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GSE49485: Hypoxia transcriptome sequencing of rat brain.
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Results for Hic2
Z-value: 2.20
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Transcription factors associated with Hic2
Activity-expression correlation:
| Gene | Promoter | Pearson corr. coef. | P-value | Plot |
|---|---|---|---|---|
| Hic2 | rn6_v1_chr11_-_88016825_88016825 | -0.71 | 1.8e-01 | Click! |
| Promoter | Log-likelihood | Transcript | Gene | Gene Info |
|---|---|---|---|---|
| chr3_-_123119460 Show fit | 3.00 |
ENSRNOT00000028833
|
arginine vasopressin |
|
| chr3_+_123106694 Show fit | 2.08 |
ENSRNOT00000028829
|
oxytocin/neurophysin 1 prepropeptide |
|
| chr12_-_30304036 Show fit | 2.01 |
ENSRNOT00000001218
|
nuclear protein 2, transcriptional regulator |
|
| chr5_-_156811650 Show fit | 1.48 |
ENSRNOT00000068065
|
family with sequence similarity 43, member B |
|
| chr2_-_187160373 Show fit | 1.45 |
ENSRNOT00000018961
|
neurotrophic receptor tyrosine kinase 1 |
|
| chr9_+_82120059 Show fit | 1.33 |
ENSRNOT00000057368
|
cyclin-dependent kinase 5 regulatory subunit 2 |
|
| chr15_+_37790141 Show fit | 1.19 |
ENSRNOT00000076392
ENSRNOT00000091953 |
interleukin 17D |
|
| chr8_+_116776494 Show fit | 1.18 |
ENSRNOT00000050702
|
cadherin-related family member 4 |
|
| chr11_+_89008008 Show fit | 1.09 |
ENSRNOT00000074586
|
CCAAT/enhancer binding protein delta |
|
| chr1_-_216080287 Show fit | 1.06 |
ENSRNOT00000027682
|
tyrosine hydroxylase |
Network of associatons between targets according to the STRING database.
First level regulatory network of Hic2
Gene Ontology Analysis
Gene overrepresentation in biological process category:
| Log-likelihood per target | Total log-likelihood | Term | Description |
|---|---|---|---|
| 1.3 | 5.1 | GO:0002125 | maternal aggressive behavior(GO:0002125) |
| 0.1 | 2.4 | GO:0071157 | negative regulation of cell cycle arrest(GO:0071157) |
| 0.0 | 1.4 | GO:0045746 | negative regulation of Notch signaling pathway(GO:0045746) |
| 0.3 | 1.3 | GO:0021586 | pons maturation(GO:0021586) |
| 0.1 | 1.2 | GO:0045820 | negative regulation of glycolytic process(GO:0045820) |
| 0.3 | 1.1 | GO:0052314 | phytoalexin metabolic process(GO:0052314) |
| 0.2 | 1.1 | GO:0061366 | behavioral response to chemical pain(GO:0061366) behavioral response to formalin induced pain(GO:0061368) |
| 0.2 | 1.1 | GO:0021759 | globus pallidus development(GO:0021759) |
| 0.2 | 1.0 | GO:0010037 | response to carbon dioxide(GO:0010037) |
| 0.1 | 0.9 | GO:0060754 | positive regulation of mast cell chemotaxis(GO:0060754) |
Gene overrepresentation in cellular component category:
| Log-likelihood per target | Total log-likelihood | Term | Description |
|---|---|---|---|
| 0.0 | 2.1 | GO:0043195 | terminal bouton(GO:0043195) |
| 0.0 | 1.7 | GO:0031902 | late endosome membrane(GO:0031902) |
| 0.4 | 1.3 | GO:0016533 | cyclin-dependent protein kinase 5 holoenzyme complex(GO:0016533) |
| 0.0 | 1.3 | GO:0030863 | cortical cytoskeleton(GO:0030863) |
| 0.1 | 1.1 | GO:0033162 | melanosome membrane(GO:0033162) chitosome(GO:0045009) |
| 0.1 | 1.0 | GO:0005922 | connexon complex(GO:0005922) |
| 0.0 | 1.0 | GO:0022625 | cytosolic large ribosomal subunit(GO:0022625) |
| 0.1 | 0.9 | GO:0005833 | hemoglobin complex(GO:0005833) |
| 0.0 | 0.9 | GO:0045271 | mitochondrial respiratory chain complex I(GO:0005747) NADH dehydrogenase complex(GO:0030964) respiratory chain complex I(GO:0045271) |
| 0.1 | 0.8 | GO:0005641 | nuclear envelope lumen(GO:0005641) |
