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GSE49485: Hypoxia transcriptome sequencing of rat brain.

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Results for Hes5_Hes7

Z-value: 0.41

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Transcription factors associated with Hes5_Hes7

Gene Symbol Gene ID Gene Info
ENSRNOG00000013850 hes family bHLH transcription factor 5
ENSRNOG00000007391 hes family bHLH transcription factor 7

Activity-expression correlation:

GenePromoterPearson corr. coef.P-valuePlot
Hes7rn6_v1_chr10_+_55707164_557071640.424.8e-01Click!
Hes5rn6_v1_chr5_+_172364421_172364421-0.118.6e-01Click!

Activity profile of Hes5_Hes7 motif

Sorted Z-values of Hes5_Hes7 motif

Promoter Log-likelihood Transcript Gene Gene Info
chr17_-_90315492 0.31 ENSRNOT00000070807
G protein subunit gamma 4
chr17_-_13393243 0.29 ENSRNOT00000018252
growth arrest and DNA-damage-inducible, gamma
chr3_+_159569363 0.18 ENSRNOT00000064159
TOX high mobility group box family member 2
chr10_+_91710495 0.10 ENSRNOT00000033276
reprimo-like
chr2_+_206064394 0.10 ENSRNOT00000077739
synaptotagmin 6
chr5_+_152681101 0.10 ENSRNOT00000076052
ENSRNOT00000022574
stathmin 1
chr3_+_59981959 0.10 ENSRNOT00000030460
Sp9 transcription factor
chr11_-_60613718 0.08 ENSRNOT00000002906
autophagy related 3
chr9_-_10054359 0.08 ENSRNOT00000072001
caseinolytic mitochondrial matrix peptidase proteolytic subunit
chr2_+_197682000 0.07 ENSRNOT00000066821
HORMA domain containing 1
chr10_+_103438303 0.07 ENSRNOT00000085262
Cd300a molecule
chr10_+_83476107 0.07 ENSRNOT00000075733
prohibitin
chr5_+_64789456 0.06 ENSRNOT00000009584
zinc finger protein 189
chr10_+_40208223 0.06 ENSRNOT00000000772
histidine triad nucleotide binding protein 1
chr2_+_147006830 0.06 ENSRNOT00000080780

chr10_-_40375605 0.06 ENSRNOT00000014464
annexin A6
chr5_-_173098816 0.05 ENSRNOT00000023696
mindbomb E3 ubiquitin protein ligase 2
chr2_+_150211898 0.05 ENSRNOT00000018767
succinate receptor 1
chr11_+_47090245 0.05 ENSRNOT00000060645

chr6_-_59950586 0.05 ENSRNOT00000005800
ADP-ribosylation factor like GTPase 4A
chr10_+_10889488 0.05 ENSRNOT00000071746
UBA-like domain containing 1
chr3_+_138770574 0.05 ENSRNOT00000012510
ENSRNOT00000066986
D-tyrosyl-tRNA deacylase 1
chr5_-_156141537 0.05 ENSRNOT00000019004
alkaline phosphatase, liver/bone/kidney
chr1_-_239378095 0.05 ENSRNOT00000078466

chr12_-_16934706 0.05 ENSRNOT00000001720
MAF bZIP transcription factor K
chr12_+_8976585 0.04 ENSRNOT00000071796
proteasome maturation protein-like
chr12_-_8759599 0.04 ENSRNOT00000073155
proteasome maturation protein
chr3_+_112346627 0.04 ENSRNOT00000074392
synaptosomal-associated protein 23
chr6_-_26486695 0.04 ENSRNOT00000073236
keratinocyte associated protein 3
chr20_-_5754773 0.04 ENSRNOT00000035977
inositol hexakisphosphate kinase 3
chr3_-_92242318 0.04 ENSRNOT00000007018
tripartite motif-containing 44
chr20_+_4576514 0.04 ENSRNOT00000090125
ENSRNOT00000047370
euchromatic histone lysine methyltransferase 2
chr9_+_20213776 0.04 ENSRNOT00000071439
triosephosphate isomerase-like
chr5_-_156105867 0.04 ENSRNOT00000078851
alkaline phosphatase, liver/bone/kidney
chr2_-_93641497 0.03 ENSRNOT00000013720
charged multivesicular body protein 4C
chr1_-_220787238 0.03 ENSRNOT00000083656
testis specific 10 interacting protein
chr3_-_81282157 0.03 ENSRNOT00000051258
LARGE xylosyl- and glucuronyltransferase 2
chr18_+_62174670 0.03 ENSRNOT00000025362
phorbol-12-myristate-13-acetate-induced protein 1
chr8_-_59607275 0.03 ENSRNOT00000019307
cholinergic receptor nicotinic alpha 3 subunit
chr17_-_56909992 0.03 ENSRNOT00000021801
BMP and activin membrane-bound inhibitor
chr2_-_196415530 0.03 ENSRNOT00000064238
similar to hypothetical protein FLJ20519
chr1_-_164143818 0.03 ENSRNOT00000022557
diacylglycerol O-acyltransferase 2
chr19_+_57484634 0.03 ENSRNOT00000025695
ARV1 homolog, fatty acid homeostasis modulator
chr4_-_157331905 0.03 ENSRNOT00000020647
triosephosphate isomerase 1
chr10_-_20818128 0.03 ENSRNOT00000011061
WW and C2 domain containing 1
chr5_+_157434481 0.03 ENSRNOT00000088556
transmembrane and coiled-coil domains 4
chr9_+_80118029 0.03 ENSRNOT00000023068
insulin-like growth factor binding protein 2
chr2_-_93985378 0.03 ENSRNOT00000075493
fatty acid binding protein 5, epidermal
chr7_-_12779862 0.03 ENSRNOT00000080292
transmembrane protein 259
chr3_-_92290919 0.02 ENSRNOT00000007077
four jointed box 1
chr9_-_15410943 0.02 ENSRNOT00000074217
cyclin D3
chr5_+_60809762 0.02 ENSRNOT00000016839
FERM and PDZ domain containing 1
chr1_+_78546012 0.02 ENSRNOT00000058172
G protein subunit gamma 5
chr8_+_21669236 0.02 ENSRNOT00000027818
peptidylprolyl cis/trans isomerase, NIMA-interacting 1
chr16_-_75855745 0.02 ENSRNOT00000031291
1-acylglycerol-3-phosphate O-acyltransferase 5
chr9_-_82419288 0.02 ENSRNOT00000004797
tubulin, alpha 4A
chr5_+_136112417 0.02 ENSRNOT00000025990
transmembrane protein 53
chr4_+_157453069 0.02 ENSRNOT00000088622
myeloid leukemia factor 2
chr1_+_82089922 0.02 ENSRNOT00000071251
zinc finger protein 526
chr2_-_183031214 0.02 ENSRNOT00000013260
similar to RIKEN cDNA D930015E06
chr20_+_12225202 0.02 ENSRNOT00000045315
collagen type XVIII alpha 1 chain
chr16_+_71889235 0.02 ENSRNOT00000038266
ADAM metallopeptidase domain 32
chr17_+_9837402 0.02 ENSRNOT00000076436
RAB24, member RAS oncogene family
chr19_-_57422093 0.02 ENSRNOT00000025512
similar to RIKEN cDNA 2310022B05
chr4_+_157452607 0.02 ENSRNOT00000022467
myeloid leukemia factor 2
chr10_-_36716601 0.02 ENSRNOT00000038838
similar to hypothetical protein 4930503F14
chr20_+_4576057 0.02 ENSRNOT00000081456
ENSRNOT00000085701
euchromatic histone lysine methyltransferase 2
chr4_-_179339795 0.02 ENSRNOT00000080410
branched chain amino acid transaminase 1
chr1_+_224933920 0.02 ENSRNOT00000066823
WD repeat domain 74
chr3_+_113415774 0.02 ENSRNOT00000056151
small EDRK-rich factor 2
chr3_+_2288667 0.02 ENSRNOT00000012289
ectonucleoside triphosphate diphosphohydrolase 8
chr10_+_11338306 0.02 ENSRNOT00000033695
protein FAM100A-like
chr5_+_141560192 0.02 ENSRNOT00000023354
Myc binding protein
chr2_+_211176556 0.02 ENSRNOT00000055880
proline and serine rich coiled-coil 1
chr19_+_54314865 0.02 ENSRNOT00000024069
interferon regulatory factor 8
chr2_+_95320283 0.02 ENSRNOT00000015537
hes-related family bHLH transcription factor with YRPW motif 1
chr14_-_6786144 0.02 ENSRNOT00000091558
matrix extracellular phosphoglycoprotein
chr5_+_165405168 0.01 ENSRNOT00000014934
spermidine synthase
chr7_-_12905339 0.01 ENSRNOT00000088330
cell division cycle 34
chr5_-_36683356 0.01 ENSRNOT00000009043
POU class 3 homeobox 2
chr20_+_44436403 0.01 ENSRNOT00000000733
ENSRNOT00000076859
FYN proto-oncogene, Src family tyrosine kinase
chr7_+_99609191 0.01 ENSRNOT00000012883
squalene epoxidase
chr7_-_130347587 0.01 ENSRNOT00000040541
thymidine phosphorylase
chr4_-_157486844 0.01 ENSRNOT00000038281
ENSRNOT00000022874
COP9 signalosome subunit 7A
chr5_-_59063592 0.01 ENSRNOT00000022400
talin 1
chr6_+_136050422 0.01 ENSRNOT00000080304
microtubule affinity regulating kinase 3
chr1_+_219390523 0.01 ENSRNOT00000054852
G protein-coupled receptor 152
chr7_+_77899322 0.01 ENSRNOT00000006195
frizzled class receptor 6
chr10_+_35133252 0.01 ENSRNOT00000051916
secretoglobin, family 3A, member 1
chr7_+_126619196 0.01 ENSRNOT00000030082
peroxisome proliferator activated receptor alpha
chr5_-_136112344 0.01 ENSRNOT00000050195
RGD1563714
chr16_-_21347968 0.01 ENSRNOT00000068554
lysophosphatidic acid receptor 2
chr6_-_49851677 0.01 ENSRNOT00000007287
ENSRNOT00000077442
acid phosphatase 1, soluble
chr19_-_25134055 0.01 ENSRNOT00000007519
MISP family member 3
chr14_+_84211600 0.01 ENSRNOT00000005996
pescadillo ribosomal biogenesis factor 1
chr1_+_102017263 0.01 ENSRNOT00000028680
nodal modulator 1
chr1_+_247871807 0.01 ENSRNOT00000089563
melan-A
chr2_+_189400696 0.01 ENSRNOT00000046919
ENSRNOT00000089801
similar to NICE-3
chr4_-_157679962 0.01 ENSRNOT00000050443
glyceraldehyde-3-phosphate dehydrogenase
chr11_+_64861768 0.01 ENSRNOT00000038439
ADP-ribosylarginine hydrolase
chr13_+_71179910 0.01 ENSRNOT00000032236
regulator of G-protein signaling 16
chr11_+_24266345 0.01 ENSRNOT00000046973
junctional adhesion molecule 2
chr11_+_60073383 0.01 ENSRNOT00000087508
transgelin 3
chr20_-_48758905 0.01 ENSRNOT00000000710
D-aspartate oxidase
chr4_-_153465203 0.01 ENSRNOT00000016776
BH3 interacting domain death agonist
chr19_-_46167950 0.01 ENSRNOT00000071024

