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GSE49485: Hypoxia transcriptome sequencing of rat brain.

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Results for Gata2_Gata1

Z-value: 0.40

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Transcription factors associated with Gata2_Gata1

Gene Symbol Gene ID Gene Info
ENSRNOG00000012347 GATA binding protein 2
ENSRNOG00000025534 GATA binding protein 1

Activity-expression correlation:

GenePromoterPearson corr. coef.P-valuePlot
Gata2rn6_v1_chr4_+_120133713_120133713-0.296.3e-01Click!
Gata1rn6_v1_chrX_+_15378789_153787890.217.3e-01Click!

Activity profile of Gata2_Gata1 motif

Sorted Z-values of Gata2_Gata1 motif

Promoter Log-likelihood Transcript Gene Gene Info
chr1_+_72882806 0.23 ENSRNOT00000024640
troponin I3, cardiac type
chr1_-_261446570 0.23 ENSRNOT00000020182
secreted frizzled-related protein 5
chr2_-_48501436 0.20 ENSRNOT00000017305
ISL LIM homeobox 1
chr10_+_103874383 0.20 ENSRNOT00000038935
otopetrin 2
chr17_-_22143324 0.20 ENSRNOT00000019361
endothelin 1
chr8_-_33661049 0.18 ENSRNOT00000068037
Fli-1 proto-oncogene, ETS transcription factor
chr5_+_153197459 0.17 ENSRNOT00000023187
Rh blood group, D antigen
chr1_-_164205222 0.16 ENSRNOT00000035774
monoacylglycerol O-acyltransferase 2
chr5_+_138685624 0.16 ENSRNOT00000011867
guanylate cyclase activator 2A
chr8_+_50525091 0.15 ENSRNOT00000074357
apolipoprotein A1
chr7_+_138707426 0.14 ENSRNOT00000037874
PC-esterase domain containing 1B
chr1_+_279798187 0.13 ENSRNOT00000024065
pancreatic lipase
chr3_+_59153280 0.13 ENSRNOT00000002066
cell division cycle associated 7
chr2_+_190073815 0.13 ENSRNOT00000015473
S100 calcium binding protein A8
chr16_-_61791091 0.12 ENSRNOT00000042003
membrane bound O-acyltransferase domain containing 4
chr19_-_10450186 0.12 ENSRNOT00000088048
adhesion G protein-coupled receptor G1
chr11_-_35749464 0.11 ENSRNOT00000078818
ENSRNOT00000078425
ERG, ETS transcription factor
chr2_+_116970344 0.09 ENSRNOT00000039603
EGF-like and EMI domain containing 1
chr1_+_199720038 0.09 ENSRNOT00000027297
alpha hemoglobin stabilizing protein
chr14_+_37130743 0.09 ENSRNOT00000031756
leucine rich repeat containing 66
chr11_-_64952687 0.09 ENSRNOT00000087892
popeye domain containing 2
chrX_-_78496847 0.09 ENSRNOT00000003265
integral membrane protein 2A
chr9_+_82647071 0.09 ENSRNOT00000027135
acid sensing ion channel subunit family member 4
chr20_-_22459025 0.08 ENSRNOT00000000792
early growth response 2
chrX_+_112270986 0.08 ENSRNOT00000091441
ENSRNOT00000082652
V-set and immunoglobulin domain containing 1
chr11_-_60679555 0.07 ENSRNOT00000059735
coiled-coil domain containing 80
chr17_-_84247038 0.07 ENSRNOT00000068553
nebulette
chr17_-_21677477 0.07 ENSRNOT00000035448
glucosaminyl (N-acetyl) transferase 2, I-branching enzyme
chr4_+_119225040 0.06 ENSRNOT00000012365
bone morphogenetic protein 10
chr9_-_88357182 0.06 ENSRNOT00000041176
collagen type IV alpha 4 chain
chr5_+_25168295 0.06 ENSRNOT00000020245
fibrinogen silencer binding protein
chr9_-_82146874 0.06 ENSRNOT00000024190
FEV, ETS transcription factor
chr13_-_80745347 0.06 ENSRNOT00000041908
flavin containing monooxygenase 1
chr16_+_6970342 0.06 ENSRNOT00000061294
ENSRNOT00000048344
inter-alpha-trypsin inhibitor heavy chain family, member 4
chr3_+_55910177 0.06 ENSRNOT00000009969
kelch-like family member 41
chr4_-_65780799 0.06 ENSRNOT00000079883
ATPase H+ transporting V0 subunit a4
chr13_-_53870428 0.06 ENSRNOT00000000812
nuclear receptor subfamily 5, group A, member 2
chr10_-_55965216 0.06 ENSRNOT00000057058
chromodomain helicase DNA binding protein 3
chr13_+_48513008 0.06 ENSRNOT00000009742
solute carrier family 26 member 9
chr3_-_112985318 0.05 ENSRNOT00000015556
erythrocyte membrane protein band 4.2
chr7_+_71023976 0.05 ENSRNOT00000005679
tachykinin 3
chr6_+_7961413 0.05 ENSRNOT00000007638
ENSRNOT00000061871
ATP binding cassette subfamily G member 8
chr9_-_23493081 0.05 ENSRNOT00000072144
Rh-associated glycoprotein
chrX_-_13601069 0.05 ENSRNOT00000004686
ornithine carbamoyltransferase
chr8_-_117820413 0.05 ENSRNOT00000075819
translation machinery associated 7 homolog
chr7_-_143538579 0.05 ENSRNOT00000081518
keratin 79
chr2_-_123851854 0.05 ENSRNOT00000023327
interleukin 2
chr10_-_102227554 0.05 ENSRNOT00000078035

