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GSE49485: Hypoxia transcriptome sequencing of rat brain.
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Results for Ets1
Z-value: 0.79
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Transcription factors associated with Ets1
Activity-expression correlation:
| Gene | Promoter | Pearson corr. coef. | P-value | Plot |
|---|---|---|---|---|
| Ets1 | rn6_v1_chr8_+_33816386_33816386 | 0.62 | 2.6e-01 | Click! |
| Promoter | Log-likelihood | Transcript | Gene | Gene Info |
|---|---|---|---|---|
| chrX_-_73778595 Show fit | 0.49 |
ENSRNOT00000076081
ENSRNOT00000075926 ENSRNOT00000003782 |
ring finger protein, LIM domain interacting |
|
| chr10_-_64642292 Show fit | 0.45 |
ENSRNOT00000084670
|
active BCR-related |
|
| chr6_+_104291071 Show fit | 0.45 |
ENSRNOT00000006798
|
solute carrier family 39, member 9 |
|
| chr8_-_21968415 Show fit | 0.44 |
ENSRNOT00000067325
ENSRNOT00000064932 |
DNA methyltransferase 1 |
|
| chr2_+_190003223 Show fit | 0.38 |
ENSRNOT00000015712
|
S100 calcium binding protein A5 |
|
| chr3_-_152382529 Show fit | 0.38 |
ENSRNOT00000027076
|
SCAN domain-containing 1 |
|
| chr15_-_57805184 Show fit | 0.36 |
ENSRNOT00000000168
|
component of oligomeric golgi complex 3 |
|
| chr3_-_38277440 Show fit | 0.36 |
ENSRNOT00000037857
|
signal transducing adaptor molecule 2 |
|
| chr4_-_63039422 Show fit | 0.34 |
ENSRNOT00000015808
|
myotrophin |
|
| chr5_-_169630340 Show fit | 0.33 |
ENSRNOT00000087043
|
potassium voltage-gated channel subfamily A regulatory beta subunit 2 |
Network of associatons between targets according to the STRING database.
First level regulatory network of Ets1
Gene Ontology Analysis
Gene overrepresentation in biological process category:
| Log-likelihood per target | Total log-likelihood | Term | Description |
|---|---|---|---|
| 0.2 | 0.7 | GO:0043314 | negative regulation of neutrophil degranulation(GO:0043314) |
| 0.2 | 0.5 | GO:0060816 | random inactivation of X chromosome(GO:0060816) regulation of dosage compensation by inactivation of X chromosome(GO:1900095) |
| 0.0 | 0.5 | GO:0006829 | zinc II ion transport(GO:0006829) |
| 0.1 | 0.4 | GO:0090309 | DNA methylation on cytosine within a CG sequence(GO:0010424) positive regulation of methylation-dependent chromatin silencing(GO:0090309) |
| 0.1 | 0.4 | GO:1901098 | positive regulation of autophagosome maturation(GO:1901098) |
| 0.0 | 0.4 | GO:1900364 | negative regulation of mRNA polyadenylation(GO:1900364) |
| 0.0 | 0.4 | GO:0000301 | retrograde transport, vesicle recycling within Golgi(GO:0000301) |
| 0.1 | 0.3 | GO:1901097 | negative regulation of autophagosome maturation(GO:1901097) |
| 0.0 | 0.3 | GO:1903361 | protein localization to basolateral plasma membrane(GO:1903361) |
| 0.0 | 0.3 | GO:0038096 | immune response-regulating cell surface receptor signaling pathway involved in phagocytosis(GO:0002433) Fc-gamma receptor signaling pathway involved in phagocytosis(GO:0038096) |
Gene overrepresentation in cellular component category:
| Log-likelihood per target | Total log-likelihood | Term | Description |
|---|---|---|---|
| 0.0 | 0.4 | GO:1990316 | ATG1/ULK1 kinase complex(GO:1990316) |
| 0.0 | 0.4 | GO:0017119 | Golgi transport complex(GO:0017119) |
| 0.1 | 0.3 | GO:0097025 | MPP7-DLG1-LIN7 complex(GO:0097025) |
| 0.0 | 0.3 | GO:0016602 | CCAAT-binding factor complex(GO:0016602) |
| 0.0 | 0.3 | GO:0008290 | F-actin capping protein complex(GO:0008290) |
