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GSE49485: Hypoxia transcriptome sequencing of rat brain.
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Results for Erg
Z-value: 0.66
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Transcription factors associated with Erg
Activity-expression correlation:
| Gene | Promoter | Pearson corr. coef. | P-value | Plot |
|---|---|---|---|---|
| Erg | rn6_v1_chr11_-_35697072_35697072 | 0.85 | 6.6e-02 | Click! |
| Promoter | Log-likelihood | Transcript | Gene | Gene Info |
|---|---|---|---|---|
| chr2_+_190003223 Show fit | 0.81 |
ENSRNOT00000015712
|
S100 calcium binding protein A5 |
|
| chr1_-_83993270 Show fit | 0.41 |
ENSRNOT00000002050
|
melanoma inhibitory activity |
|
| chr10_-_64642292 Show fit | 0.37 |
ENSRNOT00000084670
|
active BCR-related |
|
| chr12_+_38144855 Show fit | 0.30 |
ENSRNOT00000032274
|
hydroxycarboxylic acid receptor 1 |
|
| chrX_-_115175299 Show fit | 0.30 |
ENSRNOT00000074322
|
doublecortin |
|
| chr1_+_255801694 Show fit | 0.24 |
ENSRNOT00000018878
|
|
|
| chr2_-_190100276 Show fit | 0.23 |
ENSRNOT00000015351
|
S100 calcium binding protein A9 |
|
| chr7_-_36408588 Show fit | 0.22 |
ENSRNOT00000063946
|
CASP2 and RIPK1 domain containing adaptor with death domain |
|
| chr7_-_143966863 Show fit | 0.22 |
ENSRNOT00000018828
|
Sp7 transcription factor |
|
| chr11_+_84745904 Show fit | 0.21 |
ENSRNOT00000002617
|
kelch-like family member 6 |
Network of associatons between targets according to the STRING database.
First level regulatory network of Erg
Gene Ontology Analysis
Gene overrepresentation in biological process category:
| Log-likelihood per target | Total log-likelihood | Term | Description |
|---|---|---|---|
| 0.1 | 0.4 | GO:0043314 | negative regulation of neutrophil degranulation(GO:0043314) |
| 0.0 | 0.4 | GO:0021860 | pyramidal neuron development(GO:0021860) |
| 0.0 | 0.4 | GO:0060218 | hematopoietic stem cell differentiation(GO:0060218) |
| 0.0 | 0.3 | GO:0006977 | DNA damage response, signal transduction by p53 class mediator resulting in cell cycle arrest(GO:0006977) |
| 0.1 | 0.2 | GO:0002148 | hypochlorous acid metabolic process(GO:0002148) hypochlorous acid biosynthetic process(GO:0002149) |
| 0.1 | 0.2 | GO:1900095 | random inactivation of X chromosome(GO:0060816) regulation of dosage compensation by inactivation of X chromosome(GO:1900095) |
| 0.1 | 0.2 | GO:0035606 | peptidyl-cysteine S-trans-nitrosylation(GO:0035606) |
| 0.1 | 0.2 | GO:0042489 | negative regulation of odontogenesis of dentin-containing tooth(GO:0042489) |
| 0.1 | 0.2 | GO:1905072 | cardiac jelly development(GO:1905072) |
| 0.1 | 0.2 | GO:0010070 | zygote asymmetric cell division(GO:0010070) |
Gene overrepresentation in cellular component category:
| Log-likelihood per target | Total log-likelihood | Term | Description |
|---|---|---|---|
| 0.0 | 0.2 | GO:0070436 | Grb2-EGFR complex(GO:0070436) |
| 0.0 | 0.2 | GO:0016012 | sarcoglycan complex(GO:0016012) |
| 0.0 | 0.2 | GO:0042582 | primary lysosome(GO:0005766) azurophil granule(GO:0042582) |
| 0.0 | 0.1 | GO:0097427 | microtubule bundle(GO:0097427) |
| 0.0 | 0.1 | GO:0043259 | laminin-1 complex(GO:0005606) laminin-2 complex(GO:0005607) laminin-10 complex(GO:0043259) |
| 0.0 | 0.1 | GO:0035867 | alphav-beta3 integrin-IGF-1-IGF1R complex(GO:0035867) |
| 0.0 | 0.1 | GO:0005964 | phosphorylase kinase complex(GO:0005964) |
| 0.0 | 0.1 | GO:0098574 | cytoplasmic side of lysosomal membrane(GO:0098574) |
| 0.0 | 0.1 | GO:0097025 | MPP7-DLG1-LIN7 complex(GO:0097025) |
| 0.0 | 0.1 | GO:0097441 | basilar dendrite(GO:0097441) |
Gene overrepresentation in molecular function category:
| Log-likelihood per target | Total log-likelihood | Term | Description |
|---|---|---|---|
| 0.0 | 0.8 | GO:0005507 | copper ion binding(GO:0005507) |
| 0.0 | 0.4 | GO:0017151 | DEAD/H-box RNA helicase binding(GO:0017151) |
| 0.0 | 0.2 | GO:0005534 | galactose binding(GO:0005534) |
| 0.0 | 0.2 | GO:0019960 | C-X3-C chemokine binding(GO:0019960) |
| 0.0 | 0.2 | GO:0035662 | Toll-like receptor 4 binding(GO:0035662) |
| 0.0 | 0.2 | GO:0070513 | death domain binding(GO:0070513) |
| 0.0 | 0.2 | GO:0003680 | AT DNA binding(GO:0003680) |
| 0.0 | 0.2 | GO:0030159 | receptor signaling complex scaffold activity(GO:0030159) |
| 0.0 | 0.2 | GO:0043522 | leucine zipper domain binding(GO:0043522) |
| 0.0 | 0.1 | GO:0051916 | granulocyte colony-stimulating factor binding(GO:0051916) |
Gene overrepresentation in curated gene sets: canonical pathways category:
| Log-likelihood per target | Total log-likelihood | Term | Description |
|---|---|---|---|
| 0.0 | 0.3 | PID TOLL ENDOGENOUS PATHWAY | Endogenous TLR signaling |
Gene overrepresentation in curated gene sets: REACTOME pathways category:
| Log-likelihood per target | Total log-likelihood | Term | Description |
|---|---|---|---|
| 0.0 | 0.3 | REACTOME SIGNAL REGULATORY PROTEIN SIRP FAMILY INTERACTIONS | Genes involved in Signal regulatory protein (SIRP) family interactions |
| 0.0 | 0.1 | REACTOME BINDING AND ENTRY OF HIV VIRION | Genes involved in Binding and entry of HIV virion |