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GSE49485: Hypoxia transcriptome sequencing of rat brain.

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Results for Egr1

Z-value: 0.94

Motif logo

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Transcription factors associated with Egr1

Gene Symbol Gene ID Gene Info
Egr1
ENSRNOG00000019422 early growth response 1

Activity-expression correlation:

GenePromoterPearson corr. coef.P-valuePlot
Egr1rn6_v1_chr18_+_27657628_276576280.819.7e-02Click!

Activity profile of Egr1 motif

Sorted Z-values of Egr1 motif

Top targets:  

Promoter Log-likelihood Transcript Gene Gene Info
chr7_-_115910522 0.58 ENSRNOT00000076998
ENSRNOT00000067442
Arc
activity-regulated cytoskeleton-associated protein
chr6_+_135856218 0.53 ENSRNOT00000066715
RGD1560608
similar to novel protein
chr8_-_64572850 0.36 ENSRNOT00000015415
Senp8
SUMO/sentrin peptidase family member, NEDD8 specific
chr5_+_58393603 0.36 ENSRNOT00000080082
Dnajb5
DnaJ heat shock protein family (Hsp40) member B5
chr10_+_109107389 0.35 ENSRNOT00000068437
ENSRNOT00000005687
Baiap2
BAI1-associated protein 2
chr5_+_58393233 0.33 ENSRNOT00000000142
Dnajb5
DnaJ heat shock protein family (Hsp40) member B5
chr8_+_96551245 0.31 ENSRNOT00000039850
Bcl2a1
BCL2-related protein A1
chr3_+_170550314 0.31 ENSRNOT00000006991
Tfap2c
transcription factor AP-2 gamma
chrX_+_13117239 0.29 ENSRNOT00000088998
AABR07037112.1

