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GSE49485: Hypoxia transcriptome sequencing of rat brain.

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Results for Hoxa4

Z-value: 0.52

Motif logo

Transcription factors associated with Hoxa4

Gene Symbol Gene ID Gene Info
ENSRNOG00000027365 homeo box A4

Activity-expression correlation:

GenePromoterPearson corr. coef.P-valuePlot
Hoxa4rn6_v1_chr4_-_82160240_821602400.819.9e-02Click!

Activity profile of Hoxa4 motif

Sorted Z-values of Hoxa4 motif

Promoter Log-likelihood Transcript Gene Gene Info
chr12_-_17186679 0.84 ENSRNOT00000001730
UNC homeobox
chr3_-_66417741 0.37 ENSRNOT00000007662
neuronal differentiation 1
chr9_+_25410669 0.27 ENSRNOT00000030912
ENSRNOT00000090920
transcription factor AP-2 beta
chr7_+_144647587 0.22 ENSRNOT00000022398
homeo box C4
chr2_+_206342066 0.18 ENSRNOT00000026556
protein tyrosine phosphatase, non-receptor type 22
chr5_-_12526962 0.17 ENSRNOT00000092104
suppression of tumorigenicity 18
chrX_-_124464963 0.16 ENSRNOT00000036472
ENSRNOT00000077697
transmembrane protein 255A
chr3_+_95715193 0.14 ENSRNOT00000089525
paired box 6
chrX_+_158835811 0.12 ENSRNOT00000071888
ENSRNOT00000080110
integrator complex subunit 6 like
chr16_+_54332660 0.11 ENSRNOT00000037685
microtubule associated tumor suppressor 1
chr3_+_56766475 0.11 ENSRNOT00000078819
Sp5 transcription factor
chrX_-_63165759 0.11 ENSRNOT00000076765
zinc finger protein X-linked
chr9_+_121831716 0.11 ENSRNOT00000056250
ENSRNOT00000056251
YES proto-oncogene 1, Src family tyrosine kinase
chr1_-_163554839 0.10 ENSRNOT00000081509
EMSY BRCA2-interacting transcriptional repressor
chr4_-_82160240 0.10 ENSRNOT00000038775
ENSRNOT00000058985
homeo box A4
chr2_+_207930796 0.10 ENSRNOT00000047827
potassium voltage-gated channel subfamily D member 3
chr4_+_100166863 0.10 ENSRNOT00000014505
surfactant protein B
chr16_+_50152008 0.09 ENSRNOT00000019237
kallikrein B1
chr19_-_26053762 0.08 ENSRNOT00000004646
microtubule associated serine/threonine kinase 1
chr14_-_13058172 0.08 ENSRNOT00000002746
ENSRNOT00000071706
PR/SET domain 8
chr8_+_110982777 0.08 ENSRNOT00000010992
kyphoscoliosis peptidase
chr10_-_87286387 0.08 ENSRNOT00000044206
keratin 28
chr6_-_51018050 0.07 ENSRNOT00000082691
G protein-coupled receptor 22
chr6_+_96834525 0.07 ENSRNOT00000077935
hypoxia inducible factor 1 alpha subunit
chr1_-_33275540 0.07 ENSRNOT00000017019
iroquois homeobox 2
chr16_-_74700815 0.07 ENSRNOT00000081297
thrombospondin type 1 domain containing 1
chr17_+_70262363 0.07 ENSRNOT00000048933
family with sequence similarity 208, member B
chr1_+_140998240 0.07 ENSRNOT00000023506
ENSRNOT00000090897
abhydrolase domain containing 2
chr3_-_80601410 0.07 ENSRNOT00000022841
autophagy related 13
chr3_-_146396299 0.07 ENSRNOT00000040188
ENSRNOT00000008931
adipocyte plasma membrane associated protein
chrX_-_135419704 0.06 ENSRNOT00000044435
zinc finger protein 280C
chr7_-_140172448 0.06 ENSRNOT00000077672
cyclin-T1-like
chr2_+_2729829 0.06 ENSRNOT00000017068
spermatogenesis associated 9
chr5_+_116421894 0.06 ENSRNOT00000080577
ENSRNOT00000086628
ENSRNOT00000004017
nuclear factor I/A
chr2_+_196334626 0.06 ENSRNOT00000050914
ENSRNOT00000028645
ENSRNOT00000090729
semaphorin 6C
chr6_-_125723732 0.06 ENSRNOT00000084815
fibulin 5
chr6_-_51019407 0.06 ENSRNOT00000011659
G protein-coupled receptor 22
chr6_-_67084234 0.06 ENSRNOT00000050372
NOVA alternative splicing regulator 1
chr1_-_275882444 0.06 ENSRNOT00000083215
glycerol-3-phosphate acyltransferase, mitochondrial
chr6_-_8344574 0.05 ENSRNOT00000009660
prolyl endopeptidase-like
chr15_+_11298478 0.05 ENSRNOT00000007672
leucine rich repeat containing 3B
chr11_-_1836897 0.05 ENSRNOT00000050533
zinc finger protein 654
chr16_-_27472687 0.05 ENSRNOT00000046984

