ISMARA results: Esr2

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GSE49485: Hypoxia transcriptome sequencing of rat brain.

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Results for Esr2

Z-value: 1.49

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Transcription factors associated with Esr2

Gene Symbol	Gene ID	Gene Info
Esr2 NCBI RGD Ensembl	ENSRNOG00000005343	estrogen receptor 2

Activity-expression correlation:

Gene	Promoter	Pearson corr. coef.	P-value	Plot
Esr2	rn6_v1_chr6_-_99214251_99214251	-0.76	1.3e-01	Click!

Activity profile of Esr2 motif

Sorted Z-values of Esr2 motif

Top targets:

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Promoter	Log-likelihood	Transcript	Gene	Gene Info
chr3_+_123106694 Show fit	1.70	ENSRNOT00000028829	Oxt NCBI RGD Ensembl Show fit	oxytocin/neurophysin 1 prepropeptide
chr2_+_190003223 Show fit	1.23	ENSRNOT00000015712	S100a5 NCBI RGD Ensembl Show fit	S100 calcium binding protein A5
chr7_-_28715224 Show fit	1.19	ENSRNOT00000065899	Parpbp NCBI RGD Ensembl Show fit	PARP1 binding protein
chr3_-_123119460 Show fit	1.12	ENSRNOT00000028833	Avp NCBI RGD Ensembl Show fit	arginine vasopressin
chr10_-_15603649 Show fit	1.02	ENSRNOT00000051483	Hba-a2 NCBI RGD Ensembl Show fit	hemoglobin alpha, adult chain 2
chr1_-_80744831 Show fit	0.99	ENSRNOT00000025913	Bcl3 NCBI RGD Ensembl Show fit	B-cell CLL/lymphoma 3
chr10_-_15577977 Show fit	0.92	ENSRNOT00000052292	Hba-a3 NCBI RGD Ensembl Show fit	hemoglobin alpha, adult chain 3
chr10_-_15590220 Show fit	0.87	ENSRNOT00000048977	Hba-a2 NCBI RGD Ensembl Show fit	hemoglobin alpha, adult chain 2
chr12_-_23841049 Show fit	0.77	ENSRNOT00000031555	Hspb1 NCBI RGD Ensembl Show fit	heat shock protein family B (small) member 1
chr17_+_76002275 Show fit	0.76	ENSRNOT00000092665 ENSRNOT00000086701	Echdc3 NCBI RGD Ensembl Show fit	enoyl CoA hydratase domain containing 3

Showing 1 to 10 of 200 entries

Network of associatons between targets according to the STRING database.

First level regulatory network of Esr2

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Gene Ontology Analysis

Gene overrepresentation in biological process category:

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Log-likelihood per target	Total log-likelihood	Term	Description
0.3	3.1	GO:0015671	oxygen transport(GO:0015671)
0.7	2.8	GO:0002125	maternal aggressive behavior(GO:0002125)
0.0	1.5	GO:0007218	neuropeptide signaling pathway(GO:0007218)
0.1	1.4	GO:0015986	energy coupled proton transport, down electrochemical gradient(GO:0015985) ATP synthesis coupled proton transport(GO:0015986)
0.0	1.3	GO:0032094	response to food(GO:0032094)
0.3	1.0	GO:0045082	positive regulation of interleukin-10 biosynthetic process(GO:0045082)
0.3	1.0	GO:0071348	cellular response to interleukin-11(GO:0071348)
0.0	1.0	GO:0050911	detection of chemical stimulus involved in sensory perception of smell(GO:0050911)
0.1	0.9	GO:2000042	negative regulation of double-strand break repair via homologous recombination(GO:2000042)
0.1	0.8	GO:0006123	mitochondrial electron transport, cytochrome c to oxygen(GO:0006123)

Showing 1 to 10 of 526 entries

Gene overrepresentation in cellular component category:

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Log-likelihood per target	Total log-likelihood	Term	Description
0.0	3.9	GO:0030141	secretory granule(GO:0030141)
0.1	3.5	GO:0070469	respiratory chain(GO:0070469)
0.5	1.9	GO:0031838	haptoglobin-hemoglobin complex(GO:0031838)
0.0	1.7	GO:0022627	cytosolic small ribosomal subunit(GO:0022627)
0.0	1.6	GO:0005761	organellar ribosome(GO:0000313) mitochondrial ribosome(GO:0005761)
0.0	1.5	GO:0015934	large ribosomal subunit(GO:0015934)
0.1	1.3	GO:0033256	I-kappaB/NF-kappaB complex(GO:0033256)
0.1	1.3	GO:0042612	MHC class I protein complex(GO:0042612)
0.1	1.1	GO:0097512	cardiac myofibril(GO:0097512)
0.1	1.1	GO:0005751	mitochondrial respiratory chain complex IV(GO:0005751)

Showing 1 to 10 of 139 entries

Gene overrepresentation in molecular function category:

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Log-likelihood per target	Total log-likelihood	Term	Description
0.0	6.6	GO:0003735	structural constituent of ribosome(GO:0003735)
0.2	4.3	GO:0005184	neuropeptide hormone activity(GO:0005184)
0.6	1.9	GO:0031720	haptoglobin binding(GO:0031720)
0.0	1.6	GO:0005179	hormone activity(GO:0005179)
0.0	1.5	GO:0016675	oxidoreductase activity, acting on a heme group of donors(GO:0016675)
0.0	1.5	GO:0008083	growth factor activity(GO:0008083)
0.0	1.3	GO:0005507	copper ion binding(GO:0005507)
0.1	1.2	GO:0005344	oxygen transporter activity(GO:0005344)
0.1	1.2	GO:0046933	proton-transporting ATP synthase activity, rotational mechanism(GO:0046933)
0.4	1.1	GO:0031893	vasopressin receptor binding(GO:0031893)

Showing 1 to 10 of 320 entries

Gene overrepresentation in curated gene sets: canonical pathways category:

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Log-likelihood per target	Total log-likelihood	Term	Description
0.0	3.4	NABA SECRETED FACTORS	Genes encoding secreted soluble factors
0.0	1.3	PID IL4 2PATHWAY	IL4-mediated signaling events
0.0	1.2	PID HNF3B PATHWAY	FOXA2 and FOXA3 transcription factor networks
0.1	1.1	PID NFKAPPAB ATYPICAL PATHWAY	Atypical NF-kappaB pathway
0.0	1.0	PID INTEGRIN2 PATHWAY	Beta2 integrin cell surface interactions
0.0	0.9	PID AURORA B PATHWAY	Aurora B signaling
0.0	0.9	PID AP1 PATHWAY	AP-1 transcription factor network
0.0	0.7	PID P38 MK2 PATHWAY	p38 signaling mediated by MAPKAP kinases
0.0	0.6	PID FRA PATHWAY	Validated transcriptional targets of AP1 family members Fra1 and Fra2
0.1	0.5	SA G2 AND M PHASES	Cdc25 activates the cdc2/cyclin B complex to induce the G2/M transition.

Showing 1 to 10 of 41 entries

Gene overrepresentation in curated gene sets: REACTOME pathways category:

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Log-likelihood per target	Total log-likelihood	Term	Description
0.0	6.0	REACTOME PEPTIDE LIGAND BINDING RECEPTORS	Genes involved in Peptide ligand-binding receptors
0.1	4.4	REACTOME RESPIRATORY ELECTRON TRANSPORT	Genes involved in Respiratory electron transport
0.0	1.6	REACTOME DESTABILIZATION OF MRNA BY AUF1 HNRNP D0	Genes involved in Destabilization of mRNA by AUF1 (hnRNP D0)
0.1	1.2	REACTOME FORMATION OF ATP BY CHEMIOSMOTIC COUPLING	Genes involved in Formation of ATP by chemiosmotic coupling
0.0	1.2	REACTOME STRIATED MUSCLE CONTRACTION	Genes involved in Striated Muscle Contraction
0.0	1.2	REACTOME IMMUNOREGULATORY INTERACTIONS BETWEEN A LYMPHOID AND A NON LYMPHOID CELL	Genes involved in Immunoregulatory interactions between a Lymphoid and a non-Lymphoid cell
0.0	1.2	REACTOME FORMATION OF THE TERNARY COMPLEX AND SUBSEQUENTLY THE 43S COMPLEX	Genes involved in Formation of the ternary complex, and subsequently, the 43S complex
0.0	1.2	REACTOME SRP DEPENDENT COTRANSLATIONAL PROTEIN TARGETING TO MEMBRANE	Genes involved in SRP-dependent cotranslational protein targeting to membrane
0.1	1.1	REACTOME TRANSPORT OF ORGANIC ANIONS	Genes involved in Transport of organic anions
0.0	1.1	REACTOME MITOCHONDRIAL PROTEIN IMPORT	Genes involved in Mitochondrial Protein Import

Showing 1 to 10 of 79 entries

Results for Esr2

Z-value: 1.49

Motif logo

Transcription factors associated with Esr2

Activity-expression correlation:

Activity profile of Esr2 motif

Sorted Z-values of Esr2 motif

Top targets:

Network of associatons between targets according to the STRING database.

First level regulatory network of Esr2

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Gene Ontology Analysis

Gene overrepresentation in biological process category:

Gene overrepresentation in cellular component category:

Gene overrepresentation in molecular function category:

Gene overrepresentation in curated gene sets: canonical pathways category:

Gene overrepresentation in curated gene sets: REACTOME pathways category: