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GSE49485: Hypoxia transcriptome sequencing of rat brain.

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Results for Foxa3

Z-value: 0.42

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Transcription factors associated with Foxa3

Gene Symbol Gene ID Gene Info
ENSRNOG00000014256 forkhead box A3

Activity-expression correlation:

GenePromoterPearson corr. coef.P-valuePlot
Foxa3rn6_v1_chr1_-_79930263_79930263-0.662.3e-01Click!

Activity profile of Foxa3 motif

Sorted Z-values of Foxa3 motif

Promoter Log-likelihood Transcript Gene Gene Info
chr4_+_51614676 0.22 ENSRNOT00000060494
ankyrin repeat and SOCS box containing 15
chr12_-_36398206 0.22 ENSRNOT00000090944
ENSRNOT00000058492
transmembrane protein 132B
chr9_+_27034022 0.20 ENSRNOT00000029696
progestin and adipoQ receptor family member 8
chr10_-_27179900 0.18 ENSRNOT00000082445
gamma-aminobutyric acid type A receptor gamma 2 subunit
chr3_-_158328881 0.17 ENSRNOT00000044466
protein tyrosine phosphatase, receptor type, T
chr1_-_78521999 0.17 ENSRNOT00000021223
Rho GTPase activating protein 35
chr10_-_37311625 0.16 ENSRNOT00000043343
jade family PHD finger 2
chr7_+_23403891 0.15 ENSRNOT00000037918
synapsin III
chr13_+_43850751 0.14 ENSRNOT00000004995
mannosyl (alpha-1,6-)-glycoprotein beta-1,6-N-acetyl-glucosaminyltransferase
chr18_+_30890869 0.14 ENSRNOT00000060466
protocadherin gamma subfamily B, 6
chr14_+_63405408 0.14 ENSRNOT00000086658

chr3_+_131351587 0.14 ENSRNOT00000010835
BTB domain containing 3
chr3_-_119330345 0.13 ENSRNOT00000077398
ENSRNOT00000079191
transient receptor potential cation channel, subfamily M, member 7
chr9_+_118849302 0.13 ENSRNOT00000087592
DLG associated protein 1
chr6_+_135313008 0.13 ENSRNOT00000030864
tectonin beta-propeller repeat containing 2
chr20_-_6251634 0.12 ENSRNOT00000059194
serine/threonine kinase 38
chr7_+_71157664 0.12 ENSRNOT00000005919
short chain dehydrogenase/reductase family 9C, member 7
chr10_-_27179254 0.12 ENSRNOT00000004619
gamma-aminobutyric acid type A receptor gamma 2 subunit
chr8_-_115981910 0.12 ENSRNOT00000019867
dedicator of cyto-kinesis 3
chr12_-_40822159 0.12 ENSRNOT00000001826
HECT domain E3 ubiquitin protein ligase 4
chr2_-_258997138 0.11 ENSRNOT00000045020
ENSRNOT00000042256
adhesion G protein-coupled receptor L2
chr1_-_267203986 0.11 ENSRNOT00000027574
SH3 and PX domains 2A
chr1_+_214562897 0.10 ENSRNOT00000085125
adaptor-related protein complex 2, alpha 2 subunit
chr1_+_156552328 0.10 ENSRNOT00000055401
discs large MAGUK scaffold protein 2
chr16_-_81980027 0.09 ENSRNOT00000043170
MCF.2 cell line derived transforming sequence-like
chr5_+_165415136 0.09 ENSRNOT00000016317
ENSRNOT00000079407
mannan-binding lectin serine peptidase 2
chr2_-_111065413 0.09 ENSRNOT00000041111
neuroligin 1
chr3_-_71845232 0.09 ENSRNOT00000078645
calcitonin receptor like receptor
chr6_-_104631355 0.09 ENSRNOT00000007825
solute carrier family 10 member 1
chr7_-_120770435 0.08 ENSRNOT00000077000
DEAD-box helicase 17
chr8_-_102149912 0.08 ENSRNOT00000011263
similar to Ab2-095
chr10_+_11393103 0.08 ENSRNOT00000076022
adenylate cyclase 9
chr4_+_170518673 0.08 ENSRNOT00000011803
activating transcription factor 7 interacting protein
chr8_+_77107536 0.07 ENSRNOT00000083255
ADAM metallopeptidase domain 10
chr3_-_162059524 0.07 ENSRNOT00000033873
zinc finger protein 334
chr10_-_103687425 0.07 ENSRNOT00000039284
Cd300 molecule-like family member F
chr10_+_86399827 0.07 ENSRNOT00000009299
growth factor receptor bound protein 7
chr6_-_67084234 0.07 ENSRNOT00000050372
NOVA alternative splicing regulator 1
chr12_-_1195591 0.06 ENSRNOT00000001446
StAR-related lipid transfer domain containing 13
chr1_+_80141630 0.06 ENSRNOT00000029552
optic atrophy 3
chr16_-_25192675 0.06 ENSRNOT00000032289
membrane associated ring-CH-type finger 1
chr5_+_58359498 0.06 ENSRNOT00000000141
PHD finger protein 24
chr2_+_44289393 0.06 ENSRNOT00000018877
interleukin 6 signal transducer
chr11_-_45124423 0.06 ENSRNOT00000046383
filamin A interacting protein 1-like
chr4_+_181103774 0.05 ENSRNOT00000084207
ENSRNOT00000055473
ENSRNOT00000077619
aryl hydrocarbon receptor nuclear translocator-like 2
chr20_-_27308069 0.05 ENSRNOT00000056047
solute carrier family 25 member 16
chr1_-_131460473 0.05 ENSRNOT00000084336
nuclear receptor subfamily 2, group F, member 2
chr14_+_17228856 0.05 ENSRNOT00000003082
C-X-C motif chemokine ligand 9
chr20_-_38985036 0.05 ENSRNOT00000001066
serine incorporator 1
chr9_+_66888393 0.05 ENSRNOT00000023536
calcium responsive transcription factor
chr1_+_277459200 0.05 ENSRNOT00000086008

chr15_-_28406046 0.04 ENSRNOT00000015418
zinc finger protein 219
chr14_+_39964588 0.04 ENSRNOT00000003240
gamma-aminobutyric acid type A receptor gamma 1 subunit
chr13_-_84619023 0.04 ENSRNOT00000089827
ENSRNOT00000045056
pogo transposable element with KRAB domain
chr14_-_21128505 0.04 ENSRNOT00000004776
RUN and FYVE domain containing 3
chr7_-_138483612 0.04 ENSRNOT00000085620
solute carrier family 38, member 4
chr6_+_93462852 0.04 ENSRNOT00000089473
AT-rich interaction domain 4A
chr8_-_94920441 0.04 ENSRNOT00000014165
centrosomal protein 162
chr13_+_83073866 0.04 ENSRNOT00000075996
dermatopontin
chr6_+_50528823 0.04 ENSRNOT00000008321
laminin subunit beta 1
chr1_+_234252757 0.04 ENSRNOT00000091814
RAR-related orphan receptor B
chr15_+_34216833 0.04 ENSRNOT00000025260
phosphoenolpyruvate carboxykinase 2 (mitochondrial)
chr6_-_108167185 0.04 ENSRNOT00000015545
aldehyde dehydrogenase 6 family, member A1
chr11_-_70498391 0.04 ENSRNOT00000040167
ENSRNOT00000086495
solute carrier family 12, member 8
chr2_-_27364906 0.04 ENSRNOT00000078639
DNA polymerase kappa
chr10_-_88060561 0.04 ENSRNOT00000019133
keratin 19
chr14_+_8080275 0.04 ENSRNOT00000065965
ENSRNOT00000092542
mitogen activated protein kinase 10
chr1_-_40921508 0.03 ENSRNOT00000026433
zinc finger and BTB domain containing 2
chr2_+_34546988 0.03 ENSRNOT00000072577
ADAM metallopeptidase with thrombospondin type 1 motif, 6
chr6_-_108660063 0.03 ENSRNOT00000006240
apoptosis resistant E3 ubiquitin protein ligase 1
chr3_+_122836446 0.03 ENSRNOT00000028816
early B-cell factor 4
chr13_-_50509916 0.03 ENSRNOT00000076747
renin
chrX_+_35599258 0.03 ENSRNOT00000072627
ENSRNOT00000005061
cyclin-dependent kinase-like 5
chr18_+_16146447 0.03 ENSRNOT00000022117
polypeptide N-acetylgalactosaminyltransferase 1
chr11_-_87924816 0.03 ENSRNOT00000031819
serpin family D member 1
chr20_+_7330250 0.03 ENSRNOT00000090993
LRRGT00097
chr18_+_59748444 0.03 ENSRNOT00000024752
ST8 alpha-N-acetyl-neuraminide alpha-2,8-sialyltransferase 3
chr7_+_63467216 0.03 ENSRNOT00000064349
N-acetylglucosamine-6-sulfatase-like
chr18_-_58097316 0.03 ENSRNOT00000088527

chr14_-_21127868 0.03 ENSRNOT00000020608
ENSRNOT00000092172
RUN and FYVE domain containing 3
chr13_-_91872954 0.03 ENSRNOT00000004613
ENSRNOT00000079263
cell adhesion molecule 3
chr13_+_74456487 0.03 ENSRNOT00000065801
angiopoietin-like 1
chr1_+_264741911 0.03 ENSRNOT00000019956
semaphorin 4G
chr14_+_42714315 0.03 ENSRNOT00000084095
ENSRNOT00000091449
paired-like homeobox 2b
chr6_+_108167716 0.03 ENSRNOT00000064426
lin-52 DREAM MuvB core complex component
chr3_-_90751055 0.03 ENSRNOT00000040741
LRRGT00091
chr7_+_26522314 0.03 ENSRNOT00000011572
solute carrier family 41 member 2
chr6_+_42947334 0.03 ENSRNOT00000041376
similar to 60S ribosomal protein L35
chr2_+_69415057 0.03 ENSRNOT00000013152
cadherin 10
chr6_+_86872903 0.02 ENSRNOT00000086894
Fanconi anemia, complementation group M
chr7_-_15072703 0.02 ENSRNOT00000087294
zinc finger protein 799
chr8_+_85417838 0.02 ENSRNOT00000012257
intestinal cell kinase
chr11_+_74984613 0.02 ENSRNOT00000035049
ATPase 13A5
chr16_-_20994379 0.02 ENSRNOT00000027639
transmembrane protein 161A
chr13_-_74331214 0.02 ENSRNOT00000006018
FAM20B, glycosaminoglycan xylosylkinase
chr2_-_23909016 0.02 ENSRNOT00000084044
secretory carrier membrane protein 1
chr3_+_148635775 0.02 ENSRNOT00000067261
transmembrane 9 superfamily member 4
chr1_-_220165678 0.02 ENSRNOT00000026915
Bardet-Biedl syndrome 1
chr7_-_97605113 0.02 ENSRNOT00000089734

chr20_+_29655226 0.02 ENSRNOT00000089059
SPARC/osteonectin, cwcv and kazal like domains proteoglycan 2
chr2_-_147819335 0.02 ENSRNOT00000057909
ankyrin repeat and ubiquitin domain containing 1
chr20_+_44060731 0.02 ENSRNOT00000000737
laminin subunit alpha 4
chr7_+_132857628 0.02 ENSRNOT00000005438
leucine-rich repeat kinase 2
chr19_-_11669578 0.02 ENSRNOT00000026373
G protein subunit alpha o1
chr8_-_90483077 0.02 ENSRNOT00000011864
pleckstrin homology domain interacting protein
chr11_-_782954 0.02 ENSRNOT00000040065
Eph receptor A3
chr5_+_120568242 0.02 ENSRNOT00000050597
leptin receptor
chr1_-_189182306 0.02 ENSRNOT00000021249
glycoprotein 2
chr5_+_49311030 0.02 ENSRNOT00000010850
cannabinoid receptor 1
chr9_-_17206994 0.02 ENSRNOT00000026195
GTP binding protein 2
chr9_+_111649631 0.01 ENSRNOT00000056430
FER tyrosine kinase
chrX_+_113510621 0.01 ENSRNOT00000025912
nuclear transport factor 2-like export factor 2
chr2_+_144861455 0.01 ENSRNOT00000093284
ENSRNOT00000019748
ENSRNOT00000072110
doublecortin-like kinase 1
chr1_-_134870255 0.01 ENSRNOT00000055829
chromodomain helicase DNA binding protein 2
chr10_-_46404642 0.01 ENSRNOT00000083698
phosphatidylethanolamine N-methyltransferase
chr2_+_197752544 0.01 ENSRNOT00000079196
ENSRNOT00000075511
endosulfine alpha
chr11_-_69223158 0.01 ENSRNOT00000067060
myosin light chain kinase
chr10_-_55783489 0.01 ENSRNOT00000010415
arachidonate 15-lipoxygenase, type B
chr1_+_72545596 0.01 ENSRNOT00000022698
shisa family member 7
chr7_-_15073052 0.01 ENSRNOT00000037708
zinc finger protein 799
chr18_+_3887419 0.01 ENSRNOT00000093089
laminin subunit alpha 3
chr11_-_15858281 0.01 ENSRNOT00000090586

chr8_+_91099491 0.01 ENSRNOT00000084852
SH3 domain binding glutamate-rich protein like 2
chr1_+_178636544 0.01 ENSRNOT00000092099
spondin 1
chr1_+_107262659 0.01 ENSRNOT00000022499
growth arrest-specific 2
chr5_+_61657507 0.00 ENSRNOT00000013228
tropomodulin 1
chr1_-_90520012 0.00 ENSRNOT00000028698
potassium channel tetramerization domain containing 15
chr3_+_137154086 0.00 ENSRNOT00000034252
otoraplin
chr13_-_1946508 0.00 ENSRNOT00000043890
dermatan sulfate epimerase-like
chr16_-_3765917 0.00 ENSRNOT00000088284
double homeobox B-like 1
chr10_-_87521514 0.00 ENSRNOT00000084668
ENSRNOT00000071705
keratin associated protein 2-4-like
chr2_+_154555871 0.00 ENSRNOT00000076292
guanine monophosphate synthase
chr9_-_55256340 0.00 ENSRNOT00000028907
serum deprivation response
chr4_+_62220736 0.00 ENSRNOT00000086377
caldesmon 1

Network of associatons between targets according to the STRING database.

First level regulatory network of Foxa3

PNG image of the network

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Gene Ontology Analysis

Gene overrepresentation in biological process category:

Log-likelihood per target  Total log-likelihood Term Description
0.0 0.1 GO:0070103 regulation of interleukin-6-mediated signaling pathway(GO:0070103)
0.0 0.2 GO:0030950 establishment or maintenance of actin cytoskeleton polarity(GO:0030950)
0.0 0.1 GO:0051088 PMA-inducible membrane protein ectodomain proteolysis(GO:0051088)
0.0 0.3 GO:0071420 cellular response to histamine(GO:0071420)
0.0 0.1 GO:0098923 retrograde trans-synaptic signaling by soluble gas(GO:0098923) trans-synaptic signaling by soluble gas(GO:0099543) trans-synaptic signaling by trans-synaptic complex(GO:0099545)
0.0 0.1 GO:2000426 regulation of interleukin-4-mediated signaling pathway(GO:1902214) negative regulation of apoptotic cell clearance(GO:2000426)
0.0 0.1 GO:0010961 cellular magnesium ion homeostasis(GO:0010961)
0.0 0.1 GO:0097498 endothelial tube lumen extension(GO:0097498)
0.0 0.1 GO:0072675 osteoclast fusion(GO:0072675)
0.0 0.1 GO:0060849 lymphatic endothelial cell fate commitment(GO:0060838) regulation of transcription involved in lymphatic endothelial cell fate commitment(GO:0060849)
0.0 0.0 GO:1904219 regulation of CDP-diacylglycerol-serine O-phosphatidyltransferase activity(GO:1904217) positive regulation of CDP-diacylglycerol-serine O-phosphatidyltransferase activity(GO:1904219) positive regulation of serine C-palmitoyltransferase activity(GO:1904222)
0.0 0.1 GO:0070842 aggresome assembly(GO:0070842)
0.0 0.2 GO:0043983 histone H4-K12 acetylation(GO:0043983)
0.0 0.1 GO:0043137 DNA replication, removal of RNA primer(GO:0043137)
0.0 0.0 GO:0021812 neuronal-glial interaction involved in cerebral cortex radial glia guided migration(GO:0021812)
0.0 0.0 GO:0006116 NADH oxidation(GO:0006116)
0.0 0.0 GO:0006574 valine catabolic process(GO:0006574)
0.0 0.0 GO:1990743 protein sialylation(GO:1990743)

Gene overrepresentation in cellular component category:

Log-likelihood per target  Total log-likelihood Term Description
0.0 0.1 GO:0070110 interleukin-6 receptor complex(GO:0005896) ciliary neurotrophic factor receptor complex(GO:0070110)
0.0 0.1 GO:0005760 gamma DNA polymerase complex(GO:0005760)
0.0 0.3 GO:1902711 GABA-A receptor complex(GO:1902711)

Gene overrepresentation in molecular function category:

Log-likelihood per target  Total log-likelihood Term Description
0.0 0.1 GO:0030144 alpha-1,6-mannosylglycoprotein 6-beta-N-acetylglucosaminyltransferase activity(GO:0030144)
0.0 0.1 GO:0001605 adrenomedullin receptor activity(GO:0001605)
0.0 0.1 GO:0008508 bile acid:sodium symporter activity(GO:0008508)
0.0 0.3 GO:0005237 inhibitory extracellular ligand-gated ion channel activity(GO:0005237)
0.0 0.1 GO:0004924 oncostatin-M receptor activity(GO:0004924)
0.0 0.1 GO:0005136 interleukin-4 receptor binding(GO:0005136)
0.0 0.1 GO:0016890 site-specific endodeoxyribonuclease activity, specific for altered base(GO:0016890)
0.0 0.2 GO:0045294 alpha-catenin binding(GO:0045294) delta-catenin binding(GO:0070097)
0.0 0.0 GO:0008502 melatonin receptor activity(GO:0008502)
0.0 0.1 GO:0016176 superoxide-generating NADPH oxidase activator activity(GO:0016176)
0.0 0.1 GO:0001846 opsonin binding(GO:0001846)
0.0 0.0 GO:0003828 alpha-N-acetylneuraminate alpha-2,8-sialyltransferase activity(GO:0003828)
0.0 0.1 GO:0048248 CXCR3 chemokine receptor binding(GO:0048248)

Gene overrepresentation in curated gene sets: REACTOME pathways category:

Log-likelihood per target  Total log-likelihood Term Description
0.0 0.3 REACTOME GABA A RECEPTOR ACTIVATION Genes involved in GABA A receptor activation
0.0 0.1 REACTOME RECYCLING OF BILE ACIDS AND SALTS Genes involved in Recycling of bile acids and salts
0.0 0.2 REACTOME DOPAMINE NEUROTRANSMITTER RELEASE CYCLE Genes involved in Dopamine Neurotransmitter Release Cycle
0.0 0.2 REACTOME N GLYCAN ANTENNAE ELONGATION Genes involved in N-Glycan antennae elongation