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GSE49485: Hypoxia transcriptome sequencing of rat brain.
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Results for Hey1_Myc_Mxi1
Z-value: 1.02
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Transcription factors associated with Hey1_Myc_Mxi1
Activity-expression correlation:
| Gene | Promoter | Pearson corr. coef. | P-value | Plot |
|---|---|---|---|---|
| Mxi1 | rn6_v1_chr1_+_274030978_274030978 | 0.60 | 2.9e-01 | Click! |
| Hey1 | rn6_v1_chr2_+_95320283_95320283 | -0.10 | 8.7e-01 | Click! |
| Myc | rn6_v1_chr7_+_102586313_102586313 | 0.06 | 9.3e-01 | Click! |
| Promoter | Log-likelihood | Transcript | Gene | Gene Info |
|---|---|---|---|---|
| chr3_-_123119460 Show fit | 2.14 |
ENSRNOT00000028833
|
arginine vasopressin |
|
| chr2_-_197991198 Show fit | 1.61 |
ENSRNOT00000056322
|
circadian associated repressor of transcription |
|
| chr2_-_197991574 Show fit | 1.52 |
ENSRNOT00000085632
|
circadian associated repressor of transcription |
|
| chr2_-_187160373 Show fit | 0.87 |
ENSRNOT00000018961
|
neurotrophic receptor tyrosine kinase 1 |
|
| chr2_-_260596777 Show fit | 0.80 |
ENSRNOT00000009370
|
LIM homeobox 8 |
|
| chr17_-_9695292 Show fit | 0.77 |
ENSRNOT00000036162
|
proline rich 7 (synaptic) |
|
| chr14_+_4362717 Show fit | 0.62 |
ENSRNOT00000002887
|
BarH-like homeobox 2 |
|
| chr4_+_33638709 Show fit | 0.58 |
ENSRNOT00000009888
ENSRNOT00000034719 ENSRNOT00000052333 |
tachykinin, precursor 1 |
|
| chr16_+_49462889 Show fit | 0.57 |
ENSRNOT00000039909
|
ankyrin repeat domain 37 |
|
| chr3_+_113415774 Show fit | 0.57 |
ENSRNOT00000056151
|
small EDRK-rich factor 2 |
Network of associatons between targets according to the STRING database.
First level regulatory network of Hey1_Myc_Mxi1
Gene Ontology Analysis
Gene overrepresentation in biological process category:
| Log-likelihood per target | Total log-likelihood | Term | Description |
|---|---|---|---|
| 0.1 | 3.1 | GO:0045475 | locomotor rhythm(GO:0045475) |
| 0.5 | 2.1 | GO:0002125 | maternal aggressive behavior(GO:0002125) |
| 0.2 | 0.8 | GO:0061366 | behavioral response to chemical pain(GO:0061366) behavioral response to formalin induced pain(GO:0061368) |
| 0.1 | 0.6 | GO:2000851 | positive regulation of saliva secretion(GO:0046878) positive regulation of glucocorticoid secretion(GO:2000851) |
| 0.2 | 0.5 | GO:0046833 | positive regulation of RNA export from nucleus(GO:0046833) |
| 0.0 | 0.5 | GO:0000185 | activation of MAPKKK activity(GO:0000185) |
| 0.1 | 0.4 | GO:0071387 | cellular response to cortisol stimulus(GO:0071387) |
| 0.1 | 0.4 | GO:0045041 | protein import into mitochondrial intermembrane space(GO:0045041) |
| 0.1 | 0.4 | GO:1902219 | negative regulation of intrinsic apoptotic signaling pathway in response to osmotic stress(GO:1902219) |
| 0.1 | 0.4 | GO:0033387 | putrescine biosynthetic process from ornithine(GO:0033387) |
Gene overrepresentation in cellular component category:
| Log-likelihood per target | Total log-likelihood | Term | Description |
|---|---|---|---|
| 0.0 | 1.0 | GO:0031902 | late endosome membrane(GO:0031902) |
| 0.0 | 0.9 | GO:0005758 | mitochondrial intermembrane space(GO:0005758) |
| 0.1 | 0.8 | GO:0001674 | female germ cell nucleus(GO:0001674) |
| 0.0 | 0.8 | GO:0022627 | cytosolic small ribosomal subunit(GO:0022627) |
| 0.1 | 0.6 | GO:0005833 | hemoglobin complex(GO:0005833) |
| 0.0 | 0.6 | GO:0005921 | gap junction(GO:0005921) |
| 0.1 | 0.3 | GO:0000408 | EKC/KEOPS complex(GO:0000408) |
| 0.1 | 0.3 | GO:0042719 | mitochondrial intermembrane space protein transporter complex(GO:0042719) |
| 0.0 | 0.3 | GO:0090543 | Flemming body(GO:0090543) |
| 0.0 | 0.3 | GO:0097452 | GAIT complex(GO:0097452) |
Gene overrepresentation in molecular function category:
| Log-likelihood per target | Total log-likelihood | Term | Description |
|---|---|---|---|
| 0.1 | 3.4 | GO:0070888 | E-box binding(GO:0070888) |
| 0.7 | 2.1 | GO:0031893 | vasopressin receptor binding(GO:0031893) |
| 0.2 | 0.9 | GO:0005030 | neurotrophin receptor activity(GO:0005030) |
| 0.0 | 0.7 | GO:0071855 | neuropeptide receptor binding(GO:0071855) |
| 0.0 | 0.6 | GO:0008143 | poly(A) binding(GO:0008143) |
| 0.0 | 0.5 | GO:0044183 | protein binding involved in protein folding(GO:0044183) |
| 0.1 | 0.4 | GO:0004586 | ornithine decarboxylase activity(GO:0004586) |
| 0.0 | 0.4 | GO:0017049 | GTP-Rho binding(GO:0017049) |
| 0.0 | 0.4 | GO:0003746 | translation elongation factor activity(GO:0003746) |
| 0.0 | 0.4 | GO:0016799 | hydrolase activity, hydrolyzing N-glycosyl compounds(GO:0016799) |
Gene overrepresentation in curated gene sets: canonical pathways category:
| Log-likelihood per target | Total log-likelihood | Term | Description |
|---|---|---|---|
| 0.0 | 0.9 | SA TRKA RECEPTOR | The TrkA receptor binds nerve growth factor to activate MAP kinase pathways and promote cell growth. |
| 0.0 | 0.7 | PID HIF2PATHWAY | HIF-2-alpha transcription factor network |
| 0.0 | 0.6 | ST P38 MAPK PATHWAY | p38 MAPK Pathway |
| 0.0 | 0.6 | PID P38 MKK3 6PATHWAY | p38 MAPK signaling pathway |
| 0.0 | 0.3 | PID RANBP2 PATHWAY | Sumoylation by RanBP2 regulates transcriptional repression |
| 0.0 | 0.2 | SA FAS SIGNALING | The TNF-type receptor Fas induces apoptosis on ligand binding. |
| 0.0 | 0.1 | PID IL2 1PATHWAY | IL2-mediated signaling events |
| 0.0 | 0.1 | PID ER NONGENOMIC PATHWAY | Plasma membrane estrogen receptor signaling |
| 0.0 | 0.1 | PID P38 GAMMA DELTA PATHWAY | Signaling mediated by p38-gamma and p38-delta |
| 0.0 | 0.0 | PID EPO PATHWAY | EPO signaling pathway |
Gene overrepresentation in curated gene sets: REACTOME pathways category:
| Log-likelihood per target | Total log-likelihood | Term | Description |
|---|---|---|---|
| 0.2 | 2.1 | REACTOME TRANSPORT OF ORGANIC ANIONS | Genes involved in Transport of organic anions |
| 0.0 | 1.0 | REACTOME ACTIVATION OF THE MRNA UPON BINDING OF THE CAP BINDING COMPLEX AND EIFS AND SUBSEQUENT BINDING TO 43S | Genes involved in Activation of the mRNA upon binding of the cap-binding complex and eIFs, and subsequent binding to 43S |
| 0.1 | 0.9 | REACTOME RETROGRADE NEUROTROPHIN SIGNALLING | Genes involved in Retrograde neurotrophin signalling |
| 0.0 | 0.8 | REACTOME METABOLISM OF POLYAMINES | Genes involved in Metabolism of polyamines |
| 0.0 | 0.8 | REACTOME 3 UTR MEDIATED TRANSLATIONAL REGULATION | Genes involved in 3' -UTR-mediated translational regulation |
| 0.0 | 0.6 | REACTOME MICRORNA MIRNA BIOGENESIS | Genes involved in MicroRNA (miRNA) Biogenesis |
| 0.0 | 0.3 | REACTOME NEF MEDIATED DOWNREGULATION OF MHC CLASS I COMPLEX CELL SURFACE EXPRESSION | Genes involved in Nef mediated downregulation of MHC class I complex cell surface expression |
| 0.0 | 0.3 | REACTOME BASE FREE SUGAR PHOSPHATE REMOVAL VIA THE SINGLE NUCLEOTIDE REPLACEMENT PATHWAY | Genes involved in Base-free sugar-phosphate removal via the single-nucleotide replacement pathway |
| 0.0 | 0.3 | REACTOME SYNTHESIS AND INTERCONVERSION OF NUCLEOTIDE DI AND TRIPHOSPHATES | Genes involved in Synthesis and interconversion of nucleotide di- and triphosphates |
| 0.0 | 0.3 | REACTOME FORMATION OF TUBULIN FOLDING INTERMEDIATES BY CCT TRIC | Genes involved in Formation of tubulin folding intermediates by CCT/TriC |