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GSE49485: Hypoxia transcriptome sequencing of rat brain.
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Results for Gata2_Gata1
Z-value: 0.40
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Transcription factors associated with Gata2_Gata1
Activity-expression correlation:
| Gene | Promoter | Pearson corr. coef. | P-value | Plot |
|---|---|---|---|---|
| Gata2 | rn6_v1_chr4_+_120133713_120133713 | -0.29 | 6.3e-01 | Click! |
| Gata1 | rn6_v1_chrX_+_15378789_15378789 | 0.21 | 7.3e-01 | Click! |
| Promoter | Log-likelihood | Transcript | Gene | Gene Info |
|---|---|---|---|---|
| chr1_+_72882806 Show fit | 0.23 |
ENSRNOT00000024640
|
troponin I3, cardiac type |
|
| chr1_-_261446570 Show fit | 0.23 |
ENSRNOT00000020182
|
secreted frizzled-related protein 5 |
|
| chr2_-_48501436 Show fit | 0.20 |
ENSRNOT00000017305
|
ISL LIM homeobox 1 |
|
| chr10_+_103874383 Show fit | 0.20 |
ENSRNOT00000038935
|
otopetrin 2 |
|
| chr17_-_22143324 Show fit | 0.20 |
ENSRNOT00000019361
|
endothelin 1 |
|
| chr8_-_33661049 Show fit | 0.18 |
ENSRNOT00000068037
|
Fli-1 proto-oncogene, ETS transcription factor |
|
| chr5_+_153197459 Show fit | 0.17 |
ENSRNOT00000023187
|
Rh blood group, D antigen |
|
| chr1_-_164205222 Show fit | 0.16 |
ENSRNOT00000035774
|
monoacylglycerol O-acyltransferase 2 |
|
| chr5_+_138685624 Show fit | 0.16 |
ENSRNOT00000011867
|
guanylate cyclase activator 2A |
|
| chr8_+_50525091 Show fit | 0.15 |
ENSRNOT00000074357
|
apolipoprotein A1 |
Network of associatons between targets according to the STRING database.
First level regulatory network of Gata2_Gata1
Gene Ontology Analysis
Gene overrepresentation in biological process category:
| Log-likelihood per target | Total log-likelihood | Term | Description |
|---|---|---|---|
| 0.1 | 0.2 | GO:2000041 | Wnt signaling pathway involved in digestive tract morphogenesis(GO:0044333) regulation of planar cell polarity pathway involved in axis elongation(GO:2000040) negative regulation of planar cell polarity pathway involved in axis elongation(GO:2000041) |
| 0.1 | 0.2 | GO:1901258 | visceral motor neuron differentiation(GO:0021524) sensory system development(GO:0048880) positive regulation of granulocyte colony-stimulating factor production(GO:0071657) positive regulation of macrophage colony-stimulating factor production(GO:1901258) |
| 0.1 | 0.2 | GO:0031583 | phospholipase D-activating G-protein coupled receptor signaling pathway(GO:0031583) |
| 0.1 | 0.2 | GO:0006651 | diacylglycerol biosynthetic process(GO:0006651) |
| 0.0 | 0.2 | GO:0031284 | positive regulation of guanylate cyclase activity(GO:0031284) |
| 0.0 | 0.2 | GO:0032780 | negative regulation of ATPase activity(GO:0032780) |
| 0.0 | 0.2 | GO:0072488 | ammonium transmembrane transport(GO:0072488) |
| 0.0 | 0.1 | GO:0010903 | negative regulation of very-low-density lipoprotein particle remodeling(GO:0010903) |
| 0.0 | 0.1 | GO:0060931 | sinoatrial node cell development(GO:0060931) |
| 0.0 | 0.1 | GO:0071691 | cardiac muscle thin filament assembly(GO:0071691) |
Gene overrepresentation in cellular component category:
| Log-likelihood per target | Total log-likelihood | Term | Description |
|---|---|---|---|
| 0.1 | 0.2 | GO:1990584 | cardiac Troponin complex(GO:1990584) |
| 0.0 | 0.2 | GO:0048237 | rough endoplasmic reticulum lumen(GO:0048237) |
| 0.0 | 0.1 | GO:0034365 | discoidal high-density lipoprotein particle(GO:0034365) |
| 0.0 | 0.1 | GO:0097451 | glial limiting end-foot(GO:0097451) |
| 0.0 | 0.1 | GO:0043190 | ATP-binding cassette (ABC) transporter complex(GO:0043190) |
| 0.0 | 0.1 | GO:0000220 | vacuolar proton-transporting V-type ATPase, V0 domain(GO:0000220) |
Gene overrepresentation in molecular function category:
| Log-likelihood per target | Total log-likelihood | Term | Description |
|---|---|---|---|
| 0.1 | 0.2 | GO:0031708 | endothelin B receptor binding(GO:0031708) |
| 0.1 | 0.2 | GO:0030172 | troponin C binding(GO:0030172) |
| 0.0 | 0.2 | GO:0003846 | 2-acylglycerol O-acyltransferase activity(GO:0003846) |
| 0.0 | 0.2 | GO:0030250 | cyclase activator activity(GO:0010853) guanylate cyclase activator activity(GO:0030250) |
| 0.0 | 0.1 | GO:0070653 | high-density lipoprotein particle receptor binding(GO:0070653) |
| 0.0 | 0.1 | GO:0035662 | Toll-like receptor 4 binding(GO:0035662) |
| 0.0 | 0.1 | GO:0030492 | hemoglobin binding(GO:0030492) |
| 0.0 | 0.1 | GO:0008109 | N-acetyllactosaminide beta-1,6-N-acetylglucosaminyltransferase activity(GO:0008109) |
| 0.0 | 0.1 | GO:0031433 | telethonin binding(GO:0031433) |
Gene overrepresentation in curated gene sets: REACTOME pathways category:
| Log-likelihood per target | Total log-likelihood | Term | Description |
|---|---|---|---|
| 0.0 | 0.2 | REACTOME SYNTHESIS SECRETION AND INACTIVATION OF GIP | Genes involved in Synthesis, Secretion, and Inactivation of Glucose-dependent Insulinotropic Polypeptide (GIP) |
| 0.0 | 0.2 | REACTOME ABCA TRANSPORTERS IN LIPID HOMEOSTASIS | Genes involved in ABCA transporters in lipid homeostasis |
| 0.0 | 0.1 | REACTOME SYNTHESIS SECRETION AND DEACYLATION OF GHRELIN | Genes involved in Synthesis, Secretion, and Deacylation of Ghrelin |