ISMARA results: Hes5

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GSE49485: Hypoxia transcriptome sequencing of rat brain.

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Results for Hes5_Hes7

Z-value: 0.41

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Transcription factors associated with Hes5_Hes7

Gene Symbol	Gene ID	Gene Info
Hes5 NCBI RGD Ensembl	ENSRNOG00000013850	hes family bHLH transcription factor 5
Hes7 NCBI RGD Ensembl	ENSRNOG00000007391	hes family bHLH transcription factor 7

Activity-expression correlation:

Gene	Promoter	Pearson corr. coef.	P-value	Plot
Hes7	rn6_v1_chr10_+_55707164_55707164	0.42	4.8e-01	Click!
Hes5	rn6_v1_chr5_+_172364421_172364421	-0.11	8.6e-01	Click!

Activity profile of Hes5_Hes7 motif

Sorted Z-values of Hes5_Hes7 motif

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Promoter	Log-likelihood	Transcript	Gene	Gene Info
chr17_-_90315492 Show fit	0.31	ENSRNOT00000070807	Gng4 NCBI RGD Ensembl Show fit	G protein subunit gamma 4
chr17_-_13393243 Show fit	0.29	ENSRNOT00000018252	Gadd45g NCBI RGD Ensembl Show fit	growth arrest and DNA-damage-inducible, gamma
chr3_+_159569363 Show fit	0.18	ENSRNOT00000064159	Tox2 NCBI RGD Ensembl Show fit	TOX high mobility group box family member 2
chr10_+_91710495 Show fit	0.10	ENSRNOT00000033276	Rprml NCBI RGD Ensembl Show fit	reprimo-like
chr2_+_206064394 Show fit	0.10	ENSRNOT00000077739	Syt6 NCBI RGD Ensembl Show fit	synaptotagmin 6
chr5_+_152681101 Show fit	0.10	ENSRNOT00000076052 ENSRNOT00000022574	Stmn1 NCBI RGD Ensembl Show fit	stathmin 1
chr3_+_59981959 Show fit	0.10	ENSRNOT00000030460	Sp9 NCBI RGD Ensembl Show fit	Sp9 transcription factor
chr11_-_60613718 Show fit	0.08	ENSRNOT00000002906	Atg3 NCBI RGD Ensembl Show fit	autophagy related 3
chr9_-_10054359 Show fit	0.08	ENSRNOT00000072001	Clpp NCBI RGD Ensembl Show fit	caseinolytic mitochondrial matrix peptidase proteolytic subunit
chr2_+_197682000 Show fit	0.07	ENSRNOT00000066821	Hormad1 NCBI RGD Ensembl Show fit	HORMA domain containing 1

Showing 1 to 10 of 131 entries

Network of associatons between targets according to the STRING database.

First level regulatory network of Hes5_Hes7

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Gene Ontology Analysis

Gene overrepresentation in biological process category:

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Total log-likelihood	Term	Description
0.3	GO:0000185	activation of MAPKKK activity(GO:0000185)
0.1	GO:0060478	acrosomal vesicle exocytosis(GO:0060478)
0.1	GO:0071529	cementum mineralization(GO:0071529)
0.1	GO:0070494	regulation of thrombin receptor signaling pathway(GO:0070494) negative regulation of thrombin receptor signaling pathway(GO:0070495)
0.1	GO:2000417	negative regulation of phagocytosis, engulfment(GO:0060101) negative regulation of eosinophil migration(GO:2000417)
0.1	GO:2000259	positive regulation of complement activation(GO:0045917) positive regulation of protein activation cascade(GO:2000259)
0.1	GO:0010424	DNA methylation on cytosine within a CG sequence(GO:0010424) phenotypic switching(GO:0036166)
0.1	GO:0060631	meiotic DNA double-strand break formation(GO:0042138) regulation of meiosis I(GO:0060631)
0.0	GO:1900740	regulation of protein insertion into mitochondrial membrane involved in apoptotic signaling pathway(GO:1900739) positive regulation of protein insertion into mitochondrial membrane involved in apoptotic signaling pathway(GO:1900740)
0.0	GO:0060084	synaptic transmission involved in micturition(GO:0060084)

Showing 1 to 10 of 10 entries

Gene overrepresentation in cellular component category:

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Log-likelihood per target	Total log-likelihood	Term	Description
0.0	0.1	GO:0031315	extrinsic component of mitochondrial outer membrane(GO:0031315)
0.0	0.1	GO:0065010	extracellular membrane-bounded organelle(GO:0065010)

Showing 1 to 2 of 2 entries

Gene overrepresentation in molecular function category:

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Total log-likelihood	Term	Description
0.1	GO:0004807	triose-phosphate isomerase activity(GO:0004807)
0.1	GO:0031871	proteinase activated receptor binding(GO:0031871)
0.1	GO:0019776	Atg8 ligase activity(GO:0019776)
0.1	GO:0004035	alkaline phosphatase activity(GO:0004035)
0.0	GO:0071535	RING-like zinc finger domain binding(GO:0071535)

Showing 1 to 5 of 5 entries

Gene overrepresentation in curated gene sets: REACTOME pathways category:

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Log-likelihood per target	Total log-likelihood	Term	Description
0.0	0.3	REACTOME G BETA GAMMA SIGNALLING THROUGH PLC BETA	Genes involved in G beta:gamma signalling through PLC beta

Showing 1 to 1 of 1 entries

Results for Hes5_Hes7

Z-value: 0.41

Motif logo

Transcription factors associated with Hes5_Hes7

Activity-expression correlation:

Activity profile of Hes5_Hes7 motif

Sorted Z-values of Hes5_Hes7 motif

Top targets:

Network of associatons between targets according to the STRING database.

First level regulatory network of Hes5_Hes7

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Gene Ontology Analysis

Gene overrepresentation in biological process category:

Gene overrepresentation in cellular component category:

Gene overrepresentation in molecular function category:

Gene overrepresentation in curated gene sets: REACTOME pathways category: