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GSE49485: Hypoxia transcriptome sequencing of rat brain.
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Results for Epas1_Bcl3
Z-value: 1.54
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Transcription factors associated with Epas1_Bcl3
Activity-expression correlation:
| Gene | Promoter | Pearson corr. coef. | P-value | Plot |
|---|---|---|---|---|
| Epas1 | rn6_v1_chr6_+_10348308_10348308 | 0.84 | 7.8e-02 | Click! |
| Bcl3 | rn6_v1_chr1_-_80744831_80744831 | -0.35 | 5.6e-01 | Click! |
| Promoter | Log-likelihood | Transcript | Gene | Gene Info |
|---|---|---|---|---|
| chr1_-_245817809 Show fit | 2.56 |
ENSRNOT00000080607
|
|
|
| chr12_-_45801842 Show fit | 1.75 |
ENSRNOT00000078837
|
|
|
| chr17_+_20619324 Show fit | 1.74 |
ENSRNOT00000079788
|
|
|
| chr3_+_71210301 Show fit | 1.50 |
ENSRNOT00000006504
|
family with sequence similarity 171, member B |
|
| chr2_+_30094421 Show fit | 1.30 |
ENSRNOT00000082226
|
|
|
| chr1_+_226435979 Show fit | 1.29 |
ENSRNOT00000048704
ENSRNOT00000036232 ENSRNOT00000035576 ENSRNOT00000036180 ENSRNOT00000036168 ENSRNOT00000047964 ENSRNOT00000036283 ENSRNOT00000007429 |
synaptotagmin 7 |
|
| chr18_-_18079560 Show fit | 1.13 |
ENSRNOT00000072093
|
|
|
| chr4_-_123713319 Show fit | 1.04 |
ENSRNOT00000012875
ENSRNOT00000086982 |
solute carrier family 6 member 6 |
|
| chr10_+_14136883 Show fit | 1.01 |
ENSRNOT00000082295
|
|
|
| chr1_+_100577056 Show fit | 0.94 |
ENSRNOT00000026992
|
napsin A aspartic peptidase |
Network of associatons between targets according to the STRING database.
First level regulatory network of Epas1_Bcl3
Gene Ontology Analysis
Gene overrepresentation in biological process category:
| Log-likelihood per target | Total log-likelihood | Term | Description |
|---|---|---|---|
| 0.4 | 1.3 | GO:1990926 | short-term synaptic potentiation(GO:1990926) |
| 0.1 | 1.2 | GO:0043129 | surfactant homeostasis(GO:0043129) |
| 0.0 | 1.0 | GO:0072348 | sulfur compound transport(GO:0072348) |
| 0.2 | 0.9 | GO:0021564 | vagus nerve development(GO:0021564) |
| 0.1 | 0.8 | GO:0061302 | smooth muscle cell-matrix adhesion(GO:0061302) |
| 0.2 | 0.6 | GO:0021834 | chemorepulsion involved in embryonic olfactory bulb interneuron precursor migration(GO:0021834) |
| 0.1 | 0.6 | GO:1900623 | regulation of mast cell cytokine production(GO:0032763) regulation of monocyte aggregation(GO:1900623) positive regulation of monocyte aggregation(GO:1900625) |
| 0.1 | 0.6 | GO:0098989 | receptor diffusion trapping(GO:0098953) postsynaptic neurotransmitter receptor diffusion trapping(GO:0098970) NMDA selective glutamate receptor signaling pathway(GO:0098989) neurotransmitter receptor diffusion trapping(GO:0099628) |
| 0.0 | 0.6 | GO:0035019 | somatic stem cell population maintenance(GO:0035019) |
| 0.2 | 0.5 | GO:0009644 | response to high light intensity(GO:0009644) cellular response to iron(III) ion(GO:0071283) |
Gene overrepresentation in cellular component category:
| Log-likelihood per target | Total log-likelihood | Term | Description |
|---|---|---|---|
| 0.1 | 1.3 | GO:0032009 | early phagosome(GO:0032009) |
| 0.1 | 0.9 | GO:0097208 | alveolar lamellar body(GO:0097208) |
| 0.0 | 0.9 | GO:0005614 | interstitial matrix(GO:0005614) |
| 0.1 | 0.7 | GO:0043202 | lysosomal lumen(GO:0043202) |
| 0.2 | 0.6 | GO:0099522 | region of cytosol(GO:0099522) postsynaptic cytosol(GO:0099524) |
| 0.0 | 0.6 | GO:0042629 | mast cell granule(GO:0042629) |
| 0.2 | 0.5 | GO:0098830 | presynaptic endosome(GO:0098830) presynaptic endocytic zone(GO:0098833) presynaptic endocytic zone membrane(GO:0098835) |
| 0.0 | 0.4 | GO:0035631 | CD40 receptor complex(GO:0035631) |
| 0.0 | 0.4 | GO:0044294 | dendritic growth cone(GO:0044294) |
| 0.1 | 0.3 | GO:0098574 | cytoplasmic side of lysosomal membrane(GO:0098574) |
Gene overrepresentation in molecular function category:
| Log-likelihood per target | Total log-likelihood | Term | Description |
|---|---|---|---|
| 0.1 | 1.3 | GO:0004190 | aspartic-type endopeptidase activity(GO:0004190) |
| 0.0 | 1.2 | GO:0001786 | phosphatidylserine binding(GO:0001786) |
| 0.3 | 1.0 | GO:0030977 | taurine binding(GO:0030977) |
| 0.1 | 0.8 | GO:0038062 | protein tyrosine kinase collagen receptor activity(GO:0038062) |
| 0.1 | 0.6 | GO:0048495 | Roundabout binding(GO:0048495) |
| 0.1 | 0.6 | GO:0035615 | clathrin adaptor activity(GO:0035615) endocytic adaptor activity(GO:0098748) |
| 0.1 | 0.6 | GO:0009931 | calcium-dependent protein serine/threonine kinase activity(GO:0009931) |
| 0.0 | 0.6 | GO:0035259 | glucocorticoid receptor binding(GO:0035259) |
| 0.1 | 0.5 | GO:0015193 | L-proline transmembrane transporter activity(GO:0015193) |
| 0.0 | 0.5 | GO:0001968 | fibronectin binding(GO:0001968) |
Gene overrepresentation in curated gene sets: canonical pathways category:
| Log-likelihood per target | Total log-likelihood | Term | Description |
|---|---|---|---|
| 0.0 | 1.0 | SIG PIP3 SIGNALING IN B LYMPHOCYTES | Genes related to PIP3 signaling in B lymphocytes |
| 0.0 | 0.8 | PID AVB3 OPN PATHWAY | Osteopontin-mediated events |
| 0.0 | 0.7 | PID AJDISS 2PATHWAY | Posttranslational regulation of adherens junction stability and dissassembly |
| 0.0 | 0.6 | ST WNT CA2 CYCLIC GMP PATHWAY | Wnt/Ca2+/cyclic GMP signaling. |
| 0.0 | 0.5 | SIG CHEMOTAXIS | Genes related to chemotaxis |
| 0.0 | 0.4 | SIG IL4RECEPTOR IN B LYPHOCYTES | Genes related to IL4 rceptor signaling in B lymphocytes |
| 0.0 | 0.4 | ST ERK1 ERK2 MAPK PATHWAY | ERK1/ERK2 MAPK Pathway |
| 0.0 | 0.2 | PID TCR JNK PATHWAY | JNK signaling in the CD4+ TCR pathway |
| 0.0 | 0.2 | PID HEDGEHOG 2PATHWAY | Signaling events mediated by the Hedgehog family |
Gene overrepresentation in curated gene sets: REACTOME pathways category:
| Log-likelihood per target | Total log-likelihood | Term | Description |
|---|---|---|---|
| 0.1 | 1.3 | REACTOME NA CL DEPENDENT NEUROTRANSMITTER TRANSPORTERS | Genes involved in Na+/Cl- dependent neurotransmitter transporters |
| 0.1 | 0.9 | REACTOME UNBLOCKING OF NMDA RECEPTOR GLUTAMATE BINDING AND ACTIVATION | Genes involved in Unblocking of NMDA receptor, glutamate binding and activation |
| 0.0 | 0.6 | REACTOME DEGRADATION OF THE EXTRACELLULAR MATRIX | Genes involved in Degradation of the extracellular matrix |
| 0.0 | 0.6 | REACTOME NETRIN1 SIGNALING | Genes involved in Netrin-1 signaling |
| 0.0 | 0.5 | REACTOME ACTIVATION OF RAC | Genes involved in Activation of Rac |
| 0.0 | 0.5 | REACTOME SIGNALING BY ROBO RECEPTOR | Genes involved in Signaling by Robo receptor |
| 0.0 | 0.4 | REACTOME TRAF3 DEPENDENT IRF ACTIVATION PATHWAY | Genes involved in TRAF3-dependent IRF activation pathway |
| 0.0 | 0.4 | REACTOME SIGNALING BY NODAL | Genes involved in Signaling by NODAL |
| 0.0 | 0.4 | REACTOME NEGATIVE REGULATORS OF RIG I MDA5 SIGNALING | Genes involved in Negative regulators of RIG-I/MDA5 signaling |
| 0.0 | 0.4 | REACTOME SPHINGOLIPID DE NOVO BIOSYNTHESIS | Genes involved in Sphingolipid de novo biosynthesis |