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GSE49485: Hypoxia transcriptome sequencing of rat brain.

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Results for Esr1

Z-value: 1.08

Motif logo

Transcription factors associated with Esr1

Gene Symbol Gene ID Gene Info
ENSRNOG00000019358 estrogen receptor 1

Activity-expression correlation:

GenePromoterPearson corr. coef.P-valuePlot
Esr1rn6_v1_chr1_+_41325462_413255310.701.8e-01Click!

Activity profile of Esr1 motif

Sorted Z-values of Esr1 motif

Promoter Log-likelihood Transcript Gene Gene Info
chr3_-_123119460 1.27 ENSRNOT00000028833
arginine vasopressin
chr1_+_242572533 1.07 ENSRNOT00000035123
transmembrane protein 252
chr8_+_48438259 1.01 ENSRNOT00000059813
membrane frizzled-related protein
chr5_-_152324469 0.92 ENSRNOT00000020688
CD52 molecule
chr1_+_213595240 0.67 ENSRNOT00000017137
secretoglobin, family 1C, member 1
chr12_+_22641104 0.61 ENSRNOT00000001916
serpin family E member 1
chr3_+_138174054 0.47 ENSRNOT00000007946
barrier to autointegration factor 2
chr20_-_14020007 0.46 ENSRNOT00000093521
gamma-glutamyltransferase 1
chr16_+_36116258 0.45 ENSRNOT00000017652
Sin3A associated protein 30
chr17_+_76002275 0.44 ENSRNOT00000092665
ENSRNOT00000086701
enoyl CoA hydratase domain containing 3
chr15_-_60289763 0.43 ENSRNOT00000038579
family with sequence similarity 216, member B
chr11_+_67465236 0.42 ENSRNOT00000042374
stefin A2
chr8_+_53678994 0.42 ENSRNOT00000083419
dopamine receptor D2
chr1_-_190914610 0.41 ENSRNOT00000023189
cerebellar degeneration-related protein 2
chr1_+_101178104 0.41 ENSRNOT00000028072
parathyroid hormone 2
chr5_-_161035368 0.39 ENSRNOT00000091640

chrX_+_136460215 0.39 ENSRNOT00000093538
Rho GTPase activating protein 36
chr12_+_47698947 0.39 ENSRNOT00000001586
transient receptor potential cation channel, subfamily V, member 4
chr2_-_208633945 0.38 ENSRNOT00000049155
primary cilia formation
chr5_-_148392689 0.38 ENSRNOT00000018464
ENSRNOT00000080166
tubulointerstitial nephritis antigen-like 1
chr20_+_29951637 0.38 ENSRNOT00000074387
rCG22048-like
chr20_-_46305157 0.37 ENSRNOT00000000340
coiled-coil domain containing 162
chr2_-_187160373 0.36 ENSRNOT00000018961
neurotrophic receptor tyrosine kinase 1
chr10_+_14828597 0.34 ENSRNOT00000025434
tektin 4
chr3_-_176816114 0.34 ENSRNOT00000079262
ENSRNOT00000018697
stathmin 3
chr1_-_80744831 0.34 ENSRNOT00000025913
B-cell CLL/lymphoma 3
chr8_+_119137728 0.33 ENSRNOT00000078170
protease, serine, 50
chr12_+_19714324 0.33 ENSRNOT00000072303
similar to cell surface receptor FDFACT
chr15_+_41069507 0.33 ENSRNOT00000018533
C1q and tumor necrosis factor related protein 9
chr13_-_50535389 0.33 ENSRNOT00000076506
KiSS-1 metastasis-suppressor
chr8_+_14060394 0.32 ENSRNOT00000014827
single-pass membrane protein with coiled-coil domains 4
chr8_+_53678777 0.29 ENSRNOT00000045944
dopamine receptor D2
chr4_-_10269748 0.29 ENSRNOT00000074662
family with sequence similarity 185, member A
chr20_+_6018374 0.29 ENSRNOT00000000621
mitogen activated protein kinase 13
chr19_-_57699113 0.27 ENSRNOT00000026767
egl-9 family hypoxia-inducible factor 1
chr1_-_219438779 0.27 ENSRNOT00000029237
TBC1 domain family, member 10C
chr14_-_84937725 0.27 ENSRNOT00000083839
ubiquinol-cytochrome c reductase, complex III subunit X
chr15_-_34479741 0.27 ENSRNOT00000027759
receptor-interacting serine-threonine kinase 3
chr20_-_12938891 0.26 ENSRNOT00000017141
similar to Protein C21orf58
chr2_-_30127269 0.26 ENSRNOT00000023869
CART prepropeptide
chr15_+_34452116 0.26 ENSRNOT00000027647
leukotriene B4 receptor
chr13_-_36101411 0.25 ENSRNOT00000074471
transmembrane protein 37
chr5_+_135997052 0.25 ENSRNOT00000024921
Tctex1 domain containing 4
chr12_+_16170162 0.23 ENSRNOT00000001686
galectin-related inter-fiber protein
chr20_+_3945601 0.23 ENSRNOT00000075342
RT1 class II, locus DMb
chr19_+_52647070 0.22 ENSRNOT00000068389
ENSRNOT00000087857
cysteine-rich secretory protein LCCL domain containing 2
chr16_-_6675746 0.22 ENSRNOT00000025858
protein kinase C, delta
chr12_-_2007516 0.22 ENSRNOT00000037564
peroxisomal biogenesis factor 11 gamma
chr8_+_67753279 0.22 ENSRNOT00000009716
calmodulin-like 4
chr9_+_94702129 0.22 ENSRNOT00000080930
neuraminidase 2
chr2_+_150211898 0.22 ENSRNOT00000018767
succinate receptor 1
chrX_-_123708211 0.22 ENSRNOT00000092456
ribosomal protein L39
chr4_-_157252104 0.22 ENSRNOT00000082739
protein tyrosine phosphatase, non-receptor type 6
chr3_-_17081510 0.22 ENSRNOT00000063862

chr17_+_8299131 0.22 ENSRNOT00000083687
predicted gene 45623
chr5_-_58019836 0.21 ENSRNOT00000066977
energy homeostasis associated
chr9_-_82146874 0.21 ENSRNOT00000024190
FEV, ETS transcription factor
chr9_-_43127887 0.21 ENSRNOT00000021685
ankyrin repeat domain 39
chr20_-_30327361 0.21 ENSRNOT00000000689
solute carrier family 29 member 3
chr1_-_225077079 0.21 ENSRNOT00000074747
ubiquinol-cytochrome c reductase complex assembly factor 3
chrX_+_1787266 0.20 ENSRNOT00000011183
NADH:ubiquinone oxidoreductase subunit B11
chr7_+_70614617 0.20 ENSRNOT00000035382
Rho GTPase activating protein 9
chr8_+_72743426 0.20 ENSRNOT00000072573
ribosomal protein S27-like
chr1_+_81643816 0.20 ENSRNOT00000027214
carcinoembryonic antigen-related cell adhesion molecule 1-like
chr7_+_64292466 0.20 ENSRNOT00000051577
similar to sentrin 15
chr5_+_64789456 0.20 ENSRNOT00000009584
zinc finger protein 189
chr4_-_120041238 0.20 ENSRNOT00000073799
40S ribosomal protein S25-like
chr5_-_144345531 0.20 ENSRNOT00000014721
tektin 2
chr10_-_88677055 0.20 ENSRNOT00000025590
GH3 domain containing
chr1_-_87221826 0.20 ENSRNOT00000046611
ENSRNOT00000028006
serine peptidase inhibitor, Kunitz type, 2
chr10_+_14240219 0.20 ENSRNOT00000020233
insulin-like growth factor binding protein, acid labile subunit
chr20_+_13732198 0.19 ENSRNOT00000008608
macrophage migration inhibitory factor
chr1_-_94610854 0.19 ENSRNOT00000020383
pleckstrin homology and FYVE domain containing 1
chr4_-_155923079 0.19 ENSRNOT00000013308
C-type lectin domain family 4, member A3
chr7_+_117409576 0.19 ENSRNOT00000017067
cytochrome c-1
chr3_-_142752325 0.19 ENSRNOT00000006200
thrombomodulin
chr5_+_63192298 0.19 ENSRNOT00000008329
Sec61 translocon beta subunit
chr7_-_12283608 0.19 ENSRNOT00000029791
ribosomal protein S15
chr16_-_75346122 0.19 ENSRNOT00000018529
defensin alpha 24
chr9_-_27511176 0.19 ENSRNOT00000036813
similar to Glutathione S-transferase A1 (GTH1) (HA subunit 1) (GST-epsilon) (GSTA1-1) (GST class-alpha)
chr10_-_104163634 0.19 ENSRNOT00000005198
MIF4G domain containing
chr8_+_52829085 0.19 ENSRNOT00000007754
similar to hypothetical protein FLJ20010
chr5_-_155252003 0.19 ENSRNOT00000017060
complement C1q B chain
chr2_+_266141581 0.18 ENSRNOT00000078187
ENSRNOT00000051951
RPE65, retinoid isomerohydrolase
chr8_-_127900463 0.18 ENSRNOT00000078303
solute carrier family 22 member 13
chr14_+_71649274 0.18 ENSRNOT00000004128
fibroblast growth factor binding protein 1
chr20_+_4374807 0.18 ENSRNOT00000084557
1-acylglycerol-3-phosphate O-acyltransferase 1
chrX_+_33443186 0.18 ENSRNOT00000005622
S100 calcium binding protein G
chr1_-_183763664 0.18 ENSRNOT00000044231
similar to 6.8 kDa mitochondrial proteolipid
chr17_+_10537365 0.18 ENSRNOT00000023651
clathrin, light chain B
chr2_+_60180215 0.18 ENSRNOT00000084624
prolactin receptor
chr2_+_198417619 0.18 ENSRNOT00000085945
histone cluster 2, H3c2
chr9_-_64096265 0.18 ENSRNOT00000013502
tRNA-yW synthesizing protein 5
chr14_-_91979500 0.18 ENSRNOT00000073892
dopa decarboxylase
chr17_+_69960160 0.18 ENSRNOT00000023887
urocortin 3
chr10_-_109891879 0.18 ENSRNOT00000077930
centromere protein X
chr15_-_34647421 0.18 ENSRNOT00000072426
mast cell protease 8
chr7_-_12518684 0.18 ENSRNOT00000018691
ENSRNOT00000093426
glutathione peroxidase 4
chr18_+_79406381 0.18 ENSRNOT00000022303
ENSRNOT00000058295
ENSRNOT00000058296
ENSRNOT00000022280
myelin basic protein
chr1_-_47502952 0.18 ENSRNOT00000025580
T-cell activation RhoGTPase activating protein
chr19_-_9931930 0.17 ENSRNOT00000085144
coiled-coil domain containing 113
chr20_+_32450733 0.17 ENSRNOT00000036449
radial spoke head 4 homolog A
chr6_-_136550371 0.17 ENSRNOT00000065971
retinal degeneration 3-like
chr1_-_89084859 0.17 ENSRNOT00000032026
cytochrome c oxidase subunit 6B1
chr1_-_89399039 0.17 ENSRNOT00000028585
ENSRNOT00000044678
lipolysis stimulated lipoprotein receptor
chr10_+_15088935 0.17 ENSRNOT00000030273
G protein subunit gamma 13
chr5_-_157268903 0.17 ENSRNOT00000022716
phospholipase A2, group V
chr13_-_111474411 0.17 ENSRNOT00000072729
hedgehog acyltransferase
chr7_-_12519154 0.17 ENSRNOT00000093376
ENSRNOT00000077681
glutathione peroxidase 4
chr8_-_56393233 0.17 ENSRNOT00000016263
ferredoxin 1
chr10_-_57618527 0.17 ENSRNOT00000037517
complement C1q binding protein
chr5_-_64789318 0.17 ENSRNOT00000078957
mitochondrial ribosomal protein L50
chr16_+_7292096 0.17 ENSRNOT00000025606
troponin C1, slow skeletal and cardiac type
chr4_+_78735279 0.17 ENSRNOT00000011970
mitochondrial assembly of ribosomal large subunit 1
chr15_-_34198921 0.17 ENSRNOT00000024991
neural retina leucine zipper
chr19_+_24456976 0.17 ENSRNOT00000004900
uncoupling protein 1
chr10_-_29026002 0.17 ENSRNOT00000005070
pituitary tumor-transforming 1
chr7_+_11582984 0.16 ENSRNOT00000026893
G protein subunit gamma 7
chr8_-_122841477 0.16 ENSRNOT00000014861
CKLF-like MARVEL transmembrane domain containing 7
chr6_+_135724455 0.16 ENSRNOT00000012469
amnion associated transmembrane protein
chr20_-_10013190 0.16 ENSRNOT00000084726
ENSRNOT00000089112
radial spoke head 1 homolog
chr15_+_38069320 0.16 ENSRNOT00000014397
Sin3-associated polypeptide 18
chr4_+_100407658 0.16 ENSRNOT00000018562
capping actin protein, gelsolin like
chr2_+_221823687 0.16 ENSRNOT00000072735
dihydropyrimidine dehydrogenase
chr4_-_119188251 0.16 ENSRNOT00000057350
gastrokine 3
chr5_-_157573183 0.16 ENSRNOT00000064418
mitochondrial inner membrane organizing system 1
chr7_-_76035096 0.16 ENSRNOT00000072255

chr14_+_46649971 0.15 ENSRNOT00000085875

chr13_+_89386023 0.15 ENSRNOT00000086223
Fc fragment of IgG receptor IIIa
chr10_+_104155805 0.15 ENSRNOT00000005089
mitochondrial ribosomal protein S7
chr3_+_171037957 0.15 ENSRNOT00000008764
RNA binding motif protein 38
chr20_-_3439983 0.15 ENSRNOT00000080822
ENSRNOT00000001099
immediate early response 3
chr10_+_83856280 0.15 ENSRNOT00000008964
SNF8, ESCRT-II complex subunit
chr20_+_33945829 0.15 ENSRNOT00000064063
radial spoke head protein 4 homolog A
chr8_-_116349896 0.15 ENSRNOT00000087306
leucine-rich single-pass membrane protein 2
chr9_-_99818262 0.15 ENSRNOT00000056600
COP9 signalosome subunit 9
chr4_-_28437676 0.15 ENSRNOT00000012995
HEPACAM family member 2
chr3_+_110918243 0.15 ENSRNOT00000056432
RAD51 recombinase
chr17_-_35958077 0.15 ENSRNOT00000038532
angiotensin II receptor, type 1a
chr18_-_29562153 0.15 ENSRNOT00000023977
CD14 molecule
chr2_-_189856090 0.15 ENSRNOT00000020307
natriuretic peptide receptor 1
chr5_+_173274774 0.15 ENSRNOT00000025952
cyclin L2
chr5_+_135562034 0.14 ENSRNOT00000056967
coiled-coil domain containing 163
chr17_-_2705123 0.14 ENSRNOT00000024940
olfactory receptor 1652
chr6_-_111267734 0.14 ENSRNOT00000074037
NADP-dependent oxidoreductase domain containing 1
chr17_+_89171250 0.14 ENSRNOT00000024901
glutamate decarboxylase 2
chr11_-_24294179 0.14 ENSRNOT00000002116
ATP synthase, H+ transporting, mitochondrial Fo complex, subunit F6
chr16_+_74810938 0.14 ENSRNOT00000058091
NIMA-related kinase 5
chr7_-_125497691 0.14 ENSRNOT00000049445

chr5_-_164747083 0.14 ENSRNOT00000010433
procollagen-lysine, 2-oxoglutarate 5-dioxygenase 1
chr9_+_94721681 0.14 ENSRNOT00000022818
neuraminidase 2
chr4_-_28248458 0.14 ENSRNOT00000047419

chr1_-_89488223 0.14 ENSRNOT00000028624
FXYD domain-containing ion transport regulator 1
chr7_-_126701872 0.14 ENSRNOT00000041057
polycystin (PKD) family receptor for egg jelly
chrX_+_136466779 0.14 ENSRNOT00000093268
ENSRNOT00000068717
Rho GTPase activating protein 36
chr11_+_67221359 0.14 ENSRNOT00000086097
calcium-sensing receptor
chr11_+_57505005 0.14 ENSRNOT00000002942
transgelin-3
chr19_+_58565576 0.14 ENSRNOT00000026965
nucleoside-triphosphatase, cancer-related
chr9_-_30251388 0.14 ENSRNOT00000035033
succinate dehydrogenase complex assembly factor 4
chr13_-_50535110 0.14 ENSRNOT00000077054
KiSS-1 metastasis-suppressor
chr12_+_47024442 0.14 ENSRNOT00000001545
cytochrome c oxidase subunit 6A1
chr20_-_3822754 0.14 ENSRNOT00000000541
ENSRNOT00000077357
solute carrier family 39 member 7
chr1_+_89220083 0.14 ENSRNOT00000093144
dermokine
chrX_+_43497763 0.14 ENSRNOT00000005014
peroxiredoxin 4
chr9_-_97290639 0.14 ENSRNOT00000026491
ENSRNOT00000056724
IQ motif containing with AAA domain 1
chr9_-_10897240 0.13 ENSRNOT00000074502
TNF alpha induced protein 8 like 1
chr16_-_49574314 0.13 ENSRNOT00000017568
ENSRNOT00000085535
ENSRNOT00000017054
PDZ and LIM domain 3
chr1_-_267598639 0.13 ENSRNOT00000031925
cilia and flagella associated protein 43
chr1_-_89560719 0.13 ENSRNOT00000028653
sodium voltage-gated channel beta subunit 1
chr11_+_60907015 0.13 ENSRNOT00000002797
GTP-binding protein 8 (putative)
chr15_+_38096994 0.13 ENSRNOT00000064635
mitochondrial ribosomal protein L57
chr8_+_73593310 0.13 ENSRNOT00000012048
C2 calcium-dependent domain containing 4B
chr13_-_98023829 0.13 ENSRNOT00000075426
kinesin family member 28, pseudogene
chr3_-_150412179 0.13 ENSRNOT00000023786
eukaryotic translation initiation factor 2 subunit beta
chr13_+_95416242 0.13 ENSRNOT00000072611
ribosomal protein L30-like 1
chr1_+_256786124 0.13 ENSRNOT00000034563
free fatty acid receptor 4
chr7_-_2623781 0.13 ENSRNOT00000004173
SPRY domain containing 4
chr17_-_44793927 0.13 ENSRNOT00000086309
histone cluster 1 H2B family member o
chr6_+_30638733 0.13 ENSRNOT00000082885
rRNA promoter binding protein
chr1_+_215609036 0.13 ENSRNOT00000076187
troponin I2, fast skeletal type
chr20_-_5166252 0.13 ENSRNOT00000001138
allograft inflammatory factor 1
chr2_-_235852708 0.13 ENSRNOT00000009046
ENSRNOT00000005772
ribosomal protein L34
chr9_-_16807966 0.13 ENSRNOT00000073160
ribosomal protein S19
chr10_-_74001895 0.13 ENSRNOT00000005658
vacuole membrane protein 1
chr4_-_179904844 0.13 ENSRNOT00000085386
lamin tail domain containing 1
chrX_+_156854594 0.13 ENSRNOT00000083442
renin binding protein
chr4_-_129430251 0.13 ENSRNOT00000067881
family with sequence similarity 19 member A4, C-C motif chemokine like
chr11_-_64583994 0.13 ENSRNOT00000004289
beta-1,4-galactosyltransferase 4
chr1_-_265498831 0.13 ENSRNOT00000023558
fibroblast growth factor 8
chr12_-_21760292 0.13 ENSRNOT00000059592
TSC22 domain family protein 4-like
chr10_-_59743315 0.13 ENSRNOT00000093646
ER membrane protein complex subunit 6
chr4_+_122835436 0.13 ENSRNOT00000009696
fibulin 2
chr1_+_170471238 0.13 ENSRNOT00000076961
ENSRNOT00000075597
ENSRNOT00000076631
ENSRNOT00000076783
translocase of inner mitochondrial membrane 10B
dynein heavy chain domain 1
chr15_+_5904569 0.13 ENSRNOT00000072599
disks large homolog 5-like
chr9_+_95274707 0.13 ENSRNOT00000045163
UDP glucuronosyltransferase family 1 member A5
chr1_+_219247672 0.12 ENSRNOT00000024237
nudix hydrolase 8
chr11_+_65022100 0.12 ENSRNOT00000003934
nuclear receptor subfamily 1, group I, member 2
chr1_+_100501676 0.12 ENSRNOT00000043724
family with sequence similarity 71, member E1
chr1_+_245237736 0.12 ENSRNOT00000035814
very low density lipoprotein receptor
chr4_+_6946634 0.12 ENSRNOT00000040373
WD repeat domain 86

Network of associatons between targets according to the STRING database.

First level regulatory network of Esr1

PNG image of the network

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Gene Ontology Analysis

Gene overrepresentation in biological process category:

Log-likelihood per target  Total log-likelihood Term Description
0.3 1.3 GO:0002125 maternal aggressive behavior(GO:0002125)
0.2 0.7 GO:2000097 regulation of smooth muscle cell-matrix adhesion(GO:2000097)
0.2 0.7 GO:0044467 glial cell-derived neurotrophic factor secretion(GO:0044467) positive regulation of neurotransmitter uptake(GO:0051582) positive regulation of dopamine uptake involved in synaptic transmission(GO:0051586) positive regulation of catecholamine uptake involved in synaptic transmission(GO:0051944) negative regulation of dopamine receptor signaling pathway(GO:0060160) regulation of glial cell-derived neurotrophic factor secretion(GO:1900166) positive regulation of glial cell-derived neurotrophic factor secretion(GO:1900168)
0.1 0.4 GO:0042539 hypotonic salinity response(GO:0042539) cellular hypotonic salinity response(GO:0071477)
0.1 0.3 GO:0007468 regulation of rhodopsin gene expression(GO:0007468)
0.1 0.5 GO:0031179 peptide modification(GO:0031179)
0.1 0.3 GO:0045082 positive regulation of interleukin-10 biosynthetic process(GO:0045082)
0.1 0.5 GO:0060112 generation of ovulation cycle rhythm(GO:0060112)
0.1 0.3 GO:2000407 CD8-positive, alpha-beta T cell extravasation(GO:0035697) regulation of T cell extravasation(GO:2000407)
0.1 0.4 GO:0051692 cellular oligosaccharide catabolic process(GO:0051692)
0.1 0.2 GO:0014739 positive regulation of muscle hyperplasia(GO:0014739)
0.1 0.3 GO:0033277 abortive mitotic cell cycle(GO:0033277)
0.1 0.3 GO:2001190 positive regulation of T cell activation via T cell receptor contact with antigen bound to MHC molecule on antigen presenting cell(GO:2001190)
0.1 0.2 GO:0060697 positive regulation of phospholipid catabolic process(GO:0060697)
0.1 0.2 GO:0044375 regulation of peroxisome size(GO:0044375)
0.1 0.2 GO:0060128 corticotropin hormone secreting cell differentiation(GO:0060128)
0.1 0.4 GO:0061366 behavioral response to chemical pain(GO:0061366) behavioral response to formalin induced pain(GO:0061368)
0.1 0.3 GO:0080154 regulation of fertilization(GO:0080154)
0.1 0.3 GO:0051344 negative regulation of cyclic-nucleotide phosphodiesterase activity(GO:0051344)
0.1 0.2 GO:0060672 epithelial cell differentiation involved in embryonic placenta development(GO:0060671) epithelial cell morphogenesis involved in placental branching(GO:0060672)
0.1 0.3 GO:0070093 negative regulation of glucagon secretion(GO:0070093)
0.1 0.2 GO:0031204 posttranslational protein targeting to membrane, translocation(GO:0031204)
0.1 0.3 GO:0039534 negative regulation of MDA-5 signaling pathway(GO:0039534)
0.1 0.2 GO:1904209 regulation of chemokine (C-C motif) ligand 2 secretion(GO:1904207) positive regulation of chemokine (C-C motif) ligand 2 secretion(GO:1904209) positive regulation of metalloendopeptidase activity(GO:1904685)
0.1 0.5 GO:0097033 mitochondrial respiratory chain complex III biogenesis(GO:0097033)
0.1 0.2 GO:0006663 platelet activating factor biosynthetic process(GO:0006663)
0.1 0.1 GO:0043134 hindgut contraction(GO:0043133) regulation of hindgut contraction(GO:0043134)
0.1 0.2 GO:0032972 diaphragm contraction(GO:0002086) regulation of muscle filament sliding speed(GO:0032972)
0.1 0.2 GO:0006214 thymidine catabolic process(GO:0006214) pyrimidine deoxyribonucleoside catabolic process(GO:0046127)
0.1 0.2 GO:0006538 glutamate catabolic process(GO:0006538)
0.1 0.1 GO:0051542 elastin biosynthetic process(GO:0051542)
0.1 0.2 GO:0010796 regulation of multivesicular body size(GO:0010796)
0.0 0.1 GO:0032430 regulation of renal output by angiotensin(GO:0002019) positive regulation of phospholipase A2 activity(GO:0032430)
0.0 0.2 GO:0042776 mitochondrial ATP synthesis coupled proton transport(GO:0042776)
0.0 0.1 GO:0046946 hydroxylysine metabolic process(GO:0046946) hydroxylysine biosynthetic process(GO:0046947)
0.0 0.2 GO:0052314 phytoalexin metabolic process(GO:0052314)
0.0 0.3 GO:0061737 leukotriene signaling pathway(GO:0061737)
0.0 0.2 GO:0090071 negative regulation of ribosome biogenesis(GO:0090071)
0.0 0.3 GO:0007168 receptor guanylyl cyclase signaling pathway(GO:0007168)
0.0 0.2 GO:0002337 B-1a B cell differentiation(GO:0002337)
0.0 0.1 GO:0034436 glycoprotein transport(GO:0034436)
0.0 0.2 GO:0015889 cobalamin transport(GO:0015889)
0.0 0.4 GO:0035021 negative regulation of Rac protein signal transduction(GO:0035021)
0.0 0.1 GO:0051106 regulation of DNA ligation(GO:0051105) positive regulation of DNA ligation(GO:0051106)
0.0 0.1 GO:0019375 galactosylceramide biosynthetic process(GO:0006682) galactolipid biosynthetic process(GO:0019375)
0.0 0.1 GO:0006121 mitochondrial electron transport, succinate to ubiquinone(GO:0006121)
0.0 0.1 GO:1903575 cornified envelope assembly(GO:1903575)
0.0 0.2 GO:0071400 cellular response to oleic acid(GO:0071400)
0.0 0.1 GO:0046066 purine deoxyribonucleoside diphosphate metabolic process(GO:0009182) dGDP metabolic process(GO:0046066)
0.0 0.1 GO:2000255 negative regulation of male germ cell proliferation(GO:2000255)
0.0 0.1 GO:0090481 pyrimidine nucleotide-sugar transmembrane transport(GO:0090481)
0.0 0.1 GO:0042222 interleukin-1 biosynthetic process(GO:0042222)
0.0 0.1 GO:0060266 negative regulation of respiratory burst involved in inflammatory response(GO:0060266)
0.0 0.3 GO:0071726 response to diacyl bacterial lipopeptide(GO:0071724) cellular response to diacyl bacterial lipopeptide(GO:0071726)
0.0 0.1 GO:0019262 N-acetylneuraminate catabolic process(GO:0019262)
0.0 0.1 GO:1903630 regulation of aminoacyl-tRNA ligase activity(GO:1903630)
0.0 0.1 GO:0090648 regulation of endoplasmic reticulum stress-induced eIF2 alpha phosphorylation(GO:0060734) response to methyl methanesulfonate(GO:0072702) cellular response to methyl methanesulfonate(GO:0072703) response to environmental enrichment(GO:0090648) positive regulation of peptidyl-serine dephosphorylation(GO:1902310)
0.0 0.0 GO:0042590 antigen processing and presentation of exogenous peptide antigen via MHC class I(GO:0042590)
0.0 0.1 GO:0060392 negative regulation of SMAD protein import into nucleus(GO:0060392)
0.0 0.1 GO:0015864 pyrimidine nucleoside transport(GO:0015864)
0.0 0.1 GO:1901873 regulation of post-translational protein modification(GO:1901873)
0.0 0.3 GO:0052697 xenobiotic glucuronidation(GO:0052697)
0.0 0.1 GO:0002481 antigen processing and presentation of exogenous peptide antigen via MHC class Ib(GO:0002477) antigen processing and presentation of exogenous protein antigen via MHC class Ib, TAP-dependent(GO:0002481)
0.0 0.2 GO:0016185 synaptic vesicle budding from presynaptic endocytic zone membrane(GO:0016185)
0.0 0.1 GO:0034316 negative regulation of Arp2/3 complex-mediated actin nucleation(GO:0034316)
0.0 0.1 GO:1901896 positive regulation of calcium-transporting ATPase activity(GO:1901896)
0.0 0.1 GO:0043179 rhythmic excitation(GO:0043179)
0.0 0.1 GO:0097360 chorionic trophoblast cell proliferation(GO:0097360) regulation of chorionic trophoblast cell proliferation(GO:1901382)
0.0 0.1 GO:0072181 mesonephric duct formation(GO:0072181)
0.0 0.1 GO:0070634 transepithelial ammonium transport(GO:0070634)
0.0 0.1 GO:2000318 positive regulation of T-helper 17 type immune response(GO:2000318)
0.0 0.1 GO:1903275 positive regulation of sodium ion export(GO:1903275) positive regulation of sodium ion export from cell(GO:1903278)
0.0 0.1 GO:0034241 positive regulation of macrophage fusion(GO:0034241)
0.0 0.2 GO:0000056 ribosomal small subunit export from nucleus(GO:0000056)
0.0 0.1 GO:0021966 corticospinal neuron axon guidance(GO:0021966)
0.0 0.1 GO:0075509 receptor-mediated endocytosis of virus by host cell(GO:0019065) endocytosis involved in viral entry into host cell(GO:0075509)
0.0 0.2 GO:0045743 positive regulation of fibroblast growth factor receptor signaling pathway(GO:0045743)
0.0 0.1 GO:0002184 cytoplasmic translational termination(GO:0002184)
0.0 0.1 GO:0035928 rRNA import into mitochondrion(GO:0035928)
0.0 0.1 GO:0071492 cellular response to UV-A(GO:0071492)
0.0 0.1 GO:0098759 response to interleukin-8(GO:0098758) cellular response to interleukin-8(GO:0098759)
0.0 0.1 GO:0046726 positive regulation by virus of viral protein levels in host cell(GO:0046726)
0.0 0.1 GO:2000435 regulation of protein neddylation(GO:2000434) negative regulation of protein neddylation(GO:2000435)
0.0 0.1 GO:0009186 dUDP biosynthetic process(GO:0006227) pyrimidine nucleoside diphosphate biosynthetic process(GO:0009139) deoxyribonucleoside diphosphate metabolic process(GO:0009186) deoxyribonucleoside diphosphate biosynthetic process(GO:0009189) pyrimidine deoxyribonucleoside diphosphate metabolic process(GO:0009196) pyrimidine deoxyribonucleoside diphosphate biosynthetic process(GO:0009197) dUDP metabolic process(GO:0046077)
0.0 0.2 GO:0002176 male germ cell proliferation(GO:0002176)
0.0 0.1 GO:1902308 regulation of peptidyl-serine dephosphorylation(GO:1902308)
0.0 0.1 GO:0006990 positive regulation of transcription from RNA polymerase II promoter involved in unfolded protein response(GO:0006990)
0.0 0.1 GO:0019355 nicotinamide nucleotide biosynthetic process from aspartate(GO:0019355) 'de novo' NAD biosynthetic process from aspartate(GO:0034628)
0.0 0.1 GO:0030186 melatonin metabolic process(GO:0030186)
0.0 0.1 GO:0060370 susceptibility to T cell mediated cytotoxicity(GO:0060370)
0.0 0.1 GO:0097010 eukaryotic translation initiation factor 4F complex assembly(GO:0097010)
0.0 0.4 GO:0002227 innate immune response in mucosa(GO:0002227)
0.0 0.1 GO:0060613 fat pad development(GO:0060613)
0.0 0.1 GO:0010958 regulation of amino acid import(GO:0010958)
0.0 0.2 GO:0042989 sequestering of actin monomers(GO:0042989)
0.0 0.1 GO:2000609 regulation of thyroid hormone generation(GO:2000609)
0.0 0.1 GO:0015882 L-ascorbic acid transport(GO:0015882) transepithelial L-ascorbic acid transport(GO:0070904)
