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GSE49485: Hypoxia transcriptome sequencing of rat brain.

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Results for Evx2

Z-value: 0.68

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Transcription factors associated with Evx2

Gene Symbol Gene ID Gene Info
ENSRNOG00000001589 even-skipped homeobox 2

Activity-expression correlation:

GenePromoterPearson corr. coef.P-valuePlot
Evx2rn6_v1_chr3_-_61581598_61581598-0.069.2e-01Click!

Activity profile of Evx2 motif

Sorted Z-values of Evx2 motif

Promoter Log-likelihood Transcript Gene Gene Info
chr10_-_88670430 2.23 ENSRNOT00000025547
hypocretin neuropeptide precursor
chr12_-_2174131 1.28 ENSRNOT00000001313
Purkinje cell protein 2
chr4_+_148782479 1.04 ENSRNOT00000018133
similar to hypothetical protein MGC6835
chr20_-_9855443 0.46 ENSRNOT00000090275
ENSRNOT00000066266
trefoil factor 3
chr7_-_28711761 0.40 ENSRNOT00000006249
PARP1 binding protein
chr9_+_98924134 0.29 ENSRNOT00000027597
twist family bHLH transcription factor 2
chr20_+_44680449 0.26 ENSRNOT00000000728
Traf3 interacting protein 2
chr17_-_43776460 0.18 ENSRNOT00000089055
histone cluster 2, H3c2
chr13_+_89480058 0.16 ENSRNOT00000050804
cilia and flagella associated protein 126
chr2_+_188583664 0.16 ENSRNOT00000045477
dolichyl-phosphate mannosyltransferase subunit 3
chr8_+_57983556 0.15 ENSRNOT00000009562
similar to RIKEN cDNA 4930550C14
chr14_-_115052450 0.15 ENSRNOT00000067998
acylphosphatase 2
chr19_-_37938857 0.14 ENSRNOT00000026730
solute carrier family 12 member 4
chr12_-_19167015 0.14 ENSRNOT00000001797
gap junction protein, gamma 3
chr10_+_103395511 0.14 ENSRNOT00000004256
G protein-coupled receptor, class C, group 5, member C
chr3_+_80072489 0.11 ENSRNOT00000057176
protein kinase C and casein kinase substrate in neurons 3
chr5_+_28485619 0.10 ENSRNOT00000093341
ENSRNOT00000093129
uncharacterized LOC100912373
chr5_-_151473750 0.09 ENSRNOT00000011357
transmembrane protein 222
chr13_+_90514336 0.09 ENSRNOT00000088996
ENSRNOT00000085377
peroxisomal biogenesis factor 19
chr12_-_48627297 0.08 ENSRNOT00000000890
iron-sulfur cluster assembly enzyme
chr1_-_189238776 0.08 ENSRNOT00000020817
protein disulfide isomerase-like, testis expressed
chr16_+_51748970 0.08 ENSRNOT00000059182
a disintegrin and metallopeptidase domain 26A
chr13_-_73638073 0.08 ENSRNOT00000005195
centrosomal protein 350
chr7_+_38900593 0.08 ENSRNOT00000072166
epiphycan
chr3_-_165537940 0.08 ENSRNOT00000071119
ENSRNOT00000070964
spalt-like transcription factor 4
chr10_+_11046221 0.08 ENSRNOT00000005109
NmrA like redox sensor 1
chr13_+_90943255 0.08 ENSRNOT00000011539
V-set and immunoglobulin domain containing 8
chr9_+_15166118 0.07 ENSRNOT00000020432
MyoD family inhibitor
chr11_-_61234944 0.07 ENSRNOT00000059680
cilia and flagella associated protein 44
chr16_-_70242979 0.07 ENSRNOT00000071269
vacuolar ATPase assembly integral membrane protein Vma21
chr1_+_189432604 0.07 ENSRNOT00000034610
acyl-CoA synthetase medium-chain family member 4
chr4_+_70977556 0.06 ENSRNOT00000031984
hypothetical protein LOC680112
chr7_-_12311149 0.06 ENSRNOT00000046886
DAZ associated protein 1
chr4_-_21920651 0.06 ENSRNOT00000066211
transmembrane protein 243
chr1_+_185863043 0.06 ENSRNOT00000079072
SRY box 6
chr17_-_34945317 0.06 ENSRNOT00000090457
VMA21 vacuolar H+-ATPase homolog (S. cerevisiae)
chrX_-_134866210 0.06 ENSRNOT00000005331
apelin
chr1_-_88657845 0.05 ENSRNOT00000074211
calpain small subunit 1-like
chr20_+_7409401 0.05 ENSRNOT00000000586
small nuclear ribonucleoprotein polypeptide C
chr3_+_113319456 0.05 ENSRNOT00000051354
creatine kinase, mitochondrial 1
chr11_-_87403367 0.05 ENSRNOT00000057751
THAP domain containing 7
chr10_-_14324170 0.05 ENSRNOT00000035513
ENSRNOT00000090587
hematological and neurological expressed 1-like
chr17_+_9797907 0.05 ENSRNOT00000021638
lectin, mannose-binding 2
chr1_-_57518458 0.05 ENSRNOT00000002040
programmed cell death 2
chr1_-_252461461 0.04 ENSRNOT00000026093
ankyrin repeat domain 22
chr15_-_12889102 0.04 ENSRNOT00000061214
ENSRNOT00000084687
similar to HT021
chr20_-_157665 0.04 ENSRNOT00000048858
ENSRNOT00000079494
RT1 class I, locus CE10
chr13_+_82438697 0.03 ENSRNOT00000003759
selectin P
chr8_+_126975833 0.03 ENSRNOT00000088348

