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GSE49485: Hypoxia transcriptome sequencing of rat brain.
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Results for Hoxa13
Z-value: 0.94
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Transcription factors associated with Hoxa13
| Promoter | Log-likelihood | Transcript | Gene | Gene Info |
|---|---|---|---|---|
| chr10_-_27862868 Show fit | 2.92 |
ENSRNOT00000004877
|
gamma-aminobutyric acid type A receptor alpha 6 subunit |
|
| chr4_+_170149029 Show fit | 0.85 |
ENSRNOT00000073287
|
histone H2A.J |
|
| chr17_-_61332391 Show fit | 0.63 |
ENSRNOT00000034599
|
SNRPN upstream reading frame protein-like |
|
| chr3_-_64554953 Show fit | 0.52 |
ENSRNOT00000067452
|
serine/arginine repetitive matrix protein 1-like |
|
| chr20_-_5064469 Show fit | 0.52 |
ENSRNOT00000001120
|
lymphocyte antigen 6 complex, locus G6D |
|
| chr2_+_198359754 Show fit | 0.44 |
ENSRNOT00000048582
|
histone cluster 2 H2A family member b |
|
| chr10_-_59888198 Show fit | 0.43 |
ENSRNOT00000093482
ENSRNOT00000049311 ENSRNOT00000093230 |
aspartoacylase |
|
| chr1_-_124803363 Show fit | 0.41 |
ENSRNOT00000066380
|
Kruppel-like factor 13 |
|
| chrX_+_33884499 Show fit | 0.36 |
ENSRNOT00000090041
|
RALBP1 associated Eps domain containing protein 2 |
|
| chr7_-_136997050 Show fit | 0.36 |
ENSRNOT00000009143
|
developing brain homeobox 2 |
Network of associatons between targets according to the STRING database.
First level regulatory network of Hoxa13
Gene Ontology Analysis
Gene overrepresentation in biological process category:
| Log-likelihood per target | Total log-likelihood | Term | Description |
|---|---|---|---|
| 0.1 | 2.9 | GO:0007214 | gamma-aminobutyric acid signaling pathway(GO:0007214) |
| 0.0 | 1.7 | GO:0006342 | chromatin silencing(GO:0006342) |
| 0.0 | 0.6 | GO:1905145 | acetylcholine receptor signaling pathway(GO:0095500) signal transduction involved in cellular response to ammonium ion(GO:1903831) response to acetylcholine(GO:1905144) cellular response to acetylcholine(GO:1905145) |
| 0.0 | 0.4 | GO:0045647 | negative regulation of erythrocyte differentiation(GO:0045647) |
| 0.0 | 0.4 | GO:0032291 | central nervous system myelination(GO:0022010) axon ensheathment in central nervous system(GO:0032291) |
| 0.1 | 0.3 | GO:0065001 | positive regulation of epithelial cell proliferation involved in prostate gland development(GO:0060769) specification of axis polarity(GO:0065001) negative regulation of cholesterol efflux(GO:0090370) negative regulation of dopaminergic neuron differentiation(GO:1904339) positive regulation of mesenchymal cell proliferation involved in ureter development(GO:2000729) |
| 0.1 | 0.3 | GO:0035022 | positive regulation of Rac protein signal transduction(GO:0035022) |
| 0.1 | 0.3 | GO:1902856 | negative regulation of nonmotile primary cilium assembly(GO:1902856) |
| 0.1 | 0.3 | GO:0021615 | glossopharyngeal nerve morphogenesis(GO:0021615) |
| 0.0 | 0.3 | GO:0035610 | protein side chain deglutamylation(GO:0035610) |
Gene overrepresentation in cellular component category:
| Log-likelihood per target | Total log-likelihood | Term | Description |
|---|---|---|---|
| 0.1 | 2.9 | GO:1902711 | GABA-A receptor complex(GO:1902711) |
| 0.0 | 1.6 | GO:0000786 | nucleosome(GO:0000786) |
| 0.0 | 0.4 | GO:0034364 | high-density lipoprotein particle(GO:0034364) |
| 0.1 | 0.3 | GO:0005594 | collagen type IX trimer(GO:0005594) |
| 0.0 | 0.3 | GO:0071565 | nBAF complex(GO:0071565) |
| 0.0 | 0.3 | GO:0098644 | complex of collagen trimers(GO:0098644) |
| 0.0 | 0.3 | GO:0001891 | phagocytic cup(GO:0001891) |
| 0.1 | 0.2 | GO:0070821 | azurophil granule membrane(GO:0035577) tertiary granule membrane(GO:0070821) |
| 0.0 | 0.2 | GO:0016602 | CCAAT-binding factor complex(GO:0016602) |
| 0.0 | 0.2 | GO:0043205 | microfibril(GO:0001527) fibril(GO:0043205) |
Gene overrepresentation in molecular function category:
| Log-likelihood per target | Total log-likelihood | Term | Description |
|---|---|---|---|
| 0.6 | 2.9 | GO:0008503 | benzodiazepine receptor activity(GO:0008503) |
| 0.0 | 0.5 | GO:0030550 | acetylcholine receptor inhibitor activity(GO:0030550) |
| 0.1 | 0.4 | GO:0019807 | aspartoacylase activity(GO:0019807) |
| 0.1 | 0.3 | GO:0030977 | taurine binding(GO:0030977) |
| 0.1 | 0.3 | GO:0019002 | GMP binding(GO:0019002) |
| 0.1 | 0.3 | GO:0034186 | apolipoprotein A-I binding(GO:0034186) |
| 0.0 | 0.3 | GO:0043237 | laminin-1 binding(GO:0043237) |
| 0.0 | 0.3 | GO:0004181 | metallocarboxypeptidase activity(GO:0004181) |
| 0.1 | 0.2 | GO:0031735 | CCR10 chemokine receptor binding(GO:0031735) |
| 0.0 | 0.2 | GO:0070180 | large ribosomal subunit rRNA binding(GO:0070180) |
Gene overrepresentation in curated gene sets: canonical pathways category:
| Log-likelihood per target | Total log-likelihood | Term | Description |
|---|---|---|---|
| 0.0 | 0.3 | PID TCR RAS PATHWAY | Ras signaling in the CD4+ TCR pathway |
| 0.0 | 0.3 | PID INSULIN GLUCOSE PATHWAY | Insulin-mediated glucose transport |
| 0.0 | 0.2 | PID VEGF VEGFR PATHWAY | VEGF and VEGFR signaling network |
| 0.0 | 0.2 | PID HEDGEHOG 2PATHWAY | Signaling events mediated by the Hedgehog family |
Gene overrepresentation in curated gene sets: REACTOME pathways category:
| Log-likelihood per target | Total log-likelihood | Term | Description |
|---|---|---|---|
| 0.2 | 2.9 | REACTOME GABA A RECEPTOR ACTIVATION | Genes involved in GABA A receptor activation |
| 0.0 | 0.3 | REACTOME LIGAND GATED ION CHANNEL TRANSPORT | Genes involved in Ligand-gated ion channel transport |
| 0.0 | 0.3 | REACTOME HORMONE LIGAND BINDING RECEPTORS | Genes involved in Hormone ligand-binding receptors |
| 0.0 | 0.3 | REACTOME RAF MAP KINASE CASCADE | Genes involved in RAF/MAP kinase cascade |
| 0.0 | 0.3 | REACTOME CS DS DEGRADATION | Genes involved in CS/DS degradation |
| 0.0 | 0.3 | REACTOME HDL MEDIATED LIPID TRANSPORT | Genes involved in HDL-mediated lipid transport |
| 0.0 | 0.3 | REACTOME PROTEOLYTIC CLEAVAGE OF SNARE COMPLEX PROTEINS | Genes involved in Proteolytic cleavage of SNARE complex proteins |
| 0.0 | 0.2 | REACTOME GAP JUNCTION DEGRADATION | Genes involved in Gap junction degradation |
| 0.0 | 0.2 | REACTOME TETRAHYDROBIOPTERIN BH4 SYNTHESIS RECYCLING SALVAGE AND REGULATION | Genes involved in Tetrahydrobiopterin (BH4) synthesis, recycling, salvage and regulation |
| 0.0 | 0.2 | REACTOME BILE SALT AND ORGANIC ANION SLC TRANSPORTERS | Genes involved in Bile salt and organic anion SLC transporters |