chr7_+_142877086 0.28 ENSRNOT00000088730
Grasp
general receptor for phosphoinositides 1 associated scaffold protein
chr9_+_53906073 0.28 ENSRNOT00000017813
Nab1
Ngfi-A binding protein 1
chr1_+_101517714 0.26 ENSRNOT00000028423
Plekha4
pleckstrin homology domain containing A4
chr7_+_122456799 0.23 ENSRNOT00000025564
Mchr1
melanin-concentrating hormone receptor 1
chr8_-_128266639 0.23 ENSRNOT00000064555
ENSRNOT00000066932
Scn5a
sodium voltage-gated channel alpha subunit 5
chr8_-_40023193 0.23 ENSRNOT00000014404
Nrgn
neurogranin
chr2_+_113984824 0.22 ENSRNOT00000086399
Tnik
TRAF2 and NCK interacting kinase
chr9_-_104350308 0.21 ENSRNOT00000033958
Slco4c1
solute carrier organic anion transporter family, member 4C1
chr2_-_188645196 0.21 ENSRNOT00000083793
Efna3
ephrin A3
chr4_-_16130563 0.21 ENSRNOT00000090240
ENSRNOT00000034969
Cacna2d1
calcium voltage-gated channel auxiliary subunit alpha2delta 1
chr16_-_9709347 0.21 ENSRNOT00000083933
Mapk8
mitogen-activated protein kinase 8
chr4_+_25825567 0.20 ENSRNOT00000009417
Cdk14
cyclin-dependent kinase 14
chr2_+_113984646 0.20 ENSRNOT00000016799
Tnik
TRAF2 and NCK interacting kinase
chr20_+_4572100 0.20 ENSRNOT00000000476
Zbtb12
zinc finger and BTB domain containing 12
chr3_-_110492398 0.19 ENSRNOT00000056450
Ankrd63
ankyrin repeat domain 63
chrX_+_1321315 0.19 ENSRNOT00000014250
Syn1
synapsin I
chr10_-_88667345 0.19 ENSRNOT00000025518
Kcnh4
potassium voltage-gated channel subfamily H member 4
chr1_-_222590112 0.19 ENSRNOT00000028763
ENSRNOT00000091990
Mark2
microtubule affinity regulating kinase 2
chr7_-_84023316 0.18 ENSRNOT00000005556
Kcnv1
potassium voltage-gated channel modifier subfamily V member 1
chr5_-_36683356 0.18 ENSRNOT00000009043
Pou3f2
POU class 3 homeobox 2
chr8_-_120446455 0.18 ENSRNOT00000085161
ENSRNOT00000042854
ENSRNOT00000037199
Arpp21
cAMP regulated phosphoprotein 21
chr10_-_37645802 0.18 ENSRNOT00000008022
Tcf7
transcription factor 7 (T-cell specific, HMG-box)
chr9_+_54212767 0.17 ENSRNOT00000078073
ENSRNOT00000090026
Gls
glutaminase
chr11_+_86512797 0.17 ENSRNOT00000051680
Gp1bb
glycoprotein Ib platelet beta subunit
chr12_-_22680630 0.16 ENSRNOT00000041808
Vgf
VGF nerve growth factor inducible
chr7_+_12006710 0.16 ENSRNOT00000045421
Klf16
Kruppel-like factor 16
chr1_-_141349881 0.16 ENSRNOT00000021109
Rhcg
Rh family, C glycoprotein
chr4_-_16130848 0.16 ENSRNOT00000042914
Cacna2d1
calcium voltage-gated channel auxiliary subunit alpha2delta 1
chr16_-_6404578 0.16 ENSRNOT00000051371
Cacna1d
calcium voltage-gated channel subunit alpha1 D
chr2_-_186245771 0.16 ENSRNOT00000066004
ENSRNOT00000079954
Dclk2
doublecortin-like kinase 2
chrX_-_38196060 0.15 ENSRNOT00000006741
ENSRNOT00000006438
Sh3kbp1
SH3 domain-containing kinase-binding protein 1
chr7_-_140437467 0.14 ENSRNOT00000087181
Fkbp11
FK506 binding protein 11
chr10_+_85744568 0.14 ENSRNOT00000005522
Lasp1
LIM and SH3 protein 1
chr19_-_11341863 0.14 ENSRNOT00000025694
Mt4
metallothionein 4
chr11_+_69484293 0.14 ENSRNOT00000049292
Kalrn
kalirin, RhoGEF kinase
chr17_+_9653561 0.14 ENSRNOT00000018899
Pdlim7
PDZ and LIM domain 7
chr11_+_83868655 0.14 ENSRNOT00000072402
NEWGENE_621438
thrombopoietin
chr11_-_83546674 0.14 ENSRNOT00000044896
Ephb3
Eph receptor B3
chr16_-_6405117 0.14 ENSRNOT00000047737
Cacna1d
calcium voltage-gated channel subunit alpha1 D
chr2_-_186245342 0.14 ENSRNOT00000057062
ENSRNOT00000022292
Dclk2
doublecortin-like kinase 2
chr3_-_111560556 0.14 ENSRNOT00000030532
Ltk
leukocyte receptor tyrosine kinase
chr7_+_41115154 0.13 ENSRNOT00000066174
Atp2b1
ATPase plasma membrane Ca2+ transporting 1
chr6_+_10912383 0.13 ENSRNOT00000061747
ENSRNOT00000086247
Ttc7a
tetratricopeptide repeat domain 7A
chr10_-_13515448 0.13 ENSRNOT00000067660
Pdpk1
3-phosphoinositide dependent protein kinase-1
chr7_-_36499784 0.13 ENSRNOT00000011948
AC124896.1
suppressor of cytokine signaling 2
chr19_-_55490426 0.13 ENSRNOT00000081800
Cbfa2t3
CBFA2/RUNX1 translocation partner 3
chr8_-_97115027 0.13 ENSRNOT00000018685
Ankrd34c
ankyrin repeat domain 34C
chr1_-_78440738 0.13 ENSRNOT00000020855
Npas1
neuronal PAS domain protein 1
chr3_-_123376455 0.12 ENSRNOT00000028842
RGD1565616
RGD1565616
chr11_+_82466071 0.12 ENSRNOT00000036958
Igf2bp2
insulin-like growth factor 2 mRNA binding protein 2
chr16_-_6404957 0.12 ENSRNOT00000048459
Cacna1d
calcium voltage-gated channel subunit alpha1 D
chr7_-_121232741 0.12 ENSRNOT00000023196
Pdgfb
platelet derived growth factor subunit B
chr8_+_22050222 0.12 ENSRNOT00000028096
Icam5
intercellular adhesion molecule 5
chr1_+_220428481 0.11 ENSRNOT00000027335
LOC108348044
ras and Rab interactor 1
chrX_+_122808605 0.11 ENSRNOT00000017567
Zcchc12
zinc finger CCHC-type containing 12
chr1_-_101360971 0.11 ENSRNOT00000028164
Lin7b
lin-7 homolog B, crumbs cell polarity complex component
chr7_+_73588163 0.11 ENSRNOT00000015707
Kcns2
potassium voltage-gated channel, modifier subfamily S, member 2
chr9_+_71230108 0.11 ENSRNOT00000018326
Creb1
cAMP responsive element binding protein 1
chr17_+_9746485 0.11 ENSRNOT00000072298
Pfn3
profilin 3
chr1_-_103256823 0.11 ENSRNOT00000018860
Ptpn5
protein tyrosine phosphatase, non-receptor type 5
chr2_+_198721724 0.11 ENSRNOT00000043535
Ankrd34a
ankyrin repeat domain 34A
chr1_-_64350338 0.11 ENSRNOT00000078444
Cacng8
calcium voltage-gated channel auxiliary subunit gamma 8
chr6_-_29483460 0.11 ENSRNOT00000007160
Klhl29
kelch-like family member 29
chr2_-_34185682 0.11 ENSRNOT00000066925
ENSRNOT00000082755
Nln
neurolysin
chrX_-_15467875 0.11 ENSRNOT00000011207
Pim2
Pim-2 proto-oncogene, serine/threonine kinase
chr1_-_7064870 0.11 ENSRNOT00000019983
Stx11
syntaxin 11
chrX_+_39711201 0.11 ENSRNOT00000080512
ENSRNOT00000009802
Cnksr2
connector enhancer of kinase suppressor of Ras 2
chr18_-_31071371 0.11 ENSRNOT00000060432
Diaph1
diaphanous-related formin 1
chr16_+_71629525 0.11 ENSRNOT00000035347
ENSRNOT00000088462
Tacc1
transforming, acidic coiled-coil containing protein 1
chr10_+_55687050 0.11 ENSRNOT00000057136
Per1
period circadian clock 1
chr6_+_132246602 0.10 ENSRNOT00000009896
Cyp46a1
cytochrome P450, family 46, subfamily a, polypeptide 1
chr7_-_59514939 0.10 ENSRNOT00000085579
Kcnmb4
potassium calcium-activated channel subfamily M regulatory beta subunit 4
chrX_-_30831483 0.10 ENSRNOT00000004443
Glra2
glycine receptor, alpha 2
chr1_-_80544825 0.10 ENSRNOT00000057802
ENSRNOT00000040060
ENSRNOT00000067049
ENSRNOT00000052387
ENSRNOT00000073352
Relb
RELB proto-oncogene, NF-kB subunit
chr11_+_61661724 0.10 ENSRNOT00000079423
Zdhhc23
zinc finger, DHHC-type containing 23
chr8_+_22189600 0.10 ENSRNOT00000061100
Pde4a
phosphodiesterase 4A
chrX_+_120859968 0.10 ENSRNOT00000085185
Wdr44
WD repeat domain 44
chr2_+_34186091 0.10 ENSRNOT00000016129
Sgtb
small glutamine rich tetratricopeptide repeat containing beta
chr10_-_85517683 0.10 ENSRNOT00000016070
Srcin1
SRC kinase signaling inhibitor 1
chr4_-_90882285 0.10 ENSRNOT00000039247
Snca
synuclein alpha
chr10_+_56627411 0.10 ENSRNOT00000089108
ENSRNOT00000068493
Dlg4
discs large MAGUK scaffold protein 4
chr4_+_117215064 0.10 ENSRNOT00000020909
Smyd5
SMYD family member 5
chr12_+_22665112 0.09 ENSRNOT00000001918
Ap1s1
adaptor-related protein complex 1, sigma 1 subunit
chr7_+_140464999 0.09 ENSRNOT00000090156
Wnt1
wingless-type MMTV integration site family, member 1
chr20_+_4576057 0.09 ENSRNOT00000081456
ENSRNOT00000085701
Ehmt2
euchromatic histone lysine methyltransferase 2
chr17_+_82065937 0.09 ENSRNOT00000051349
Arl5b
ADP-ribosylation factor like GTPase 5B
chr1_-_174495258 0.09 ENSRNOT00000052377
ENSRNOT00000086349
Scube2
signal peptide, CUB domain and EGF like domain containing 2
chr7_+_120125633 0.09 ENSRNOT00000012480
Sh3bp1
SH3-domain binding protein 1
chr3_+_2396143 0.09 ENSRNOT00000012388
Nrarp
Notch-regulated ankyrin repeat protein
chr20_-_4879779 0.09 ENSRNOT00000081924
Hspa1b
heat shock protein family A (Hsp70) member 1B
chr7_-_105592804 0.09 ENSRNOT00000006789
Adcy8
adenylate cyclase 8
chr3_-_163935617 0.09 ENSRNOT00000074023
Kcnb1
potassium voltage-gated channel subfamily B member 1
chr1_+_220335254 0.09 ENSRNOT00000072261
Rin1
Ras and Rab interactor 1
chr5_+_148051126 0.09 ENSRNOT00000074415
Ptp4a2
protein tyrosine phosphatase type IVA, member 2
chr20_-_2701637 0.09 ENSRNOT00000049667
Hspa1a
heat shock protein family A (Hsp70) member 1A
chr11_+_61662270 0.09 ENSRNOT00000079521
Zdhhc23
zinc finger, DHHC-type containing 23
chr7_-_14302552 0.09 ENSRNOT00000091368
Brd4
bromodomain containing 4
chr1_+_82480195 0.09 ENSRNOT00000028051
Tgfb1
transforming growth factor, beta 1
chr6_+_27975849 0.09 ENSRNOT00000060810
Dtnb
dystrobrevin, beta
chr10_-_103736973 0.09 ENSRNOT00000004372
Nat9
N-acetyltransferase 9
chr9_-_119818310 0.08 ENSRNOT00000019359
Smchd1
structural maintenance of chromosomes flexible hinge domain containing 1
chr20_-_2701815 0.08 ENSRNOT00000061950
Hspa1a
heat shock protein family A (Hsp70) member 1A
chr14_+_84417320 0.08 ENSRNOT00000008788
Tbc1d10a
TBC1 domain family, member 10a
chr8_+_128577345 0.08 ENSRNOT00000082356
Wdr48
WD repeat domain 48
chr15_-_61772516 0.08 ENSRNOT00000015605
ENSRNOT00000093399
Wbp4
WW domain binding protein 4
chr1_+_165237847 0.08 ENSRNOT00000022963
Pgm2l1
phosphoglucomutase 2-like 1
chr1_-_82120902 0.08 ENSRNOT00000027684
Erf
Ets2 repressor factor
chr3_-_92290919 0.08 ENSRNOT00000007077
Fjx1
four jointed box 1
chr8_+_53295222 0.08 ENSRNOT00000009724
ENSRNOT00000067420
Usp28
ubiquitin specific peptidase 28
chr6_+_27975417 0.08 ENSRNOT00000077830
Dtnb
dystrobrevin, beta
chr5_-_136112344 0.08 ENSRNOT00000050195
RGD1563714
RGD1563714
chr1_+_91363492 0.08 ENSRNOT00000014517
Cebpa
CCAAT/enhancer binding protein alpha
chr16_+_47717951 0.08 ENSRNOT00000018689
Ing2
inhibitor of growth family, member 2
chr7_-_70969905 0.08 ENSRNOT00000057745
Nab2
Ngfi-A binding protein 2
chr9_+_112293388 0.08 ENSRNOT00000020767
Man2a1
mannosidase, alpha, class 2A, member 1
chr8_-_55408464 0.08 ENSRNOT00000066893
Sik2
salt-inducible kinase 2
chr12_+_16084266 0.08 ENSRNOT00000079866
ENSRNOT00000080774
Ttyh3
tweety family member 3
chr11_-_86890390 0.08 ENSRNOT00000046183
Trmt2a
tRNA methyltransferase 2 homolog A
chr1_+_144070754 0.08 ENSRNOT00000079989
Sh3gl3
SH3 domain-containing GRB2-like 3
chr12_+_22727335 0.08 ENSRNOT00000077293
Znhit1
zinc finger, HIT-type containing 1
chr7_-_75422268 0.08 ENSRNOT00000080218
Pabpc1
poly(A) binding protein, cytoplasmic 1
chr14_+_15059387 0.08 ENSRNOT00000002843
Cnot6l
CCR4-NOT transcription complex, subunit 6-like
chr9_+_47386626 0.08 ENSRNOT00000021270
Slc9a2
solute carrier family 9 member A2
chr10_+_67762995 0.07 ENSRNOT00000000253
Zfp207
zinc finger protein 207
chr8_+_118206698 0.07 ENSRNOT00000082607
ENSRNOT00000064140
Smarcc1
SWI/SNF related, matrix associated, actin dependent regulator of chromatin, subfamily c, member 1
chr7_-_14303055 0.07 ENSRNOT00000008963
Brd4
bromodomain containing 4
chr9_+_65763437 0.07 ENSRNOT00000043558
Stradb
STE20-related kinase adaptor beta
chr8_+_117126692 0.07 ENSRNOT00000083046
ENSRNOT00000085609
Usp4
ubiquitin specific peptidase 4
chr3_+_108795235 0.07 ENSRNOT00000007028
Spred1
sprouty-related, EVH1 domain containing 1
chrX_+_120860178 0.07 ENSRNOT00000088661
Wdr44
WD repeat domain 44
chr10_+_93520132 0.07 ENSRNOT00000055137
Mrc2
mannose receptor, C type 2
chr4_-_153028129 0.07 ENSRNOT00000074558
Cecr6
cat eye syndrome chromosome region, candidate 6
chr9_-_44456554 0.07 ENSRNOT00000080011
Tsga10
testis specific 10
chr10_-_65766050 0.07 ENSRNOT00000013639
Sarm1
sterile alpha and TIR motif containing 1
chr13_+_85110098 0.07 ENSRNOT00000087368
Fam78b
family with sequence similarity 78, member B
chr1_-_165967069 0.07 ENSRNOT00000089359
Arhgef17
Rho guanine nucleotide exchange factor (GEF) 17
chr9_+_81783349 0.06 ENSRNOT00000021548
Cnot9
CCR4-NOT transcription complex subunit 9
chr18_+_70733872 0.06 ENSRNOT00000067018
Acaa2
acetyl-CoA acyltransferase 2
chr20_-_3299420 0.06 ENSRNOT00000090999
Gnl1
G protein nucleolar 1
chr1_+_190964885 0.06 ENSRNOT00000039186
Mettl9
methyltransferase like 9
chr8_+_44990014 0.06 ENSRNOT00000044608
Hspa8
heat shock protein family A (Hsp70) member 8
chr12_+_22726643 0.06 ENSRNOT00000040015
Znhit1
zinc finger, HIT-type containing 1
chr1_+_64031859 0.06 ENSRNOT00000090873
Mboat7l1
membrane bound O-acyltransferase domain containing 7-like 1
chr11_+_86890585 0.06 ENSRNOT00000002579
Ranbp1
RAN binding protein 1
chr20_-_35449280 0.06 ENSRNOT00000057422
Man1a1
mannosidase, alpha, class 1A, member 1
chr1_+_246954980 0.06 ENSRNOT00000020272
Slc1a1
solute carrier family 1 member 1
chr11_-_61499557 0.06 ENSRNOT00000046208
Usf3
upstream transcription factor family member 3
chr1_+_264670841 0.06 ENSRNOT00000034814
ENSRNOT00000082412
Slf2
SMC5-SMC6 complex localization factor 2
chr3_+_82081906 0.06 ENSRNOT00000057001
Tp53i11
tumor protein p53 inducible protein 11
chr7_-_117300662 0.06 ENSRNOT00000006376
Parp10
poly (ADP-ribose) polymerase family, member 10
chr4_+_122282279 0.06 ENSRNOT00000038244
Zxdc
ZXD family zinc finger C
chr1_-_72727112 0.06 ENSRNOT00000031172
Brsk1
BR serine/threonine kinase 1
chr1_-_199159125 0.06 ENSRNOT00000025618
Bcl7c
BCL tumor suppressor 7C
chr9_-_65763273 0.06 ENSRNOT00000015034
Trak2
trafficking kinesin protein 2
chr12_-_46920952 0.06 ENSRNOT00000001532
Msi1
musashi RNA-binding protein 1
chr10_+_55675575 0.06 ENSRNOT00000057295
Vamp2
vesicle-associated membrane protein 2
chr8_+_64573358 0.06 ENSRNOT00000083558
Myo9a
myosin IXA
chr6_-_98566523 0.06 ENSRNOT00000077715
Ppp2r5e
protein phosphatase 2 regulatory subunit B', epsilon
chr1_-_94494980 0.06 ENSRNOT00000020014
Ccne1
cyclin E1
chr18_+_29110242 0.06 ENSRNOT00000025756
Pura
purine rich element binding protein A
chr8_-_48762342 0.05 ENSRNOT00000049125
Foxr1
forkhead box R1
chr12_+_22153983 0.05 ENSRNOT00000080775
ENSRNOT00000001894
Pcolce
procollagen C-endopeptidase enhancer
chr3_+_14299479 0.05 ENSRNOT00000092745
Cntrl
centriolin
chr6_+_109466060 0.05 ENSRNOT00000011339
Jdp2
Jun dimerization protein 2
chr7_+_130474279 0.05 ENSRNOT00000092388
Shank3
SH3 and multiple ankyrin repeat domains 3
chr3_-_171134655 0.05 ENSRNOT00000028960
RGD1561252
similar to Ubiquitin carboxyl-terminal hydrolase isozyme L3 (Ubiquitin thiolesterase L3)
chr3_-_15433252 0.05 ENSRNOT00000008817
Lhx6
LIM homeobox 6
chr4_-_28953067 0.05 ENSRNOT00000013989
Tfpi2
tissue factor pathway inhibitor 2
chrX_+_157150655 0.05 ENSRNOT00000090795
Pnck
pregnancy up-regulated nonubiquitous CaM kinase
chr11_-_17340373 0.05 ENSRNOT00000089762
AABR07033324.1

chr6_+_42568220 0.05 ENSRNOT00000074829
Pdia6
protein disulfide isomerase family A, member 6
chrX_-_156379189 0.05 ENSRNOT00000083148
Plxna3
plexin A3
chr5_+_57028467 0.05 ENSRNOT00000010061
Dnaja1
DnaJ heat shock protein family (Hsp40) member A1
chr2_+_209433103 0.05 ENSRNOT00000024036
Lrif1
ligand dependent nuclear receptor interacting factor 1
chr13_+_51384389 0.04 ENSRNOT00000087025
Kdm5b
lysine demethylase 5B
chr8_+_128577080 0.04 ENSRNOT00000024172
Wdr48
WD repeat domain 48
chr1_+_116587815 0.04 ENSRNOT00000021366
Ube3a
ubiquitin protein ligase E3A
chr8_-_48564722 0.04 ENSRNOT00000067902
Cbl
Cbl proto-oncogene
chr20_-_3299580 0.04 ENSRNOT00000050373
Gnl1
G protein nucleolar 1
chr17_+_45467015 0.04 ENSRNOT00000081408
Gpx5
glutathione peroxidase 5
chr5_-_99033107 0.04 ENSRNOT00000041306
Hspa8
heat shock protein family A (Hsp70) member 8
chr3_-_2534663 0.04 ENSRNOT00000049297
ENSRNOT00000044246
Grin1
glutamate ionotropic receptor NMDA type subunit 1
chr11_-_71108184 0.04 ENSRNOT00000051989
ENSRNOT00000073865
ENSRNOT00000063883
Lrch3
leucine rich repeats and calponin homology domain containing 3
chr10_-_56531483 0.04 ENSRNOT00000022343
Eif5a
eukaryotic translation initiation factor 5A
chr3_+_177188044 0.04 ENSRNOT00000022073
Tcea2
transcription elongation factor A2
chr14_+_83226601 0.04 ENSRNOT00000072368
Prr14l
proline rich 14-like
chr13_-_96238474 0.04 ENSRNOT00000044477
ENSRNOT00000078061
Hnrnpu
heterogeneous nuclear ribonucleoprotein U
chr12_-_22726982 0.04 ENSRNOT00000001921
Plod3
procollagen-lysine, 2-oxoglutarate 5-dioxygenase 3
chr7_+_12144162 0.04 ENSRNOT00000077122
Tcf3
transcription factor 3
chr10_-_47857326 0.04 ENSRNOT00000085703
ENSRNOT00000091963
Epn2
epsin 2
chr5_-_122746839 0.04 ENSRNOT00000032126
Slc35d1
solute carrier family 35 member D1

