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GSE49485: Hypoxia transcriptome sequencing of rat brain.
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Results for Gli3_Zic1
Z-value: 0.60
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Transcription factors associated with Gli3_Zic1
Activity-expression correlation:
| Gene | Promoter | Pearson corr. coef. | P-value | Plot |
|---|---|---|---|---|
| Gli3 | rn6_v1_chr17_-_52477575_52477575 | -0.84 | 7.4e-02 | Click! |
| Zic1 | rn6_v1_chr8_-_98738446_98738446 | 0.36 | 5.5e-01 | Click! |
| Promoter | Log-likelihood | Transcript | Gene | Gene Info |
|---|---|---|---|---|
| chr10_-_90312386 Show fit | 0.44 |
ENSRNOT00000028445
|
solute carrier family 4 member 1 |
|
| chr1_-_216080287 Show fit | 0.39 |
ENSRNOT00000027682
|
tyrosine hydroxylase |
|
| chr6_-_27190126 Show fit | 0.34 |
ENSRNOT00000068412
ENSRNOT00000013107 |
potassium two pore domain channel subfamily K member 3 |
|
| chr1_-_80744831 Show fit | 0.31 |
ENSRNOT00000025913
|
B-cell CLL/lymphoma 3 |
|
| chr3_+_154043873 Show fit | 0.20 |
ENSRNOT00000072502
ENSRNOT00000034166 |
neuronatin |
|
| chr18_-_28454756 Show fit | 0.19 |
ENSRNOT00000040091
|
spermatogenesis associated 24 |
|
| chr5_-_77945016 Show fit | 0.18 |
ENSRNOT00000076223
|
zinc finger protein 37 |
|
| chr16_+_54332660 Show fit | 0.17 |
ENSRNOT00000037685
|
microtubule associated tumor suppressor 1 |
|
| chr10_+_91710495 Show fit | 0.16 |
ENSRNOT00000033276
|
reprimo-like |
|
| chr7_-_12326392 Show fit | 0.14 |
ENSRNOT00000039728
|
NADH dehydrogenase (ubiquinone) Fe-S protein 7 |
Network of associatons between targets according to the STRING database.
First level regulatory network of Gli3_Zic1
Gene Ontology Analysis
Gene overrepresentation in biological process category:
| Log-likelihood per target | Total log-likelihood | Term | Description |
|---|---|---|---|
| 0.1 | 0.4 | GO:0052314 | phytoalexin metabolic process(GO:0052314) |
| 0.1 | 0.4 | GO:0010037 | response to carbon dioxide(GO:0010037) |
| 0.1 | 0.3 | GO:0045082 | positive regulation of interleukin-10 biosynthetic process(GO:0045082) |
| 0.0 | 0.3 | GO:0071294 | cellular response to zinc ion(GO:0071294) |
| 0.0 | 0.1 | GO:0051867 | general adaptation syndrome, behavioral process(GO:0051867) |
| 0.0 | 0.1 | GO:1903002 | regulation of lipid transport across blood brain barrier(GO:1903000) positive regulation of lipid transport across blood brain barrier(GO:1903002) |
| 0.0 | 0.1 | GO:0007525 | somatic muscle development(GO:0007525) |
| 0.0 | 0.1 | GO:0071031 | nuclear mRNA surveillance of mRNA 3'-end processing(GO:0071031) nuclear polyadenylation-dependent tRNA catabolic process(GO:0071038) nuclear retention of pre-mRNA with aberrant 3'-ends at the site of transcription(GO:0071049) |
| 0.0 | 0.1 | GO:0043366 | beta selection(GO:0043366) |
| 0.0 | 0.1 | GO:0071921 | establishment of sister chromatid cohesion(GO:0034085) cohesin loading(GO:0071921) regulation of cohesin loading(GO:0071922) |
Gene overrepresentation in cellular component category:
| Log-likelihood per target | Total log-likelihood | Term | Description |
|---|---|---|---|
| 0.0 | 0.4 | GO:0045009 | melanosome membrane(GO:0033162) chitosome(GO:0045009) |
| 0.0 | 0.3 | GO:0033256 | I-kappaB/NF-kappaB complex(GO:0033256) |
| 0.0 | 0.1 | GO:0043293 | apoptosome(GO:0043293) |
| 0.0 | 0.1 | GO:0042571 | immunoglobulin complex, circulating(GO:0042571) |
| 0.0 | 0.1 | GO:0032280 | symmetric synapse(GO:0032280) |
| 0.0 | 0.1 | GO:0034365 | discoidal high-density lipoprotein particle(GO:0034365) |
| 0.0 | 0.1 | GO:0045098 | type III intermediate filament(GO:0045098) |
| 0.0 | 0.0 | GO:0098837 | postsynaptic recycling endosome(GO:0098837) |
| 0.0 | 0.0 | GO:0010009 | cytoplasmic side of endosome membrane(GO:0010009) |
| 0.0 | 0.0 | GO:1990761 | growth cone lamellipodium(GO:1990761) growth cone filopodium(GO:1990812) |
Gene overrepresentation in molecular function category:
| Log-likelihood per target | Total log-likelihood | Term | Description |
|---|---|---|---|
| 0.1 | 0.4 | GO:0016714 | oxidoreductase activity, acting on paired donors, with incorporation or reduction of molecular oxygen, reduced pteridine as one donor, and incorporation of one atom of oxygen(GO:0016714) |
| 0.0 | 0.4 | GO:0015106 | bicarbonate transmembrane transporter activity(GO:0015106) |
| 0.1 | 0.3 | GO:0022841 | potassium ion leak channel activity(GO:0022841) |
| 0.0 | 0.2 | GO:0005212 | structural constituent of eye lens(GO:0005212) |
| 0.0 | 0.1 | GO:0046911 | metal chelating activity(GO:0046911) |
| 0.0 | 0.1 | GO:0001515 | opioid peptide activity(GO:0001515) |
| 0.0 | 0.1 | GO:0045505 | nitric-oxide synthase regulator activity(GO:0030235) dynein intermediate chain binding(GO:0045505) |
| 0.0 | 0.1 | GO:0031995 | insulin-like growth factor II binding(GO:0031995) |
| 0.0 | 0.1 | GO:0050501 | hyaluronan synthase activity(GO:0050501) |
| 0.0 | 0.0 | GO:0004096 | catalase activity(GO:0004096) |
Gene overrepresentation in curated gene sets: canonical pathways category:
| Log-likelihood per target | Total log-likelihood | Term | Description |
|---|---|---|---|
| 0.0 | 0.4 | PID P38 MK2 PATHWAY | p38 signaling mediated by MAPKAP kinases |
| 0.0 | 0.3 | PID NFKAPPAB ATYPICAL PATHWAY | Atypical NF-kappaB pathway |
Gene overrepresentation in curated gene sets: REACTOME pathways category:
| Log-likelihood per target | Total log-likelihood | Term | Description |
|---|---|---|---|
| 0.0 | 0.4 | REACTOME AMINE DERIVED HORMONES | Genes involved in Amine-derived hormones |
| 0.0 | 0.3 | REACTOME TANDEM PORE DOMAIN POTASSIUM CHANNELS | Genes involved in Tandem pore domain potassium channels |