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GSE49485: Hypoxia transcriptome sequencing of rat brain.
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Results for Gcm2
Z-value: 0.86
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Transcription factors associated with Gcm2
Activity-expression correlation:
| Gene | Promoter | Pearson corr. coef. | P-value | Plot |
|---|---|---|---|---|
| Gcm2 | rn6_v1_chr17_+_21490402_21490402 | 0.01 | 9.8e-01 | Click! |
| Promoter | Log-likelihood | Transcript | Gene | Gene Info |
|---|---|---|---|---|
| chr12_+_47551935 Show fit | 0.79 |
ENSRNOT00000056932
|
RGD1560398 |
|
| chr4_+_438668 Show fit | 0.75 |
ENSRNOT00000008951
|
engrailed homeobox 2 |
|
| chr14_-_78707861 Show fit | 0.66 |
ENSRNOT00000091927
|
protein phosphatase 2, regulatory subunit B, gamma |
|
| chr1_+_274245184 Show fit | 0.57 |
ENSRNOT00000018889
|
dual specificity phosphatase 5 |
|
| chr9_+_10305470 Show fit | 0.53 |
ENSRNOT00000072592
|
neurturin |
|
| chr10_-_63952726 Show fit | 0.53 |
ENSRNOT00000090461
|
double C2 domain beta |
|
| chr7_+_11152038 Show fit | 0.52 |
ENSRNOT00000006168
|
nuclear factor I/C |
|
| chr6_-_99783047 Show fit | 0.52 |
ENSRNOT00000009028
|
spectrin, beta, erythrocytic |
|
| chr10_-_15166457 Show fit | 0.50 |
ENSRNOT00000026676
|
meteorin, glial cell differentiation regulator |
|
| chr7_+_11215328 Show fit | 0.47 |
ENSRNOT00000061194
|
hypothetical protein LOC690617 |
Network of associatons between targets according to the STRING database.
First level regulatory network of Gcm2
Gene Ontology Analysis
Gene overrepresentation in biological process category:
| Log-likelihood per target | Total log-likelihood | Term | Description |
|---|---|---|---|
| 0.1 | 0.7 | GO:1990403 | embryonic brain development(GO:1990403) |
| 0.0 | 0.6 | GO:0035970 | peptidyl-threonine dephosphorylation(GO:0035970) |
| 0.0 | 0.6 | GO:0070262 | peptidyl-serine dephosphorylation(GO:0070262) |
| 0.0 | 0.5 | GO:0031340 | positive regulation of vesicle fusion(GO:0031340) |
| 0.0 | 0.5 | GO:0048172 | regulation of short-term neuronal synaptic plasticity(GO:0048172) |
| 0.1 | 0.4 | GO:0048372 | ventricular zone neuroblast division(GO:0021847) fibroblast growth factor receptor signaling pathway involved in orbitofrontal cortex development(GO:0035607) lateral mesodermal cell fate commitment(GO:0048372) lateral mesodermal cell fate specification(GO:0048377) regulation of lateral mesodermal cell fate specification(GO:0048378) |
| 0.1 | 0.4 | GO:0072081 | proximal/distal pattern formation involved in nephron development(GO:0072047) specification of nephron tubule identity(GO:0072081) |
| 0.1 | 0.4 | GO:0060449 | bud elongation involved in lung branching(GO:0060449) |
| 0.1 | 0.4 | GO:0051970 | negative regulation of transmission of nerve impulse(GO:0051970) |
| 0.0 | 0.4 | GO:0034067 | protein localization to Golgi apparatus(GO:0034067) |
Gene overrepresentation in cellular component category:
| Log-likelihood per target | Total log-likelihood | Term | Description |
|---|---|---|---|
| 0.1 | 0.6 | GO:0008091 | spectrin(GO:0008091) |
| 0.0 | 0.6 | GO:0000159 | protein phosphatase type 2A complex(GO:0000159) |
| 0.1 | 0.4 | GO:0071148 | TEAD-1-YAP complex(GO:0071148) |
| 0.0 | 0.4 | GO:0005921 | gap junction(GO:0005921) |
| 0.0 | 0.3 | GO:0043196 | varicosity(GO:0043196) |
| 0.0 | 0.3 | GO:0005721 | pericentric heterochromatin(GO:0005721) |
| 0.1 | 0.2 | GO:0060187 | cell pole(GO:0060187) |
| 0.1 | 0.2 | GO:1990257 | piccolo-bassoon transport vesicle(GO:1990257) |
| 0.1 | 0.2 | GO:0002947 | tumor necrosis factor receptor superfamily complex(GO:0002947) |
| 0.0 | 0.2 | GO:0031085 | BLOC-3 complex(GO:0031085) |
Gene overrepresentation in molecular function category:
| Log-likelihood per target | Total log-likelihood | Term | Description |
|---|---|---|---|
| 0.0 | 0.6 | GO:0030506 | ankyrin binding(GO:0030506) |
| 0.2 | 0.5 | GO:0030977 | taurine binding(GO:0030977) |
| 0.0 | 0.5 | GO:0017017 | MAP kinase tyrosine/serine/threonine phosphatase activity(GO:0017017) |
| 0.1 | 0.3 | GO:0046920 | alpha-(1->3)-fucosyltransferase activity(GO:0046920) |
| 0.1 | 0.3 | GO:0005052 | peroxisome matrix targeting signal-1 binding(GO:0005052) |
| 0.0 | 0.3 | GO:0031749 | D2 dopamine receptor binding(GO:0031749) |
| 0.0 | 0.3 | GO:0005007 | fibroblast growth factor-activated receptor activity(GO:0005007) |
| 0.0 | 0.3 | GO:0030160 | GKAP/Homer scaffold activity(GO:0030160) |
| 0.0 | 0.3 | GO:0004089 | carbonate dehydratase activity(GO:0004089) |
| 0.0 | 0.3 | GO:0005313 | L-glutamate transmembrane transporter activity(GO:0005313) |
Gene overrepresentation in curated gene sets: canonical pathways category:
| Log-likelihood per target | Total log-likelihood | Term | Description |
|---|---|---|---|
| 0.0 | 0.7 | PID RET PATHWAY | Signaling events regulated by Ret tyrosine kinase |
| 0.0 | 0.6 | PID ERBB4 PATHWAY | ErbB4 signaling events |
| 0.0 | 0.6 | PID ATF2 PATHWAY | ATF-2 transcription factor network |
| 0.0 | 0.4 | PID INTEGRIN5 PATHWAY | Beta5 beta6 beta7 and beta8 integrin cell surface interactions |
| 0.0 | 0.4 | PID HNF3A PATHWAY | FOXA1 transcription factor network |
| 0.0 | 0.3 | PID EPHRINB REV PATHWAY | Ephrin B reverse signaling |
| 0.0 | 0.3 | PID PDGFRA PATHWAY | PDGFR-alpha signaling pathway |
| 0.0 | 0.3 | PID GLYPICAN 1PATHWAY | Glypican 1 network |
| 0.0 | 0.3 | PID S1P META PATHWAY | Sphingosine 1-phosphate (S1P) pathway |
| 0.0 | 0.2 | PID ALK2 PATHWAY | ALK2 signaling events |
Gene overrepresentation in curated gene sets: REACTOME pathways category:
| Log-likelihood per target | Total log-likelihood | Term | Description |
|---|---|---|---|
| 0.0 | 0.6 | REACTOME INTERACTION BETWEEN L1 AND ANKYRINS | Genes involved in Interaction between L1 and Ankyrins |
| 0.0 | 0.5 | REACTOME HS GAG DEGRADATION | Genes involved in HS-GAG degradation |
| 0.0 | 0.5 | REACTOME NCAM1 INTERACTIONS | Genes involved in NCAM1 interactions |
| 0.0 | 0.4 | REACTOME SIGNALING BY ACTIVATED POINT MUTANTS OF FGFR1 | Genes involved in Signaling by activated point mutants of FGFR1 |
| 0.0 | 0.4 | REACTOME SIGNALING BY HIPPO | Genes involved in Signaling by Hippo |
| 0.0 | 0.4 | REACTOME COLLAGEN FORMATION | Genes involved in Collagen formation |
| 0.0 | 0.3 | REACTOME GAP JUNCTION DEGRADATION | Genes involved in Gap junction degradation |
| 0.0 | 0.3 | REACTOME LIGAND GATED ION CHANNEL TRANSPORT | Genes involved in Ligand-gated ion channel transport |
| 0.0 | 0.3 | REACTOME INWARDLY RECTIFYING K CHANNELS | Genes involved in Inwardly rectifying K+ channels |
| 0.0 | 0.2 | REACTOME PROSTANOID LIGAND RECEPTORS | Genes involved in Prostanoid ligand receptors |