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GSE49485: Hypoxia transcriptome sequencing of rat brain.

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Results for Hand1

Z-value: 0.30

Motif logo

Transcription factors associated with Hand1

Gene Symbol Gene ID Gene Info
ENSRNOG00000002582 heart and neural crest derivatives expressed 1

Activity profile of Hand1 motif

Sorted Z-values of Hand1 motif

Promoter Log-likelihood Transcript Gene Gene Info
chr20_+_5067330 0.27 ENSRNOT00000037482
lymphocyte antigen 6 complex, locus G6E
chr4_+_86275717 0.15 ENSRNOT00000016414
protein phosphatase 1, regulatory subunit 17
chr7_+_123168811 0.15 ENSRNOT00000007091
cold shock domain containing C2
chr1_+_198690794 0.15 ENSRNOT00000023999
zinc finger protein 771
chr7_+_142905758 0.12 ENSRNOT00000078663
nuclear receptor subfamily 4, group A, member 1
chr1_-_261446570 0.12 ENSRNOT00000020182
secreted frizzled-related protein 5
chr16_+_7303578 0.11 ENSRNOT00000025656
semaphorin 3G
chr20_+_5094468 0.10 ENSRNOT00000078576
abhydrolase domain containing 16A
chr1_+_86873253 0.10 ENSRNOT00000071239
F-box protein 27
chr1_-_216080287 0.09 ENSRNOT00000027682
tyrosine hydroxylase
chr10_-_64657089 0.09 ENSRNOT00000080703
active BCR-related
chr16_-_73827488 0.08 ENSRNOT00000064070
ankyrin 1
chr11_+_83048636 0.08 ENSRNOT00000002408
RGD1562339
chr12_-_46889082 0.08 ENSRNOT00000001525
phospholipase A2 group IB
chr6_-_136379348 0.07 ENSRNOT00000016208
X-ray repair cross complementing 3
chr3_-_11410732 0.07 ENSRNOT00000034930
similar to Hypothetical UPF0184 protein C9orf16 homolog
chr3_+_110982553 0.07 ENSRNOT00000030754
hypothetical protein LOC691418
chr3_+_175144495 0.07 ENSRNOT00000082601
ENSRNOT00000088026
cadherin 4
chr10_-_38838272 0.07 ENSRNOT00000089495
sosondowah ankyrin repeat domain family member A
chr8_-_119012671 0.07 ENSRNOT00000028435
parathyroid hormone 1 receptor
chr8_+_44847157 0.06 ENSRNOT00000080288
CXADR-like membrane protein
chr3_+_72540538 0.06 ENSRNOT00000012379
apelin receptor
chr6_-_15191660 0.06 ENSRNOT00000092654
neurexin 1
chr1_+_218076116 0.06 ENSRNOT00000028374
oral cancer overexpressed 1
chr15_-_26678420 0.06 ENSRNOT00000041420
similar to 3632451O06Rik protein
chr5_+_152613255 0.06 ENSRNOT00000037097
platelet-activating factor acetylhydrolase 2
chr8_+_70603249 0.06 ENSRNOT00000067016
ENSRNOT00000072486
immunoglobulin superfamily, DCC subclass, member 4
chr11_+_72044096 0.05 ENSRNOT00000034757
SUMO1/sentrin specific peptidase 5
chr3_+_101010899 0.05 ENSRNOT00000073258
lin-7 homolog C, crumbs cell polarity complex component
chr1_+_72661211 0.05 ENSRNOT00000033197
cytochrome c oxidase subunit VIb polypeptide 2
chr1_-_275906686 0.05 ENSRNOT00000092170
glycerol-3-phosphate acyltransferase, mitochondrial
chr4_+_66276835 0.05 ENSRNOT00000007544
formation of mitochondrial complex V assembly factor 1
chr4_-_117575154 0.05 ENSRNOT00000075813
probable N-acetyltransferase CML2-like
chr1_+_88182585 0.05 ENSRNOT00000044145
Yip1 interacting factor homolog B, membrane trafficking protein
chr13_+_52624878 0.05 ENSRNOT00000076054
ENSRNOT00000076299
troponin I1, slow skeletal type
chr17_-_10818835 0.05 ENSRNOT00000091046
complexin 2
chr16_+_35573058 0.05 ENSRNOT00000059580
polypeptide N-acetylgalactosaminyltransferase-like 6
chr20_+_3246739 0.05 ENSRNOT00000061299
RT1 class I, locus T24, gene 2
chr13_-_91872954 0.05 ENSRNOT00000004613
ENSRNOT00000079263
cell adhesion molecule 3
chr1_+_44446765 0.05 ENSRNOT00000030132
claudin 20
chr8_+_118662335 0.05 ENSRNOT00000029755
neutrophilic granule protein
chr1_+_217173199 0.05 ENSRNOT00000075078
SH3 and multiple ankyrin repeat domains 2
chr17_+_12762752 0.04 ENSRNOT00000044842
DIRAS family GTPase 2
chr15_-_48445588 0.04 ENSRNOT00000077197
ENSRNOT00000018583
exostosin-like glycosyltransferase 3
chr18_+_74299931 0.04 ENSRNOT00000078403
ectopic P-granules autophagy protein 5 homolog
chr14_+_60657686 0.04 ENSRNOT00000070892
Sep (O-phosphoserine) tRNA:Sec (selenocysteine) tRNA synthase
chr14_+_2613406 0.04 ENSRNOT00000000083
transmembrane p24 trafficking protein 5
chr3_-_3541947 0.04 ENSRNOT00000024786
NACC family member 2
chr11_+_9642365 0.04 ENSRNOT00000087080
ENSRNOT00000042384
roundabout guidance receptor 1
chr10_+_106264434 0.04 ENSRNOT00000003891
septin 9
chr12_+_16950728 0.04 ENSRNOT00000060370
integrator complex subunit 1
chr1_+_199196059 0.04 ENSRNOT00000090428
F-box and leucine-rich repeat protein 19
chr12_+_18074033 0.04 ENSRNOT00000001727
integrator complex subunit 1-like
chr4_-_155959993 0.04 ENSRNOT00000029072
C-type lectin domain family 4, member A1
chr3_+_62648447 0.04 ENSRNOT00000002111
alkylglycerone phosphate synthase
chrX_-_118998300 0.04 ENSRNOT00000025575

chr1_-_88826302 0.04 ENSRNOT00000028275
leucine rich repeat and fibronectin type III domain containing 3
chr20_+_4355175 0.04 ENSRNOT00000000510
G-protein signaling modulator 3
chr16_+_50152008 0.04 ENSRNOT00000019237
kallikrein B1
chr8_+_130538651 0.04 ENSRNOT00000026343
atypical chemokine receptor 2
chr10_-_95434688 0.04 ENSRNOT00000074809

chr9_+_92859988 0.03 ENSRNOT00000085332
calcium binding protein 39
chr2_+_198303168 0.03 ENSRNOT00000056262
myotubularin related protein 11
chr17_+_28504623 0.03 ENSRNOT00000021568
coagulation factor XIII A1 chain
chr2_+_144646308 0.03 ENSRNOT00000078337
ENSRNOT00000093407
doublecortin-like kinase 1
chr17_+_23135985 0.03 ENSRNOT00000090794
neural precursor cell expressed, developmentally down-regulated 9
chr7_+_120176530 0.03 ENSRNOT00000087548
TRIO and F-actin binding protein
chr1_+_87180624 0.03 ENSRNOT00000056933
ENSRNOT00000027987
protein YIF1B
chr20_-_2083688 0.03 ENSRNOT00000001011
ZNRD1 antisense RNA 1
chr10_+_69434941 0.03 ENSRNOT00000009756
C-C motif chemokine ligand 11
chr5_-_60559329 0.03 ENSRNOT00000017046
zinc finger and BTB domain containing 5
chr3_+_65816569 0.03 ENSRNOT00000079672
ubiquitin-conjugating enzyme E2E 3
chr3_-_94182714 0.03 ENSRNOT00000015073
hypothetical protein LOC100362814
chr4_-_123510217 0.03 ENSRNOT00000080734
solute carrier family 41, member 3
chr6_+_143938040 0.03 ENSRNOT00000005876
vasoactive intestinal peptide receptor 2
chr12_-_46809849 0.03 ENSRNOT00000081134
paxillin
chr11_-_70961358 0.03 ENSRNOT00000002427
leishmanolysin like peptidase
chr14_-_112946204 0.03 ENSRNOT00000056813
coiled-coil domain-containing protein 85A-like
chr9_-_121931564 0.03 ENSRNOT00000056243
thymidylate synthetase
chr10_-_90240509 0.03 ENSRNOT00000028407
ataxin 7-like 3
chr5_-_158439078 0.03 ENSRNOT00000025517
kelch domain containing 7A
chr6_+_12362813 0.03 ENSRNOT00000022370
stonin 1
chr10_+_34185898 0.03 ENSRNOT00000003339
tripartite motif-containing 7
chr12_+_15857805 0.03 ENSRNOT00000001667
IQ motif containing E
chr1_+_27476375 0.03 ENSRNOT00000047224
ENSRNOT00000075427
sodium/potassium-transporting ATPase subunit beta-1-interacting protein 2-like
chr8_+_58347736 0.03 ENSRNOT00000080227
ENSRNOT00000066222
solute carrier family 35, member F2
chr16_+_20432899 0.03 ENSRNOT00000026271
MPV17 mitochondrial inner membrane protein like 2
chr7_+_18409147 0.03 ENSRNOT00000086336
ENSRNOT00000011849
ADAM metallopeptidase with thrombospondin type 1 motif, 10
chr12_+_49665282 0.03 ENSRNOT00000086397
G protein-coupled receptor kinase 3
chr2_+_248398917 0.03 ENSRNOT00000045855
guanylate binding protein 1
chr2_+_58448917 0.03 ENSRNOT00000082562
RAN binding protein 3-like
chr2_+_200572502 0.03 ENSRNOT00000074666
zinc finger protein 697
chr8_-_132027006 0.03 ENSRNOT00000050963
similar to 60S RIBOSOMAL PROTEIN L7
chr3_+_162181974 0.03 ENSRNOT00000030203
solute carrier family 2 member 10
chr14_-_33677031 0.03 ENSRNOT00000002908
hypothetical LOC289568
chr1_+_88182155 0.03 ENSRNOT00000083176
Yip1 interacting factor homolog B, membrane trafficking protein
chr8_-_50526843 0.03 ENSRNOT00000092188

