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GSE49485: Hypoxia transcriptome sequencing of rat brain.

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Results for Foxc2

Z-value: 0.41

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Transcription factors associated with Foxc2

Gene Symbol Gene ID Gene Info
ENSRNOG00000047446 forkhead box C2

Activity-expression correlation:

GenePromoterPearson corr. coef.P-valuePlot
Foxc2rn6_v1_chr19_+_53044379_530443790.256.9e-01Click!

Activity profile of Foxc2 motif

Sorted Z-values of Foxc2 motif

Promoter Log-likelihood Transcript Gene Gene Info
chr2_+_145174876 0.70 ENSRNOT00000040631
mab-21 like 1
chr10_-_71849293 0.42 ENSRNOT00000003799
LIM homeobox 1
chr4_+_51614676 0.37 ENSRNOT00000060494
ankyrin repeat and SOCS box containing 15
chr18_-_15540177 0.37 ENSRNOT00000022113
transthyretin
chr15_-_25505691 0.16 ENSRNOT00000074488
homeobox protein OTX2-like
chr18_-_5314511 0.15 ENSRNOT00000022637
ENSRNOT00000079682
zinc finger protein 521
chr20_+_46429222 0.13 ENSRNOT00000076818
forkhead box O3
chr14_+_42714315 0.11 ENSRNOT00000084095
ENSRNOT00000091449
paired-like homeobox 2b
chr4_-_115239723 0.11 ENSRNOT00000042699
actin, gamma 2, smooth muscle, enteric
chr2_-_3124543 0.10 ENSRNOT00000036547
family with sequence similarity 81, member B
chr9_+_51298426 0.09 ENSRNOT00000065212
GULP, engulfment adaptor PTB domain containing 1
chr1_+_154606490 0.08 ENSRNOT00000024095
coiled-coil domain containing 89
chr1_+_29432152 0.08 ENSRNOT00000019436
ENSRNOT00000083276
tRNA methyltransferase 11 homolog
chr7_-_114848414 0.07 ENSRNOT00000032620
solute carrier family 45, member 4
chr1_+_227592635 0.07 ENSRNOT00000072135
membrane-spanning 4-domains, subfamily A, member 4A
chr16_+_27399467 0.07 ENSRNOT00000065642
tolloid-like 1
chr1_-_156327352 0.06 ENSRNOT00000074282
coiled-coil domain-containing protein 89-like
chr7_+_130071122 0.06 ENSRNOT00000078620
selenoprotein O
chr18_-_58097316 0.06 ENSRNOT00000088527

chr6_-_44363915 0.06 ENSRNOT00000085925
inhibitor of DNA binding 2, HLH protein
chr4_-_176528110 0.06 ENSRNOT00000049569
solute carrier organic anion transporter family, member 1A2
chr2_-_30634243 0.06 ENSRNOT00000077537
MARVEL domain containing 2
chr6_-_104631355 0.05 ENSRNOT00000007825
solute carrier family 10 member 1
chr15_-_95514259 0.05 ENSRNOT00000038433
SLIT and NTRK-like family, member 6
chr3_+_60024013 0.05 ENSRNOT00000025255
secernin 3
chr4_+_62221011 0.05 ENSRNOT00000041264
caldesmon 1
chr3_+_95939260 0.05 ENSRNOT00000041291

chr13_+_78979321 0.05 ENSRNOT00000003857
ankyrin repeat domain 45
chr16_+_47665816 0.05 ENSRNOT00000030519
CDKN2A interacting protein
chr6_+_95826546 0.04 ENSRNOT00000043587

