ISMARA results: Evx2

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GSE49485: Hypoxia transcriptome sequencing of rat brain.

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Results for Evx2

Z-value: 0.68

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Transcription factors associated with Evx2

Gene Symbol	Gene ID	Gene Info
Evx2 NCBI RGD Ensembl	ENSRNOG00000001589	even-skipped homeobox 2

Activity-expression correlation:

Gene	Promoter	Pearson corr. coef.	P-value	Plot
Evx2	rn6_v1_chr3_-_61581598_61581598	-0.06	9.2e-01	Click!

Activity profile of Evx2 motif

Sorted Z-values of Evx2 motif

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Promoter	Log-likelihood	Transcript	Gene	Gene Info
chr10_-_88670430 Show fit	2.23	ENSRNOT00000025547	Hcrt NCBI RGD Ensembl Show fit	hypocretin neuropeptide precursor
chr12_-_2174131 Show fit	1.28	ENSRNOT00000001313	Pcp2 NCBI RGD Ensembl Show fit	Purkinje cell protein 2
chr4_+_148782479 Show fit	1.04	ENSRNOT00000018133	LOC500300 NCBI RGD Ensembl Show fit	similar to hypothetical protein MGC6835
chr20_-_9855443 Show fit	0.46	ENSRNOT00000090275 ENSRNOT00000066266	Tff3 NCBI RGD Ensembl Show fit	trefoil factor 3
chr7_-_28711761 Show fit	0.40	ENSRNOT00000006249	Parpbp NCBI RGD Ensembl Show fit	PARP1 binding protein
chr9_+_98924134 Show fit	0.29	ENSRNOT00000027597	Twist2 NCBI RGD Ensembl Show fit	twist family bHLH transcription factor 2
chr20_+_44680449 Show fit	0.26	ENSRNOT00000000728	Traf3ip2 NCBI RGD Ensembl Show fit	Traf3 interacting protein 2
chr17_-_43776460 Show fit	0.18	ENSRNOT00000089055	Hist2h3c2 NCBI RGD Ensembl Show fit	histone cluster 2, H3c2
chr13_+_89480058 Show fit	0.16	ENSRNOT00000050804	Cfap126 NCBI RGD Ensembl Show fit	cilia and flagella associated protein 126
chr2_+_188583664 Show fit	0.16	ENSRNOT00000045477	Dpm3 NCBI RGD Ensembl Show fit	dolichyl-phosphate mannosyltransferase subunit 3

Showing 1 to 10 of 69 entries

Network of associatons between targets according to the STRING database.

First level regulatory network of Evx2

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Gene Ontology Analysis

Gene overrepresentation in biological process category:

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Log-likelihood per target	Total log-likelihood	Term	Description
0.3	2.2	GO:0051970	negative regulation of transmission of nerve impulse(GO:0051970)
0.2	1.3	GO:0016056	rhodopsin mediated signaling pathway(GO:0016056)
0.0	0.4	GO:2000042	negative regulation of double-strand break repair via homologous recombination(GO:2000042)
0.0	0.3	GO:0061303	cornea development in camera-type eye(GO:0061303)
0.0	0.3	GO:0002230	positive regulation of defense response to virus by host(GO:0002230)
0.0	0.2	GO:0035269	protein O-linked mannosylation(GO:0035269)
0.0	0.1	GO:0016557	peroxisome membrane biogenesis(GO:0016557)
0.0	0.1	GO:0043396	corticotropin-releasing hormone secretion(GO:0043396) regulation of corticotropin-releasing hormone secretion(GO:0043397)
0.0	0.1	GO:0097428	protein maturation by iron-sulfur cluster transfer(GO:0097428)
0.0	0.1	GO:0021779	oligodendrocyte cell fate specification(GO:0021778) oligodendrocyte cell fate commitment(GO:0021779) glial cell fate specification(GO:0021780)

Showing 1 to 10 of 10 entries

Gene overrepresentation in cellular component category:

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Log-likelihood per target	Total log-likelihood	Term	Description
0.0	2.2	GO:0005791	rough endoplasmic reticulum(GO:0005791)
0.1	0.2	GO:0033185	dolichol-phosphate-mannose synthase complex(GO:0033185)
0.0	0.0	GO:0031092	platelet alpha granule membrane(GO:0031092)

Showing 1 to 3 of 3 entries

Gene overrepresentation in molecular function category:

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Log-likelihood per target	Total log-likelihood	Term	Description
0.1	2.2	GO:0005184	neuropeptide hormone activity(GO:0005184)
0.1	0.2	GO:0004582	dolichyl-phosphate beta-D-mannosyltransferase activity(GO:0004582)
0.0	0.1	GO:0000268	peroxisome targeting sequence binding(GO:0000268)
0.0	0.1	GO:0022820	potassium:chloride symporter activity(GO:0015379) potassium ion symporter activity(GO:0022820)
0.0	0.1	GO:0019855	calcium channel inhibitor activity(GO:0019855)
0.0	0.1	GO:0031545	peptidyl-proline 4-dioxygenase activity(GO:0031545)

Showing 1 to 6 of 6 entries

Gene overrepresentation in curated gene sets: REACTOME pathways category:

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Log-likelihood per target	Total log-likelihood	Term	Description
0.0	2.2	REACTOME PEPTIDE LIGAND BINDING RECEPTORS	Genes involved in Peptide ligand-binding receptors

Showing 1 to 1 of 1 entries

Results for Evx2

Z-value: 0.68

Motif logo

Transcription factors associated with Evx2

Activity-expression correlation:

Activity profile of Evx2 motif

Sorted Z-values of Evx2 motif

Top targets:

Network of associatons between targets according to the STRING database.

First level regulatory network of Evx2

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Gene Ontology Analysis

Gene overrepresentation in biological process category:

Gene overrepresentation in cellular component category:

Gene overrepresentation in molecular function category:

Gene overrepresentation in curated gene sets: REACTOME pathways category: