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GSE49485: Hypoxia transcriptome sequencing of rat brain.
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Results for Esrrb_Esrra
Z-value: 1.85
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Transcription factors associated with Esrrb_Esrra
Activity-expression correlation:
| Gene | Promoter | Pearson corr. coef. | P-value | Plot |
|---|---|---|---|---|
| Esrra | rn6_v1_chr1_-_222178725_222178725 | 0.51 | 3.8e-01 | Click! |
| Esrrb | rn6_v1_chr6_+_110410141_110410141 | 0.28 | 6.4e-01 | Click! |
| Promoter | Log-likelihood | Transcript | Gene | Gene Info |
|---|---|---|---|---|
| chr3_+_123106694 Show fit | 5.49 |
ENSRNOT00000028829
|
oxytocin/neurophysin 1 prepropeptide |
|
| chr10_-_71849293 Show fit | 1.56 |
ENSRNOT00000003799
|
LIM homeobox 1 |
|
| chr20_+_14095914 Show fit | 1.37 |
ENSRNOT00000093404
|
guanylyl cyclase domain containing 1 |
|
| chr5_+_50381244 Show fit | 1.22 |
ENSRNOT00000012385
|
glycoprotein hormones, alpha polypeptide |
|
| chr1_+_276659542 Show fit | 1.18 |
ENSRNOT00000019681
|
transcription factor 7 like 2 |
|
| chr10_+_110139783 Show fit | 1.15 |
ENSRNOT00000054939
|
solute carrier family 16 member 3 |
|
| chr2_-_123396147 Show fit | 1.01 |
ENSRNOT00000079004
|
transient receptor potential cation channel, subfamily C, member 3 |
|
| chr2_-_14701903 Show fit | 0.96 |
ENSRNOT00000051895
|
cytochrome c oxidase subunit 7C |
|
| chr19_-_37427989 Show fit | 0.95 |
ENSRNOT00000022863
|
tubulin polymerization-promoting protein family member 3 |
|
| chrX_-_40086870 Show fit | 0.94 |
ENSRNOT00000010027
|
small muscle protein, X-linked |
Network of associatons between targets according to the STRING database.
First level regulatory network of Esrrb_Esrra
Gene Ontology Analysis
Gene overrepresentation in biological process category:
| Log-likelihood per target | Total log-likelihood | Term | Description |
|---|---|---|---|
| 1.8 | 5.5 | GO:0043133 | hindgut contraction(GO:0043133) regulation of hindgut contraction(GO:0043134) |
| 0.2 | 2.7 | GO:0006123 | mitochondrial electron transport, cytochrome c to oxygen(GO:0006123) |
| 0.5 | 1.6 | GO:0060066 | oviduct development(GO:0060066) |
| 0.4 | 1.6 | GO:1903244 | positive regulation of cardiac muscle adaptation(GO:0010615) positive regulation of cardiac muscle hypertrophy in response to stress(GO:1903244) |
| 0.1 | 1.4 | GO:0006590 | thyroid hormone generation(GO:0006590) |
| 0.1 | 1.4 | GO:0015985 | energy coupled proton transport, down electrochemical gradient(GO:0015985) ATP synthesis coupled proton transport(GO:0015986) |
| 0.3 | 1.3 | GO:0042776 | mitochondrial ATP synthesis coupled proton transport(GO:0042776) |
| 0.0 | 1.3 | GO:1900027 | regulation of ruffle assembly(GO:1900027) |
| 0.4 | 1.2 | GO:0010908 | regulation of heparan sulfate proteoglycan biosynthetic process(GO:0010908) positive regulation of heparan sulfate proteoglycan biosynthetic process(GO:0010909) embryonic hindgut morphogenesis(GO:0048619) |
| 0.1 | 1.2 | GO:0035879 | plasma membrane lactate transport(GO:0035879) |
Gene overrepresentation in cellular component category:
| Log-likelihood per target | Total log-likelihood | Term | Description |
|---|---|---|---|
| 0.0 | 5.5 | GO:0043195 | terminal bouton(GO:0043195) |
| 0.1 | 3.8 | GO:0070469 | respiratory chain(GO:0070469) |
| 0.2 | 3.5 | GO:0005751 | mitochondrial respiratory chain complex IV(GO:0005751) |
| 0.0 | 2.5 | GO:0005743 | mitochondrial inner membrane(GO:0005743) |
| 0.0 | 1.7 | GO:0005758 | mitochondrial intermembrane space(GO:0005758) |
| 0.4 | 1.2 | GO:1990907 | beta-catenin-TCF complex(GO:1990907) |
| 0.1 | 1.2 | GO:0005750 | mitochondrial respiratory chain complex III(GO:0005750) |
| 0.1 | 1.2 | GO:0000276 | mitochondrial proton-transporting ATP synthase complex, coupling factor F(o)(GO:0000276) |
| 0.1 | 1.1 | GO:0045261 | mitochondrial proton-transporting ATP synthase complex, catalytic core F(1)(GO:0000275) proton-transporting ATP synthase complex, catalytic core F(1)(GO:0045261) |
| 0.0 | 1.1 | GO:0015934 | large ribosomal subunit(GO:0015934) |
Gene overrepresentation in molecular function category:
| Log-likelihood per target | Total log-likelihood | Term | Description |
|---|---|---|---|
| 0.2 | 5.5 | GO:0005184 | neuropeptide hormone activity(GO:0005184) |
| 0.1 | 3.6 | GO:0015002 | cytochrome-c oxidase activity(GO:0004129) heme-copper terminal oxidase activity(GO:0015002) oxidoreductase activity, acting on a heme group of donors, oxygen as acceptor(GO:0016676) |
| 0.1 | 1.6 | GO:0070679 | inositol 1,4,5 trisphosphate binding(GO:0070679) |
| 0.0 | 1.5 | GO:0001158 | enhancer sequence-specific DNA binding(GO:0001158) |
| 0.1 | 1.3 | GO:0046933 | proton-transporting ATP synthase activity, rotational mechanism(GO:0046933) |
| 0.0 | 1.3 | GO:0005179 | hormone activity(GO:0005179) |
| 0.1 | 1.2 | GO:0070016 | armadillo repeat domain binding(GO:0070016) |
| 0.2 | 1.1 | GO:0004111 | creatine kinase activity(GO:0004111) |
| 0.1 | 1.1 | GO:0015129 | lactate transmembrane transporter activity(GO:0015129) |
| 0.1 | 0.9 | GO:0031702 | type 1 angiotensin receptor binding(GO:0031702) |
Gene overrepresentation in curated gene sets: canonical pathways category:
| Log-likelihood per target | Total log-likelihood | Term | Description |
|---|---|---|---|
| 0.0 | 1.6 | PID PI3K PLC TRK PATHWAY | Trk receptor signaling mediated by PI3K and PLC-gamma |
| 0.0 | 1.6 | PID BETA CATENIN NUC PATHWAY | Regulation of nuclear beta catenin signaling and target gene transcription |
| 0.0 | 1.2 | PID PRL SIGNALING EVENTS PATHWAY | Signaling events mediated by PRL |
| 0.0 | 1.2 | PID ILK PATHWAY | Integrin-linked kinase signaling |
| 0.0 | 1.1 | PID REG GR PATHWAY | Glucocorticoid receptor regulatory network |
| 0.0 | 0.9 | PID NOTCH PATHWAY | Notch signaling pathway |
| 0.0 | 0.5 | PID ATF2 PATHWAY | ATF-2 transcription factor network |
| 0.0 | 0.4 | SA PROGRAMMED CELL DEATH | Programmed cell death, or apoptosis, eliminates damaged or unneeded cells. |
| 0.0 | 0.3 | PID AVB3 OPN PATHWAY | Osteopontin-mediated events |
| 0.0 | 0.2 | PID TCR RAS PATHWAY | Ras signaling in the CD4+ TCR pathway |
Gene overrepresentation in curated gene sets: REACTOME pathways category:
| Log-likelihood per target | Total log-likelihood | Term | Description |
|---|---|---|---|
| 0.1 | 7.6 | REACTOME RESPIRATORY ELECTRON TRANSPORT | Genes involved in Respiratory electron transport |
| 0.0 | 5.8 | REACTOME G ALPHA Q SIGNALLING EVENTS | Genes involved in G alpha (q) signalling events |
| 0.1 | 1.7 | REACTOME FORMATION OF ATP BY CHEMIOSMOTIC COUPLING | Genes involved in Formation of ATP by chemiosmotic coupling |
| 0.1 | 1.6 | REACTOME ROLE OF SECOND MESSENGERS IN NETRIN1 SIGNALING | Genes involved in Role of second messengers in netrin-1 signaling |
| 0.0 | 1.6 | REACTOME MITOCHONDRIAL PROTEIN IMPORT | Genes involved in Mitochondrial Protein Import |
| 0.0 | 1.5 | REACTOME GPVI MEDIATED ACTIVATION CASCADE | Genes involved in GPVI-mediated activation cascade |
| 0.0 | 1.4 | REACTOME GLUCONEOGENESIS | Genes involved in Gluconeogenesis |
| 0.1 | 1.2 | REACTOME GLYCOPROTEIN HORMONES | Genes involved in Glycoprotein hormones |
| 0.1 | 1.1 | REACTOME BILE SALT AND ORGANIC ANION SLC TRANSPORTERS | Genes involved in Bile salt and organic anion SLC transporters |
| 0.0 | 1.0 | REACTOME GLYCOSPHINGOLIPID METABOLISM | Genes involved in Glycosphingolipid metabolism |