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GSE49485: Hypoxia transcriptome sequencing of rat brain.

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Results for Gsx2_Hoxd3_Vax1

Z-value: 0.36

Motif logo

Transcription factors associated with Gsx2_Hoxd3_Vax1

Gene Symbol Gene ID Gene Info
ENSRNOG00000002266 GS homeobox 2
ENSRNOG00000001577 homeo box D3
ENSRNOG00000008824 ventral anterior homeobox 1

Activity-expression correlation:

GenePromoterPearson corr. coef.P-valuePlot
Vax1rn6_v1_chr1_-_280338813_280338813-0.761.4e-01Click!
Hoxd3rn6_v1_chr3_+_61658245_61658245-0.682.1e-01Click!
Gsx2rn6_v1_chr14_-_35652709_356527090.543.5e-01Click!

Activity profile of Gsx2_Hoxd3_Vax1 motif

Sorted Z-values of Gsx2_Hoxd3_Vax1 motif

Promoter Log-likelihood Transcript Gene Gene Info
chr7_-_143353925 0.31 ENSRNOT00000068533
keratin 71
chr5_+_50381244 0.20 ENSRNOT00000012385
glycoprotein hormones, alpha polypeptide
chr2_-_219262901 0.16 ENSRNOT00000037068
G-protein coupled receptor 88
chr8_+_33239139 0.13 ENSRNOT00000011589
Rho GTPase activating protein 32
chr13_+_60619309 0.11 ENSRNOT00000082129

chr2_+_66940057 0.10 ENSRNOT00000043050
cadherin 9
chrX_-_106607352 0.08 ENSRNOT00000082858

chr13_-_89545182 0.08 ENSRNOT00000078402
Purkinje cell protein 4-like 1
chr4_-_55011415 0.08 ENSRNOT00000056996
glutamate metabotropic receptor 8
chr2_-_60657712 0.08 ENSRNOT00000040348
retinoic acid induced 14
chr3_-_90751055 0.07 ENSRNOT00000040741
LRRGT00091
chr2_-_138833933 0.07 ENSRNOT00000013343
protocadherin 18
chr9_-_44419998 0.07 ENSRNOT00000091397
ENSRNOT00000083747
testis specific 10
chr5_-_17061837 0.07 ENSRNOT00000011892
proenkephalin
chr8_-_33121002 0.07 ENSRNOT00000047211
LRRGT00010-like
chr7_-_76488216 0.07 ENSRNOT00000080024
neurocalcin delta
chr5_-_17061361 0.06 ENSRNOT00000089318
proenkephalin
chr3_+_15560712 0.06 ENSRNOT00000010218
prostaglandin-endoperoxide synthase 1
chr7_+_71157664 0.06 ENSRNOT00000005919
short chain dehydrogenase/reductase family 9C, member 7
chr7_-_14364178 0.06 ENSRNOT00000090673
A-kinase anchoring protein 8 like
chr7_-_101138860 0.05 ENSRNOT00000077137

chr6_-_108660063 0.05 ENSRNOT00000006240
apoptosis resistant E3 ubiquitin protein ligase 1
chr8_+_22559098 0.05 ENSRNOT00000041091
hypothetical protein LOC691141
chr20_-_13994794 0.05 ENSRNOT00000093466
gamma-glutamyltransferase 5
chr1_+_59156251 0.05 ENSRNOT00000017442
limb and CNS expressed 1
chr8_+_22648323 0.04 ENSRNOT00000013165
SWI/SNF related, matrix associated, actin dependent regulator of chromatin, subfamily a, member 4
chr8_+_44136496 0.04 ENSRNOT00000087022
sodium voltage-gated channel beta subunit 3
chr11_-_32550539 0.04 ENSRNOT00000002715
regulator of calcineurin 1
chr3_+_72385666 0.04 ENSRNOT00000011168
proteoglycan 2
chr8_-_104155775 0.04 ENSRNOT00000042885
60S ribosomal protein L31-like
chr16_+_71889235 0.04 ENSRNOT00000038266
ADAM metallopeptidase domain 32
chr3_-_145810834 0.04 ENSRNOT00000075429
zinc finger protein 120-like
chr2_+_187447501 0.04 ENSRNOT00000038589
IQ motif containing GTPase activating protein 3
chr11_-_62067655 0.03 ENSRNOT00000093382
zinc finger and BTB domain containing 20
chr9_-_30844199 0.03 ENSRNOT00000017169
collagen type XIX alpha 1 chain
chr2_+_54466280 0.03 ENSRNOT00000033112
complement C6
chr2_+_252090669 0.03 ENSRNOT00000020656
lysophosphatidic acid receptor 3
chr7_-_107203897 0.03 ENSRNOT00000086263
leucine rich repeat containing 6
chr20_-_30947484 0.03 ENSRNOT00000065614
phosphatase domain containing, paladin 1
chr3_-_165537940 0.03 ENSRNOT00000071119
ENSRNOT00000070964
spalt-like transcription factor 4
chr11_-_29710849 0.03 ENSRNOT00000029345
keratin associated protein 11-1
chr9_+_111279495 0.03 ENSRNOT00000072791
diphosphoinositol pentakisphosphate kinase 2
chr7_-_145062956 0.03 ENSRNOT00000055274
similar to CDNA sequence BC048502
chr2_-_149432106 0.03 ENSRNOT00000051027
purinergic receptor P2Y13
chr5_-_161981441 0.03 ENSRNOT00000020316
podoplanin
chr18_-_69780922 0.03 ENSRNOT00000079093
malic enzyme 2
chr6_-_104290579 0.03 ENSRNOT00000066014
enhancer of rudimentary homolog (Drosophila)
chr1_+_48077033 0.03 ENSRNOT00000020100
MAS1 proto-oncogene, G protein-coupled receptor
chr3_-_111087347 0.03 ENSRNOT00000018277
ras homolog family member V
chr7_+_133856101 0.03 ENSRNOT00000038686
PDZ domain containing RING finger 4
chr7_-_15821927 0.03 ENSRNOT00000050658
similar to zinc finger protein 101
chr2_+_158097843 0.03 ENSRNOT00000016541
pentraxin 3
chr5_+_187312 0.03 ENSRNOT00000030857
zinc finger protein 120-like
chr20_+_3176107 0.02 ENSRNOT00000001036
RT1 class Ib, locus S3
chr2_-_25235275 0.02 ENSRNOT00000061580
F2R like trypsin receptor 1
chr1_+_141767940 0.02 ENSRNOT00000064034
zinc finger protein 710
chr8_+_59344083 0.02 ENSRNOT00000031175
cellular retinoic acid binding protein 1
chr20_-_5166448 0.02 ENSRNOT00000076331
allograft inflammatory factor 1
chr17_-_43807540 0.02 ENSRNOT00000074763
similar to CG31613-PA
chr19_+_25143428 0.02 ENSRNOT00000007535
paralemmin 3
chr1_+_80279706 0.02 ENSRNOT00000047105
protein phosphatase 1, regulatory subunit 13 like
chr17_-_54678710 0.02 ENSRNOT00000046013
zinc finger E-box binding homeobox 1
chr1_+_260093641 0.02 ENSRNOT00000019521
cyclin J
chr9_-_44237117 0.02 ENSRNOT00000068496
similar to putative protein (5S487)
chr7_-_143967484 0.02 ENSRNOT00000081758
Sp7 transcription factor
chr7_-_143497108 0.02 ENSRNOT00000048613
keratin 76
chr5_-_133959447 0.02 ENSRNOT00000011985
cytochrome P450, family 4, subfamily x, polypeptide 1
chrX_+_144994139 0.02 ENSRNOT00000071783
pre-mRNA-splicing factor CWC22 homolog
chr17_-_84247038 0.02 ENSRNOT00000068553
nebulette
chr2_+_143656793 0.02 ENSRNOT00000084527
ENSRNOT00000017453
periostin
chr13_-_82005741 0.02 ENSRNOT00000076404
methyltransferase like 11B
chr6_-_144123596 0.02 ENSRNOT00000006144
ENSRNOT00000087845
WD repeat domain 60
chr6_+_29977797 0.02 ENSRNOT00000071784
FK506 binding protein 1B
chr1_-_252461461 0.02 ENSRNOT00000026093
ankyrin repeat domain 22
chr5_-_147412705 0.02 ENSRNOT00000010688
similar to mKIAA1522 protein
chr8_-_84835060 0.02 ENSRNOT00000007867
leucine rich repeat containing 1
chr11_-_14304603 0.02 ENSRNOT00000040202
ENSRNOT00000082143
SAM domain, SH3 domain and nuclear localization signals, 1
chr3_-_114251647 0.02 ENSRNOT00000024245
dual oxidase maturation factor 1
chr13_-_50916982 0.02 ENSRNOT00000004408
BTG anti-proliferation factor 2
chr5_+_64476317 0.02 ENSRNOT00000017217
collagen alpha-1(XV) chain-like
chr3_-_2309179 0.02 ENSRNOT00000012375
NADPH oxidase activator 1
chr1_-_276228574 0.02 ENSRNOT00000021746
guanylate cyclase 2G
chr1_+_170205591 0.02 ENSRNOT00000071063
similar to olfactory receptor 692
chr3_+_63510293 0.02 ENSRNOT00000058093
deafness, autosomal recessive 59
chr4_+_31704747 0.02 ENSRNOT00000047850

chr8_-_53362006 0.02 ENSRNOT00000077145
claudin 25-like
chr2_+_240642847 0.02 ENSRNOT00000079694
ubiquitin-conjugating enzyme E2D 3
chr15_-_11912806 0.02 ENSRNOT00000068171
ENSRNOT00000008759
ENSRNOT00000049771
solute carrier family 4 member 7
chr10_+_94260197 0.02 ENSRNOT00000063973
translational activator of cytochrome c oxidase I
chr1_+_265157379 0.01 ENSRNOT00000022426
beta-transducin repeat containing E3 ubiquitin protein ligase
chr3_-_52664209 0.01 ENSRNOT00000065126
ENSRNOT00000079020
sodium voltage-gated channel alpha subunit 9
chr10_+_61685645 0.01 ENSRNOT00000003933
MAX network transcriptional repressor
chr3_+_112242270 0.01 ENSRNOT00000080533
ENSRNOT00000082876
calpain 3
chr12_-_6078411 0.01 ENSRNOT00000001197
relaxin/insulin-like family peptide receptor 2
chr9_+_66058047 0.01 ENSRNOT00000071819
cyclin-dependent kinase 15
chr9_+_61692154 0.01 ENSRNOT00000082300
heat shock protein family E member 1
chr17_-_78812111 0.01 ENSRNOT00000021506
DNA cross-link repair 1C
chr10_-_103619083 0.01 ENSRNOT00000029092
Cd300e molecule
chr14_-_2032593 0.01 ENSRNOT00000000037
fibroblast growth factor receptor-like 1
chr15_+_45712821 0.01 ENSRNOT00000083381
ENSRNOT00000045833
family with sequence similarity 124 member A
chr11_+_36851038 0.01 ENSRNOT00000002221
ENSRNOT00000061047
Purkinje cell protein 4
chr5_+_142986526 0.01 ENSRNOT00000012811
R-spondin 1
chr6_+_122254841 0.01 ENSRNOT00000005055
G-protein coupled receptor 65
chr1_-_43638161 0.01 ENSRNOT00000024460
interaction protein for cytohesin exchange factors 1
chr18_+_4084228 0.01 ENSRNOT00000071392
calcium binding tyrosine phosphorylation regulated
chrX_+_78042859 0.01 ENSRNOT00000003286
lysophosphatidic acid receptor 4
chr2_-_170301348 0.01 ENSRNOT00000088131
sucrase-isomaltase
chr14_-_34218961 0.01 ENSRNOT00000072588
similar to Exocyst complex component 1 (Exocyst complex component Sec3)
chrX_-_69218526 0.01 ENSRNOT00000092321
ENSRNOT00000074071
ENSRNOT00000092571
praja ring finger ubiquitin ligase 1
chr4_+_180291389 0.01 ENSRNOT00000002465
sarcospan
chr3_-_160561741 0.01 ENSRNOT00000018364
potassium voltage-gated channel, modifier subfamily S, member 1
chr15_+_33555640 0.01 ENSRNOT00000021096
poly(A) binding protein, nuclear 1
chrX_+_84064427 0.01 ENSRNOT00000046364
zinc finger protein 711
chr6_+_132510757 0.01 ENSRNOT00000080230
Enah/Vasp-like
chr6_+_18880737 0.01 ENSRNOT00000003432
alkB homolog 8, tRNA methyltransferase
chr7_-_144837583 0.01 ENSRNOT00000055289
chromobox 5
chr1_+_1825872 0.01 ENSRNOT00000020417
katanin catalytic subunit A1
chr13_-_82006005 0.01 ENSRNOT00000039581
methyltransferase like 11B
chr9_-_119190698 0.01 ENSRNOT00000021534
TGFB-induced factor homeobox 1
chr2_+_187988925 0.01 ENSRNOT00000093033
ENSRNOT00000093016
Rho/Rac guanine nucleotide exchange factor 2
chr6_+_104291071 0.01 ENSRNOT00000006798
solute carrier family 39, member 9
chr1_-_215033460 0.01 ENSRNOT00000044565
dual specificity phosphatase 8
chr7_+_143122269 0.01 ENSRNOT00000082542
ENSRNOT00000045495
ENSRNOT00000081386
ENSRNOT00000067422
keratin 86
chr14_-_6900733 0.01 ENSRNOT00000061224
dentin matrix acidic phosphoprotein 1
chr9_+_67234303 0.01 ENSRNOT00000050179
abl-interactor 2
chr8_-_40137390 0.01 ENSRNOT00000042717
pannexin 3
chr18_-_16543992 0.01 ENSRNOT00000036306
solute carrier family 39 member 6
chr20_+_3246739 0.01 ENSRNOT00000061299
RT1 class I, locus T24, gene 2
chr3_+_72395218 0.01 ENSRNOT00000057616
proteoglycan 3, pro eosinophil major basic protein 2
chr10_-_88000423 0.01 ENSRNOT00000076787
ENSRNOT00000046751
ENSRNOT00000091394
keratin 32
chr15_-_28517335 0.01 ENSRNOT00000060514
ENSRNOT00000090378
heterogeneous nuclear ribonucleoproteins C1/C2-like
chrX_+_68627313 0.01 ENSRNOT00000076699
ENSRNOT00000076795
ENSRNOT00000008705
Yip1 domain family, member 6
chr18_+_30036887 0.01 ENSRNOT00000077824
protocadherin alpha 4
chr8_+_70447040 0.01 ENSRNOT00000016798
integrator complex subunit 14
chr8_+_2604962 0.01 ENSRNOT00000009993
caspase 1
chr4_-_72143748 0.01 ENSRNOT00000024428
TRPM8 channel-associated factor 1
chr1_-_256734719 0.01 ENSRNOT00000021546
ENSRNOT00000089456
myoferlin
chr3_-_165700489 0.01 ENSRNOT00000017008
zinc finger protein 93
chrX_-_152642531 0.01 ENSRNOT00000085037
gamma-aminobutyric acid type A receptor alpha3 subunit
chr9_-_85243001 0.01 ENSRNOT00000020219
secretogranin II
chr12_+_30441055 0.01 ENSRNOT00000081099

chr6_+_104291340 0.01 ENSRNOT00000089313
solute carrier family 39, member 9
chr1_-_63293635 0.01 ENSRNOT00000090337
zinc finger protein interacting with K protein 1
chr11_-_61234944 0.01 ENSRNOT00000059680
cilia and flagella associated protein 44
chr9_+_10013854 0.01 ENSRNOT00000077653
ENSRNOT00000072033
KH-type splicing regulatory protein
chr3_-_15376767 0.01 ENSRNOT00000044885
NADH:ubiquinone oxidoreductase subunit A8
chr16_+_20825044 0.01 ENSRNOT00000027268
UPF1, RNA helicase and ATPase
chrX_+_112311251 0.01 ENSRNOT00000086698

chr18_+_17043903 0.01 ENSRNOT00000068139
formin homology 2 domain containing 3
chr3_-_14643897 0.01 ENSRNOT00000082008
ENSRNOT00000025983
glycoprotein, alpha-galactosyltransferase 1
chr1_-_23556241 0.01 ENSRNOT00000072943
syntaxin-7-like
chr6_+_137323713 0.01 ENSRNOT00000029017
phospholipase D family, member 4
chr20_+_3230052 0.01 ENSRNOT00000078454
RT1 class I, locus T24, gene 3
chr2_+_202200797 0.01 ENSRNOT00000042263
ENSRNOT00000071938
sperm associated antigen 17
chr2_-_93985378 0.01 ENSRNOT00000075493
fatty acid binding protein 5, epidermal
chr9_+_65614142 0.01 ENSRNOT00000016613
caspase 8
chr4_+_6827429 0.01 ENSRNOT00000071737
Ras homolog enriched in brain
chr9_+_60883981 0.01 ENSRNOT00000081002
coiled-coil domain containing 150
chr5_+_18901039 0.01 ENSRNOT00000012066
family with sequence similarity 110, member B
chr17_+_55065621 0.01 ENSRNOT00000086342
zinc finger protein 438
chr4_+_153805993 0.00 ENSRNOT00000056174
ubiquitin specific peptidase 18
chr2_+_19823234 0.00 ENSRNOT00000022348
ribosomal protein S23
chrX_-_70978952 0.00 ENSRNOT00000076910
solute carrier family 7 member 3
chr15_+_108526014 0.00 ENSRNOT00000017211
transmembrane 9 superfamily member 2
chr2_-_250862419 0.00 ENSRNOT00000017943
chloride channel accessory 4
chr7_-_55604403 0.00 ENSRNOT00000088732
ataxin 7-like 3B
chr4_+_158088505 0.00 ENSRNOT00000026643
von Willebrand factor
chr4_+_24612205 0.00 ENSRNOT00000057382
EWS RNA-binding protein 1
chr14_+_39964588 0.00 ENSRNOT00000003240
gamma-aminobutyric acid type A receptor gamma 1 subunit
chr13_+_76962504 0.00 ENSRNOT00000076581
ring finger and WD repeat domain 2
chr20_-_13458110 0.00 ENSRNOT00000072183
solute carrier family 5 member 4
chr16_+_74865516 0.00 ENSRNOT00000058072
ATPase copper transporting beta
chr13_-_78885464 0.00 ENSRNOT00000003828
aspartyl-tRNA synthetase 2 (mitochondrial)
chr2_-_187113717 0.00 ENSRNOT00000020147
leucine rich repeat containing 71
chr1_+_229416489 0.00 ENSRNOT00000028617
olfactory receptor 336
chr10_-_71491743 0.00 ENSRNOT00000038955
uncharacterized LOC102552988
chr1_-_221420115 0.00 ENSRNOT00000028475
mitochondrial ribosomal protein L49
chr18_+_32336102 0.00 ENSRNOT00000018577
fibroblast growth factor 1
chr15_-_54528480 0.00 ENSRNOT00000066888
fibronectin type III domain containing 3a
chr3_+_72134731 0.00 ENSRNOT00000083592
yippee-like 4
chr8_+_103938520 0.00 ENSRNOT00000067835
glycerol kinase 5 (putative)
chr1_-_81550598 0.00 ENSRNOT00000051671
similar to BC049730 protein
chr6_+_95205153 0.00 ENSRNOT00000007339
leucine rich repeat containing 9
chr10_+_88227360 0.00 ENSRNOT00000041033
eukaryotic translation initiation factor 1
chr8_-_17525906 0.00 ENSRNOT00000007855
N-acetylated alpha-linked acidic dipeptidase 2
chr17_+_89951752 0.00 ENSRNOT00000057572
ENSRNOT00000091023
abl-interactor 1
chrX_+_66314418 0.00 ENSRNOT00000035405
G protein-coupled receptor 15-like
chr2_+_266315036 0.00 ENSRNOT00000055245
wntless Wnt ligand secretion mediator
chr8_-_78233430 0.00 ENSRNOT00000083220
cingulin-like 1
chr20_+_13817795 0.00 ENSRNOT00000036518
glutathione S-transferase, theta 3
chr7_+_2504695 0.00 ENSRNOT00000003965
ATP synthase, H+ transporting, mitochondrial F1 complex, beta polypeptide
chr3_-_3594475 0.00 ENSRNOT00000064861
RGD1564379
chr12_+_2140203 0.00 ENSRNOT00000084906
calmodulin regulated spectrin-associated protein family, member 3
chrM_+_5323 0.00 ENSRNOT00000050156
mitochondrially encoded cytochrome c oxidase 1
chr16_+_60925093 0.00 ENSRNOT00000015813
tankyrase
chrM_+_9870 0.00 ENSRNOT00000044582
mitochondrially encoded NADH 4L dehydrogenase
chrX_+_14019961 0.00 ENSRNOT00000004785
synaptotagmin-like 5
chr6_-_127319362 0.00 ENSRNOT00000012256
DEAD-box helicase 24
chr12_+_17253791 0.00 ENSRNOT00000083814
zinc finger AN1-type containing 2A
chr13_+_47935163 0.00 ENSRNOT00000006768
eukaryotic translation initiation factor 2D

Network of associatons between targets according to the STRING database.

First level regulatory network of Gsx2_Hoxd3_Vax1

PNG image of the network

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Gene Ontology Analysis

Gene overrepresentation in biological process category:

Log-likelihood per target  Total log-likelihood Term Description
0.0 0.1 GO:0051867 general adaptation syndrome, behavioral process(GO:0051867)
0.0 0.2 GO:0061743 motor learning(GO:0061743)
0.0 0.0 GO:1901750 leukotriene D4 metabolic process(GO:1901748) leukotriene D4 biosynthetic process(GO:1901750)
0.0 0.0 GO:1902659 regulation of glucose mediated signaling pathway(GO:1902659)
0.0 0.0 GO:0002215 defense response to nematode(GO:0002215)
0.0 0.2 GO:0006590 thyroid hormone generation(GO:0006590)
0.0 0.1 GO:0019371 cyclooxygenase pathway(GO:0019371)
0.0 0.3 GO:0045109 intermediate filament organization(GO:0045109)
0.0 0.0 GO:0001905 activation of membrane attack complex(GO:0001905) regulation of activation of membrane attack complex(GO:0001969)
0.0 0.0 GO:0006480 N-terminal protein amino acid methylation(GO:0006480)

Gene overrepresentation in cellular component category:

Log-likelihood per target  Total log-likelihood Term Description
0.0 0.1 GO:0032280 symmetric synapse(GO:0032280)

Gene overrepresentation in molecular function category:

Log-likelihood per target  Total log-likelihood Term Description
0.0 0.1 GO:0001515 opioid peptide activity(GO:0001515)
0.0 0.1 GO:0001642 group III metabotropic glutamate receptor activity(GO:0001642)
0.0 0.0 GO:0070915 lysophosphatidic acid receptor activity(GO:0070915)
0.0 0.0 GO:0008597 calcium-dependent protein serine/threonine phosphatase regulator activity(GO:0008597)
0.0 0.0 GO:0071885 N-terminal protein N-methyltransferase activity(GO:0071885)

Gene overrepresentation in curated gene sets: REACTOME pathways category:

Log-likelihood per target  Total log-likelihood Term Description
0.0 0.2 REACTOME GLYCOPROTEIN HORMONES Genes involved in Glycoprotein hormones