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GSE49485: Hypoxia transcriptome sequencing of rat brain.
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Results for Etv1_Etv5_Gabpa
Z-value: 1.08
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Transcription factors associated with Etv1_Etv5_Gabpa
Activity-expression correlation:
| Gene | Promoter | Pearson corr. coef. | P-value | Plot |
|---|---|---|---|---|
| Gabpa | rn6_v1_chr11_+_24263281_24263281 | -0.59 | 3.0e-01 | Click! |
| Etv5 | rn6_v1_chr11_+_82194657_82194657 | -0.58 | 3.1e-01 | Click! |
| Etv1 | rn6_v1_chr6_+_58467254_58467254 | 0.42 | 4.8e-01 | Click! |
| Promoter | Log-likelihood | Transcript | Gene | Gene Info |
|---|---|---|---|---|
| chr3_-_152382529 Show fit | 0.89 |
ENSRNOT00000027076
|
SCAN domain-containing 1 |
|
| chr20_+_5441876 Show fit | 0.87 |
ENSRNOT00000092476
|
ribosomal protein S18 |
|
| chr3_+_121660110 Show fit | 0.81 |
ENSRNOT00000024942
|
coiled-coil-helix-coiled-coil-helix domain containing 5 |
|
| chr3_-_122703705 Show fit | 0.74 |
ENSRNOT00000079923
ENSRNOT00000049857 |
small nuclear ribonucleoprotein polypeptides B and B1 |
|
| chr7_-_28715224 Show fit | 0.74 |
ENSRNOT00000065899
|
PARP1 binding protein |
|
| chr1_-_224974203 Show fit | 0.70 |
ENSRNOT00000065694
|
transmembrane protein 179B |
|
| chr15_-_34352673 Show fit | 0.65 |
ENSRNOT00000064916
|
neural precursor cell expressed, developmentally down-regulated 8 |
|
| chr6_-_104290579 Show fit | 0.65 |
ENSRNOT00000066014
|
enhancer of rudimentary homolog (Drosophila) |
|
| chr4_-_87019219 Show fit | 0.61 |
ENSRNOT00000065625
|
LSM5 homolog, U6 small nuclear RNA and mRNA degradation associated |
|
| chr10_-_88551056 Show fit | 0.61 |
ENSRNOT00000032737
|
zinc finger protein 385C |
Network of associatons between targets according to the STRING database.
First level regulatory network of Etv1_Etv5_Gabpa
Gene Ontology Analysis
Gene overrepresentation in biological process category:
| Log-likelihood per target | Total log-likelihood | Term | Description |
|---|---|---|---|
| 0.1 | 1.6 | GO:0000028 | ribosomal small subunit assembly(GO:0000028) |
| 0.1 | 1.4 | GO:0033617 | mitochondrial respiratory chain complex IV assembly(GO:0033617) |
| 0.1 | 1.2 | GO:0031125 | rRNA 3'-end processing(GO:0031125) |
| 0.0 | 1.2 | GO:0070527 | platelet aggregation(GO:0070527) |
| 0.0 | 1.1 | GO:0015986 | energy coupled proton transport, down electrochemical gradient(GO:0015985) ATP synthesis coupled proton transport(GO:0015986) |
| 0.1 | 1.0 | GO:0045116 | protein neddylation(GO:0045116) |
| 0.0 | 1.0 | GO:0000387 | spliceosomal snRNP assembly(GO:0000387) |
| 0.0 | 1.0 | GO:0021762 | substantia nigra development(GO:0021762) |
| 0.1 | 0.9 | GO:0006123 | mitochondrial electron transport, cytochrome c to oxygen(GO:0006123) |
| 0.1 | 0.9 | GO:0043248 | proteasome assembly(GO:0043248) |
Gene overrepresentation in cellular component category:
| Log-likelihood per target | Total log-likelihood | Term | Description |
|---|---|---|---|
| 0.1 | 5.9 | GO:0022627 | cytosolic small ribosomal subunit(GO:0022627) |
| 0.0 | 4.0 | GO:0022625 | cytosolic large ribosomal subunit(GO:0022625) |
| 0.0 | 2.8 | GO:0000315 | organellar large ribosomal subunit(GO:0000315) mitochondrial large ribosomal subunit(GO:0005762) |
| 0.0 | 2.5 | GO:0005747 | mitochondrial respiratory chain complex I(GO:0005747) NADH dehydrogenase complex(GO:0030964) respiratory chain complex I(GO:0045271) |
| 0.0 | 2.5 | GO:0005759 | mitochondrial matrix(GO:0005759) |
| 0.0 | 1.7 | GO:0005758 | mitochondrial intermembrane space(GO:0005758) |
| 0.0 | 1.4 | GO:0033116 | endoplasmic reticulum-Golgi intermediate compartment membrane(GO:0033116) |