Gene overrepresentation in molecular function category:
| Log-likelihood per target | Total log-likelihood | Term | Description |
|---|---|---|---|
| 1.0 | 3.0 | GO:0031893 | vasopressin receptor binding(GO:0031893) |
| 0.1 | 2.8 | GO:0005184 | neuropeptide hormone activity(GO:0005184) |
| 0.4 | 1.4 | GO:0005030 | neurotrophin receptor activity(GO:0005030) |
| 0.0 | 1.4 | GO:0043539 | protein serine/threonine kinase activator activity(GO:0043539) |
| 0.2 | 1.1 | GO:0016714 | oxidoreductase activity, acting on paired donors, with incorporation or reduction of molecular oxygen, reduced pteridine as one donor, and incorporation of one atom of oxygen(GO:0016714) |
| 0.1 | 1.0 | GO:0005172 | vascular endothelial growth factor receptor binding(GO:0005172) |
| 0.1 | 1.0 | GO:0001206 | transcriptional repressor activity, RNA polymerase II distal enhancer sequence-specific binding(GO:0001206) |
| 0.1 | 0.9 | GO:0005344 | oxygen transporter activity(GO:0005344) |
| 0.3 | 0.8 | GO:0050220 | prostaglandin-E synthase activity(GO:0050220) |
| 0.1 | 0.8 | GO:0004966 | galanin receptor activity(GO:0004966) |
Gene overrepresentation in curated gene sets: canonical pathways category:
| Log-likelihood per target | Total log-likelihood | Term | Description |
|---|---|---|---|
| 0.1 | 2.6 | PID HNF3B PATHWAY | FOXA2 and FOXA3 transcription factor networks |
| 0.1 | 2.3 | SA TRKA RECEPTOR | The TrkA receptor binds nerve growth factor to activate MAP kinase pathways and promote cell growth. |
| 0.0 | 1.5 | PID LIS1 PATHWAY | Lissencephaly gene (LIS1) in neuronal migration and development |
| 0.0 | 1.1 | PID P38 MK2 PATHWAY | p38 signaling mediated by MAPKAP kinases |
| 0.0 | 1.0 | WNT SIGNALING | Genes related to Wnt-mediated signal transduction |
| 0.0 | 0.8 | PID INTEGRIN A9B1 PATHWAY | Alpha9 beta1 integrin signaling events |
| 0.0 | 0.8 | PID BCR 5PATHWAY | BCR signaling pathway |
| 0.0 | 0.8 | PID CMYB PATHWAY | C-MYB transcription factor network |
| 0.1 | 0.6 | PID VEGF VEGFR PATHWAY | VEGF and VEGFR signaling network |
| 0.0 | 0.6 | PID IL23 PATHWAY | IL23-mediated signaling events |
Gene overrepresentation in curated gene sets: REACTOME pathways category:
| Log-likelihood per target | Total log-likelihood | Term | Description |
|---|---|---|---|
| 0.0 | 4.2 | REACTOME PEPTIDE LIGAND BINDING RECEPTORS | Genes involved in Peptide ligand-binding receptors |
| 0.3 | 3.0 | REACTOME TRANSPORT OF ORGANIC ANIONS | Genes involved in Transport of organic anions |
| 0.1 | 1.6 | REACTOME RETROGRADE NEUROTROPHIN SIGNALLING | Genes involved in Retrograde neurotrophin signalling |
| 0.0 | 1.3 | REACTOME TRANSCRIPTIONAL REGULATION OF WHITE ADIPOCYTE DIFFERENTIATION | Genes involved in Transcriptional Regulation of White Adipocyte Differentiation |
| 0.0 | 1.1 | REACTOME ACTIVATED NOTCH1 TRANSMITS SIGNAL TO THE NUCLEUS | Genes involved in Activated NOTCH1 Transmits Signal to the Nucleus |
| 0.1 | 0.9 | REACTOME AMINE DERIVED HORMONES | Genes involved in Amine-derived hormones |
| 0.0 | 0.9 | REACTOME SEMA4D INDUCED CELL MIGRATION AND GROWTH CONE COLLAPSE | Genes involved in Sema4D induced cell migration and growth-cone collapse |
| 0.0 | 0.8 | REACTOME VOLTAGE GATED POTASSIUM CHANNELS | Genes involved in Voltage gated Potassium channels |
| 0.0 | 0.7 | REACTOME AKT PHOSPHORYLATES TARGETS IN THE CYTOSOL | Genes involved in AKT phosphorylates targets in the cytosol |
| 0.0 | 0.7 | REACTOME REGULATION OF IFNA SIGNALING | Genes involved in Regulation of IFNA signaling |