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GSE49485: Hypoxia transcriptome sequencing of rat brain.

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Results for Foxo3

Z-value: 0.34

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Transcription factors associated with Foxo3

Gene Symbol Gene ID Gene Info
ENSRNOG00000000299 forkhead box O3

Activity-expression correlation:

GenePromoterPearson corr. coef.P-valuePlot
Foxo3rn6_v1_chr20_+_46428124_464281240.983.1e-03Click!

Activity profile of Foxo3 motif

Sorted Z-values of Foxo3 motif

Promoter Log-likelihood Transcript Gene Gene Info
chr10_-_71849293 0.20 ENSRNOT00000003799
LIM homeobox 1
chr3_+_131351587 0.16 ENSRNOT00000010835
BTB domain containing 3
chr10_-_46720907 0.14 ENSRNOT00000083093
ENSRNOT00000067866
target of myb1 like 2 membrane trafficking protein
chr20_+_46519431 0.14 ENSRNOT00000077765

chr10_+_86399827 0.13 ENSRNOT00000009299
growth factor receptor bound protein 7
chr20_+_46429222 0.13 ENSRNOT00000076818
forkhead box O3
chr18_-_5314511 0.11 ENSRNOT00000022637
ENSRNOT00000079682
zinc finger protein 521
chr18_+_27558089 0.10 ENSRNOT00000027499
family with sequence similarity 53, member C
chr7_-_120770435 0.10 ENSRNOT00000077000
DEAD-box helicase 17
chr4_-_115516296 0.10 ENSRNOT00000019399
poly(A) binding protein interacting protein 2B
chr14_+_87448692 0.10 ENSRNOT00000077177
insulin-like growth factor binding protein 1
chr3_+_61658245 0.09 ENSRNOT00000033511
homeo box D3
chr16_-_15798974 0.09 ENSRNOT00000046842
ENSRNOT00000065946
neuregulin 3
chr3_+_116899878 0.08 ENSRNOT00000090802
ENSRNOT00000066101
semaphorin 6D
chr2_-_258997138 0.08 ENSRNOT00000045020
ENSRNOT00000042256
adhesion G protein-coupled receptor L2
chr2_+_127525285 0.08 ENSRNOT00000093247
inturned planar cell polarity protein
chr10_+_11393103 0.08 ENSRNOT00000076022
adenylate cyclase 9
chr14_+_104191517 0.08 ENSRNOT00000006573
sprouty-related, EVH1 domain containing 2
chr1_+_88750462 0.07 ENSRNOT00000028247
CAP-Gly domain-containing linker protein 3
chr15_-_108120279 0.07 ENSRNOT00000090572
dedicator of cytokinesis 9
chr3_+_79498179 0.07 ENSRNOT00000030750
nucleoporin 160
chr2_-_30634243 0.07 ENSRNOT00000077537
MARVEL domain containing 2
chr1_-_124803363 0.06 ENSRNOT00000066380
Kruppel-like factor 13
chrX_+_65040934 0.06 ENSRNOT00000044006
zinc finger CCCH-type containing 12B
chr5_+_150787043 0.06 ENSRNOT00000082945
EYA transcriptional coactivator and phosphatase 3
chr18_-_58097316 0.06 ENSRNOT00000088527

chr3_-_94419048 0.05 ENSRNOT00000015775
homeodomain interacting protein kinase 3
chr2_-_3124543 0.05 ENSRNOT00000036547
family with sequence similarity 81, member B
chr15_+_2374582 0.05 ENSRNOT00000019644
zinc finger protein 503
chr3_-_37480984 0.05 ENSRNOT00000030373
N-myc (and STAT) interactor
chr3_-_94418711 0.04 ENSRNOT00000089554
homeodomain interacting protein kinase 3
chr16_+_27399467 0.04 ENSRNOT00000065642
tolloid-like 1
chr2_+_262914327 0.04 ENSRNOT00000029312
neuronal growth regulator 1
chr6_-_44363915 0.04 ENSRNOT00000085925
inhibitor of DNA binding 2, HLH protein
chr7_+_59326518 0.04 ENSRNOT00000085231
protein tyrosine phosphatase, receptor type, B
chr6_-_67084234 0.03 ENSRNOT00000050372
NOVA alternative splicing regulator 1
chr7_-_107775712 0.03 ENSRNOT00000010811
ENSRNOT00000093459
N-myc downstream regulated 1
chr3_+_176479335 0.03 ENSRNOT00000055038
ENSRNOT00000082267
ADP-ribosylation factor GTPase activating protein 1
chr5_+_124690214 0.03 ENSRNOT00000011237
phospholipid phosphatase 3
chr2_-_208225888 0.03 ENSRNOT00000054860

chr7_-_123767797 0.02 ENSRNOT00000012699
transcription factor 20
chr15_+_108956448 0.02 ENSRNOT00000046324

chr9_-_43454078 0.02 ENSRNOT00000023550
transmembrane protein 131
chr20_-_54517709 0.02 ENSRNOT00000076234
glutamate ionotropic receptor kainate type subunit 2
chr2_-_188596222 0.02 ENSRNOT00000027920
ephrin A1
chr6_-_51018050 0.01 ENSRNOT00000082691
G protein-coupled receptor 22
chr4_+_157524423 0.01 ENSRNOT00000036654
zinc finger protein 384
chr5_+_113725717 0.01 ENSRNOT00000032248
TEK receptor tyrosine kinase
chr6_-_27487284 0.01 ENSRNOT00000084344
selenoprotein I
chr18_-_74059533 0.01 ENSRNOT00000038767
similar to hypothetical protein
chr1_+_190671696 0.01 ENSRNOT00000084934

chr11_+_73693814 0.01 ENSRNOT00000081081
ENSRNOT00000002354
ENSRNOT00000090940
large 60S subunit nuclear export GTPase 1
chr6_+_135156984 0.01 ENSRNOT00000009709
ENSRNOT00000082595
WD repeat domain 20
chr9_-_65693822 0.01 ENSRNOT00000038431
amyotrophic lateral sclerosis 2 chromosome region, candidate 12
chr20_+_45458558 0.01 ENSRNOT00000000713
cyclin-dependent kinase 19
chr10_-_87459652 0.00 ENSRNOT00000018804
keratin 40
chr10_-_25845634 0.00 ENSRNOT00000004269
methionine adenosyltransferase 2B
chr10_-_87335823 0.00 ENSRNOT00000079297
keratin 12
chr2_+_34255305 0.00 ENSRNOT00000016649
ENSRNOT00000016596
tripartite motif-containing 23
chr9_+_42315682 0.00 ENSRNOT00000071995

chr13_+_89597138 0.00 ENSRNOT00000004662
apolipoprotein A2

Network of associatons between targets according to the STRING database.

First level regulatory network of Foxo3

PNG image of the network

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Gene Ontology Analysis

Gene overrepresentation in biological process category:

Log-likelihood per target  Total log-likelihood Term Description
0.1 0.2 GO:0060066 metanephric part of ureteric bud development(GO:0035502) oviduct development(GO:0060066)
0.0 0.1 GO:0021615 glossopharyngeal nerve morphogenesis(GO:0021615)
0.0 0.1 GO:0021842 directional guidance of interneurons involved in migration from the subpallium to the cortex(GO:0021840) chemorepulsion involved in interneuron migration from the subpallium to the cortex(GO:0021842)
0.0 0.1 GO:0071386 cellular response to corticosterone stimulus(GO:0071386)
0.0 0.0 GO:0001966 thigmotaxis(GO:0001966)
0.0 0.0 GO:0070315 G1 to G0 transition involved in cell differentiation(GO:0070315)
0.0 0.0 GO:0032687 negative regulation of interferon-alpha production(GO:0032687)
0.0 0.1 GO:0034063 stress granule assembly(GO:0034063)

Gene overrepresentation in cellular component category:

Log-likelihood per target  Total log-likelihood Term Description
0.0 0.1 GO:0061689 tricellular tight junction(GO:0061689)

Gene overrepresentation in molecular function category:

Log-likelihood per target  Total log-likelihood Term Description
0.0 0.1 GO:0031995 insulin-like growth factor II binding(GO:0031995)
0.0 0.1 GO:0005173 stem cell factor receptor binding(GO:0005173)
0.0 0.1 GO:0097001 ceramide binding(GO:0097001)