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GSE49485: Hypoxia transcriptome sequencing of rat brain.
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Results for Hcfc1_Six5_Smarcc2_Zfp143
Z-value: 2.16
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Transcription factors associated with Hcfc1_Six5_Smarcc2_Zfp143
| Gene Symbol | Gene ID | Gene Info |
|---|---|---|
| ENSRNOG00000051948 | host cell factor C1 | |
| ENSRNOG00000060146 | SIX homeobox 5 | |
| ENSRNOG00000031135 | SWI/SNF related, matrix associated, actin dependent regulator of chromatin, subfamily c, member 2 | |
| ENSRNOG00000010087 | zinc finger protein 143 |
Activity-expression correlation:
| Gene | Promoter | Pearson corr. coef. | P-value | Plot |
|---|---|---|---|---|
| Six5 | rn6_v1_chr1_+_80000165_80000165 | 0.79 | 1.1e-01 | Click! |
| Hcfc1 | rn6_v1_chrX_+_156812064_156812064 | 0.72 | 1.7e-01 | Click! |
| Zfp143 | rn6_v1_chr1_+_174702373_174702373 | 0.52 | 3.6e-01 | Click! |
| Smarcc2 | rn6_v1_chr7_+_2875909_2875909 | 0.14 | 8.2e-01 | Click! |
| Promoter | Log-likelihood | Transcript | Gene | Gene Info |
|---|---|---|---|---|
| chr19_+_54766589 Show fit | 1.83 |
ENSRNOT00000025894
|
Btg3 associated nuclear protein |
|
| chr13_-_68785760 Show fit | 1.47 |
ENSRNOT00000086460
ENSRNOT00000044255 |
SWT1 RNA endoribonuclease homolog |
|
| chr6_-_115616766 Show fit | 1.24 |
ENSRNOT00000006143
ENSRNOT00000045870 |
SEL1L ERAD E3 ligase adaptor subunit |
|
| chr13_+_68785827 Show fit | 1.17 |
ENSRNOT00000003517
|
tRNA methyltransferase 1-like |
|
| chr14_+_38192446 Show fit | 0.99 |
ENSRNOT00000090242
|
nuclear transcription factor, X-box binding-like 1 |
|
| chr5_+_165922915 Show fit | 0.94 |
ENSRNOT00000089179
ENSRNOT00000059522 |
DNA fragmentation factor subunit alpha |
|
| chr13_-_51784639 Show fit | 0.93 |
ENSRNOT00000089068
|
protein phosphatase 1, regulatory subunit 12B |
|
| chr5_+_152606847 Show fit | 0.83 |
ENSRNOT00000089070
|
platelet-activating factor acetylhydrolase 2 |
|
| chr11_+_47146308 Show fit | 0.79 |
ENSRNOT00000002191
|
centrosomal protein 97 |
|
| chr5_-_169167831 Show fit | 0.77 |
ENSRNOT00000012407
|
PHD finger protein 13 |
Network of associatons between targets according to the STRING database.
First level regulatory network of Hcfc1_Six5_Smarcc2_Zfp143
Gene Ontology Analysis
Gene overrepresentation in biological process category:
| Log-likelihood per target | Total log-likelihood | Term | Description |
|---|---|---|---|
| 0.1 | 1.7 | GO:0030488 | tRNA methylation(GO:0030488) |
| 0.0 | 1.6 | GO:0042177 | negative regulation of protein catabolic process(GO:0042177) |
| 0.1 | 1.5 | GO:0030970 | retrograde protein transport, ER to cytosol(GO:0030970) |
| 0.0 | 1.3 | GO:0000245 | spliceosomal complex assembly(GO:0000245) |
| 0.2 | 1.1 | GO:0032074 | negative regulation of nuclease activity(GO:0032074) |
| 0.1 | 1.0 | GO:0014029 | neural crest formation(GO:0014029) |
| 0.1 | 0.9 | GO:0051292 | nuclear pore complex assembly(GO:0051292) |
| 0.1 | 0.8 | GO:0007076 | mitotic chromosome condensation(GO:0007076) |
| 0.1 | 0.8 | GO:1902018 | negative regulation of cilium assembly(GO:1902018) |
| 0.0 | 0.8 | GO:0006284 | base-excision repair(GO:0006284) |
Gene overrepresentation in cellular component category:
| Log-likelihood per target | Total log-likelihood | Term | Description |
|---|---|---|---|
| 0.0 | 2.1 | GO:0035097 | histone methyltransferase complex(GO:0035097) |
| 0.0 | 1.5 | GO:0005788 | endoplasmic reticulum lumen(GO:0005788) |
| 0.0 | 1.3 | GO:0005643 | nuclear pore(GO:0005643) |
| 0.0 | 1.2 | GO:0034451 | centriolar satellite(GO:0034451) |
| 0.4 | 1.1 | GO:0000839 | Hrd1p ubiquitin ligase ERAD-L complex(GO:0000839) |
| 0.0 | 1.0 | GO:0031463 | Cul3-RING ubiquitin ligase complex(GO:0031463) |
| 0.0 | 0.7 | GO:0035102 | PRC1 complex(GO:0035102) |
| 0.0 | 0.7 | GO:0031672 | A band(GO:0031672) |
| 0.2 | 0.6 | GO:0030956 | glutamyl-tRNA(Gln) amidotransferase complex(GO:0030956) |
| 0.1 | 0.6 | GO:0070044 | synaptobrevin 2-SNAP-25-syntaxin-1a complex(GO:0070044) |
Gene overrepresentation in molecular function category:
| Log-likelihood per target | Total log-likelihood | Term | Description |
|---|---|---|---|
| 0.0 | 2.2 | GO:0001078 | transcriptional repressor activity, RNA polymerase II core promoter proximal region sequence-specific binding(GO:0001078) |
| 0.0 | 1.6 | GO:0002039 | p53 binding(GO:0002039) |
| 0.4 | 1.2 | GO:0004809 | tRNA (guanine-N2-)-methyltransferase activity(GO:0004809) |
| 0.1 | 0.8 | GO:0003847 | 1-alkyl-2-acetylglycerophosphocholine esterase activity(GO:0003847) |
| 0.1 | 0.8 | GO:0070016 | armadillo repeat domain binding(GO:0070016) |
| 0.0 | 0.8 | GO:0016864 | protein disulfide isomerase activity(GO:0003756) intramolecular oxidoreductase activity, transposing S-S bonds(GO:0016864) |
| 0.0 | 0.8 | GO:0004198 | calcium-dependent cysteine-type endopeptidase activity(GO:0004198) |
| 0.0 | 0.8 | GO:0044183 | protein binding involved in protein folding(GO:0044183) |
| 0.0 | 0.8 | GO:0030374 | ligand-dependent nuclear receptor transcription coactivator activity(GO:0030374) |
| 0.1 | 0.7 | GO:1904264 | ubiquitin protein ligase activity involved in ERAD pathway(GO:1904264) |
Gene overrepresentation in curated gene sets: canonical pathways category:
| Log-likelihood per target | Total log-likelihood | Term | Description |
|---|---|---|---|
| 0.0 | 0.9 | SA CASPASE CASCADE | Apoptosis is mediated by caspases, cysteine proteases arranged in a proteolytic cascade. |
| 0.0 | 0.7 | PID MYC PATHWAY | C-MYC pathway |
| 0.0 | 0.7 | PID LKB1 PATHWAY | LKB1 signaling events |
| 0.0 | 0.2 | PID CIRCADIAN PATHWAY | Circadian rhythm pathway |
| 0.0 | 0.2 | PID SMAD2 3PATHWAY | Regulation of cytoplasmic and nuclear SMAD2/3 signaling |
Gene overrepresentation in curated gene sets: REACTOME pathways category:
| Log-likelihood per target | Total log-likelihood | Term | Description |
|---|---|---|---|
| 0.1 | 1.2 | REACTOME PRE NOTCH PROCESSING IN GOLGI | Genes involved in Pre-NOTCH Processing in Golgi |
| 0.0 | 0.8 | REACTOME TRANSPORT OF RIBONUCLEOPROTEINS INTO THE HOST NUCLEUS | Genes involved in Transport of Ribonucleoproteins into the Host Nucleus |
| 0.1 | 0.7 | REACTOME APOPTOSIS INDUCED DNA FRAGMENTATION | Genes involved in Apoptosis induced DNA fragmentation |
| 0.0 | 0.6 | REACTOME CIRCADIAN REPRESSION OF EXPRESSION BY REV ERBA | Genes involved in Circadian Repression of Expression by REV-ERBA |
| 0.2 | 0.5 | REACTOME CYCLIN E ASSOCIATED EVENTS DURING G1 S TRANSITION | Genes involved in Cyclin E associated events during G1/S transition |
| 0.0 | 0.5 | REACTOME HYALURONAN METABOLISM | Genes involved in Hyaluronan metabolism |
| 0.0 | 0.5 | REACTOME DEADENYLATION OF MRNA | Genes involved in Deadenylation of mRNA |
| 0.0 | 0.4 | REACTOME MRNA DECAY BY 3 TO 5 EXORIBONUCLEASE | Genes involved in mRNA Decay by 3' to 5' Exoribonuclease |
| 0.0 | 0.4 | REACTOME BRANCHED CHAIN AMINO ACID CATABOLISM | Genes involved in Branched-chain amino acid catabolism |
| 0.0 | 0.4 | REACTOME AMINO ACID SYNTHESIS AND INTERCONVERSION TRANSAMINATION | Genes involved in Amino acid synthesis and interconversion (transamination) |