chr1_+_264741911 0.04 ENSRNOT00000019956
semaphorin 4G
chr3_+_149624712 0.04 ENSRNOT00000018581
BPI fold containing family A, member 1
chr4_+_179481263 0.04 ENSRNOT00000021284
electron transfer flavoprotein regulatory factor 1
chr2_+_195996521 0.04 ENSRNOT00000082849
pogo transposable element with ZNF domain
chr6_-_51257625 0.04 ENSRNOT00000012004
HMG-box transcription factor 1
chr4_+_62220736 0.03 ENSRNOT00000086377
caldesmon 1
chr4_+_62380914 0.03 ENSRNOT00000029845
transmembrane protein 140
chr4_+_139670092 0.03 ENSRNOT00000008879
leucine rich repeat neuronal 1
chr13_+_97838361 0.03 ENSRNOT00000003641
consortin, connexin sorting protein
chr2_-_233743866 0.03 ENSRNOT00000087062
glutamyl aminopeptidase
chr3_-_60023913 0.03 ENSRNOT00000064662
corepressor interacting with RBPJ, 1
chr10_-_85825735 0.03 ENSRNOT00000055379
F-box protein 47
chr13_-_97838228 0.03 ENSRNOT00000003618
transcription factor B2, mitochondrial
chr2_-_172361779 0.03 ENSRNOT00000085876
schwannomin interacting protein 1
chr10_+_105393072 0.02 ENSRNOT00000013359
UBA-like domain containing 2
chr8_-_61595032 0.02 ENSRNOT00000023428
sorting nexin 33
chr9_-_55256340 0.02 ENSRNOT00000028907
serum deprivation response
chr18_-_69671199 0.02 ENSRNOT00000082484
SMAD family member 4
chr20_-_31597830 0.02 ENSRNOT00000085877
collagen type XIII alpha 1 chain
chrX_+_78991223 0.02 ENSRNOT00000031200
family with sequence similarity 46, member D
chr7_-_143523457 0.02 ENSRNOT00000012943
ENSRNOT00000082264
keratin 4
chr9_+_86874685 0.01 ENSRNOT00000041337
neuronal tyrosine-phosphorylated phosphoinositide-3-kinase adaptor 2
chr3_+_63536166 0.01 ENSRNOT00000016132
pleckstrin homology domain containing A3
chrX_+_159703578 0.01 ENSRNOT00000001162
CD40 ligand
chr5_+_162808646 0.01 ENSRNOT00000021155
dehydrogenase/reductase 3
chr20_+_29655226 0.01 ENSRNOT00000089059
SPARC/osteonectin, cwcv and kazal like domains proteoglycan 2
chr4_-_81241152 0.01 ENSRNOT00000015325
ENSRNOT00000015152
heterogeneous nuclear ribonucleoprotein A2/B1
chr4_+_71512695 0.01 ENSRNOT00000037220
taste receptor, type 2, member 139
chr3_-_160038078 0.01 ENSRNOT00000013445
serine incorporator 3
chr17_-_45746753 0.01 ENSRNOT00000077475
similar to brain Zn-finger protein
chr19_+_53055745 0.01 ENSRNOT00000074430
forkhead box L1
chr3_+_51687809 0.01 ENSRNOT00000087242
sodium voltage-gated channel alpha subunit 2
chr16_+_50181316 0.01 ENSRNOT00000077662
coagulation factor XI
chr2_-_100249811 0.01 ENSRNOT00000086760
hepatocyte nuclear factor 4, gamma
chr6_-_95890325 0.01 ENSRNOT00000050217
similar to 60S ribosomal protein L23a
chr5_+_103251986 0.01 ENSRNOT00000008757
centlein
chr4_+_181428664 0.00 ENSRNOT00000002518
RAB15 effector protein
chr12_-_7186873 0.00 ENSRNOT00000050438
uncharacterized LOC103690996
chr1_-_100845392 0.00 ENSRNOT00000027436
TBC1 domain family, member 17
chr6_+_135139292 0.00 ENSRNOT00000043508
ribosomal protein L35a-like 1
chr13_+_74456487 0.00 ENSRNOT00000065801
angiopoietin-like 1
chr2_+_241909832 0.00 ENSRNOT00000047975
protein phosphatase 3 catalytic subunit alpha
chr18_+_3887419 0.00 ENSRNOT00000093089
laminin subunit alpha 3
chr3_-_63535991 0.00 ENSRNOT00000015722
FK506 binding protein 7
chr3_+_44806106 0.00 ENSRNOT00000035158
uridine phosphorylase 2
chr4_+_14070553 0.00 ENSRNOT00000077505
CD36 molecule
chr5_+_164923302 0.00 ENSRNOT00000042285
60S ribosomal protein L35a
chr18_+_68408890 0.00 ENSRNOT00000039702
coiled-coil domain containing 68

Network of associatons between targets according to the STRING database.

First level regulatory network of Foxc2

PNG image of the network

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Gene Ontology Analysis

Gene overrepresentation in biological process category:

Log-likelihood per target  Total log-likelihood Term Description
0.1 0.4 GO:0060066 metanephric part of ureteric bud development(GO:0035502) oviduct development(GO:0060066)
0.0 0.4 GO:0070327 thyroid hormone transport(GO:0070327)
0.0 0.1 GO:0048880 medulla oblongata development(GO:0021550) sensory system development(GO:0048880)
0.0 0.1 GO:0015770 disaccharide transport(GO:0015766) sucrose transport(GO:0015770) oligosaccharide transport(GO:0015772)
0.0 0.1 GO:0090131 mesenchyme migration(GO:0090131)
0.0 0.1 GO:0071386 cellular response to corticosterone stimulus(GO:0071386)
0.0 0.1 GO:0001966 thigmotaxis(GO:0001966)
0.0 0.0 GO:0050828 regulation of liquid surface tension(GO:0050828)

Gene overrepresentation in cellular component category:

Log-likelihood per target  Total log-likelihood Term Description
0.0 0.1 GO:0030478 actin cap(GO:0030478)
0.0 0.1 GO:0061689 tricellular tight junction(GO:0061689)

Gene overrepresentation in molecular function category:

Log-likelihood per target  Total log-likelihood Term Description
0.0 0.4 GO:0070324 thyroid hormone binding(GO:0070324)
0.0 0.1 GO:0004809 tRNA (guanine-N2-)-methyltransferase activity(GO:0004809)
0.0 0.1 GO:0008506 sucrose:proton symporter activity(GO:0008506) sucrose transmembrane transporter activity(GO:0008515) disaccharide transmembrane transporter activity(GO:0015154) oligosaccharide transmembrane transporter activity(GO:0015157)
0.0 0.1 GO:0008508 bile acid:sodium symporter activity(GO:0008508)

Gene overrepresentation in curated gene sets: REACTOME pathways category:

Log-likelihood per target  Total log-likelihood Term Description
0.0 0.1 REACTOME RECYCLING OF BILE ACIDS AND SALTS Genes involved in Recycling of bile acids and salts
0.0 0.4 REACTOME AMYLOIDS Genes involved in Amyloids