chrX_+_80213332 0.03 ENSRNOT00000042827
SH3 domain binding glutamate-rich protein like
chr4_+_34282625 0.03 ENSRNOT00000011138
ENSRNOT00000086735
glucocorticoid induced 1
chr10_+_105500290 0.03 ENSRNOT00000079080
ENSRNOT00000083593
sphingosine kinase 1
chr1_-_101008266 0.03 ENSRNOT00000081430
SR-related CTD-associated factor 1
chr7_+_54247460 0.03 ENSRNOT00000005361
pleckstrin homology-like domain, family A, member 1
chr6_+_136720266 0.03 ENSRNOT00000018278
kinesin family member 26A
chr8_-_55467579 0.03 ENSRNOT00000040162
ENSRNOT00000088607
layilin
chr1_+_84067938 0.03 ENSRNOT00000057213
NUMB-like, endocytic adaptor protein
chr14_+_108826831 0.03 ENSRNOT00000083146
ENSRNOT00000009421
B-cell CLL/lymphoma 11A
chr13_-_52197205 0.03 ENSRNOT00000009712
shisa family member 4
chr7_+_144080614 0.03 ENSRNOT00000077687
poly(rC) binding protein 2
chr12_-_37047628 0.03 ENSRNOT00000001337
refilin A
chr6_-_21112734 0.02 ENSRNOT00000079819
RAS guanyl releasing protein 3
chr6_+_44230985 0.02 ENSRNOT00000005858
kinase D-interacting substrate 220
chr12_-_50313976 0.02 ENSRNOT00000000824
Hermansky-Pudlak syndrome 4
chr1_+_225015616 0.02 ENSRNOT00000026416
heterogeneous nuclear ribonucleoprotein U-like 2
chr15_+_43298794 0.02 ENSRNOT00000012736
adrenoceptor alpha 1A
chr7_-_118396728 0.02 ENSRNOT00000066431
RNA binding protein, fox-1 homolog 2
chr11_+_61662270 0.02 ENSRNOT00000079521
zinc finger, DHHC-type containing 23
chr1_-_90962466 0.02 ENSRNOT00000080613
alpha-ketoglutarate-dependent dioxygenase alkB homolog 6
chr8_-_125645898 0.02 ENSRNOT00000036672
RNA binding motif, single stranded interacting protein 3
chr16_+_70081035 0.02 ENSRNOT00000016098
ubiquitin carboxyl-terminal hydrolase 12-like
chr1_-_125967756 0.02 ENSRNOT00000031488
family with sequence similarity 189, member A1
chr12_+_37211316 0.02 ENSRNOT00000032739
coiled-coil domain containing 92
chr13_-_79744939 0.02 ENSRNOT00000076706
SUN domain containing ossification factor
chr14_-_12387102 0.02 ENSRNOT00000038872
bone morphogenetic protein 3
chr1_+_217345154 0.02 ENSRNOT00000092516
SH3 and multiple ankyrin repeat domains 2
chr12_+_41200718 0.02 ENSRNOT00000038426
ENSRNOT00000048450
ENSRNOT00000067176
2'-5' oligoadenylate synthetase 1A
chr7_+_72924799 0.02 ENSRNOT00000008969
lysosomal protein transmembrane 4 beta
chr19_-_25345790 0.02 ENSRNOT00000010050
zinc finger, SWIM-type containing 4
chr1_+_84685931 0.02 ENSRNOT00000063839
zinc finger protein 780B
chr12_-_50314406 0.02 ENSRNOT00000079256
Hermansky-Pudlak syndrome 4
chr14_+_84417320 0.02 ENSRNOT00000008788
TBC1 domain family, member 10a
chr1_-_69743616 0.02 ENSRNOT00000030259
zinc finger protein 772
chr5_+_139790395 0.02 ENSRNOT00000015033
regulating synaptic membrane exocytosis 3
chr5_-_147828449 0.02 ENSRNOT00000083369
coiled coil domain containing 28B
chr1_-_100234040 0.02 ENSRNOT00000079199
acid phosphatase, testicular
chr1_-_64446818 0.02 ENSRNOT00000081980
myeloid-associated differentiation marker
chr2_+_188141350 0.02 ENSRNOT00000078913
gon-4 like
chr1_+_140762758 0.02 ENSRNOT00000047848
aggrecan
chrX_+_151103576 0.02 ENSRNOT00000015401
SLIT and NTRK-like family, member 2
chr1_+_218569510 0.02 ENSRNOT00000019652
carnitine palmitoyltransferase 1A
chr7_+_2827247 0.02 ENSRNOT00000090689
ring finger protein 41
chr10_-_70172739 0.02 ENSRNOT00000010015
ring finger and FYVE-like domain containing E3 ubiquitin protein ligase
chr20_+_3156170 0.02 ENSRNOT00000082880
RT1 class Ib, locus S2
chr4_-_157008947 0.02 ENSRNOT00000073341
peroxisomal biogenesis factor 5
chr2_-_189395746 0.02 ENSRNOT00000089042
ubiquitin associated protein 2-like
chr1_+_280383579 0.02 ENSRNOT00000064022
ENSRNOT00000042977
potassium two pore domain channel subfamily K member 18
chr3_+_22854768 0.02 ENSRNOT00000014630
NIMA-related kinase 6
chr7_+_130474279 0.02 ENSRNOT00000092388
SH3 and multiple ankyrin repeat domains 3
chr4_-_156427755 0.02 ENSRNOT00000085675
ENSRNOT00000014030
peroxisomal targeting signal 1 receptor-like
chr20_+_48212378 0.02 ENSRNOT00000040519

