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GSE49485: Hypoxia transcriptome sequencing of rat brain.
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Results for Foxi1_Foxo1
Z-value: 0.95
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Transcription factors associated with Foxi1_Foxo1
Activity-expression correlation:
| Gene | Promoter | Pearson corr. coef. | P-value | Plot |
|---|---|---|---|---|
| Foxi1 | rn6_v1_chr10_-_19164505_19164505 | 0.29 | 6.4e-01 | Click! |
| Foxo1 | rn6_v1_chr2_+_141451234_141451234 | 0.01 | 9.9e-01 | Click! |
| Promoter | Log-likelihood | Transcript | Gene | Gene Info |
|---|---|---|---|---|
| chr18_-_15540177 Show fit | 1.67 |
ENSRNOT00000022113
|
transthyretin |
|
| chr4_+_148782479 Show fit | 1.02 |
ENSRNOT00000018133
|
similar to hypothetical protein MGC6835 |
|
| chr7_+_28654733 Show fit | 0.79 |
ENSRNOT00000006174
|
pro-melanin-concentrating hormone |
|
| chr17_+_78793336 Show fit | 0.79 |
ENSRNOT00000057898
|
metallothionein 1 |
|
| chr16_-_20807070 Show fit | 0.78 |
ENSRNOT00000072536
|
cartilage oligomeric matrix protein |
|
| chr1_-_215536980 Show fit | 0.49 |
ENSRNOT00000027344
|
interferon induced transmembrane protein 10 |
|
| chr18_-_5314511 Show fit | 0.48 |
ENSRNOT00000022637
ENSRNOT00000079682 |
zinc finger protein 521 |
|
| chr12_-_17186679 Show fit | 0.46 |
ENSRNOT00000001730
|
UNC homeobox |
|
| chr8_+_48438259 Show fit | 0.46 |
ENSRNOT00000059813
|
membrane frizzled-related protein |
|
| chr10_-_90307658 Show fit | 0.44 |
ENSRNOT00000092102
|
solute carrier family 4 member 1 |
Network of associatons between targets according to the STRING database.
First level regulatory network of Foxi1_Foxo1
Gene Ontology Analysis
Gene overrepresentation in biological process category:
| Log-likelihood per target | Total log-likelihood | Term | Description |
|---|---|---|---|
| 0.2 | 2.0 | GO:0070327 | thyroid hormone transport(GO:0070327) |
| 0.2 | 0.9 | GO:0010037 | response to carbon dioxide(GO:0010037) |
| 0.2 | 0.8 | GO:0032227 | negative regulation of synaptic transmission, dopaminergic(GO:0032227) |
| 0.2 | 0.8 | GO:0046687 | response to chromate(GO:0046687) |
| 0.1 | 0.7 | GO:0015671 | oxygen transport(GO:0015671) |
| 0.0 | 0.7 | GO:0003417 | growth plate cartilage development(GO:0003417) |
| 0.0 | 0.5 | GO:0006730 | one-carbon metabolic process(GO:0006730) |
| 0.1 | 0.4 | GO:0060435 | bronchiole development(GO:0060435) |
| 0.1 | 0.4 | GO:0070447 | positive regulation of oligodendrocyte progenitor proliferation(GO:0070447) |
| 0.1 | 0.4 | GO:0035726 | common myeloid progenitor cell proliferation(GO:0035726) |
Gene overrepresentation in cellular component category:
| Log-likelihood per target | Total log-likelihood | Term | Description |
|---|---|---|---|
| 0.1 | 0.7 | GO:0005833 | hemoglobin complex(GO:0005833) |
| 0.0 | 0.4 | GO:0005826 | actomyosin contractile ring(GO:0005826) |
| 0.1 | 0.3 | GO:0030121 | AP-1 adaptor complex(GO:0030121) |
| 0.1 | 0.3 | GO:0033269 | internode region of axon(GO:0033269) |
| 0.0 | 0.3 | GO:0097197 | tetraspanin-enriched microdomain(GO:0097197) |
| 0.0 | 0.3 | GO:0044305 | calyx of Held(GO:0044305) |
| 0.1 | 0.2 | GO:0070557 | PCNA-p21 complex(GO:0070557) |
| 0.0 | 0.2 | GO:0043293 | apoptosome(GO:0043293) |
| 0.0 | 0.2 | GO:0033093 | Weibel-Palade body(GO:0033093) |
| 0.0 | 0.2 | GO:0030478 | actin cap(GO:0030478) |
Gene overrepresentation in molecular function category:
| Log-likelihood per target | Total log-likelihood | Term | Description |
|---|---|---|---|
| 0.1 | 1.6 | GO:0070324 | thyroid hormone binding(GO:0070324) |
| 0.2 | 0.9 | GO:0043120 | tumor necrosis factor binding(GO:0043120) |
| 0.2 | 0.8 | GO:0005499 | vitamin D binding(GO:0005499) |
| 0.1 | 0.7 | GO:0005344 | oxygen transporter activity(GO:0005344) |
| 0.1 | 0.7 | GO:0004089 | carbonate dehydratase activity(GO:0004089) |
| 0.0 | 0.6 | GO:0015106 | bicarbonate transmembrane transporter activity(GO:0015106) |
| 0.2 | 0.5 | GO:0008142 | oxysterol binding(GO:0008142) |
| 0.0 | 0.5 | GO:0071855 | neuropeptide receptor binding(GO:0071855) |
| 0.1 | 0.4 | GO:0019807 | aspartoacylase activity(GO:0019807) |
| 0.0 | 0.4 | GO:0098748 | clathrin adaptor activity(GO:0035615) endocytic adaptor activity(GO:0098748) |
Gene overrepresentation in curated gene sets: canonical pathways category:
| Log-likelihood per target | Total log-likelihood | Term | Description |
|---|---|---|---|
| 0.0 | 1.7 | PID HNF3B PATHWAY | FOXA2 and FOXA3 transcription factor networks |
| 0.0 | 1.2 | PID HIF1 TFPATHWAY | HIF-1-alpha transcription factor network |
| 0.0 | 0.2 | SA G2 AND M PHASES | Cdc25 activates the cdc2/cyclin B complex to induce the G2/M transition. |
| 0.0 | 0.1 | ST G ALPHA I PATHWAY | G alpha i Pathway |
| 0.0 | 0.0 | SIG PIP3 SIGNALING IN B LYMPHOCYTES | Genes related to PIP3 signaling in B lymphocytes |
| 0.0 | 0.0 | PID FAS PATHWAY | FAS (CD95) signaling pathway |
Gene overrepresentation in curated gene sets: REACTOME pathways category:
| Log-likelihood per target | Total log-likelihood | Term | Description |
|---|---|---|---|
| 0.1 | 1.9 | REACTOME AMYLOIDS | Genes involved in Amyloids |
| 0.0 | 0.5 | REACTOME INTRINSIC PATHWAY | Genes involved in Intrinsic Pathway |
| 0.0 | 0.5 | REACTOME TIGHT JUNCTION INTERACTIONS | Genes involved in Tight junction interactions |
| 0.0 | 0.4 | REACTOME CHYLOMICRON MEDIATED LIPID TRANSPORT | Genes involved in Chylomicron-mediated lipid transport |
| 0.0 | 0.4 | REACTOME GLYCOSPHINGOLIPID METABOLISM | Genes involved in Glycosphingolipid metabolism |
| 0.0 | 0.3 | REACTOME RECYCLING OF BILE ACIDS AND SALTS | Genes involved in Recycling of bile acids and salts |
| 0.0 | 0.3 | REACTOME NOTCH HLH TRANSCRIPTION PATHWAY | Genes involved in Notch-HLH transcription pathway |
| 0.0 | 0.3 | REACTOME REGULATION OF PYRUVATE DEHYDROGENASE PDH COMPLEX | Genes involved in Regulation of pyruvate dehydrogenase (PDH) complex |
| 0.0 | 0.3 | REACTOME METABOLISM OF PORPHYRINS | Genes involved in Metabolism of porphyrins |
| 0.0 | 0.3 | REACTOME PROCESSIVE SYNTHESIS ON THE LAGGING STRAND | Genes involved in Processive synthesis on the lagging strand |