chr3_-_154490851 0.05 ENSRNOT00000017213
TELO2 interacting protein 1
chr3_-_103745236 0.05 ENSRNOT00000006876
NUT midline carcinoma, family member 1
chr13_-_98478327 0.05 ENSRNOT00000030135
coenzyme Q8A
chr10_+_97212432 0.05 ENSRNOT00000088599
axin 2
chr2_-_33025271 0.05 ENSRNOT00000074941
microtubule associated serine/threonine kinase family member 4
chr9_-_54351339 0.05 ENSRNOT00000080522
signal transducer and activator of transcription 1
chr1_+_100299626 0.05 ENSRNOT00000092327
ENSRNOT00000044257
SH3 and multiple ankyrin repeat domains 1
chr13_-_89242443 0.05 ENSRNOT00000029202
activating transcription factor 6
chr11_+_66713888 0.05 ENSRNOT00000003340
F-box protein 40
chr11_-_4397361 0.05 ENSRNOT00000046370
cell adhesion molecule 2
chr13_+_47454591 0.05 ENSRNOT00000005791
similar to specifically androgen-regulated protein
chr10_+_39850818 0.04 ENSRNOT00000012671
folliculin interacting protein 1
chr16_+_60925093 0.04 ENSRNOT00000015813
tankyrase
chr1_-_163611299 0.04 ENSRNOT00000043788
EMSY BRCA2-interacting transcriptional repressor
chr6_+_8219385 0.04 ENSRNOT00000040509
protein phosphatase, Mg2+/Mn2+ dependent, 1B
chr4_-_183374195 0.04 ENSRNOT00000073927
ENSRNOT00000074740
ENSRNOT00000070907
caprin family member 2
chr13_+_98311827 0.04 ENSRNOT00000082844
CDC42 binding protein kinase alpha
chr7_-_2941122 0.04 ENSRNOT00000082107
extended synaptotagmin 1
chrX_-_23246719 0.04 ENSRNOT00000085588

chr18_+_30820321 0.04 ENSRNOT00000060472
protocadherin gamma subfamily A, 3
chr11_-_62451149 0.04 ENSRNOT00000093686
ENSRNOT00000081443
zinc finger and BTB domain containing 20
chr1_+_214664537 0.04 ENSRNOT00000075002

chr12_+_22451596 0.04 ENSRNOT00000072838
thyroid hormone receptor interactor 6
chr8_-_46675544 0.04 ENSRNOT00000052293
tectorin alpha
chr2_+_252771017 0.04 ENSRNOT00000075452
ENSRNOT00000055318
tubulin tyrosine ligase like 7
chr16_+_8823872 0.03 ENSRNOT00000027186
dorsal root ganglia homeobox
chrX_+_157759624 0.03 ENSRNOT00000003192
similar to motile sperm domain containing 1
chr16_-_48437223 0.03 ENSRNOT00000013005
ENSRNOT00000059401
ectonucleotide pyrophosphatase/phosphodiesterase 6
chr9_-_16581078 0.03 ENSRNOT00000022582
peroxisomal biogenesis factor 6
chr1_+_1784078 0.03 ENSRNOT00000020098
large tumor suppressor kinase 1
chr9_-_81566642 0.03 ENSRNOT00000080345
angio-associated, migratory cell protein
chr1_+_154606490 0.03 ENSRNOT00000024095
coiled-coil domain containing 89
chr12_+_49761120 0.03 ENSRNOT00000070961
myosin XVIIIb
chr12_-_5685448 0.03 ENSRNOT00000077167
FRY microtubule binding protein
chr3_-_71798531 0.03 ENSRNOT00000088170
calcitonin receptor like receptor
chr6_+_86823684 0.03 ENSRNOT00000086081
ENSRNOT00000006574
Fanconi anemia, complementation group M
chr14_-_72025137 0.03 ENSRNOT00000080604
C1q and tumor necrosis factor related protein 7
chr17_-_44643362 0.02 ENSRNOT00000091041
zinc finger protein 184
chr18_+_30527705 0.02 ENSRNOT00000027168
protocadherin beta 14
chr10_+_55687050 0.02 ENSRNOT00000057136
period circadian clock 1
chr8_-_130429132 0.02 ENSRNOT00000026261
hedgehog acyltransferase-like
chrX_+_76083549 0.02 ENSRNOT00000003573
MAGE family member E1
chr9_+_94316717 0.02 ENSRNOT00000077005
ENSRNOT00000092534
eukaryotic translation initiation factor 4E family member 2
chr7_+_144080614 0.02 ENSRNOT00000077687
poly(rC) binding protein 2
chr17_-_76250537 0.02 ENSRNOT00000092693
UPF2 regulator of nonsense transcripts homolog (yeast)
chr4_-_135069970 0.02 ENSRNOT00000008221
contactin 3
chr2_+_149315189 0.02 ENSRNOT00000082464
mediator complex subunit 12-like
chr2_-_177924970 0.02 ENSRNOT00000029340
Rap guanine nucleotide exchange factor 2
chr5_+_148320438 0.02 ENSRNOT00000018742
penta-EF hand domain containing 1
chr18_+_64008048 0.02 ENSRNOT00000083414
low density lipoprotein receptor class A domain containing 4
chrX_+_9436707 0.02 ENSRNOT00000004187
calcium/calmodulin dependent serine protein kinase
chr10_-_65502936 0.02 ENSRNOT00000089615
SPT6 homolog, histone chaperone
chr4_-_162498052 0.02 ENSRNOT00000066349
chromobox homolog 3-like
chr4_+_34237762 0.02 ENSRNOT00000084163
meiosis regulator for oocyte development
chrX_+_70440059 0.02 ENSRNOT00000003946
arrestin 3
chr5_-_150704117 0.02 ENSRNOT00000067455
sestrin 2
chr2_-_118882562 0.01 ENSRNOT00000058860
potassium calcium-activated channel subfamily M regulatory beta subunit 3
chr1_+_224927764 0.01 ENSRNOT00000050814

