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GSE49485: Hypoxia transcriptome sequencing of rat brain.
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Results for Hnf4g
Z-value: 1.09
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Transcription factors associated with Hnf4g
Activity-expression correlation:
| Gene | Promoter | Pearson corr. coef. | P-value | Plot |
|---|---|---|---|---|
| Hnf4g | rn6_v1_chr2_-_100249811_100249811 | 0.51 | 3.8e-01 | Click! |
| Promoter | Log-likelihood | Transcript | Gene | Gene Info |
|---|---|---|---|---|
| chr20_-_9855443 Show fit | 0.95 |
ENSRNOT00000090275
ENSRNOT00000066266 |
trefoil factor 3 |
|
| chr8_+_48438259 Show fit | 0.75 |
ENSRNOT00000059813
|
membrane frizzled-related protein |
|
| chr10_-_88670430 Show fit | 0.74 |
ENSRNOT00000025547
|
hypocretin neuropeptide precursor |
|
| chr10_-_15603649 Show fit | 0.67 |
ENSRNOT00000051483
|
hemoglobin alpha, adult chain 2 |
|
| chr1_+_242572533 Show fit | 0.59 |
ENSRNOT00000035123
|
transmembrane protein 252 |
|
| chr1_-_211956858 Show fit | 0.56 |
ENSRNOT00000054886
|
cilia and flagella associated protein 46 |
|
| chr18_-_15540177 Show fit | 0.52 |
ENSRNOT00000022113
|
transthyretin |
|
| chr16_+_49462889 Show fit | 0.50 |
ENSRNOT00000039909
|
ankyrin repeat domain 37 |
|
| chr4_-_30338679 Show fit | 0.49 |
ENSRNOT00000012050
|
paraoxonase 3 |
|
| chr8_+_48437918 Show fit | 0.48 |
ENSRNOT00000085578
|
membrane frizzled-related protein |
Network of associatons between targets according to the STRING database.
First level regulatory network of Hnf4g
Gene Ontology Analysis
Gene overrepresentation in biological process category:
| Log-likelihood per target | Total log-likelihood | Term | Description |
|---|---|---|---|
| 0.0 | 1.3 | GO:0042462 | eye photoreceptor cell development(GO:0042462) |
| 0.0 | 1.2 | GO:0000028 | ribosomal small subunit assembly(GO:0000028) |
| 0.1 | 1.1 | GO:0015671 | oxygen transport(GO:0015671) |
| 0.0 | 0.8 | GO:0007586 | digestion(GO:0007586) |
| 0.1 | 0.7 | GO:0051970 | negative regulation of transmission of nerve impulse(GO:0051970) |
| 0.1 | 0.7 | GO:0070327 | thyroid hormone transport(GO:0070327) |
| 0.2 | 0.6 | GO:0050828 | regulation of liquid surface tension(GO:0050828) |
| 0.1 | 0.6 | GO:0032929 | negative regulation of superoxide anion generation(GO:0032929) |
| 0.1 | 0.6 | GO:0006063 | uronic acid metabolic process(GO:0006063) glucuronate metabolic process(GO:0019585) |
| 0.2 | 0.5 | GO:0060974 | cell migration involved in heart formation(GO:0060974) |
Gene overrepresentation in cellular component category:
| Log-likelihood per target | Total log-likelihood | Term | Description |
|---|---|---|---|
| 0.0 | 1.8 | GO:0022627 | cytosolic small ribosomal subunit(GO:0022627) |
| 0.0 | 1.0 | GO:0005761 | organellar ribosome(GO:0000313) mitochondrial ribosome(GO:0005761) |
| 0.2 | 0.6 | GO:0031838 | haptoglobin-hemoglobin complex(GO:0031838) |
| 0.0 | 0.6 | GO:0005839 | proteasome core complex(GO:0005839) |
| 0.0 | 0.5 | GO:0031362 | anchored component of external side of plasma membrane(GO:0031362) |
| 0.0 | 0.5 | GO:0001772 | immunological synapse(GO:0001772) |
| 0.1 | 0.4 | GO:0070557 | PCNA-p21 complex(GO:0070557) |
| 0.1 | 0.4 | GO:1990726 | Lsm1-7-Pat1 complex(GO:1990726) |
| 0.1 | 0.4 | GO:0061689 | tricellular tight junction(GO:0061689) |
| 0.1 | 0.4 | GO:0034715 | pICln-Sm protein complex(GO:0034715) |
Gene overrepresentation in molecular function category:
| Log-likelihood per target | Total log-likelihood | Term | Description |
|---|---|---|---|
| 0.0 | 3.5 | GO:0003735 | structural constituent of ribosome(GO:0003735) |
| 0.0 | 1.1 | GO:0005184 | neuropeptide hormone activity(GO:0005184) |
| 0.2 | 0.7 | GO:0046573 | lactonohydrolase activity(GO:0046573) acyl-L-homoserine-lactone lactonohydrolase activity(GO:0102007) |
| 0.2 | 0.7 | GO:0031720 | haptoglobin binding(GO:0031720) |
| 0.0 | 0.6 | GO:0005212 | structural constituent of eye lens(GO:0005212) |
| 0.0 | 0.6 | GO:0004602 | glutathione peroxidase activity(GO:0004602) |
| 0.2 | 0.5 | GO:0019807 | aspartoacylase activity(GO:0019807) |
| 0.1 | 0.5 | GO:0001591 | dopamine neurotransmitter receptor activity, coupled via Gi/Go(GO:0001591) |
| 0.1 | 0.5 | GO:0005344 | oxygen transporter activity(GO:0005344) |
| 0.1 | 0.5 | GO:1990446 | U1 snRNP binding(GO:1990446) |
Gene overrepresentation in curated gene sets: canonical pathways category:
| Log-likelihood per target | Total log-likelihood | Term | Description |
|---|---|---|---|
| 0.0 | 1.4 | PID HNF3B PATHWAY | FOXA2 and FOXA3 transcription factor networks |
| 0.0 | 1.2 | PID HIF1 TFPATHWAY | HIF-1-alpha transcription factor network |
| 0.0 | 0.8 | PID HDAC CLASSI PATHWAY | Signaling events mediated by HDAC Class I |
| 0.0 | 0.4 | SA G2 AND M PHASES | Cdc25 activates the cdc2/cyclin B complex to induce the G2/M transition. |
| 0.0 | 0.4 | PID IL6 7 PATHWAY | IL6-mediated signaling events |
| 0.0 | 0.2 | PID PRL SIGNALING EVENTS PATHWAY | Signaling events mediated by PRL |
| 0.0 | 0.2 | PID SYNDECAN 2 PATHWAY | Syndecan-2-mediated signaling events |
| 0.0 | 0.1 | PID PDGFRA PATHWAY | PDGFR-alpha signaling pathway |
| 0.0 | 0.1 | PID LYMPH ANGIOGENESIS PATHWAY | VEGFR3 signaling in lymphatic endothelium |
| 0.0 | 0.1 | PID THROMBIN PAR1 PATHWAY | PAR1-mediated thrombin signaling events |
Gene overrepresentation in curated gene sets: REACTOME pathways category:
| Log-likelihood per target | Total log-likelihood | Term | Description |
|---|---|---|---|
| 0.0 | 3.6 | REACTOME METABOLISM OF AMINO ACIDS AND DERIVATIVES | Genes involved in Metabolism of amino acids and derivatives |
| 0.0 | 1.3 | REACTOME FORMATION OF THE TERNARY COMPLEX AND SUBSEQUENTLY THE 43S COMPLEX | Genes involved in Formation of the ternary complex, and subsequently, the 43S complex |
| 0.0 | 1.0 | REACTOME AMYLOIDS | Genes involved in Amyloids |
| 0.0 | 0.8 | REACTOME RESPIRATORY ELECTRON TRANSPORT | Genes involved in Respiratory electron transport |
| 0.0 | 0.7 | REACTOME AMINE LIGAND BINDING RECEPTORS | Genes involved in Amine ligand-binding receptors |
| 0.0 | 0.5 | REACTOME GLUCURONIDATION | Genes involved in Glucuronidation |
| 0.0 | 0.5 | REACTOME BRANCHED CHAIN AMINO ACID CATABOLISM | Genes involved in Branched-chain amino acid catabolism |
| 0.0 | 0.5 | REACTOME GLUTATHIONE CONJUGATION | Genes involved in Glutathione conjugation |
| 0.0 | 0.5 | REACTOME TIGHT JUNCTION INTERACTIONS | Genes involved in Tight junction interactions |
| 0.0 | 0.4 | REACTOME MRNA DECAY BY 5 TO 3 EXORIBONUCLEASE | Genes involved in mRNA Decay by 5' to 3' Exoribonuclease |