0.0 0.2 GO:0032532 regulation of microvillus length(GO:0032532)
0.0 0.3 GO:0038094 Fc-gamma receptor signaling pathway(GO:0038094)
0.0 0.1 GO:1901509 regulation of endothelial tube morphogenesis(GO:1901509)
0.0 0.1 GO:0001788 antibody-dependent cellular cytotoxicity(GO:0001788)
0.0 0.1 GO:0052651 monoacylglycerol metabolic process(GO:0046462) monoacylglycerol catabolic process(GO:0052651)
0.0 0.1 GO:0006432 phenylalanyl-tRNA aminoacylation(GO:0006432)
0.0 0.1 GO:0032472 Golgi calcium ion transport(GO:0032472)
0.0 0.1 GO:0051005 negative regulation of lipoprotein lipase activity(GO:0051005)
0.0 0.1 GO:1902683 regulation of receptor localization to synapse(GO:1902683)
0.0 0.1 GO:0035606 peptidyl-cysteine S-trans-nitrosylation(GO:0035606)
0.0 0.1 GO:0032962 positive regulation of inositol trisphosphate biosynthetic process(GO:0032962)
0.0 0.1 GO:0042908 xenobiotic transport(GO:0042908)
0.0 0.1 GO:0042276 error-prone translesion synthesis(GO:0042276)
0.0 0.0 GO:0002343 peripheral B cell selection(GO:0002343) B cell affinity maturation(GO:0002344)
0.0 0.1 GO:0010901 regulation of very-low-density lipoprotein particle remodeling(GO:0010901)
0.0 0.2 GO:1901029 negative regulation of mitochondrial outer membrane permeabilization involved in apoptotic signaling pathway(GO:1901029)
0.0 0.1 GO:1903445 protein transport from ciliary membrane to plasma membrane(GO:1903445)
0.0 0.1 GO:0003166 bundle of His development(GO:0003166)
0.0 0.1 GO:0021650 vestibulocochlear nerve formation(GO:0021650)
0.0 0.2 GO:0038161 prolactin signaling pathway(GO:0038161)
0.0 0.1 GO:0018201 N-terminal protein amino acid methylation(GO:0006480) peptidyl-glycine modification(GO:0018201)
0.0 0.1 GO:1903659 regulation of complement-dependent cytotoxicity(GO:1903659)
0.0 0.1 GO:0090666 scaRNA localization to Cajal body(GO:0090666)
0.0 0.1 GO:0042350 GDP-L-fucose biosynthetic process(GO:0042350)
0.0 0.1 GO:0003419 growth plate cartilage chondrocyte proliferation(GO:0003419) sequestering of BMP in extracellular matrix(GO:0035582)
0.0 0.1 GO:0070084 protein initiator methionine removal(GO:0070084)
0.0 0.3 GO:0043252 sodium-independent organic anion transport(GO:0043252)
0.0 0.7 GO:0042462 eye photoreceptor cell development(GO:0042462)
0.0 0.1 GO:0034499 late endosome to Golgi transport(GO:0034499)
0.0 0.1 GO:0032918 polyamine acetylation(GO:0032917) spermidine acetylation(GO:0032918)
0.0 0.1 GO:0000105 histidine biosynthetic process(GO:0000105)
0.0 0.1 GO:0042628 mating plug formation(GO:0042628) post-mating behavior(GO:0045297)
0.0 0.2 GO:0035634 response to stilbenoid(GO:0035634)
0.0 0.1 GO:0043418 homocysteine catabolic process(GO:0043418)
0.0 0.1 GO:0006564 L-serine biosynthetic process(GO:0006564)
0.0 0.1 GO:0072338 cellular lactam metabolic process(GO:0072338)
0.0 0.1 GO:0018963 phthalate metabolic process(GO:0018963)
0.0 0.1 GO:2000813 negative regulation of barbed-end actin filament capping(GO:2000813)
0.0 0.1 GO:2000630 positive regulation of miRNA metabolic process(GO:2000630)
0.0 0.1 GO:1904959 regulation of cytochrome-c oxidase activity(GO:1904959)
0.0 0.1 GO:0002018 renin-angiotensin regulation of aldosterone production(GO:0002018) G-protein coupled receptor signaling pathway coupled to cGMP nucleotide second messenger(GO:0007199) negative regulation of icosanoid secretion(GO:0032304) regulation of metanephros size(GO:0035566)
0.0 0.1 GO:0048386 positive regulation of retinoic acid receptor signaling pathway(GO:0048386)
0.0 0.1 GO:0097084 vascular smooth muscle cell development(GO:0097084)
0.0 0.1 GO:0033031 positive regulation of neutrophil apoptotic process(GO:0033031)
0.0 0.1 GO:0016129 phytosteroid metabolic process(GO:0016128) phytosteroid biosynthetic process(GO:0016129)
0.0 0.1 GO:0016557 peroxisome membrane biogenesis(GO:0016557)
0.0 0.1 GO:0010936 negative regulation of macrophage cytokine production(GO:0010936)
0.0 0.1 GO:0010609 mRNA localization resulting in posttranscriptional regulation of gene expression(GO:0010609) cytidine to uridine editing(GO:0016554)
0.0 0.0 GO:1902527 positive regulation of protein monoubiquitination(GO:1902527)
0.0 0.1 GO:2000293 gastric motility(GO:0035482) regulation of defecation(GO:2000292) negative regulation of defecation(GO:2000293)
0.0 0.0 GO:1900738 positive regulation of phospholipase C-activating G-protein coupled receptor signaling pathway(GO:1900738) response to thyrotropin-releasing hormone(GO:1905225)
0.0 0.1 GO:0000379 tRNA-type intron splice site recognition and cleavage(GO:0000379)
0.0 0.1 GO:0046061 dATP catabolic process(GO:0046061)
0.0 0.1 GO:0006729 tetrahydrobiopterin biosynthetic process(GO:0006729)
0.0 0.0 GO:0021558 trochlear nerve development(GO:0021558)
0.0 0.1 GO:0006561 proline biosynthetic process(GO:0006561)
0.0 0.1 GO:0036444 calcium ion transmembrane import into mitochondrion(GO:0036444)
0.0 0.2 GO:1903862 positive regulation of oxidative phosphorylation(GO:1903862)
0.0 0.1 GO:0034080 CENP-A containing nucleosome assembly(GO:0034080) CENP-A containing chromatin organization(GO:0061641)
0.0 0.1 GO:0044336 canonical Wnt signaling pathway involved in negative regulation of apoptotic process(GO:0044336)
0.0 0.0 GO:0015015 heparan sulfate proteoglycan biosynthetic process, enzymatic modification(GO:0015015)
0.0 0.1 GO:0071415 cellular response to purine-containing compound(GO:0071415)
0.0 0.2 GO:0006390 transcription from mitochondrial promoter(GO:0006390)
0.0 0.1 GO:2000675 response to ozone(GO:0010193) positive regulation of neurotrophin TRK receptor signaling pathway(GO:0051388) negative regulation of type B pancreatic cell apoptotic process(GO:2000675)
0.0 0.1 GO:0015722 canalicular bile acid transport(GO:0015722)
0.0 0.1 GO:0036233 glycine import(GO:0036233)
0.0 0.2 GO:1904321 response to forskolin(GO:1904321) cellular response to forskolin(GO:1904322)
0.0 0.0 GO:1904569 regulation of selenocysteine incorporation(GO:1904569)
0.0 0.1 GO:0031120 snRNA pseudouridine synthesis(GO:0031120)
0.0 0.0 GO:0060298 positive regulation of sarcomere organization(GO:0060298)
0.0 0.1 GO:0061055 myotome development(GO:0061055)
0.0 0.2 GO:0002024 diet induced thermogenesis(GO:0002024)
0.0 0.1 GO:0032077 positive regulation of deoxyribonuclease activity(GO:0032077)
0.0 0.0 GO:0021648 vestibulocochlear nerve morphogenesis(GO:0021648) vestibulocochlear nerve structural organization(GO:0021649) ganglion morphogenesis(GO:0061552) dorsal root ganglion morphogenesis(GO:1904835)
0.0 0.0 GO:2000977 regulation of forebrain neuron differentiation(GO:2000977)
0.0 0.1 GO:0051725 protein de-ADP-ribosylation(GO:0051725)
0.0 0.1 GO:0030579 ubiquitin-dependent SMAD protein catabolic process(GO:0030579)
0.0 0.1 GO:0016255 attachment of GPI anchor to protein(GO:0016255)
0.0 0.0 GO:0033364 mast cell secretory granule organization(GO:0033364)
0.0 0.1 GO:0006703 estrogen biosynthetic process(GO:0006703)
0.0 0.1 GO:0045329 carnitine biosynthetic process(GO:0045329)
0.0 0.1 GO:0015871 choline transport(GO:0015871)
0.0 0.1 GO:1990705 cholangiocyte proliferation(GO:1990705)
0.0 0.1 GO:0015670 carbon dioxide transport(GO:0015670)
0.0 0.1 GO:0009597 detection of virus(GO:0009597)
0.0 0.1 GO:0044571 [2Fe-2S] cluster assembly(GO:0044571)
0.0 0.0 GO:0018406 protein C-linked glycosylation(GO:0018103) peptidyl-tryptophan modification(GO:0018211) protein C-linked glycosylation via tryptophan(GO:0018317) protein C-linked glycosylation via 2'-alpha-mannosyl-L-tryptophan(GO:0018406)
0.0 0.1 GO:0006107 oxaloacetate metabolic process(GO:0006107)
0.0 0.1 GO:0006123 mitochondrial electron transport, cytochrome c to oxygen(GO:0006123)
0.0 0.1 GO:0060600 dichotomous subdivision of an epithelial terminal unit(GO:0060600)
0.0 0.1 GO:0030311 poly-N-acetyllactosamine metabolic process(GO:0030309) poly-N-acetyllactosamine biosynthetic process(GO:0030311)
0.0 0.1 GO:0002082 regulation of oxidative phosphorylation(GO:0002082)
0.0 0.0 GO:0033986 response to methanol(GO:0033986)
0.0 0.2 GO:0036159 inner dynein arm assembly(GO:0036159)
0.0 0.0 GO:0015793 glycerol transport(GO:0015793)
0.0 0.2 GO:0060856 establishment of blood-brain barrier(GO:0060856)
0.0 0.3 GO:0000028 ribosomal small subunit assembly(GO:0000028)
0.0 0.1 GO:0099638 endosome to plasma membrane protein transport(GO:0099638)
0.0 0.0 GO:0002752 cell surface pattern recognition receptor signaling pathway(GO:0002752)
0.0 0.1 GO:0000463 maturation of LSU-rRNA from tricistronic rRNA transcript (SSU-rRNA, 5.8S rRNA, LSU-rRNA)(GO:0000463)
0.0 0.1 GO:0007341 penetration of zona pellucida(GO:0007341)
0.0 0.1 GO:0060385 axonogenesis involved in innervation(GO:0060385)
0.0 0.4 GO:0050869 negative regulation of B cell activation(GO:0050869)
0.0 0.0 GO:1904373 response to kainic acid(GO:1904373)
0.0 0.1 GO:2001269 positive regulation of cysteine-type endopeptidase activity involved in apoptotic signaling pathway(GO:2001269)
0.0 0.1 GO:0061635 regulation of protein complex stability(GO:0061635)
0.0 0.0 GO:0009153 purine deoxyribonucleotide biosynthetic process(GO:0009153) purine deoxyribonucleoside triphosphate biosynthetic process(GO:0009216)
0.0 0.0 GO:0034238 macrophage fusion(GO:0034238) regulation of macrophage fusion(GO:0034239) negative regulation of macrophage fusion(GO:0034240)
0.0 0.1 GO:0034975 protein folding in endoplasmic reticulum(GO:0034975)
0.0 0.0 GO:0060467 negative regulation of fertilization(GO:0060467) prevention of polyspermy(GO:0060468)
0.0 0.1 GO:0046085 adenosine metabolic process(GO:0046085)
0.0 0.1 GO:0060046 regulation of acrosome reaction(GO:0060046)
0.0 0.1 GO:0018065 protein-cofactor linkage(GO:0018065)
0.0 0.0 GO:1903847 regulation of aorta morphogenesis(GO:1903847) positive regulation of aorta morphogenesis(GO:1903849)
0.0 0.0 GO:1902268 negative regulation of polyamine transmembrane transport(GO:1902268)