chr17_+_9639330 0.04 ENSRNOT00000018232
docking protein 3
chr6_+_137164535 0.04 ENSRNOT00000018225
inverted formin, FH2 and WH2 domain containing
chr3_-_72447801 0.04 ENSRNOT00000088815
purinergic receptor P2X 3
chr8_+_22047697 0.04 ENSRNOT00000067741
intercellular adhesion molecule 4, Landsteiner-Wiener blood group
chr9_-_85617954 0.04 ENSRNOT00000077331
serpin family E member 2
chr6_+_83083740 0.04 ENSRNOT00000007600
leucine rich repeat and fibronectin type III domain containing 5
chr20_-_2191640 0.04 ENSRNOT00000001016
tripartite motif-containing 10
chr7_+_117967818 0.04 ENSRNOT00000073724
ribosomal protein L8-like
chr4_-_170932618 0.04 ENSRNOT00000007779
Rho GDP dissociation inhibitor beta
chr14_-_18862407 0.04 ENSRNOT00000003823
C-X-C motif chemokine ligand 6
chr18_-_19275273 0.04 ENSRNOT00000041707
lateral signaling target protein 2 homolog
chr7_-_58149061 0.04 ENSRNOT00000005157
tryptophan hydroxylase 2
chr1_+_142883040 0.04 ENSRNOT00000015898
alpha-kinase 3
chr15_-_61772516 0.03 ENSRNOT00000015605
ENSRNOT00000093399
WW domain binding protein 4
chr5_+_133864798 0.03 ENSRNOT00000091977
TAL bHLH transcription factor 1, erythroid differentiation factor
chr10_-_15610826 0.03 ENSRNOT00000027851
hemoglobin subunit zeta
chr9_-_105545854 0.03 ENSRNOT00000056434
similar to 2610034M16Rik protein
chr1_+_32199810 0.03 ENSRNOT00000036714
solute carrier family 6 member 19
chr1_-_89094530 0.03 ENSRNOT00000031873
ets variant 2
chr2_-_192027225 0.03 ENSRNOT00000016430
proline rich 9
chr15_+_33069382 0.03 ENSRNOT00000060193
mitochondrial ribosomal protein L52
chr2_-_196479770 0.03 ENSRNOT00000028693
annexin A9
chr8_-_48672732 0.03 ENSRNOT00000079275
hydroxymethylbilane synthase
chr10_-_90415070 0.03 ENSRNOT00000055179
integrin subunit alpha 2b
chr15_+_59678165 0.03 ENSRNOT00000074868
ecto-NOX disulfide-thiol exchanger 1
chr12_+_22274828 0.03 ENSRNOT00000001914
erythropoietin
chr19_-_14945302 0.03 ENSRNOT00000079391