chr2_+_68821004 0.01 ENSRNOT00000083713
epidermal growth factor
chr5_-_12199283 0.01 ENSRNOT00000007769
protein-L-isoaspartate (D-aspartate) O-methyltransferase domain containing 1
chr16_-_48692476 0.01 ENSRNOT00000013118
interferon regulatory factor 2
chr7_-_132984110 0.01 ENSRNOT00000046626
high mobility group box 1, pseudogene 3
chr4_+_183896303 0.01 ENSRNOT00000055437
similar to hypothetical protein FLJ10652
chr18_+_29386809 0.01 ENSRNOT00000082079
ENSRNOT00000024825
eukaryotic translation initiation factor 4E binding protein 3
chr1_-_192057612 0.01 ENSRNOT00000024471
NADH:ubiquinone oxidoreductase subunit AB1
chr15_-_27819376 0.01 ENSRNOT00000067400
RIKEN cDNA A930018M24 gene
chr8_-_116438038 0.01 ENSRNOT00000023791
G protein subunit alpha transducin 1
chr14_-_115391652 0.01 ENSRNOT00000002094
ChaC cation transport regulator 2
chr5_-_711033 0.01 ENSRNOT00000024199
cysteine-rich secretory protein LCCL domain containing 1
chr20_+_3558827 0.01 ENSRNOT00000088130
discoidin domain receptor tyrosine kinase 1
chr8_+_103938520 0.01 ENSRNOT00000067835
glycerol kinase 5 (putative)
chr2_+_38230757 0.01 ENSRNOT00000048598
similar to 60S ribosomal protein L23a
chr10_+_82032656 0.01 ENSRNOT00000067751
ankyrin repeat domain 40
chr1_+_154446156 0.01 ENSRNOT00000093052
phosphatidylinositol binding clathrin assembly protein
chr4_+_66091641 0.01 ENSRNOT00000043147

chr5_-_105582375 0.01 ENSRNOT00000083373
solute carrier family 24 member 2
chr6_+_80218880 0.01 ENSRNOT00000006995
melanoma inhibitory activity 2
chr5_+_25168295 0.01 ENSRNOT00000020245
fibrinogen silencer binding protein
chr6_+_73358112 0.01 ENSRNOT00000041373
Rho GTPase activating protein 5
chr20_-_6234703 0.01 ENSRNOT00000092453
serine/threonine kinase 38
chr14_-_45165207 0.01 ENSRNOT00000002960
Kruppel like factor 3
chr1_-_267463694 0.01 ENSRNOT00000084851
ENSRNOT00000016645
collagen type XVII alpha 1 chain
chr2_-_5577369 0.01 ENSRNOT00000093420
nuclear receptor subfamily 2, group F, member 1
chr11_+_72044096 0.01 ENSRNOT00000034757
SUMO1/sentrin specific peptidase 5
chr8_+_94686938 0.01 ENSRNOT00000013285
ripply transcriptional repressor 2
chr1_-_174620064 0.01 ENSRNOT00000016224
transmembrane protein 41B
chrX_-_13279082 0.00 ENSRNOT00000051898
ENSRNOT00000060857
tetraspanin 7
chr10_-_87248572 0.00 ENSRNOT00000066637
ENSRNOT00000085677
keratin 26
chr4_-_181348799 0.00 ENSRNOT00000033743
hypothetical protein LOC690783
chr9_-_74048244 0.00 ENSRNOT00000018293
LanC like 1
chr7_+_12619774 0.00 ENSRNOT00000015257
mediator complex subunit 16
chr10_-_87529599 0.00 ENSRNOT00000074099
keratin associated protein 2-1
chr1_+_225037737 0.00 ENSRNOT00000077959
BSCL2, seipin lipid droplet biogenesis associated
chr18_+_30509393 0.00 ENSRNOT00000043846
protocadherin beta 12
chrX_-_42329232 0.00 ENSRNOT00000045705
NADH dehydrogenase (ubiquinone) 1 beta subcomplex 4
chr2_-_31753528 0.00 ENSRNOT00000075057
phosphoinositide-3-kinase regulatory subunit 1
chr10_+_78111050 0.00 ENSRNOT00000079364
COX11 cytochrome c oxidase copper chaperone
chr4_+_129574264 0.00 ENSRNOT00000010185
ADP-ribosylation factor like GTPase 6 interacting protein 5
chr3_-_63836017 0.00 ENSRNOT00000030978

chr19_+_56803382 0.00 ENSRNOT00000036042
URB2 ribosome biogenesis 2 homolog (S. cerevisiae)

Network of associatons between targets according to the STRING database.

First level regulatory network of Hoxa4

PNG image of the network

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Gene Ontology Analysis

Gene overrepresentation in biological process category:

Log-likelihood per target  Total log-likelihood Term Description
0.1 0.8 GO:0035726 common myeloid progenitor cell proliferation(GO:0035726)
0.1 0.4 GO:0060729 intestinal epithelial structure maintenance(GO:0060729)
0.1 0.2 GO:1990790 response to glial cell derived neurotrophic factor(GO:1990790) cellular response to glial cell derived neurotrophic factor(GO:1990792)
0.1 0.2 GO:0072641 positive regulation of toll-like receptor 9 signaling pathway(GO:0034165) negative regulation of nucleotide-binding oligomerization domain containing signaling pathway(GO:0070425) negative regulation of nucleotide-binding oligomerization domain containing 2 signaling pathway(GO:0070433) granzyme B production(GO:0071613) regulation of granzyme B production(GO:0071661) positive regulation of granzyme B production(GO:0071663) type I interferon secretion(GO:0072641) interferon-alpha secretion(GO:0072642) regulation of interferon-alpha secretion(GO:1902739) positive regulation of interferon-alpha secretion(GO:1902741)
0.0 0.1 GO:0021905 pancreatic A cell development(GO:0003322) forebrain-midbrain boundary formation(GO:0021905) somatic motor neuron fate commitment(GO:0021917) regulation of transcription from RNA polymerase II promoter involved in somatic motor neuron fate commitment(GO:0021918) sensory neuron migration(GO:1904937)
0.0 0.3 GO:0097070 ductus arteriosus closure(GO:0097070)
0.0 0.1 GO:0050828 regulation of liquid surface tension(GO:0050828)
0.0 0.0 GO:0032423 regulation of mismatch repair(GO:0032423)
0.0 0.1 GO:0071245 cellular response to carbon monoxide(GO:0071245) cellular response to nitrite(GO:0071250) response to nitrite(GO:0080033)
0.0 0.1 GO:0072268 specification of loop of Henle identity(GO:0072086) pattern specification involved in metanephros development(GO:0072268)
0.0 0.1 GO:0051919 positive regulation of fibrinolysis(GO:0051919)
0.0 0.0 GO:1904742 protein poly-ADP-ribosylation(GO:0070212) regulation of telomeric DNA binding(GO:1904742)
0.0 0.0 GO:0060988 lipid tube assembly(GO:0060988)
0.0 0.0 GO:0034240 negative regulation of macrophage fusion(GO:0034240)
0.0 0.0 GO:0050893 sensory processing(GO:0050893)

Gene overrepresentation in cellular component category:

Log-likelihood per target  Total log-likelihood Term Description
0.0 0.1 GO:0071953 elastic fiber(GO:0071953)
0.0 0.1 GO:1990316 ATG1/ULK1 kinase complex(GO:1990316)

Gene overrepresentation in molecular function category:

Log-likelihood per target  Total log-likelihood Term Description
0.0 0.1 GO:0005250 A-type (transient outward) potassium channel activity(GO:0005250)
0.0 0.1 GO:0003680 AT DNA binding(GO:0003680)
0.0 0.3 GO:0000983 transcription factor activity, RNA polymerase II core promoter sequence-specific(GO:0000983)
0.0 0.2 GO:0071837 HMG box domain binding(GO:0071837)
0.0 0.5 GO:0070888 E-box binding(GO:0070888)

Gene overrepresentation in curated gene sets: REACTOME pathways category:

Log-likelihood per target  Total log-likelihood Term Description
0.0 0.5 REACTOME REGULATION OF GENE EXPRESSION IN BETA CELLS Genes involved in Regulation of gene expression in beta cells