Gene overrepresentation in cellular component category:

Log-likelihood per target  Total log-likelihood Term Description
0.1 0.2 GO:0031205 endoplasmic reticulum Sec complex(GO:0031205)
0.1 0.6 GO:0005750 mitochondrial respiratory chain complex III(GO:0005750)
0.1 0.6 GO:0042583 chromaffin granule(GO:0042583)
0.1 0.2 GO:0032798 Swi5-Sfr1 complex(GO:0032798)
0.1 0.2 GO:0061574 ASAP complex(GO:0061574)
0.1 0.2 GO:0000814 ESCRT II complex(GO:0000814)
0.0 1.3 GO:0097225 sperm midpiece(GO:0097225)
0.0 0.3 GO:0097342 ripoptosome(GO:0097342)
0.0 0.2 GO:1990584 cardiac Troponin complex(GO:1990584)
0.0 0.3 GO:0042105 alpha-beta T cell receptor complex(GO:0042105)
0.0 0.3 GO:0033256 I-kappaB/NF-kappaB complex(GO:0033256)
0.0 0.2 GO:0061689 tricellular tight junction(GO:0061689)
0.0 0.2 GO:0042567 insulin-like growth factor ternary complex(GO:0042567)
0.0 0.2 GO:0033269 internode region of axon(GO:0033269)
0.0 0.1 GO:0046696 lipopolysaccharide receptor complex(GO:0046696)
0.0 0.1 GO:0031510 SUMO activating enzyme complex(GO:0031510)
0.0 0.1 GO:0044214 spanning component of plasma membrane(GO:0044214) spanning component of membrane(GO:0089717)
0.0 0.1 GO:0018444 translation release factor complex(GO:0018444)
0.0 0.1 GO:0042719 mitochondrial intermembrane space protein transporter complex(GO:0042719)
0.0 0.3 GO:0030130 clathrin coat of trans-Golgi network vesicle(GO:0030130)
0.0 0.3 GO:0042613 MHC class II protein complex(GO:0042613)
0.0 0.0 GO:0036128 CatSper complex(GO:0036128)
0.0 0.1 GO:1990246 uniplex complex(GO:1990246)
0.0 0.1 GO:0042571 immunoglobulin complex, circulating(GO:0042571)
0.0 0.1 GO:0008622 epsilon DNA polymerase complex(GO:0008622)
0.0 0.2 GO:0019773 proteasome core complex, alpha-subunit complex(GO:0019773)
0.0 0.1 GO:1903349 omegasome membrane(GO:1903349) omegasome(GO:1990462)
0.0 0.2 GO:0071821 FANCM-MHF complex(GO:0071821)
0.0 0.1 GO:0046691 intracellular canaliculus(GO:0046691)
0.0 0.1 GO:0070557 PCNA-p21 complex(GO:0070557)
0.0 0.1 GO:0034657 GID complex(GO:0034657)
0.0 0.5 GO:0005763 organellar small ribosomal subunit(GO:0000314) mitochondrial small ribosomal subunit(GO:0005763)
0.0 0.2 GO:0031983 vesicle lumen(GO:0031983)
0.0 0.3 GO:0031231 integral component of peroxisomal membrane(GO:0005779) intrinsic component of peroxisomal membrane(GO:0031231)
0.0 0.1 GO:1990712 HFE-transferrin receptor complex(GO:1990712)
0.0 0.1 GO:0090543 Flemming body(GO:0090543)
0.0 0.1 GO:0070195 growth hormone receptor complex(GO:0070195)
0.0 1.3 GO:0036126 sperm flagellum(GO:0036126)
0.0 0.1 GO:0005869 dynactin complex(GO:0005869)
0.0 0.2 GO:0070852 cell body fiber(GO:0070852)
0.0 0.1 GO:0030688 preribosome, small subunit precursor(GO:0030688)
0.0 0.1 GO:0000214 tRNA-intron endonuclease complex(GO:0000214)
0.0 0.0 GO:0000839 Hrd1p ubiquitin ligase ERAD-L complex(GO:0000839)
0.0 0.1 GO:0042765 GPI-anchor transamidase complex(GO:0042765)
0.0 0.1 GO:0000506 glycosylphosphatidylinositol-N-acetylglucosaminyltransferase (GPI-GnT) complex(GO:0000506)
0.0 0.2 GO:0043196 varicosity(GO:0043196)
0.0 0.1 GO:0034663 endoplasmic reticulum chaperone complex(GO:0034663)
0.0 0.9 GO:0022627 cytosolic small ribosomal subunit(GO:0022627)
0.0 0.0 GO:0098982 glycine-gated chloride channel complex(GO:0016935) GABA-ergic synapse(GO:0098982)
0.0 0.1 GO:0016012 sarcoglycan complex(GO:0016012)
0.0 0.1 GO:1990357 terminal web(GO:1990357)
0.0 0.1 GO:0071817 MMXD complex(GO:0071817)
0.0 0.2 GO:0031527 filopodium membrane(GO:0031527)
0.0 0.3 GO:0005753 mitochondrial proton-transporting ATP synthase complex(GO:0005753)
0.0 0.1 GO:0005787 signal peptidase complex(GO:0005787)
0.0 0.1 GO:0005786 signal recognition particle, endoplasmic reticulum targeting(GO:0005786)
0.0 0.0 GO:0097451 glial limiting end-foot(GO:0097451)
0.0 0.1 GO:0005796 Golgi lumen(GO:0005796)
0.0 0.1 GO:0001652 granular component(GO:0001652)
0.0 0.1 GO:0005832 chaperonin-containing T-complex(GO:0005832)
0.0 0.1 GO:0008541 proteasome regulatory particle, lid subcomplex(GO:0008541)
0.0 0.1 GO:0005850 eukaryotic translation initiation factor 2 complex(GO:0005850)

Gene overrepresentation in molecular function category:

Log-likelihood per target  Total log-likelihood Term Description
0.4 1.3 GO:0031893 vasopressin receptor binding(GO:0031893)
0.2 0.7 GO:0001591 dopamine neurotransmitter receptor activity, coupled via Gi/Go(GO:0001591)
0.1 0.4 GO:0005030 neurotrophin receptor activity(GO:0005030)
0.1 0.4 GO:0052794 exo-alpha-(2->3)-sialidase activity(GO:0052794) exo-alpha-(2->6)-sialidase activity(GO:0052795) exo-alpha-(2->8)-sialidase activity(GO:0052796)
0.1 0.3 GO:0004704 NF-kappaB-inducing kinase activity(GO:0004704)
0.1 0.6 GO:1901611 phosphatidylglycerol binding(GO:1901611) cardiolipin binding(GO:1901612)
0.1 0.2 GO:0070976 TIR domain binding(GO:0070976)
0.1 0.3 GO:0019767 IgE receptor activity(GO:0019767)
0.1 0.2 GO:0004167 dopachrome isomerase activity(GO:0004167)
0.1 0.2 GO:0004925 prolactin receptor activity(GO:0004925)
0.1 0.2 GO:0036468 aromatic-L-amino-acid decarboxylase activity(GO:0004058) L-dopa decarboxylase activity(GO:0036468)
0.1 0.2 GO:0004159 dihydrouracil dehydrogenase (NAD+) activity(GO:0004159) dihydropyrimidine dehydrogenase (NADP+) activity(GO:0017113)
0.1 0.4 GO:0003840 gamma-glutamyltransferase activity(GO:0003840) glutathione hydrolase activity(GO:0036374)
0.1 0.2 GO:0030984 kininogen binding(GO:0030984)
0.1 0.3 GO:0004974 leukotriene receptor activity(GO:0004974)
0.0 0.2 GO:0004945 angiotensin type II receptor activity(GO:0004945)
0.0 0.1 GO:0016941 natriuretic peptide receptor activity(GO:0016941)
0.0 0.1 GO:0004735 pyrroline-5-carboxylate reductase activity(GO:0004735)
0.0 0.1 GO:0030337 DNA polymerase processivity factor activity(GO:0030337)
0.0 0.2 GO:0048408 epidermal growth factor binding(GO:0048408)
0.0 0.1 GO:0033823 procollagen-lysine 5-dioxygenase activity(GO:0008475) procollagen glucosyltransferase activity(GO:0033823)
0.0 0.2 GO:0051431 corticotropin-releasing hormone receptor 2 binding(GO:0051431)
0.0 0.3 GO:0008430 selenium binding(GO:0008430)
0.0 0.1 GO:0003945 N-acetyllactosamine synthase activity(GO:0003945)
0.0 0.3 GO:0031014 troponin T binding(GO:0031014)
0.0 0.1 GO:0034437 glycoprotein transporter activity(GO:0034437)
0.0 0.2 GO:0018812 3-hydroxyacyl-CoA dehydratase activity(GO:0018812)
0.0 0.3 GO:0031545 peptidyl-proline 4-dioxygenase activity(GO:0031545)
0.0 0.2 GO:0031686 A1 adenosine receptor binding(GO:0031686)
0.0 0.1 GO:0047631 ADP-ribose diphosphatase activity(GO:0047631)
0.0 0.3 GO:0005001 transmembrane receptor protein tyrosine phosphatase activity(GO:0005001) transmembrane receptor protein phosphatase activity(GO:0019198)
0.0 0.2 GO:0005499 vitamin D binding(GO:0005499)
0.0 0.1 GO:0030283 testosterone dehydrogenase [NAD(P)] activity(GO:0030283)
0.0 0.1 GO:0031783 corticotropin hormone receptor binding(GO:0031780) type 5 melanocortin receptor binding(GO:0031783)
0.0 0.1 GO:0044715 8-oxo-dGDP phosphatase activity(GO:0044715)
0.0 0.2 GO:0016713 oxidoreductase activity, acting on paired donors, with incorporation or reduction of molecular oxygen, reduced iron-sulfur protein as one donor, and incorporation of one atom of oxygen(GO:0016713)
0.0 0.2 GO:0019808 polyamine binding(GO:0019808)
0.0 0.3 GO:0032050 clathrin heavy chain binding(GO:0032050)
0.0 0.3 GO:0008381 mechanically-gated ion channel activity(GO:0008381) mechanically gated channel activity(GO:0022833)
0.0 0.1 GO:0050252 retinol O-fatty-acyltransferase activity(GO:0050252)
0.0 0.1 GO:0004852 uroporphyrinogen-III synthase activity(GO:0004852)
0.0 0.1 GO:0019834 phospholipase A2 inhibitor activity(GO:0019834)
0.0 0.1 GO:0005163 nerve growth factor receptor binding(GO:0005163)
0.0 0.1 GO:0070892 lipoteichoic acid receptor activity(GO:0070892)
0.0 0.1 GO:0008396 oxysterol 7-alpha-hydroxylase activity(GO:0008396)
0.0 0.1 GO:0070891 lipoteichoic acid binding(GO:0070891)
0.0 0.1 GO:0070404 NADH binding(GO:0070404)
0.0 0.1 GO:0004351 glutamate decarboxylase activity(GO:0004351)
0.0 0.1 GO:0008511 sodium:potassium:chloride symporter activity(GO:0008511)
0.0 0.1 GO:0001733 galactosylceramide sulfotransferase activity(GO:0001733)
0.0 0.2 GO:0008121 ubiquinol-cytochrome-c reductase activity(GO:0008121) oxidoreductase activity, acting on diphenols and related substances as donors, cytochrome as acceptor(GO:0016681)
0.0 0.1 GO:0086062 voltage-gated sodium channel activity involved in Purkinje myocyte action potential(GO:0086062)
0.0 0.1 GO:0005111 type 1 fibroblast growth factor receptor binding(GO:0005105) type 2 fibroblast growth factor receptor binding(GO:0005111)
0.0 0.2 GO:0008494 translation activator activity(GO:0008494)
0.0 0.1 GO:0015165 pyrimidine nucleotide-sugar transmembrane transporter activity(GO:0015165)
0.0 0.1 GO:0000150 recombinase activity(GO:0000150)
0.0 0.1 GO:0009041 uridylate kinase activity(GO:0009041) nucleoside phosphate kinase activity(GO:0050145)
0.0 0.1 GO:0035529 NADH pyrophosphatase activity(GO:0035529)
0.0 0.1 GO:0000309 nicotinamide-nucleotide adenylyltransferase activity(GO:0000309) nicotinate-nucleotide adenylyltransferase activity(GO:0004515)
0.0 0.1 GO:0034057 RNA strand-exchange activity(GO:0034057)
0.0 0.4 GO:0001871 pattern binding(GO:0001871) polysaccharide binding(GO:0030247)
0.0 0.1 GO:0098519 nucleotide phosphatase activity, acting on free nucleotides(GO:0098519)
0.0 0.1 GO:0030942 endoplasmic reticulum signal peptide binding(GO:0030942)
0.0 0.1 GO:0015229 L-ascorbate:sodium symporter activity(GO:0008520) L-ascorbic acid transporter activity(GO:0015229) sodium-dependent L-ascorbate transmembrane transporter activity(GO:0070890)
0.0 0.1 GO:0080130 L-aspartate:2-oxoglutarate aminotransferase activity(GO:0004069) L-phenylalanine:2-oxoglutarate aminotransferase activity(GO:0080130)
0.0 0.2 GO:0047498 calcium-dependent phospholipase A2 activity(GO:0047498)
0.0 0.2 GO:0039706 co-receptor binding(GO:0039706)
0.0 0.1 GO:0008169 C-methyltransferase activity(GO:0008169)
0.0 0.1 GO:0071885 N-terminal protein N-methyltransferase activity(GO:0071885)
0.0 0.5 GO:0008157 protein phosphatase 1 binding(GO:0008157)
0.0 0.4 GO:0023026 MHC class II protein complex binding(GO:0023026)
0.0 0.1 GO:0030060 L-malate dehydrogenase activity(GO:0030060)
0.0 0.1 GO:0004903 growth hormone receptor activity(GO:0004903)
0.0 0.2 GO:0043023 ribosomal large subunit binding(GO:0043023)
0.0 0.0 GO:0070546 L-phenylalanine aminotransferase activity(GO:0070546)
0.0 0.1 GO:0015220 choline transmembrane transporter activity(GO:0015220)
0.0 0.1 GO:0004826 phenylalanine-tRNA ligase activity(GO:0004826)
0.0 0.1 GO:0044388 small protein activating enzyme binding(GO:0044388)
0.0 0.1 GO:0046912 transferase activity, transferring acyl groups, acyl groups converted into alkyl on transfer(GO:0046912)
0.0 0.1 GO:0005021 vascular endothelial growth factor-activated receptor activity(GO:0005021)
0.0 0.1 GO:0008241 peptidyl-dipeptidase activity(GO:0008241)
0.0 0.5 GO:0070003 threonine-type endopeptidase activity(GO:0004298) threonine-type peptidase activity(GO:0070003)
0.0 0.1 GO:0004918 interleukin-8 receptor activity(GO:0004918)
0.0 0.1 GO:0048039 ubiquinone binding(GO:0048039)
0.0 0.1 GO:0043404 corticotrophin-releasing factor receptor activity(GO:0015056) corticotropin-releasing hormone receptor activity(GO:0043404)
0.0 0.0 GO:0070053 thrombospondin receptor activity(GO:0070053)
0.0 0.4 GO:0005549 odorant binding(GO:0005549)
0.0 0.3 GO:0005184 neuropeptide hormone activity(GO:0005184)
0.0 0.2 GO:0019911 structural constituent of myelin sheath(GO:0019911)
0.0 0.3 GO:0042288 MHC class I protein binding(GO:0042288)
0.0 0.1 GO:0003839 gamma-glutamylcyclotransferase activity(GO:0003839)
0.0 0.4 GO:0015020 glucuronosyltransferase activity(GO:0015020)
0.0 0.1 GO:0043891 glyceraldehyde-3-phosphate dehydrogenase (NAD+) (phosphorylating) activity(GO:0004365) glyceraldehyde-3-phosphate dehydrogenase (NAD(P)+) (phosphorylating) activity(GO:0043891)
0.0 0.2 GO:0003841 1-acylglycerol-3-phosphate O-acyltransferase activity(GO:0003841)
0.0 0.5 GO:0071855 neuropeptide receptor binding(GO:0071855)
0.0 0.1 GO:0051920 peroxiredoxin activity(GO:0051920)
0.0 0.2 GO:0010314 phosphatidylinositol-5-phosphate binding(GO:0010314)
0.0 0.1 GO:0004963 follicle-stimulating hormone receptor activity(GO:0004963)
0.0 1.1 GO:0004867 serine-type endopeptidase inhibitor activity(GO:0004867)
0.0 0.1 GO:0089720 caspase binding(GO:0089720)
0.0 0.1 GO:0004487 methylenetetrahydrofolate dehydrogenase (NAD+) activity(GO:0004487)
0.0 0.1 GO:0098748 clathrin adaptor activity(GO:0035615) endocytic adaptor activity(GO:0098748)
0.0 0.1 GO:0002046 opsin binding(GO:0002046)
0.0 0.1 GO:0008158 hedgehog receptor activity(GO:0008158)
0.0 0.4 GO:0004129 cytochrome-c oxidase activity(GO:0004129) heme-copper terminal oxidase activity(GO:0015002) oxidoreductase activity, acting on a heme group of donors, oxygen as acceptor(GO:0016676)
0.0 0.2 GO:0015250 water channel activity(GO:0015250)
0.0 0.2 GO:0043522 leucine zipper domain binding(GO:0043522)
0.0 0.2 GO:0008097 5S rRNA binding(GO:0008097)
0.0 0.1 GO:0031404 chloride ion binding(GO:0031404)
0.0 0.0 GO:0019238 cyclohydrolase activity(GO:0019238)
0.0 0.1 GO:0000213 tRNA-intron endonuclease activity(GO:0000213)
0.0 0.1 GO:0034235 GPI-anchor transamidase activity(GO:0003923) GPI anchor binding(GO:0034235)
0.0 0.1 GO:0017176 phosphatidylinositol N-acetylglucosaminyltransferase activity(GO:0017176)
0.0 0.2 GO:0004029 aldehyde dehydrogenase (NAD) activity(GO:0004029)
0.0 0.5 GO:0004869 cysteine-type endopeptidase inhibitor activity(GO:0004869)
0.0 0.0 GO:0019770 IgG receptor activity(GO:0019770)
0.0 0.1 GO:0070401 NADP+ binding(GO:0070401)
0.0 0.2 GO:0015347 sodium-independent organic anion transmembrane transporter activity(GO:0015347)
0.0 0.1 GO:0031726 CCR1 chemokine receptor binding(GO:0031726)
0.0 0.1 GO:0016531 copper chaperone activity(GO:0016531)
0.0 0.0 GO:0001758 3-keto sterol reductase activity(GO:0000253) retinal dehydrogenase activity(GO:0001758)
0.0 0.0 GO:0004060 arylamine N-acetyltransferase activity(GO:0004060)
0.0 0.1 GO:0019864 IgG binding(GO:0019864)
0.0 0.0 GO:0019958 C-X-C chemokine binding(GO:0019958)
0.0 0.1 GO:0030911 TPR domain binding(GO:0030911)
0.0 0.0 GO:0019002 GMP binding(GO:0019002)
0.0 0.1 GO:0004563 beta-N-acetylhexosaminidase activity(GO:0004563)
0.0 0.1 GO:0016857 racemase and epimerase activity, acting on carbohydrates and derivatives(GO:0016857)
0.0 0.0 GO:1990460 leptin receptor binding(GO:1990460)
0.0 0.1 GO:0019966 interleukin-1 binding(GO:0019966)
0.0 0.1 GO:0060228 lipase binding(GO:0035473) phosphatidylcholine-sterol O-acyltransferase activator activity(GO:0060228)
0.0 0.3 GO:0004707 MAP kinase activity(GO:0004707)
0.0 0.0 GO:0008073 ornithine decarboxylase inhibitor activity(GO:0008073)

Gene overrepresentation in curated gene sets: canonical pathways category:

Log-likelihood per target  Total log-likelihood Term Description
0.0 0.6 SA TRKA RECEPTOR The TrkA receptor binds nerve growth factor to activate MAP kinase pathways and promote cell growth.
0.0 0.2 PID FRA PATHWAY Validated transcriptional targets of AP1 family members Fra1 and Fra2
0.0 0.9 PID HIF2PATHWAY HIF-2-alpha transcription factor network
0.0 0.3 PID P38 GAMMA DELTA PATHWAY Signaling mediated by p38-gamma and p38-delta
0.0 0.1 PID VEGF VEGFR PATHWAY VEGF and VEGFR signaling network
0.0 0.3 PID NFKAPPAB ATYPICAL PATHWAY Atypical NF-kappaB pathway
0.0 0.2 PID HEDGEHOG 2PATHWAY Signaling events mediated by the Hedgehog family
0.0 0.3 SA MMP CYTOKINE CONNECTION Cytokines can induce activation of matrix metalloproteinases, which degrade extracellular matrix.
0.0 0.8 PID HEDGEHOG GLI PATHWAY Hedgehog signaling events mediated by Gli proteins
0.0 0.5 ST G ALPHA I PATHWAY G alpha i Pathway
0.0 0.3 PID CONE PATHWAY Visual signal transduction: Cones
0.0 0.1 PID AR NONGENOMIC PATHWAY Nongenotropic Androgen signaling
0.0 0.2 PID ERBB NETWORK PATHWAY ErbB receptor signaling network

Gene overrepresentation in curated gene sets: REACTOME pathways category:

Log-likelihood per target  Total log-likelihood Term Description
0.1 1.2 REACTOME TRANSPORT OF ORGANIC ANIONS Genes involved in Transport of organic anions
0.0 0.2 REACTOME GAP JUNCTION DEGRADATION Genes involved in Gap junction degradation
0.0 0.6 REACTOME RETROGRADE NEUROTROPHIN SIGNALLING Genes involved in Retrograde neurotrophin signalling
0.0 0.1 REACTOME ENDOSOMAL VACUOLAR PATHWAY Genes involved in Endosomal/Vacuolar pathway
0.0 0.5 REACTOME REGULATION OF IFNG SIGNALING Genes involved in Regulation of IFNG signaling
0.0 0.4 REACTOME P38MAPK EVENTS Genes involved in p38MAPK events
0.0 0.3 REACTOME RIP MEDIATED NFKB ACTIVATION VIA DAI Genes involved in RIP-mediated NFkB activation via DAI
0.0 0.1 REACTOME AQUAPORIN MEDIATED TRANSPORT Genes involved in Aquaporin-mediated transport
0.0 0.2 REACTOME FGFR2C LIGAND BINDING AND ACTIVATION Genes involved in FGFR2c ligand binding and activation
0.0 0.3 REACTOME ACYL CHAIN REMODELLING OF PG Genes involved in Acyl chain remodelling of PG
0.0 0.3 REACTOME COMMON PATHWAY Genes involved in Common Pathway
0.0 0.6 REACTOME AMINE LIGAND BINDING RECEPTORS Genes involved in Amine ligand-binding receptors
0.0 0.5 REACTOME SMAD2 SMAD3 SMAD4 HETEROTRIMER REGULATES TRANSCRIPTION Genes involved in SMAD2/SMAD3:SMAD4 heterotrimer regulates transcription
0.0 0.2 REACTOME PASSIVE TRANSPORT BY AQUAPORINS Genes involved in Passive Transport by Aquaporins
0.0 0.1 REACTOME IKK COMPLEX RECRUITMENT MEDIATED BY RIP1 Genes involved in IKK complex recruitment mediated by RIP1
0.0 0.3 REACTOME OXYGEN DEPENDENT PROLINE HYDROXYLATION OF HYPOXIA INDUCIBLE FACTOR ALPHA Genes involved in Oxygen-dependent Proline Hydroxylation of Hypoxia-inducible Factor Alpha
0.0 0.2 REACTOME AMINE DERIVED HORMONES Genes involved in Amine-derived hormones
0.0 0.4 REACTOME ADP SIGNALLING THROUGH P2RY1 Genes involved in ADP signalling through P2Y purinoceptor 1
0.0 1.2 REACTOME RESPIRATORY ELECTRON TRANSPORT ATP SYNTHESIS BY CHEMIOSMOTIC COUPLING AND HEAT PRODUCTION BY UNCOUPLING PROTEINS Genes involved in Respiratory electron transport, ATP synthesis by chemiosmotic coupling, and heat production by uncoupling proteins.
0.0 0.3 REACTOME PROLACTIN RECEPTOR SIGNALING Genes involved in Prolactin receptor signaling
0.0 0.3 REACTOME DOWNREGULATION OF TGF BETA RECEPTOR SIGNALING Genes involved in Downregulation of TGF-beta receptor signaling
0.0 0.2 REACTOME PYRIMIDINE CATABOLISM Genes involved in Pyrimidine catabolism
0.0 0.4 REACTOME GLUTATHIONE CONJUGATION Genes involved in Glutathione conjugation
0.0 0.2 REACTOME GLUCURONIDATION Genes involved in Glucuronidation
0.0 0.2 REACTOME EICOSANOID LIGAND BINDING RECEPTORS Genes involved in Eicosanoid ligand-binding receptors
0.0 0.2 REACTOME NRIF SIGNALS CELL DEATH FROM THE NUCLEUS Genes involved in NRIF signals cell death from the nucleus
0.0 0.1 REACTOME VEGF LIGAND RECEPTOR INTERACTIONS Genes involved in VEGF ligand-receptor interactions
0.0 0.3 REACTOME LIPOPROTEIN METABOLISM Genes involved in Lipoprotein metabolism
0.0 0.4 REACTOME GLYCOSPHINGOLIPID METABOLISM Genes involved in Glycosphingolipid metabolism
0.0 1.4 REACTOME SRP DEPENDENT COTRANSLATIONAL PROTEIN TARGETING TO MEMBRANE Genes involved in SRP-dependent cotranslational protein targeting to membrane
0.0 0.1 REACTOME P2Y RECEPTORS Genes involved in P2Y receptors
0.0 0.2 REACTOME REGULATION OF INSULIN LIKE GROWTH FACTOR IGF ACTIVITY BY INSULIN LIKE GROWTH FACTOR BINDING PROTEINS IGFBPS Genes involved in Regulation of Insulin-like Growth Factor (IGF) Activity by Insulin-like Growth Factor Binding Proteins (IGFBPs)