| 0.0 | 0.3 | GO:0044224 | juxtaparanode region of axon(GO:0044224) |
| 0.0 | 0.3 | GO:0030673 | axolemma(GO:0030673) |
| 0.0 | 0.3 | GO:0030665 | clathrin-coated vesicle membrane(GO:0030665) |
| 0.1 | 0.2 | GO:0032937 | SREBP-SCAP-Insig complex(GO:0032937) |
| 0.1 | 0.2 | GO:0034686 | integrin alphav-beta8 complex(GO:0034686) |
Gene overrepresentation in molecular function category:
| Log-likelihood per target | Total log-likelihood | Term | Description |
|---|---|---|---|
| 0.0 | 1.1 | GO:0005089 | Rho guanyl-nucleotide exchange factor activity(GO:0005089) |
| 0.1 | 0.6 | GO:0003886 | DNA (cytosine-5-)-methyltransferase activity(GO:0003886) |
| 0.1 | 0.5 | GO:0071253 | connexin binding(GO:0071253) |
| 0.0 | 0.5 | GO:0070273 | phosphatidylinositol-4-phosphate binding(GO:0070273) |
| 0.1 | 0.3 | GO:0005220 | inositol 1,4,5-trisphosphate-sensitive calcium-release channel activity(GO:0005220) |
| 0.1 | 0.3 | GO:0019960 | C-X3-C chemokine binding(GO:0019960) |
| 0.1 | 0.3 | GO:0097016 | L27 domain binding(GO:0097016) |
| 0.0 | 0.3 | GO:0004033 | aldo-keto reductase (NADP) activity(GO:0004033) |
| 0.0 | 0.3 | GO:0032794 | GTPase activating protein binding(GO:0032794) |
| 0.1 | 0.2 | GO:0051916 | granulocyte colony-stimulating factor binding(GO:0051916) |
Gene overrepresentation in curated gene sets: canonical pathways category:
| Log-likelihood per target | Total log-likelihood | Term | Description |
|---|---|---|---|
| 0.0 | 0.8 | PID RHOA REG PATHWAY | Regulation of RhoA activity |
| 0.0 | 0.4 | ST GAQ PATHWAY | G alpha q Pathway |
| 0.0 | 0.3 | PID TOLL ENDOGENOUS PATHWAY | Endogenous TLR signaling |
| 0.0 | 0.2 | ST DIFFERENTIATION PATHWAY IN PC12 CELLS | Differentiation Pathway in PC12 Cells; this is a specific case of PAC1 Receptor Pathway. |
| 0.0 | 0.2 | PID CDC42 REG PATHWAY | Regulation of CDC42 activity |
| 0.0 | 0.2 | SA MMP CYTOKINE CONNECTION | Cytokines can induce activation of matrix metalloproteinases, which degrade extracellular matrix. |
| 0.0 | 0.0 | PID ER NONGENOMIC PATHWAY | Plasma membrane estrogen receptor signaling |
Gene overrepresentation in curated gene sets: REACTOME pathways category:
| Log-likelihood per target | Total log-likelihood | Term | Description |
|---|---|---|---|
| 0.0 | 0.8 | REACTOME NRAGE SIGNALS DEATH THROUGH JNK | Genes involved in NRAGE signals death through JNK |
| 0.0 | 0.6 | REACTOME EGFR DOWNREGULATION | Genes involved in EGFR downregulation |
| 0.0 | 0.3 | REACTOME ACTIVATION OF CHAPERONE GENES BY ATF6 ALPHA | Genes involved in Activation of Chaperone Genes by ATF6-alpha |
| 0.0 | 0.2 | REACTOME ELEVATION OF CYTOSOLIC CA2 LEVELS | Genes involved in Elevation of cytosolic Ca2+ levels |
| 0.0 | 0.2 | REACTOME SIGNALING BY NOTCH2 | Genes involved in Signaling by NOTCH2 |
| 0.0 | 0.2 | REACTOME ORGANIC CATION ANION ZWITTERION TRANSPORT | Genes involved in Organic cation/anion/zwitterion transport |
| 0.0 | 0.2 | REACTOME PRE NOTCH PROCESSING IN GOLGI | Genes involved in Pre-NOTCH Processing in Golgi |
| 0.0 | 0.2 | REACTOME HORMONE SENSITIVE LIPASE HSL MEDIATED TRIACYLGLYCEROL HYDROLYSIS | Genes involved in Hormone-sensitive lipase (HSL)-mediated triacylglycerol hydrolysis |
| 0.0 | 0.2 | REACTOME GLYCOGEN BREAKDOWN GLYCOGENOLYSIS | Genes involved in Glycogen breakdown (glycogenolysis) |
| 0.0 | 0.2 | REACTOME ACTIVATED NOTCH1 TRANSMITS SIGNAL TO THE NUCLEUS | Genes involved in Activated NOTCH1 Transmits Signal to the Nucleus |