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GSE49485: Hypoxia transcriptome sequencing of rat brain.
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Results for Foxp2_Foxp3
Z-value: 0.63
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Transcription factors associated with Foxp2_Foxp3
Activity-expression correlation:
| Gene | Promoter | Pearson corr. coef. | P-value | Plot |
|---|---|---|---|---|
| Foxp3 | rn6_v1_chrX_-_15768522_15768522 | -0.46 | 4.4e-01 | Click! |
| Foxp2 | rn6_v1_chr4_+_41364441_41364441 | -0.20 | 7.4e-01 | Click! |
| Promoter | Log-likelihood | Transcript | Gene | Gene Info |
|---|---|---|---|---|
| chr16_-_20807070 Show fit | 0.50 |
ENSRNOT00000072536
|
cartilage oligomeric matrix protein |
|
| chr10_+_103395511 Show fit | 0.42 |
ENSRNOT00000004256
|
G protein-coupled receptor, class C, group 5, member C |
|
| chr1_-_215536980 Show fit | 0.38 |
ENSRNOT00000027344
|
interferon induced transmembrane protein 10 |
|
| chr18_-_5314511 Show fit | 0.32 |
ENSRNOT00000022637
ENSRNOT00000079682 |
zinc finger protein 521 |
|
| chr4_+_94696965 Show fit | 0.29 |
ENSRNOT00000064696
|
glutamate ionotropic receptor delta type subunit 2 |
|
| chr4_-_30556814 Show fit | 0.26 |
ENSRNOT00000012760
|
pyruvate dehydrogenase kinase 4 |
|
| chr4_+_154309426 Show fit | 0.25 |
ENSRNOT00000019346
|
alpha-2-macroglobulin |
|
| chr17_-_1999596 Show fit | 0.24 |
ENSRNOT00000072220
|
RIKEN cDNA 1190003K10 gene |
|
| chr13_+_97838361 Show fit | 0.21 |
ENSRNOT00000003641
|
consortin, connexin sorting protein |
|
| chr4_+_169161585 Show fit | 0.20 |
ENSRNOT00000079785
|
epithelial membrane protein 1 |
Network of associatons between targets according to the STRING database.
First level regulatory network of Foxp2_Foxp3
Gene Ontology Analysis
Gene overrepresentation in biological process category:
| Log-likelihood per target | Total log-likelihood | Term | Description |
|---|---|---|---|
| 0.0 | 0.5 | GO:0003417 | growth plate cartilage development(GO:0003417) |
| 0.1 | 0.3 | GO:0010510 | regulation of acetyl-CoA biosynthetic process from pyruvate(GO:0010510) |
| 0.1 | 0.3 | GO:1990402 | embryonic liver development(GO:1990402) |
| 0.0 | 0.3 | GO:0021707 | cerebellar granular layer formation(GO:0021684) cerebellar granule cell differentiation(GO:0021707) |
| 0.0 | 0.3 | GO:0022010 | central nervous system myelination(GO:0022010) axon ensheathment in central nervous system(GO:0032291) |
| 0.1 | 0.2 | GO:0045575 | basophil activation(GO:0045575) |
| 0.1 | 0.2 | GO:0001828 | inner cell mass cellular morphogenesis(GO:0001828) |
| 0.1 | 0.2 | GO:0042998 | positive regulation of Golgi to plasma membrane protein transport(GO:0042998) |
| 0.0 | 0.2 | GO:0014878 | response to electrical stimulus involved in regulation of muscle adaptation(GO:0014878) |
| 0.0 | 0.2 | GO:0007221 | positive regulation of transcription of Notch receptor target(GO:0007221) |
Gene overrepresentation in cellular component category:
| Log-likelihood per target | Total log-likelihood | Term | Description |
|---|---|---|---|
| 0.1 | 0.2 | GO:0035838 | growing cell tip(GO:0035838) |
| 0.0 | 0.1 | GO:0071664 | catenin-TCF7L2 complex(GO:0071664) |
| 0.0 | 0.1 | GO:0070557 | PCNA-p21 complex(GO:0070557) |
| 0.0 | 0.1 | GO:0043293 | apoptosome(GO:0043293) |
| 0.0 | 0.1 | GO:0005899 | insulin receptor complex(GO:0005899) |
| 0.0 | 0.1 | GO:0033269 | internode region of axon(GO:0033269) |
| 0.0 | 0.1 | GO:0032777 | Piccolo NuA4 histone acetyltransferase complex(GO:0032777) |
| 0.0 | 0.1 | GO:0060053 | neurofilament cytoskeleton(GO:0060053) |
| 0.0 | 0.1 | GO:0044305 | calyx of Held(GO:0044305) |
| 0.0 | 0.1 | GO:0005879 | axonemal microtubule(GO:0005879) |
Gene overrepresentation in molecular function category:
| Log-likelihood per target | Total log-likelihood | Term | Description |
|---|---|---|---|
| 0.1 | 0.5 | GO:0005499 | vitamin D binding(GO:0005499) |
| 0.1 | 0.3 | GO:0019807 | aspartoacylase activity(GO:0019807) |
| 0.1 | 0.3 | GO:0004740 | pyruvate dehydrogenase (acetyl-transferring) kinase activity(GO:0004740) |
| 0.0 | 0.3 | GO:0005234 | extracellular-glutamate-gated ion channel activity(GO:0005234) |
| 0.1 | 0.2 | GO:0019959 | interleukin-8 binding(GO:0019959) |
| 0.1 | 0.2 | GO:0035651 | AP-3 adaptor complex binding(GO:0035651) |
| 0.0 | 0.2 | GO:0071253 | connexin binding(GO:0071253) |
| 0.0 | 0.2 | GO:0019992 | diacylglycerol binding(GO:0019992) |
| 0.0 | 0.2 | GO:0008527 | taste receptor activity(GO:0008527) |
| 0.0 | 0.2 | GO:0031432 | titin binding(GO:0031432) |
Gene overrepresentation in curated gene sets: REACTOME pathways category:
| Log-likelihood per target | Total log-likelihood | Term | Description |
|---|---|---|---|
| 0.0 | 0.3 | REACTOME REGULATION OF PYRUVATE DEHYDROGENASE PDH COMPLEX | Genes involved in Regulation of pyruvate dehydrogenase (PDH) complex |
| 0.0 | 0.3 | REACTOME HDL MEDIATED LIPID TRANSPORT | Genes involved in HDL-mediated lipid transport |
| 0.0 | 0.2 | REACTOME NOTCH HLH TRANSCRIPTION PATHWAY | Genes involved in Notch-HLH transcription pathway |
| 0.0 | 0.2 | REACTOME SYNTHESIS OF PIPS AT THE EARLY ENDOSOME MEMBRANE | Genes involved in Synthesis of PIPs at the early endosome membrane |
| 0.0 | 0.1 | REACTOME ENDOSOMAL VACUOLAR PATHWAY | Genes involved in Endosomal/Vacuolar pathway |