chr20_-_5806097 0.03 ENSRNOT00000000611
colipase
chr8_+_39164916 0.02 ENSRNOT00000011309
acrosomal vesicle protein 1
chr2_-_60657712 0.02 ENSRNOT00000040348
retinoic acid induced 14
chr2_+_189423559 0.02 ENSRNOT00000029076
tropomyosin 3
chr11_+_61605937 0.02 ENSRNOT00000093455
ENSRNOT00000093242
GRAM domain containing 1C
chr10_+_108132105 0.02 ENSRNOT00000072534
chromobox 2
chr10_+_70417108 0.02 ENSRNOT00000079325
schlafen 4
chr1_+_42121636 0.02 ENSRNOT00000025616
myc target 1
chr7_+_127964752 0.02 ENSRNOT00000038168
hypothetical gene supported by NM_053561; AF062594
chr2_-_28799266 0.02 ENSRNOT00000089293
transmembrane protein 171
chr2_-_189602143 0.02 ENSRNOT00000032062
cAMP responsive element binding protein 3-like 4
chr9_+_82700468 0.02 ENSRNOT00000027227
inhibin alpha subunit
chr9_+_52023295 0.02 ENSRNOT00000004956
collagen type III alpha 1 chain
chr1_+_20331976 0.02 ENSRNOT00000070858
transmembrane protein 200A
chr1_+_17602281 0.02 ENSRNOT00000075461
jouberin-like
chr20_-_27657983 0.02 ENSRNOT00000057313
family with sequence similarity 26, member E
chr18_-_62476700 0.02 ENSRNOT00000048429
cytochrome c, somatic
chr4_+_51661654 0.02 ENSRNOT00000087359
ENSRNOT00000072470
leiomodin-2-like
chrX_+_53053609 0.02 ENSRNOT00000058357
dystrophin
chr15_-_28696122 0.02 ENSRNOT00000060467
RAB2B, member RAS oncogene family
chr2_-_198002625 0.02 ENSRNOT00000091888
cDNA sequence BC028528
chr6_-_127653124 0.02 ENSRNOT00000047324
serpin family A member 11
chr11_-_782954 0.02 ENSRNOT00000040065
Eph receptor A3
chrX_+_31054394 0.02 ENSRNOT00000037439
similar to ribonucleic acid binding protein S1
chr15_-_45524582 0.02 ENSRNOT00000081912
guanylate cyclase 1 soluble subunit beta 2
chr1_+_243375981 0.02 ENSRNOT00000080689
KN motif and ankyrin repeat domains 1
chr6_-_26385761 0.02 ENSRNOT00000073228
glucokinase regulator
chr14_-_86146744 0.02 ENSRNOT00000019335
myosin light chain 7
chrX_+_20351486 0.02 ENSRNOT00000093675
ENSRNOT00000047444
WNK lysine deficient protein kinase 3
chr5_-_28130803 0.02 ENSRNOT00000093186
solute carrier family 26 member 7
chr10_+_70411738 0.01 ENSRNOT00000078046
schlafen 4
chr2_+_198721724 0.01 ENSRNOT00000043535
ankyrin repeat domain 34A
chr5_+_33097654 0.01 ENSRNOT00000008087
cyclic nucleotide gated channel beta 3
chrX_+_106390759 0.01 ENSRNOT00000049375
basic helix-loop-helix domain containing, class B, 9
chr4_-_165541314 0.01 ENSRNOT00000013833
serine/threonine/tyrosine kinase 1
chr20_+_31265483 0.01 ENSRNOT00000079584
ENSRNOT00000000674
pyrophosphatase (inorganic) 1
chr3_+_93909156 0.01 ENSRNOT00000090365
LIM domain only 2
chr11_-_78327282 0.01 ENSRNOT00000002636
tumor protein p63
chrX_+_83678339 0.01 ENSRNOT00000005997
apolipoprotein O-like
chr11_+_80736576 0.01 ENSRNOT00000047678
mannan-binding lectin serine peptidase 1
chr5_+_154077944 0.01 ENSRNOT00000031512
interleukin 22 receptor subunit alpha 1
chr4_-_70974006 0.01 ENSRNOT00000020975
transient receptor potential cation channel, subfamily V, member 5
chr11_-_78341349 0.01 ENSRNOT00000068116
tumor protein p63
chr1_+_256955652 0.01 ENSRNOT00000020411
leucine-rich, glioma inactivated 1
chr1_-_226732736 0.01 ENSRNOT00000072343
pepsin F-like
chr6_-_8956276 0.01 ENSRNOT00000079027
SIX homeobox 2
chr19_+_27404712 0.01 ENSRNOT00000023657
myosin light chain kinase 3
chr9_-_49950093 0.01 ENSRNOT00000023014
four and a half LIM domains 2
chr14_-_45165207 0.01 ENSRNOT00000002960
Kruppel like factor 3
chrM_+_14136 0.01 ENSRNOT00000042098
mitochondrially encoded cytochrome b
chr3_+_159936856 0.01 ENSRNOT00000078703
hepatocyte nuclear factor 4, alpha
chr1_-_242373764 0.01 ENSRNOT00000076544
family with sequence similarity 122A
chr2_+_42726809 0.01 ENSRNOT00000036860

chr13_-_61591139 0.01 ENSRNOT00000005324
regulator of G-protein signaling 18
chr2_-_209973205 0.01 ENSRNOT00000024593
chymosin
chr6_-_7421456 0.01 ENSRNOT00000006725
zinc finger protein 36, C3H type-like 2
chr17_+_76008807 0.01 ENSRNOT00000070895
enoyl CoA hydratase domain containing 3
chr6_+_92229686 0.01 ENSRNOT00000046085
atlastin GTPase 1
chr1_+_20332371 0.00 ENSRNOT00000037259
transmembrane protein 200A
chr3_+_72447969 0.00 ENSRNOT00000012022
structure specific recognition protein 1
chr15_-_49467174 0.00 ENSRNOT00000019209
ADAM metallopeptidase domain 7
chr19_+_41631715 0.00 ENSRNOT00000022749
carbohydrate sulfotransferase 4
chr9_-_88356716 0.00 ENSRNOT00000077503
collagen type IV alpha 4 chain
chr6_-_7961207 0.00 ENSRNOT00000007174
ATP binding cassette subfamily G member 5
chr18_+_27047382 0.00 ENSRNOT00000027691
ENSRNOT00000090264
APC, WNT signaling pathway regulator
chr20_-_5076539 0.00 ENSRNOT00000076253
ENSRNOT00000037613
lymphocyte antigen 6 complex, locus G6F
chr4_-_7342410 0.00 ENSRNOT00000013058
nitric oxide synthase 3
chr19_-_37916813 0.00 ENSRNOT00000026585
lecithin cholesterol acyltransferase
chr15_+_28696378 0.00 ENSRNOT00000017476
TOX high mobility group box family member 4
chr2_+_208373154 0.00 ENSRNOT00000082943
ENSRNOT00000050538
adenosine receptor A3-like
chr5_-_28131133 0.00 ENSRNOT00000067331
solute carrier family 26 member 7
chr5_-_76632462 0.00 ENSRNOT00000085109
sushi domain containing 1
chr3_+_103753238 0.00 ENSRNOT00000007144
solute carrier family 12, member 6
chr2_+_206454208 0.00 ENSRNOT00000026863
putative homeodomain transcription factor 1
chr5_-_79691258 0.00 ENSRNOT00000072920
tumor necrosis factor superfamily member 8
chr1_-_222272285 0.00 ENSRNOT00000028737
fermitin family member 3
chr10_-_87232723 0.00 ENSRNOT00000015150
keratin 25
chr7_-_122247139 0.00 ENSRNOT00000064515
megakaryoblastic leukemia (translocation) 1
chr3_-_2453415 0.00 ENSRNOT00000079773
solute carrier family 34 member 3

Network of associatons between targets according to the STRING database.

First level regulatory network of Gata2_Gata1

PNG image of the network

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Gene Ontology Analysis

Gene overrepresentation in biological process category:

