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GSE49485: Hypoxia transcriptome sequencing of rat brain.
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Results for Hoxa4
Z-value: 0.52
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Transcription factors associated with Hoxa4
Activity-expression correlation:
| Gene | Promoter | Pearson corr. coef. | P-value | Plot |
|---|---|---|---|---|
| Hoxa4 | rn6_v1_chr4_-_82160240_82160240 | 0.81 | 9.9e-02 | Click! |
| Promoter | Log-likelihood | Transcript | Gene | Gene Info |
|---|---|---|---|---|
| chr12_-_17186679 Show fit | 0.84 |
ENSRNOT00000001730
|
UNC homeobox |
|
| chr3_-_66417741 Show fit | 0.37 |
ENSRNOT00000007662
|
neuronal differentiation 1 |
|
| chr9_+_25410669 Show fit | 0.27 |
ENSRNOT00000030912
ENSRNOT00000090920 |
transcription factor AP-2 beta |
|
| chr7_+_144647587 Show fit | 0.22 |
ENSRNOT00000022398
|
homeo box C4 |
|
| chr2_+_206342066 Show fit | 0.18 |
ENSRNOT00000026556
|
protein tyrosine phosphatase, non-receptor type 22 |
|
| chr5_-_12526962 Show fit | 0.17 |
ENSRNOT00000092104
|
suppression of tumorigenicity 18 |
|
| chrX_-_124464963 Show fit | 0.16 |
ENSRNOT00000036472
ENSRNOT00000077697 |
transmembrane protein 255A |
|
| chr3_+_95715193 Show fit | 0.14 |
ENSRNOT00000089525
|
paired box 6 |
|
| chrX_+_158835811 Show fit | 0.12 |
ENSRNOT00000071888
ENSRNOT00000080110 |
integrator complex subunit 6 like |
|
| chr16_+_54332660 Show fit | 0.11 |
ENSRNOT00000037685
|
microtubule associated tumor suppressor 1 |
Network of associatons between targets according to the STRING database.
First level regulatory network of Hoxa4
Gene Ontology Analysis
Gene overrepresentation in biological process category:
| Log-likelihood per target | Total log-likelihood | Term | Description |
|---|---|---|---|
| 0.1 | 0.8 | GO:0035726 | common myeloid progenitor cell proliferation(GO:0035726) |
| 0.1 | 0.4 | GO:0060729 | intestinal epithelial structure maintenance(GO:0060729) |
| 0.0 | 0.3 | GO:0097070 | ductus arteriosus closure(GO:0097070) |
| 0.1 | 0.2 | GO:1990790 | response to glial cell derived neurotrophic factor(GO:1990790) cellular response to glial cell derived neurotrophic factor(GO:1990792) |
| 0.1 | 0.2 | GO:0072641 | positive regulation of toll-like receptor 9 signaling pathway(GO:0034165) negative regulation of nucleotide-binding oligomerization domain containing signaling pathway(GO:0070425) negative regulation of nucleotide-binding oligomerization domain containing 2 signaling pathway(GO:0070433) granzyme B production(GO:0071613) regulation of granzyme B production(GO:0071661) positive regulation of granzyme B production(GO:0071663) type I interferon secretion(GO:0072641) interferon-alpha secretion(GO:0072642) regulation of interferon-alpha secretion(GO:1902739) positive regulation of interferon-alpha secretion(GO:1902741) |
| 0.0 | 0.1 | GO:0021905 | pancreatic A cell development(GO:0003322) forebrain-midbrain boundary formation(GO:0021905) somatic motor neuron fate commitment(GO:0021917) regulation of transcription from RNA polymerase II promoter involved in somatic motor neuron fate commitment(GO:0021918) sensory neuron migration(GO:1904937) |
| 0.0 | 0.1 | GO:0050828 | regulation of liquid surface tension(GO:0050828) |
| 0.0 | 0.1 | GO:0071245 | cellular response to carbon monoxide(GO:0071245) cellular response to nitrite(GO:0071250) response to nitrite(GO:0080033) |
| 0.0 | 0.1 | GO:0072268 | specification of loop of Henle identity(GO:0072086) pattern specification involved in metanephros development(GO:0072268) |
| 0.0 | 0.1 | GO:0051919 | positive regulation of fibrinolysis(GO:0051919) |
Gene overrepresentation in cellular component category:
| Log-likelihood per target | Total log-likelihood | Term | Description |
|---|---|---|---|
| 0.0 | 0.1 | GO:0071953 | elastic fiber(GO:0071953) |
| 0.0 | 0.1 | GO:1990316 | ATG1/ULK1 kinase complex(GO:1990316) |
Gene overrepresentation in molecular function category:
| Log-likelihood per target | Total log-likelihood | Term | Description |
|---|---|---|---|
| 0.0 | 0.5 | GO:0070888 | E-box binding(GO:0070888) |
| 0.0 | 0.3 | GO:0000983 | transcription factor activity, RNA polymerase II core promoter sequence-specific(GO:0000983) |
| 0.0 | 0.2 | GO:0071837 | HMG box domain binding(GO:0071837) |
| 0.0 | 0.1 | GO:0005250 | A-type (transient outward) potassium channel activity(GO:0005250) |
| 0.0 | 0.1 | GO:0003680 | AT DNA binding(GO:0003680) |
Gene overrepresentation in curated gene sets: REACTOME pathways category:
| Log-likelihood per target | Total log-likelihood | Term | Description |
|---|---|---|---|
| 0.0 | 0.5 | REACTOME REGULATION OF GENE EXPRESSION IN BETA CELLS | Genes involved in Regulation of gene expression in beta cells |