chr2_+_85377318 0.01 ENSRNOT00000016506
ENSRNOT00000085094
semaphorin 5A
chr20_-_43108198 0.01 ENSRNOT00000000742
histone deacetylase 2
chr3_+_80021440 0.01 ENSRNOT00000018620
acid phosphatase 2, lysosomal
chr19_-_57484742 0.00 ENSRNOT00000079783
tetratricopeptide repeat domain 13
chr12_-_41485122 0.00 ENSRNOT00000001859
DEAD-box helicase 54
chr6_-_36940868 0.00 ENSRNOT00000006470
GEN1 Holliday junction 5' flap endonuclease
chr18_+_72005581 0.00 ENSRNOT00000072519
zinc finger and BTB domain containing 7C
chr7_+_77678968 0.00 ENSRNOT00000006917
ATPase H+ transporting V1 subunit C1
chr10_-_84789832 0.00 ENSRNOT00000071719
CDK5 regulatory subunit associated protein 3
chr20_+_11168298 0.00 ENSRNOT00000032240
trafficking protein particle complex 10
chr14_+_84465515 0.00 ENSRNOT00000035591
oncostatin M
chr7_+_77966722 0.00 ENSRNOT00000006142
collagen triple helix repeat containing 1
chr16_-_19349080 0.00 ENSRNOT00000038494
hematopoietic SH2 domain containing
chr7_+_126096793 0.00 ENSRNOT00000047234
ENSRNOT00000088042
fibulin 1
chr8_+_128972311 0.00 ENSRNOT00000025460
myosin VIIA and Rab interacting protein
chr19_-_57484566 0.00 ENSRNOT00000025548
tetratricopeptide repeat domain 13
chr20_-_13458110 0.00 ENSRNOT00000072183
solute carrier family 5 member 4
chr1_+_185673177 0.00 ENSRNOT00000048020
SRY box 6
chr7_-_2986935 0.00 ENSRNOT00000081125
ENSRNOT00000006578
proliferation-associated 2G4
chr19_-_25914689 0.00 ENSRNOT00000091994
ENSRNOT00000039354
nuclear factor 1 X
chr12_+_37805332 0.00 ENSRNOT00000048528
phosphatidylinositol transfer protein, membrane-associated 2
chr1_-_282251257 0.00 ENSRNOT00000015186
peroxiredoxin 3
chr10_-_15960673 0.00 ENSRNOT00000036447
similar to RIKEN cDNA 4930524B15
chr3_+_138508899 0.00 ENSRNOT00000009437
lysine acetyltransferase 14
chr7_+_60316045 0.00 ENSRNOT00000064594
lysozyme C type 2

Network of associatons between targets according to the STRING database.

First level regulatory network of Hes5_Hes7

PNG image of the network

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Gene Ontology Analysis

Gene overrepresentation in biological process category:

Log-likelihood per target  Total log-likelihood Term Description
0.0 0.1 GO:0060478 acrosomal vesicle exocytosis(GO:0060478)
0.0 0.1 GO:0071529 cementum mineralization(GO:0071529)
0.0 0.1 GO:0070494 regulation of thrombin receptor signaling pathway(GO:0070494) negative regulation of thrombin receptor signaling pathway(GO:0070495)
0.0 0.1 GO:2000417 negative regulation of phagocytosis, engulfment(GO:0060101) negative regulation of eosinophil migration(GO:2000417)
0.0 0.3 GO:0000185 activation of MAPKKK activity(GO:0000185)
0.0 0.1 GO:2000259 positive regulation of complement activation(GO:0045917) positive regulation of protein activation cascade(GO:2000259)
0.0 0.1 GO:0010424 DNA methylation on cytosine within a CG sequence(GO:0010424) phenotypic switching(GO:0036166)
0.0 0.0 GO:1900740 regulation of protein insertion into mitochondrial membrane involved in apoptotic signaling pathway(GO:1900739) positive regulation of protein insertion into mitochondrial membrane involved in apoptotic signaling pathway(GO:1900740)
0.0 0.0 GO:0060084 synaptic transmission involved in micturition(GO:0060084)
0.0 0.1 GO:0060631 meiotic DNA double-strand break formation(GO:0042138) regulation of meiosis I(GO:0060631)

Gene overrepresentation in cellular component category:

Log-likelihood per target  Total log-likelihood Term Description
0.0 0.1 GO:0031315 extrinsic component of mitochondrial outer membrane(GO:0031315)
0.0 0.1 GO:0065010 extracellular membrane-bounded organelle(GO:0065010)

Gene overrepresentation in molecular function category:

Log-likelihood per target  Total log-likelihood Term Description
0.0 0.1 GO:0004807 triose-phosphate isomerase activity(GO:0004807)
0.0 0.1 GO:0031871 proteinase activated receptor binding(GO:0031871)
0.0 0.1 GO:0019776 Atg8 ligase activity(GO:0019776)
0.0 0.0 GO:0071535 RING-like zinc finger domain binding(GO:0071535)
0.0 0.1 GO:0004035 alkaline phosphatase activity(GO:0004035)

Gene overrepresentation in curated gene sets: REACTOME pathways category:

Log-likelihood per target  Total log-likelihood Term Description
0.0 0.3 REACTOME G BETA GAMMA SIGNALLING THROUGH PLC BETA Genes involved in G beta:gamma signalling through PLC beta