ISMARA results: Ezh2_Atf2

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GSE49485: Hypoxia transcriptome sequencing of rat brain.

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Results for Ezh2_Atf2_Ikzf1

Z-value: 0.49

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Transcription factors associated with Ezh2_Atf2_Ikzf1

Gene Symbol	Gene ID	Gene Info
Ezh2 NCBI RGD Ensembl	ENSRNOG00000006048	enhancer of zeste 2 polycomb repressive complex 2 subunit
Atf2 NCBI RGD Ensembl	ENSRNOG00000001597	activating transcription factor 2
Ikzf1 NCBI RGD Ensembl	ENSRNOG00000004444	IKAROS family zinc finger 1

Activity-expression correlation:

Gene	Promoter	Pearson corr. coef.	P-value	Plot
Atf2	rn6_v1_chr3_-_60795951_60795951	1.00	3.7e-04	Click!
Ikzf1	rn6_v1_chr14_+_91783514_91783514	0.97	7.6e-03	Click!
Ezh2	rn6_v1_chr4_-_77347011_77347011	0.24	7.0e-01	Click!

Activity profile of Ezh2_Atf2_Ikzf1 motif

Sorted Z-values of Ezh2_Atf2_Ikzf1 motif

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Promoter	Log-likelihood	Transcript	Gene	Gene Info
chr3_+_58965552 Show fit	0.27	ENSRNOT00000002068	Map3k20 NCBI RGD Ensembl Show fit	mitogen-activated protein kinase kinase kinase 20
chr12_-_10307265 Show fit	0.23	ENSRNOT00000092627	Wasf3 NCBI RGD Ensembl Show fit	WAS protein family, member 3
chr1_-_43638161 Show fit	0.23	ENSRNOT00000024460	Ipcef1 NCBI RGD Ensembl Show fit	interaction protein for cytohesin exchange factors 1
chr12_+_13810180 Show fit	0.22	ENSRNOT00000084865 ENSRNOT00000038203	Tnrc18 NCBI RGD Ensembl Show fit	trinucleotide repeat containing 18
chr14_+_8080565 Show fit	0.21	ENSRNOT00000092395	Mapk10 NCBI RGD Ensembl Show fit	mitogen activated protein kinase 10
chr15_-_110046687 Show fit	0.21	ENSRNOT00000057404 ENSRNOT00000006624 ENSRNOT00000089695	Nalcn NCBI RGD Ensembl Show fit	sodium leak channel, non-selective
chr18_+_27558089 Show fit	0.21	ENSRNOT00000027499	Fam53c NCBI RGD Ensembl Show fit	family with sequence similarity 53, member C
chr4_+_22859622 Show fit	0.20	ENSRNOT00000073501 ENSRNOT00000068410	Adam22 NCBI RGD Ensembl Show fit	ADAM metallopeptidase domain 22
chr4_-_11497531 Show fit	0.19	ENSRNOT00000078799	Magi2 NCBI RGD Ensembl Show fit	membrane associated guanylate kinase, WW and PDZ domain containing 2
chr10_+_47019326 Show fit	0.19	ENSRNOT00000006984	Smcr8 NCBI RGD Ensembl Show fit	Smith-Magenis syndrome chromosome region, candidate 8

Showing 1 to 10 of 200 entries

Network of associatons between targets according to the STRING database.

First level regulatory network of Ezh2_Atf2_Ikzf1

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Gene Ontology Analysis

Gene overrepresentation in biological process category:

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Total log-likelihood	Term	Description
0.4	GO:0007258	JUN phosphorylation(GO:0007258)
0.3	GO:1901098	positive regulation of autophagosome maturation(GO:1901098)
0.3	GO:0032012	regulation of ARF protein signal transduction(GO:0032012)
0.2	GO:0098735	positive regulation of the force of heart contraction(GO:0098735)
0.2	GO:0099566	regulation of postsynaptic cytosolic calcium ion concentration(GO:0099566)
0.2	GO:0098928	presynaptic signal transduction(GO:0098928) presynapse to nucleus signaling pathway(GO:0099526)
0.2	GO:0033092	positive regulation of immature T cell proliferation in thymus(GO:0033092)
0.2	GO:0071332	cellular response to fructose stimulus(GO:0071332)
0.2	GO:0097118	neuroligin clustering involved in postsynaptic membrane assembly(GO:0097118)
0.2	GO:0010606	positive regulation of cytoplasmic mRNA processing body assembly(GO:0010606)

Showing 1 to 10 of 72 entries

Gene overrepresentation in cellular component category:

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Log-likelihood per target	Total log-likelihood	Term	Description
0.1	0.4	GO:0099569	presynaptic cytoskeleton(GO:0099569)
0.0	0.3	GO:1990316	ATG1/ULK1 kinase complex(GO:1990316)
0.0	0.3	GO:1990454	L-type voltage-gated calcium channel complex(GO:1990454)
0.1	0.2	GO:0034686	integrin alphav-beta8 complex(GO:0034686)
0.0	0.2	GO:0030015	CCR4-NOT core complex(GO:0030015)
0.0	0.2	GO:0044308	axonal spine(GO:0044308)
0.0	0.2	GO:0005677	chromatin silencing complex(GO:0005677)
0.0	0.2	GO:0036057	filtration diaphragm(GO:0036056) slit diaphragm(GO:0036057)
0.0	0.2	GO:0035102	PRC1 complex(GO:0035102)
0.0	0.2	GO:0046581	intercellular canaliculus(GO:0046581)

Showing 1 to 10 of 26 entries

Gene overrepresentation in molecular function category:

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Log-likelihood per target	Total log-likelihood	Term	Description
0.0	0.4	GO:0004705	JUN kinase activity(GO:0004705) SAP kinase activity(GO:0016909)
0.1	0.3	GO:0004971	AMPA glutamate receptor activity(GO:0004971)
0.0	0.3	GO:0017075	syntaxin-1 binding(GO:0017075)
0.0	0.3	GO:0004709	MAP kinase kinase kinase activity(GO:0004709)
0.1	0.2	GO:0070699	type II activin receptor binding(GO:0070699)
0.1	0.2	GO:0001226	RNA polymerase II transcription corepressor binding(GO:0001226)
0.0	0.2	GO:1990430	extracellular matrix protein binding(GO:1990430)
0.0	0.2	GO:0022840	leak channel activity(GO:0022840) narrow pore channel activity(GO:0022842)
0.0	0.2	GO:0086059	voltage-gated calcium channel activity involved SA node cell action potential(GO:0086059)
0.0	0.2	GO:0019992	diacylglycerol binding(GO:0019992)

Showing 1 to 10 of 52 entries

Gene overrepresentation in curated gene sets: canonical pathways category:

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Total log-likelihood	Term	Description
0.3	SA PTEN PATHWAY	PTEN is a tumor suppressor that dephosphorylates the lipid messenger phosphatidylinositol triphosphate.
0.3	ST GRANULE CELL SURVIVAL PATHWAY	Granule Cell Survival Pathway is a specific case of more general PAC1 Receptor Pathway.
0.2	PID PDGFRA PATHWAY	PDGFR-alpha signaling pathway
0.1	PID ALK2 PATHWAY	ALK2 signaling events

Showing 1 to 4 of 4 entries

Gene overrepresentation in curated gene sets: REACTOME pathways category:

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Total log-likelihood	Term	Description
0.4	REACTOME ACTIVATION OF THE AP1 FAMILY OF TRANSCRIPTION FACTORS	Genes involved in Activation of the AP-1 family of transcription factors
0.3	REACTOME TRAFFICKING OF GLUR2 CONTAINING AMPA RECEPTORS	Genes involved in Trafficking of GluR2-containing AMPA receptors
0.2	REACTOME GABA A RECEPTOR ACTIVATION	Genes involved in GABA A receptor activation
0.2	REACTOME FACILITATIVE NA INDEPENDENT GLUCOSE TRANSPORTERS	Genes involved in Facilitative Na+-independent glucose transporters
0.2	REACTOME DEADENYLATION OF MRNA	Genes involved in Deadenylation of mRNA
0.1	REACTOME PECAM1 INTERACTIONS	Genes involved in PECAM1 interactions

Showing 1 to 6 of 6 entries

Results for Ezh2_Atf2_Ikzf1

Z-value: 0.49

Motif logo

Transcription factors associated with Ezh2_Atf2_Ikzf1

Activity-expression correlation:

Activity profile of Ezh2_Atf2_Ikzf1 motif

Sorted Z-values of Ezh2_Atf2_Ikzf1 motif

Top targets:

Network of associatons between targets according to the STRING database.

First level regulatory network of Ezh2_Atf2_Ikzf1

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Gene Ontology Analysis

Gene overrepresentation in biological process category:

Gene overrepresentation in cellular component category:

Gene overrepresentation in molecular function category:

Gene overrepresentation in curated gene sets: canonical pathways category:

Gene overrepresentation in curated gene sets: REACTOME pathways category: