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GSE49485: Hypoxia transcriptome sequencing of rat brain.
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Results for Elf1_Elf2_Etv2_Elf4
Z-value: 1.96
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Transcription factors associated with Elf1_Elf2_Etv2_Elf4
Activity-expression correlation:
| Gene | Promoter | Pearson corr. coef. | P-value | Plot |
|---|---|---|---|---|
| Elf2 | rn6_v1_chr2_-_140387505_140387505 | -0.86 | 6.4e-02 | Click! |
| Elf1 | rn6_v1_chr15_+_61826711_61826711 | -0.58 | 3.1e-01 | Click! |
| Etv2 | rn6_v1_chr1_-_89094530_89094530 | -0.30 | 6.2e-01 | Click! |
| Elf4 | rn6_v1_chrX_-_135250519_135250519 | -0.30 | 6.3e-01 | Click! |
| Promoter | Log-likelihood | Transcript | Gene | Gene Info |
|---|---|---|---|---|
| chr5_-_147803851 Show fit | 1.25 |
ENSRNOT00000071922
|
eukaryotic translation initiation factor 3, subunit I |
|
| chr8_+_21663325 Show fit | 1.06 |
ENSRNOT00000027749
|
ubiquitin-like 5 |
|
| chr20_+_5441876 Show fit | 1.02 |
ENSRNOT00000092476
|
ribosomal protein S18 |
|
| chr20_-_14020007 Show fit | 1.00 |
ENSRNOT00000093521
|
gamma-glutamyltransferase 1 |
|
| chr10_-_10767389 Show fit | 0.98 |
ENSRNOT00000066754
|
small integral membrane protein 22 |
|
| chr2_-_189573280 Show fit | 0.93 |
ENSRNOT00000022897
|
ribosomal protein S27 |
|
| chr16_-_71057883 Show fit | 0.88 |
ENSRNOT00000020721
|
LSM1 homolog, mRNA degradation associated |
|
| chr11_-_24294179 Show fit | 0.85 |
ENSRNOT00000002116
|
ATP synthase, H+ transporting, mitochondrial Fo complex, subunit F6 |
|
| chr6_+_108796182 Show fit | 0.84 |
ENSRNOT00000006297
|
FCF1 rRNA-processing protein |
|
| chr7_-_73216251 Show fit | 0.83 |
ENSRNOT00000057587
|
ribosomal protein L30-like |
Network of associatons between targets according to the STRING database.
First level regulatory network of Elf1_Elf2_Etv2_Elf4
Gene Ontology Analysis
Gene overrepresentation in biological process category:
| Log-likelihood per target | Total log-likelihood | Term | Description |
|---|---|---|---|
| 0.0 | 9.5 | GO:0006412 | translation(GO:0006412) |
| 0.1 | 3.2 | GO:0000028 | ribosomal small subunit assembly(GO:0000028) |
| 0.1 | 2.5 | GO:0042255 | ribosome assembly(GO:0042255) |
| 0.1 | 2.0 | GO:0015986 | energy coupled proton transport, down electrochemical gradient(GO:0015985) ATP synthesis coupled proton transport(GO:0015986) |
| 0.0 | 2.0 | GO:0032543 | mitochondrial translation(GO:0032543) |
| 0.0 | 2.0 | GO:0050911 | detection of chemical stimulus involved in sensory perception of smell(GO:0050911) |
| 0.3 | 1.8 | GO:2000435 | regulation of protein neddylation(GO:2000434) negative regulation of protein neddylation(GO:2000435) |
| 0.1 | 1.4 | GO:0045116 | protein neddylation(GO:0045116) |
| 0.1 | 1.4 | GO:0099517 | anterograde synaptic vesicle transport(GO:0048490) synaptic vesicle cytoskeletal transport(GO:0099514) synaptic vesicle transport along microtubule(GO:0099517) |
| 0.2 | 1.1 | GO:0000480 | endonucleolytic cleavage in 5'-ETS of tricistronic rRNA transcript (SSU-rRNA, 5.8S rRNA, LSU-rRNA)(GO:0000480) |
Gene overrepresentation in cellular component category:
| Log-likelihood per target | Total log-likelihood | Term | Description |
|---|---|---|---|
| 0.1 | 9.7 | GO:0022627 | cytosolic small ribosomal subunit(GO:0022627) |
| 0.1 | 7.4 | GO:0022625 | cytosolic large ribosomal subunit(GO:0022625) |
| 0.1 | 3.8 | GO:0000315 | organellar large ribosomal subunit(GO:0000315) mitochondrial large ribosomal subunit(GO:0005762) |
| 0.0 | 2.6 | GO:0098800 | inner mitochondrial membrane protein complex(GO:0098800) |
| 0.1 | 2.2 | GO:0033116 | endoplasmic reticulum-Golgi intermediate compartment membrane(GO:0033116) |
| 0.1 | 1.8 | GO:0000276 | mitochondrial proton-transporting ATP synthase complex, coupling factor F(o)(GO:0000276) |
| 0.0 | 1.7 | GO:0001669 | acrosomal vesicle(GO:0001669) |
| 0.1 | 1.6 | GO:0030008 | TRAPP complex(GO:0030008) |
| 0.1 | 1.5 | GO:0005763 | organellar small ribosomal subunit(GO:0000314) mitochondrial small ribosomal subunit(GO:0005763) |
| 0.0 | 1.5 | GO:0031304 | intrinsic component of mitochondrial inner membrane(GO:0031304) integral component of mitochondrial inner membrane(GO:0031305) |
Gene overrepresentation in molecular function category:
| Log-likelihood per target | Total log-likelihood | Term | Description |
|---|---|---|---|
| 0.1 | 22.6 | GO:0003735 | structural constituent of ribosome(GO:0003735) |
| 0.1 | 3.1 | GO:0003743 | translation initiation factor activity(GO:0003743) |
| 0.1 | 2.0 | GO:0004129 | cytochrome-c oxidase activity(GO:0004129) heme-copper terminal oxidase activity(GO:0015002) oxidoreductase activity, acting on a heme group of donors, oxygen as acceptor(GO:0016676) |
| 0.0 | 2.0 | GO:0004984 | olfactory receptor activity(GO:0004984) |
| 0.2 | 1.8 | GO:1990948 | ligase inhibitor activity(GO:0055104) ubiquitin ligase inhibitor activity(GO:1990948) |
| 0.0 | 1.8 | GO:0003684 | damaged DNA binding(GO:0003684) |
| 0.1 | 1.5 | GO:0004298 | threonine-type endopeptidase activity(GO:0004298) threonine-type peptidase activity(GO:0070003) |
| 0.1 | 1.4 | GO:0003689 | DNA clamp loader activity(GO:0003689) protein-DNA loading ATPase activity(GO:0033170) |
| 0.1 | 1.4 | GO:0098641 | cadherin binding involved in cell-cell adhesion(GO:0098641) |
| 0.1 | 1.4 | GO:0050136 | NADH dehydrogenase (ubiquinone) activity(GO:0008137) NADH dehydrogenase (quinone) activity(GO:0050136) |
Gene overrepresentation in curated gene sets: canonical pathways category:
| Log-likelihood per target | Total log-likelihood | Term | Description |
|---|---|---|---|
| 0.0 | 1.7 | PID ATR PATHWAY | ATR signaling pathway |
| 0.0 | 1.6 | PID MYC ACTIV PATHWAY | Validated targets of C-MYC transcriptional activation |
| 0.0 | 1.2 | PID FOXM1 PATHWAY | FOXM1 transcription factor network |
| 0.0 | 1.2 | PID ERA GENOMIC PATHWAY | Validated nuclear estrogen receptor alpha network |
| 0.1 | 1.0 | PID ERB GENOMIC PATHWAY | Validated nuclear estrogen receptor beta network |
| 0.0 | 1.0 | PID IL12 STAT4 PATHWAY | IL12 signaling mediated by STAT4 |
| 0.0 | 1.0 | PID SYNDECAN 2 PATHWAY | Syndecan-2-mediated signaling events |
| 0.0 | 0.9 | PID PLK1 PATHWAY | PLK1 signaling events |
| 0.0 | 0.9 | PID ERBB1 DOWNSTREAM PATHWAY | ErbB1 downstream signaling |
| 0.0 | 0.8 | PID NFKAPPAB ATYPICAL PATHWAY | Atypical NF-kappaB pathway |
Gene overrepresentation in curated gene sets: REACTOME pathways category:
| Log-likelihood per target | Total log-likelihood | Term | Description |
|---|---|---|---|
| 0.2 | 9.1 | REACTOME FORMATION OF THE TERNARY COMPLEX AND SUBSEQUENTLY THE 43S COMPLEX | Genes involved in Formation of the ternary complex, and subsequently, the 43S complex |
| 0.1 | 5.5 | REACTOME PEPTIDE CHAIN ELONGATION | Genes involved in Peptide chain elongation |
| 0.1 | 4.3 | REACTOME RESPIRATORY ELECTRON TRANSPORT | Genes involved in Respiratory electron transport |
| 0.1 | 3.2 | REACTOME CDK MEDIATED PHOSPHORYLATION AND REMOVAL OF CDC6 | Genes involved in CDK-mediated phosphorylation and removal of Cdc6 |
| 0.1 | 2.1 | REACTOME FORMATION OF ATP BY CHEMIOSMOTIC COUPLING | Genes involved in Formation of ATP by chemiosmotic coupling |
| 0.0 | 1.9 | REACTOME MITOCHONDRIAL PROTEIN IMPORT | Genes involved in Mitochondrial Protein Import |
| 0.1 | 1.8 | REACTOME SRP DEPENDENT COTRANSLATIONAL PROTEIN TARGETING TO MEMBRANE | Genes involved in SRP-dependent cotranslational protein targeting to membrane |
| 0.1 | 1.6 | REACTOME REMOVAL OF THE FLAP INTERMEDIATE FROM THE C STRAND | Genes involved in Removal of the Flap Intermediate from the C-strand |
| 0.1 | 1.4 | REACTOME APC C CDH1 MEDIATED DEGRADATION OF CDC20 AND OTHER APC C CDH1 TARGETED PROTEINS IN LATE MITOSIS EARLY G1 | Genes involved in APC/C:Cdh1 mediated degradation of Cdc20 and other APC/C:Cdh1 targeted proteins in late mitosis/early G1 |
| 0.0 | 1.4 | REACTOME GLUTATHIONE CONJUGATION | Genes involved in Glutathione conjugation |