chr11_-_62067655 0.03 ENSRNOT00000093382
zinc finger and BTB domain containing 20
chr3_-_113091770 0.03 ENSRNOT00000068132
leucine carboxyl methyltransferase 2
chr2_-_219262901 0.03 ENSRNOT00000037068
G-protein coupled receptor 88
chr5_+_117583502 0.03 ENSRNOT00000010933
ubiquitin specific peptidase 1
chr20_-_4698718 0.03 ENSRNOT00000047527
RT1 class I, locus CE7
chr2_-_158156444 0.03 ENSRNOT00000088559
ventricular zone expressed PH domain-containing 1
chr11_+_58624198 0.03 ENSRNOT00000002091
growth associated protein 43
chr8_-_114617466 0.02 ENSRNOT00000082992
ENSRNOT00000038160
collagen type VI alpha 5 chain
chrX_+_110016995 0.02 ENSRNOT00000093542
Nik related kinase
chr1_-_142759882 0.02 ENSRNOT00000015218
SEC11 homolog A, signal peptidase complex subunit
chr9_+_8052210 0.02 ENSRNOT00000073659
adhesion G protein-coupled receptor E4
chr1_+_98414226 0.02 ENSRNOT00000090785
SIGLEC family like 1
chr10_-_43931094 0.01 ENSRNOT00000039778
olfactory receptor 1415
chr15_-_12129220 0.01 ENSRNOT00000029318
olfactory receptor 1605
chr7_-_113228439 0.01 ENSRNOT00000034672
collagen type XXII alpha 1 chain
chr18_+_16544508 0.01 ENSRNOT00000020601
elongator acetyltransferase complex subunit 2
chr18_-_16543992 0.01 ENSRNOT00000036306
solute carrier family 39 member 6
chr12_+_41486076 0.01 ENSRNOT00000057242
RBPJ interacting and tubulin associated 1
chr20_+_3176107 0.01 ENSRNOT00000001036
RT1 class Ib, locus S3
chr1_-_81550598 0.00 ENSRNOT00000051671
similar to BC049730 protein

Network of associatons between targets according to the STRING database.

First level regulatory network of Evx2

PNG image of the network

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Gene Ontology Analysis

Gene overrepresentation in biological process category:

Log-likelihood per target  Total log-likelihood Term Description
0.3 2.2 GO:0051970 negative regulation of transmission of nerve impulse(GO:0051970)
0.2 1.3 GO:0016056 rhodopsin mediated signaling pathway(GO:0016056)
0.0 0.3 GO:0061303 cornea development in camera-type eye(GO:0061303)
0.0 0.4 GO:2000042 negative regulation of double-strand break repair via homologous recombination(GO:2000042)
0.0 0.1 GO:0016557 peroxisome membrane biogenesis(GO:0016557)
0.0 0.1 GO:0043396 corticotropin-releasing hormone secretion(GO:0043396) regulation of corticotropin-releasing hormone secretion(GO:0043397)
0.0 0.3 GO:0002230 positive regulation of defense response to virus by host(GO:0002230)
0.0 0.1 GO:0097428 protein maturation by iron-sulfur cluster transfer(GO:0097428)
0.0 0.1 GO:0021779 oligodendrocyte cell fate specification(GO:0021778) oligodendrocyte cell fate commitment(GO:0021779) glial cell fate specification(GO:0021780)
0.0 0.2 GO:0035269 protein O-linked mannosylation(GO:0035269)

Gene overrepresentation in cellular component category:

Log-likelihood per target  Total log-likelihood Term Description
0.1 0.2 GO:0033185 dolichol-phosphate-mannose synthase complex(GO:0033185)
0.0 2.2 GO:0005791 rough endoplasmic reticulum(GO:0005791)
0.0 0.0 GO:0031092 platelet alpha granule membrane(GO:0031092)

Gene overrepresentation in molecular function category:

Log-likelihood per target  Total log-likelihood Term Description
0.1 2.2 GO:0005184 neuropeptide hormone activity(GO:0005184)
0.1 0.2 GO:0004582 dolichyl-phosphate beta-D-mannosyltransferase activity(GO:0004582)
0.0 0.1 GO:0000268 peroxisome targeting sequence binding(GO:0000268)
0.0 0.1 GO:0022820 potassium:chloride symporter activity(GO:0015379) potassium ion symporter activity(GO:0022820)
0.0 0.1 GO:0019855 calcium channel inhibitor activity(GO:0019855)
0.0 0.1 GO:0031545 peptidyl-proline 4-dioxygenase activity(GO:0031545)

Gene overrepresentation in curated gene sets: REACTOME pathways category:

Log-likelihood per target  Total log-likelihood Term Description
0.0 2.2 REACTOME PEPTIDE LIGAND BINDING RECEPTORS Genes involved in Peptide ligand-binding receptors