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GSE49485: Hypoxia transcriptome sequencing of rat brain.
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Results for Hif1a
Z-value: 0.83
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Transcription factors associated with Hif1a
Activity-expression correlation:
| Gene | Promoter | Pearson corr. coef. | P-value | Plot |
|---|---|---|---|---|
| Hif1a | rn6_v1_chr6_+_96810907_96810907 | 0.74 | 1.5e-01 | Click! |
| Promoter | Log-likelihood | Transcript | Gene | Gene Info |
|---|---|---|---|---|
| chr14_+_4362717 Show fit | 0.92 |
ENSRNOT00000002887
|
BarH-like homeobox 2 |
|
| chr7_-_13751271 Show fit | 0.91 |
ENSRNOT00000009931
|
solute carrier family 1 member 6 |
|
| chr17_-_9695292 Show fit | 0.61 |
ENSRNOT00000036162
|
proline rich 7 (synaptic) |
|
| chr3_+_147585947 Show fit | 0.56 |
ENSRNOT00000006833
|
scratch family transcriptional repressor 2 |
|
| chr10_+_59529785 Show fit | 0.56 |
ENSRNOT00000064840
ENSRNOT00000065181 |
ATPase sarcoplasmic/endoplasmic reticulum Ca2+ transporting 3 |
|
| chr16_+_49462889 Show fit | 0.38 |
ENSRNOT00000039909
|
ankyrin repeat domain 37 |
|
| chr1_+_33910912 Show fit | 0.36 |
ENSRNOT00000044690
|
iroquois homeobox 1 |
|
| chr20_-_29511382 Show fit | 0.35 |
ENSRNOT00000085026
|
DNA-damage-inducible transcript 4 |
|
| chr7_-_119441487 Show fit | 0.33 |
ENSRNOT00000067635
|
parvalbumin |
|
| chr2_-_197991198 Show fit | 0.32 |
ENSRNOT00000056322
|
circadian associated repressor of transcription |
Network of associatons between targets according to the STRING database.
First level regulatory network of Hif1a
Gene Ontology Analysis
Gene overrepresentation in biological process category:
| Log-likelihood per target | Total log-likelihood | Term | Description |
|---|---|---|---|
| 0.1 | 0.9 | GO:0089711 | L-glutamate transmembrane transport(GO:0089711) |
| 0.0 | 0.9 | GO:0001709 | cell fate determination(GO:0001709) |
| 0.0 | 0.6 | GO:0045475 | locomotor rhythm(GO:0045475) |
| 0.1 | 0.4 | GO:0072086 | specification of loop of Henle identity(GO:0072086) pattern specification involved in metanephros development(GO:0072268) |
| 0.0 | 0.4 | GO:0045820 | negative regulation of glycolytic process(GO:0045820) |
| 0.0 | 0.3 | GO:0046007 | negative regulation of activated T cell proliferation(GO:0046007) |
| 0.1 | 0.2 | GO:0006083 | acetate metabolic process(GO:0006083) propionate metabolic process(GO:0019541) |
| 0.0 | 0.2 | GO:0009223 | pyrimidine deoxyribonucleotide catabolic process(GO:0009223) |
| 0.0 | 0.2 | GO:1903288 | positive regulation of potassium ion import(GO:1903288) |
| 0.0 | 0.2 | GO:0060971 | embryonic heart tube left/right pattern formation(GO:0060971) |
Gene overrepresentation in cellular component category:
| Log-likelihood per target | Total log-likelihood | Term | Description |
|---|---|---|---|
| 0.0 | 0.6 | GO:0033017 | sarcoplasmic reticulum membrane(GO:0033017) |
| 0.0 | 0.3 | GO:0005785 | signal recognition particle receptor complex(GO:0005785) |
| 0.0 | 0.2 | GO:0031074 | nucleocytoplasmic shuttling complex(GO:0031074) |
| 0.0 | 0.2 | GO:0005890 | sodium:potassium-exchanging ATPase complex(GO:0005890) |
| 0.0 | 0.1 | GO:0005945 | 6-phosphofructokinase complex(GO:0005945) |
| 0.0 | 0.1 | GO:0071008 | U2-type post-mRNA release spliceosomal complex(GO:0071008) |
| 0.0 | 0.1 | GO:0005787 | signal peptidase complex(GO:0005787) |
Gene overrepresentation in molecular function category:
| Log-likelihood per target | Total log-likelihood | Term | Description |
|---|---|---|---|
| 0.1 | 0.9 | GO:0005313 | L-glutamate transmembrane transporter activity(GO:0005313) |
| 0.0 | 0.7 | GO:0070888 | E-box binding(GO:0070888) |
| 0.0 | 0.6 | GO:0005388 | calcium-transporting ATPase activity(GO:0005388) |
| 0.0 | 0.4 | GO:0071889 | 14-3-3 protein binding(GO:0071889) |
| 0.0 | 0.2 | GO:0003987 | acetate-CoA ligase activity(GO:0003987) |
| 0.0 | 0.2 | GO:0019103 | pyrimidine nucleotide binding(GO:0019103) |
| 0.0 | 0.2 | GO:0050693 | LBD domain binding(GO:0050693) |
| 0.0 | 0.2 | GO:0005391 | sodium:potassium-exchanging ATPase activity(GO:0005391) |
| 0.0 | 0.1 | GO:0070883 | pre-miRNA binding(GO:0070883) |
| 0.0 | 0.1 | GO:0008508 | bile acid:sodium symporter activity(GO:0008508) |
Gene overrepresentation in curated gene sets: canonical pathways category:
| Log-likelihood per target | Total log-likelihood | Term | Description |
|---|---|---|---|
| 0.0 | 0.3 | PID HDAC CLASSIII PATHWAY | Signaling events mediated by HDAC Class III |
| 0.0 | 0.1 | PID RANBP2 PATHWAY | Sumoylation by RanBP2 regulates transcriptional repression |
Gene overrepresentation in curated gene sets: REACTOME pathways category:
| Log-likelihood per target | Total log-likelihood | Term | Description |
|---|---|---|---|
| 0.0 | 0.9 | REACTOME GLUTAMATE NEUROTRANSMITTER RELEASE CYCLE | Genes involved in Glutamate Neurotransmitter Release Cycle |
| 0.0 | 0.6 | REACTOME PRE NOTCH PROCESSING IN GOLGI | Genes involved in Pre-NOTCH Processing in Golgi |
| 0.0 | 0.2 | REACTOME PURINE CATABOLISM | Genes involved in Purine catabolism |
| 0.0 | 0.2 | REACTOME ETHANOL OXIDATION | Genes involved in Ethanol oxidation |