Gene overrepresentation in biological process category:

Log-likelihood per target  Total log-likelihood Term Description
0.0 0.1 GO:0021530 spinal cord oligodendrocyte cell differentiation(GO:0021529) spinal cord oligodendrocyte cell fate specification(GO:0021530)
0.0 0.1 GO:0002282 microglial cell activation involved in immune response(GO:0002282)
0.0 0.1 GO:0021888 cerebral cortex tangential migration using cell-axon interactions(GO:0021824) gonadotrophin-releasing hormone neuronal migration to the hypothalamus(GO:0021828) hypothalamic tangential migration using cell-axon interactions(GO:0021856) hypothalamus gonadotrophin-releasing hormone neuron differentiation(GO:0021886) hypothalamus gonadotrophin-releasing hormone neuron development(GO:0021888) facioacoustic ganglion development(GO:1903375)
0.0 0.1 GO:0035880 embryonic nail plate morphogenesis(GO:0035880)
0.0 0.1 GO:0071922 establishment of sister chromatid cohesion(GO:0034085) cohesin loading(GO:0071921) regulation of cohesin loading(GO:0071922) regulation of hepatocyte apoptotic process(GO:1903943) negative regulation of hepatocyte apoptotic process(GO:1903944)
0.0 0.0 GO:1901856 negative regulation of cellular respiration(GO:1901856) regulation of post-translational protein modification(GO:1901873)
0.0 0.1 GO:2000601 positive regulation of Arp2/3 complex-mediated actin nucleation(GO:2000601)
0.0 0.0 GO:1904694 negative regulation of vascular smooth muscle contraction(GO:1904694)
0.0 0.1 GO:0045162 clustering of voltage-gated sodium channels(GO:0045162)
0.0 0.1 GO:2000389 regulation of neutrophil extravasation(GO:2000389)
0.0 0.0 GO:0060988 lipid tube assembly(GO:0060988)

Gene overrepresentation in cellular component category:

Log-likelihood per target  Total log-likelihood Term Description
0.0 0.2 GO:0097442 CA3 pyramidal cell dendrite(GO:0097442)
0.0 0.1 GO:0031209 SCAR complex(GO:0031209)
0.0 0.1 GO:0035189 Rb-E2F complex(GO:0035189)

Gene overrepresentation in molecular function category:

Log-likelihood per target  Total log-likelihood Term Description
0.0 0.1 GO:0019960 C-X3-C chemokine binding(GO:0019960)
0.0 0.1 GO:0042392 sphingosine-1-phosphate phosphatase activity(GO:0042392)
0.0 0.2 GO:0086080 protein binding involved in heterotypic cell-cell adhesion(GO:0086080)
0.0 0.1 GO:0061676 importin-alpha family protein binding(GO:0061676)
0.0 0.0 GO:0015292 uniporter activity(GO:0015292)
0.0 0.0 GO:0008107 galactoside 2-alpha-L-fucosyltransferase activity(GO:0008107) alpha-(1,2)-fucosyltransferase activity(GO:0031127)