Log-likelihood per target  Total log-likelihood Term Description
0.1 0.2 GO:2000041 Wnt signaling pathway involved in digestive tract morphogenesis(GO:0044333) regulation of planar cell polarity pathway involved in axis elongation(GO:2000040) negative regulation of planar cell polarity pathway involved in axis elongation(GO:2000041)
0.1 0.2 GO:1901258 visceral motor neuron differentiation(GO:0021524) sensory system development(GO:0048880) positive regulation of granulocyte colony-stimulating factor production(GO:0071657) positive regulation of macrophage colony-stimulating factor production(GO:1901258)
0.1 0.2 GO:0031583 phospholipase D-activating G-protein coupled receptor signaling pathway(GO:0031583)
0.1 0.2 GO:0006651 diacylglycerol biosynthetic process(GO:0006651)
0.0 0.1 GO:0010903 negative regulation of very-low-density lipoprotein particle remodeling(GO:0010903)
0.0 0.1 GO:0060931 sinoatrial node cell development(GO:0060931)
0.0 0.1 GO:0071691 cardiac muscle thin filament assembly(GO:0071691)
0.0 0.1 GO:0002317 plasma cell differentiation(GO:0002317)
0.0 0.1 GO:2000504 positive regulation of blood vessel remodeling(GO:2000504)
0.0 0.1 GO:0021593 rhombomere morphogenesis(GO:0021593)
0.0 0.1 GO:0060298 positive regulation of sarcomere organization(GO:0060298)
0.0 0.2 GO:0031284 positive regulation of guanylate cyclase activity(GO:0031284)
0.0 0.1 GO:0061365 positive regulation of triglyceride lipase activity(GO:0061365)
0.0 0.2 GO:0032780 negative regulation of ATPase activity(GO:0032780)
0.0 0.1 GO:0061113 pancreas morphogenesis(GO:0061113)
0.0 0.1 GO:0030300 regulation of intestinal cholesterol absorption(GO:0030300)
0.0 0.0 GO:0061107 seminal vesicle development(GO:0061107)
0.0 0.2 GO:0072488 ammonium transmembrane transport(GO:0072488)
0.0 0.0 GO:0071461 cellular response to redox state(GO:0071461)
0.0 0.0 GO:0070948 regulation of neutrophil mediated cytotoxicity(GO:0070948) regulation of neutrophil mediated killing of symbiont cell(GO:0070949)
0.0 0.1 GO:0021796 cerebral cortex regionalization(GO:0021796)
0.0 0.0 GO:0046013 regulation of T cell homeostatic proliferation(GO:0046013)
0.0 0.0 GO:0045799 positive regulation of chromatin assembly or disassembly(GO:0045799)
0.0 0.1 GO:0036438 maintenance of lens transparency(GO:0036438)

Gene overrepresentation in cellular component category:

Log-likelihood per target  Total log-likelihood Term Description
0.1 0.2 GO:1990584 cardiac Troponin complex(GO:1990584)
0.0 0.2 GO:0048237 rough endoplasmic reticulum lumen(GO:0048237)
0.0 0.1 GO:0034365 discoidal high-density lipoprotein particle(GO:0034365)
0.0 0.1 GO:0097451 glial limiting end-foot(GO:0097451)
0.0 0.1 GO:0043190 ATP-binding cassette (ABC) transporter complex(GO:0043190)
0.0 0.1 GO:0000220 vacuolar proton-transporting V-type ATPase, V0 domain(GO:0000220)

Gene overrepresentation in molecular function category:

Log-likelihood per target  Total log-likelihood Term Description
0.1 0.2 GO:0031708 endothelin B receptor binding(GO:0031708)
0.1 0.2 GO:0030172 troponin C binding(GO:0030172)
0.0 0.1 GO:0070653 high-density lipoprotein particle receptor binding(GO:0070653)
0.0 0.2 GO:0003846 2-acylglycerol O-acyltransferase activity(GO:0003846)
0.0 0.2 GO:0030250 cyclase activator activity(GO:0010853) guanylate cyclase activator activity(GO:0030250)
0.0 0.1 GO:0035662 Toll-like receptor 4 binding(GO:0035662)
0.0 0.1 GO:0030492 hemoglobin binding(GO:0030492)
0.0 0.1 GO:0008109 N-acetyllactosaminide beta-1,6-N-acetylglucosaminyltransferase activity(GO:0008109)
0.0 0.1 GO:0031433 telethonin binding(GO:0031433)

Gene overrepresentation in curated gene sets: REACTOME pathways category:

Log-likelihood per target  Total log-likelihood Term Description
0.0 0.2 REACTOME SYNTHESIS SECRETION AND INACTIVATION OF GIP Genes involved in Synthesis, Secretion, and Inactivation of Glucose-dependent Insulinotropic Polypeptide (GIP)
0.0 0.1 REACTOME SYNTHESIS SECRETION AND DEACYLATION OF GHRELIN Genes involved in Synthesis, Secretion, and Deacylation of Ghrelin
0.0 0.2 REACTOME ABCA TRANSPORTERS IN LIPID HOMEOSTASIS Genes involved in ABCA transporters in lipid homeostasis