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GSE49485: Hypoxia transcriptome sequencing of rat brain.
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Results for Hnf1b
Z-value: 0.53
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Transcription factors associated with Hnf1b
Activity-expression correlation:
| Gene | Promoter | Pearson corr. coef. | P-value | Plot |
|---|---|---|---|---|
| Hnf1b | rn6_v1_chr10_+_71217966_71217966 | 0.93 | 2.4e-02 | Click! |
| Promoter | Log-likelihood | Transcript | Gene | Gene Info |
|---|---|---|---|---|
| chrX_-_32153794 Show fit | 0.32 |
ENSRNOT00000005348
|
transmembrane protein 27 |
|
| chr7_-_28711761 Show fit | 0.26 |
ENSRNOT00000006249
|
PARP1 binding protein |
|
| chrX_-_40086870 Show fit | 0.25 |
ENSRNOT00000010027
|
small muscle protein, X-linked |
|
| chr14_+_87448692 Show fit | 0.25 |
ENSRNOT00000077177
|
insulin-like growth factor binding protein 1 |
|
| chr20_+_30690810 Show fit | 0.22 |
ENSRNOT00000000687
|
pterin-4 alpha-carbinolamine dehydratase 1 |
|
| chr8_+_22856539 Show fit | 0.19 |
ENSRNOT00000015381
|
angiopoietin-like 8 |
|
| chr10_-_64108554 Show fit | 0.18 |
ENSRNOT00000081725
|
rabphilin 3A-like (without C2 domains) |
|
| chr14_-_19132208 Show fit | 0.18 |
ENSRNOT00000060535
|
afamin |
|
| chr4_-_120559078 Show fit | 0.17 |
ENSRNOT00000085730
ENSRNOT00000079575 |
kelch repeat and BTB domain containing 12 |
|
| chrX_+_33443186 Show fit | 0.16 |
ENSRNOT00000005622
|
S100 calcium binding protein G |
Network of associatons between targets according to the STRING database.
First level regulatory network of Hnf1b
Gene Ontology Analysis
Gene overrepresentation in biological process category:
| Log-likelihood per target | Total log-likelihood | Term | Description |
|---|---|---|---|
| 0.0 | 0.3 | GO:0052697 | xenobiotic glucuronidation(GO:0052697) |
| 0.0 | 0.3 | GO:0035542 | regulation of SNARE complex assembly(GO:0035542) |
| 0.0 | 0.3 | GO:0006558 | L-phenylalanine metabolic process(GO:0006558) erythrose 4-phosphate/phosphoenolpyruvate family amino acid metabolic process(GO:1902221) |
| 0.0 | 0.3 | GO:2000042 | negative regulation of double-strand break repair via homologous recombination(GO:2000042) |
| 0.1 | 0.2 | GO:0006682 | galactosylceramide biosynthetic process(GO:0006682) galactolipid biosynthetic process(GO:0019375) |
| 0.0 | 0.2 | GO:0050746 | regulation of lipoprotein metabolic process(GO:0050746) |
| 0.0 | 0.2 | GO:0042448 | progesterone metabolic process(GO:0042448) |
| 0.0 | 0.1 | GO:0010133 | proline catabolic process to glutamate(GO:0010133) |
| 0.0 | 0.1 | GO:0034441 | plasma lipoprotein particle oxidation(GO:0034441) negative regulation of lipoprotein oxidation(GO:0034443) |
| 0.0 | 0.1 | GO:0052314 | phytoalexin metabolic process(GO:0052314) |
Gene overrepresentation in cellular component category:
| Log-likelihood per target | Total log-likelihood | Term | Description |
|---|---|---|---|
| 0.1 | 0.3 | GO:0005927 | muscle tendon junction(GO:0005927) |
| 0.0 | 0.1 | GO:0034365 | discoidal high-density lipoprotein particle(GO:0034365) |
| 0.0 | 0.1 | GO:0030478 | actin cap(GO:0030478) |
| 0.0 | 0.1 | GO:0005579 | membrane attack complex(GO:0005579) |
| 0.0 | 0.1 | GO:0016012 | sarcoglycan complex(GO:0016012) |
| 0.0 | 0.0 | GO:1990730 | VCP-NSFL1C complex(GO:1990730) |
Gene overrepresentation in molecular function category:
| Log-likelihood per target | Total log-likelihood | Term | Description |
|---|---|---|---|
| 0.1 | 0.3 | GO:0008241 | peptidyl-dipeptidase activity(GO:0008241) |
| 0.0 | 0.3 | GO:0031995 | insulin-like growth factor II binding(GO:0031995) |
| 0.0 | 0.3 | GO:0015020 | glucuronosyltransferase activity(GO:0015020) |
| 0.1 | 0.2 | GO:0004505 | phenylalanine 4-monooxygenase activity(GO:0004505) |
| 0.0 | 0.2 | GO:0001733 | galactosylceramide sulfotransferase activity(GO:0001733) |
| 0.0 | 0.2 | GO:0005499 | vitamin D binding(GO:0005499) |
| 0.0 | 0.1 | GO:0004657 | proline dehydrogenase activity(GO:0004657) |
| 0.0 | 0.1 | GO:0036468 | aromatic-L-amino-acid decarboxylase activity(GO:0004058) L-dopa decarboxylase activity(GO:0036468) |
| 0.0 | 0.1 | GO:0098603 | selenol Se-methyltransferase activity(GO:0098603) |
| 0.0 | 0.1 | GO:0005134 | interleukin-2 receptor binding(GO:0005134) |
Gene overrepresentation in curated gene sets: REACTOME pathways category:
| Log-likelihood per target | Total log-likelihood | Term | Description |
|---|---|---|---|
| 0.0 | 0.4 | REACTOME GLUCURONIDATION | Genes involved in Glucuronidation |
| 0.0 | 0.3 | REACTOME REGULATION OF INSULIN LIKE GROWTH FACTOR IGF ACTIVITY BY INSULIN LIKE GROWTH FACTOR BINDING PROTEINS IGFBPS | Genes involved in Regulation of Insulin-like Growth Factor (IGF) Activity by Insulin-like Growth Factor Binding Proteins (IGFBPs) |
| 0.0 | 0.2 | REACTOME DIGESTION OF DIETARY CARBOHYDRATE | Genes involved in Digestion of dietary carbohydrate |