| 0.1 | 1.2 | GO:0005751 | mitochondrial respiratory chain complex IV(GO:0005751) |
| 0.1 | 1.1 | GO:0031595 | nuclear proteasome complex(GO:0031595) |
| 0.1 | 1.0 | GO:0005838 | proteasome regulatory particle(GO:0005838) |
Gene overrepresentation in molecular function category:
| Log-likelihood per target | Total log-likelihood | Term | Description |
|---|---|---|---|
| 0.0 | 12.7 | GO:0003735 | structural constituent of ribosome(GO:0003735) |
| 0.1 | 1.6 | GO:0004129 | cytochrome-c oxidase activity(GO:0004129) heme-copper terminal oxidase activity(GO:0015002) oxidoreductase activity, acting on a heme group of donors, oxygen as acceptor(GO:0016676) |
| 0.1 | 1.5 | GO:0003954 | NADH dehydrogenase activity(GO:0003954) |
| 0.0 | 1.4 | GO:0003743 | translation initiation factor activity(GO:0003743) |
| 0.1 | 0.9 | GO:0036402 | proteasome-activating ATPase activity(GO:0036402) |
| 0.0 | 0.9 | GO:0051087 | chaperone binding(GO:0051087) |
| 0.3 | 0.8 | GO:0071208 | histone pre-mRNA DCP binding(GO:0071208) |
| 0.1 | 0.8 | GO:0015450 | P-P-bond-hydrolysis-driven protein transmembrane transporter activity(GO:0015450) |
| 0.1 | 0.8 | GO:0051787 | misfolded protein binding(GO:0051787) |
| 0.0 | 0.8 | GO:0004298 | threonine-type endopeptidase activity(GO:0004298) threonine-type peptidase activity(GO:0070003) |
Gene overrepresentation in curated gene sets: canonical pathways category:
| Log-likelihood per target | Total log-likelihood | Term | Description |
|---|---|---|---|
| 0.0 | 0.8 | PID ERB GENOMIC PATHWAY | Validated nuclear estrogen receptor beta network |
| 0.0 | 0.8 | PID HIF1 TFPATHWAY | HIF-1-alpha transcription factor network |
| 0.0 | 0.7 | PID ALPHA SYNUCLEIN PATHWAY | Alpha-synuclein signaling |
| 0.0 | 0.6 | PID ARF 3PATHWAY | Arf1 pathway |
| 0.0 | 0.5 | PID ALK1 PATHWAY | ALK1 signaling events |
| 0.0 | 0.5 | PID ATR PATHWAY | ATR signaling pathway |
| 0.0 | 0.4 | PID HIF1A PATHWAY | Hypoxic and oxygen homeostasis regulation of HIF-1-alpha |
| 0.0 | 0.3 | ST GAQ PATHWAY | G alpha q Pathway |
| 0.0 | 0.3 | PID HDAC CLASSIII PATHWAY | Signaling events mediated by HDAC Class III |
| 0.0 | 0.2 | PID ARF6 DOWNSTREAM PATHWAY | Arf6 downstream pathway |
Gene overrepresentation in curated gene sets: REACTOME pathways category:
| Log-likelihood per target | Total log-likelihood | Term | Description |
|---|---|---|---|
| 0.1 | 5.8 | REACTOME FORMATION OF THE TERNARY COMPLEX AND SUBSEQUENTLY THE 43S COMPLEX | Genes involved in Formation of the ternary complex, and subsequently, the 43S complex |
| 0.1 | 4.0 | REACTOME RESPIRATORY ELECTRON TRANSPORT | Genes involved in Respiratory electron transport |
| 0.1 | 3.2 | REACTOME PEPTIDE CHAIN ELONGATION | Genes involved in Peptide chain elongation |
| 0.1 | 2.6 | REACTOME VIF MEDIATED DEGRADATION OF APOBEC3G | Genes involved in Vif-mediated degradation of APOBEC3G |
| 0.0 | 1.3 | REACTOME MITOCHONDRIAL PROTEIN IMPORT | Genes involved in Mitochondrial Protein Import |
| 0.1 | 1.2 | REACTOME FORMATION OF ATP BY CHEMIOSMOTIC COUPLING | Genes involved in Formation of ATP by chemiosmotic coupling |
| 0.0 | 1.2 | REACTOME PREFOLDIN MEDIATED TRANSFER OF SUBSTRATE TO CCT TRIC | Genes involved in Prefoldin mediated transfer of substrate to CCT/TriC |
| 0.0 | 1.1 | REACTOME POST TRANSLATIONAL MODIFICATION SYNTHESIS OF GPI ANCHORED PROTEINS | Genes involved in Post-translational modification: synthesis of GPI-anchored proteins |
| 0.0 | 1.0 | REACTOME SRP DEPENDENT COTRANSLATIONAL PROTEIN TARGETING TO MEMBRANE | Genes involved in SRP-dependent cotranslational protein targeting to membrane |
| 0.0 | 0.7 | REACTOME ENOS ACTIVATION AND REGULATION | Genes involved in eNOS activation and regulation |