chr1_+_88766872 0.02 ENSRNOT00000051259
alkB homolog 6
chr2_-_210282352 0.02 ENSRNOT00000075653
solute carrier family 6 member 17
chr8_+_115546893 0.02 ENSRNOT00000018932
DDB1 and CUL4 associated factor 1
chr2_-_188216482 0.02 ENSRNOT00000027579
misato 1, mitochondrial distribution and morphology regulator
chr1_-_212633304 0.02 ENSRNOT00000025611
olfactory receptor 286
chr9_+_52687868 0.02 ENSRNOT00000083864
WD repeat domain 75
chr6_+_107428508 0.02 ENSRNOT00000013431
similar to RIKEN cDNA 2410016O06
chr11_-_74315248 0.02 ENSRNOT00000002346
hes family bHLH transcription factor 1
chr1_+_105285419 0.02 ENSRNOT00000089693
solute carrier family 6 member 5
chr13_-_35668968 0.02 ENSRNOT00000042862
ENSRNOT00000003428
erythrocyte membrane protein band 4.1 like 5
chr3_+_164275095 0.02 ENSRNOT00000077581
snail family transcriptional repressor 1
chr1_-_165967069 0.02 ENSRNOT00000089359
Rho guanine nucleotide exchange factor (GEF) 17
chr10_+_15620871 0.02 ENSRNOT00000089435
ENSRNOT00000066430
NPR3-like, GATOR1 complex subunit
chr4_-_170810080 0.02 ENSRNOT00000082312
WW domain binding protein 11
chr1_+_266952561 0.02 ENSRNOT00000076452
neuralized E3 ubiquitin protein ligase 1
chr7_-_47586137 0.02 ENSRNOT00000006086
transmembrane and tetratricopeptide repeat containing 2
chr9_+_86874685 0.02 ENSRNOT00000041337
neuronal tyrosine-phosphorylated phosphoinositide-3-kinase adaptor 2
chr5_-_34813116 0.02 ENSRNOT00000017479
Sodium/potassium transporting ATPase interacting 3
chr1_-_72461547 0.02 ENSRNOT00000022480
scavenger receptor cysteine rich family member with 5 domains
chr5_-_169160987 0.02 ENSRNOT00000055487
THAP domain containing 3
chr7_+_118685022 0.02 ENSRNOT00000089135
apolipoprotein L, 3
chr7_+_38819771 0.02 ENSRNOT00000006109
lumican
chr18_-_61057365 0.02 ENSRNOT00000042352
alpha-kinase 2
chr2_-_197878142 0.02 ENSRNOT00000087052
threonyl-tRNA synthetase 2, mitochondrial (putative)
chr1_-_220188541 0.01 ENSRNOT00000026968
dipeptidylpeptidase 3
chrX_+_62727755 0.01 ENSRNOT00000077055
phosphate cytidylyltransferase 1, choline, beta
chr7_+_3216497 0.01 ENSRNOT00000008909
matrix metallopeptidase 19
chr8_-_76579387 0.01 ENSRNOT00000090747
family with sequence similarity 81, member A
chr7_+_120106901 0.01 ENSRNOT00000063876
golgi associated, gamma adaptin ear containing, ARF binding protein 1
chr5_-_99033107 0.01 ENSRNOT00000041306
heat shock protein family A (Hsp70) member 8
chr10_-_88677055 0.01 ENSRNOT00000025590
GH3 domain containing
chr15_+_52557607 0.01 ENSRNOT00000019222
GDNF family receptor alpha 2
chr2_+_189062443 0.01 ENSRNOT00000028181
adenosine deaminase, RNA-specific
chr1_-_153740905 0.01 ENSRNOT00000023239
protease, serine, 23
chr17_+_10384511 0.01 ENSRNOT00000024357
synuclein, beta
chr4_-_117568348 0.01 ENSRNOT00000071447
N-acetyltransferase 8 (GCN5-related) family member 2
chr1_-_165997751 0.01 ENSRNOT00000050227
pyrimidinergic receptor P2Y6
chr13_-_110678389 0.01 ENSRNOT00000082906

chr10_-_55783489 0.01 ENSRNOT00000010415
arachidonate 15-lipoxygenase, type B
chr14_-_37871051 0.01 ENSRNOT00000003087
SLAIN motif family, member 2
chr6_+_136720582 0.01 ENSRNOT00000086868
kinesin family member 26A
chr8_+_131845696 0.01 ENSRNOT00000005440
T cell activation inhibitor, mitochondrial
chr16_+_24797124 0.01 ENSRNOT00000018976
neuropeptide Y receptor Y5
chr5_-_137125737 0.01 ENSRNOT00000088532

chr18_+_63203063 0.01 ENSRNOT00000024144
PRELI domain containing 3A
chr14_-_2032593 0.01 ENSRNOT00000000037
fibroblast growth factor receptor-like 1
chr13_-_74331214 0.01 ENSRNOT00000006018
FAM20B, glycosaminoglycan xylosylkinase
chr7_-_98098268 0.01 ENSRNOT00000010361
F-box protein 32
chr11_-_88177448 0.01 ENSRNOT00000085475
yippee-like 1
chrX_+_1311121 0.01 ENSRNOT00000038909
complement factor properdin
chr5_+_157434481 0.01 ENSRNOT00000088556
transmembrane and coiled-coil domains 4

Network of associatons between targets according to the STRING database.

First level regulatory network of Hand1

PNG image of the network

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Gene Ontology Analysis

Gene overrepresentation in biological process category:

Log-likelihood per target  Total log-likelihood Term Description
0.0 0.1 GO:2000041 Wnt signaling pathway involved in digestive tract morphogenesis(GO:0044333) regulation of planar cell polarity pathway involved in axis elongation(GO:2000040) negative regulation of planar cell polarity pathway involved in axis elongation(GO:2000041)
0.0 0.1 GO:0043314 negative regulation of neutrophil degranulation(GO:0043314)
0.0 0.1 GO:0046462 monoacylglycerol metabolic process(GO:0046462) monoacylglycerol catabolic process(GO:0052651)
0.0 0.1 GO:0052314 phytoalexin metabolic process(GO:0052314)
0.0 0.1 GO:0043435 response to corticotropin-releasing hormone(GO:0043435) cellular response to corticotropin-releasing hormone stimulus(GO:0071376)
0.0 0.1 GO:0044778 meiotic DNA integrity checkpoint(GO:0044778)
0.0 0.0 GO:0021836 chemorepulsion involved in postnatal olfactory bulb interneuron migration(GO:0021836)
0.0 0.1 GO:0097117 guanylate kinase-associated protein clustering(GO:0097117)
0.0 0.0 GO:0001560 regulation of cell growth by extracellular stimulus(GO:0001560)
0.0 0.1 GO:0000707 meiotic DNA recombinase assembly(GO:0000707)
0.0 0.0 GO:0001983 baroreceptor response to increased systemic arterial blood pressure(GO:0001983)
0.0 0.0 GO:1901491 negative regulation of lymphangiogenesis(GO:1901491)
0.0 0.0 GO:0009177 pyrimidine deoxyribonucleoside monophosphate biosynthetic process(GO:0009177) dUMP metabolic process(GO:0046078)
0.0 0.3 GO:0022401 desensitization of G-protein coupled receptor protein signaling pathway(GO:0002029) negative adaptation of signaling pathway(GO:0022401)

Gene overrepresentation in cellular component category:

Log-likelihood per target  Total log-likelihood Term Description
0.0 0.1 GO:0033063 Rad51B-Rad51C-Rad51D-XRCC2 complex(GO:0033063)
0.0 0.0 GO:0097025 MPP7-DLG1-LIN7 complex(GO:0097025)
0.0 0.1 GO:0045009 melanosome membrane(GO:0033162) chitosome(GO:0045009)

Gene overrepresentation in molecular function category:

Log-likelihood per target  Total log-likelihood Term Description
0.0 0.2 GO:0004865 protein serine/threonine phosphatase inhibitor activity(GO:0004865)
0.0 0.3 GO:0033130 acetylcholine receptor binding(GO:0033130)
0.0 0.1 GO:0008093 cytoskeletal adaptor activity(GO:0008093)
0.0 0.1 GO:0016714 oxidoreductase activity, acting on paired donors, with incorporation or reduction of molecular oxygen, reduced pteridine as one donor, and incorporation of one atom of oxygen(GO:0016714)
0.0 0.1 GO:0000150 recombinase activity(GO:0000150)
0.0 0.0 GO:0004999 vasoactive intestinal polypeptide receptor activity(GO:0004999)
0.0 0.1 GO:0097016 L27 domain binding(GO:0097016)