Network of associatons between targets according to the STRING database.

First level regulatory network of Egr1

PNG image of the network

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Gene Ontology Analysis

Gene overrepresentation in biological process category:

Log-likelihood per target  Total log-likelihood Term Description
0.1 0.6 GO:0086048 membrane depolarization during bundle of His cell action potential(GO:0086048)
0.1 0.3 GO:1902380 positive regulation of mRNA cleavage(GO:0031439) positive regulation of endoribonuclease activity(GO:1902380) positive regulation of mRNA endonucleolytic cleavage involved in unfolded protein response(GO:1904722)
0.1 0.6 GO:2000969 positive regulation of alpha-amino-3-hydroxy-5-methyl-4-isoxazole propionate selective glutamate receptor activity(GO:2000969)
0.1 0.2 GO:1902595 regulation of DNA replication origin binding(GO:1902595)
0.1 0.4 GO:0086046 membrane depolarization during SA node cell action potential(GO:0086046)
0.1 0.4 GO:1905232 cellular response to L-glutamate(GO:1905232)
0.1 0.2 GO:0048619 embryonic hindgut morphogenesis(GO:0048619)
0.1 0.2 GO:0006543 glutamine catabolic process(GO:0006543)
0.1 0.1 GO:2001025 positive regulation of response to drug(GO:2001025)
0.1 0.2 GO:0070634 transepithelial ammonium transport(GO:0070634)
0.1 0.2 GO:0036166 phenotypic switching(GO:0036166)
0.1 0.3 GO:0030718 germ-line stem cell population maintenance(GO:0030718)
0.0 0.1 GO:2000295 regulation of hydrogen peroxide catabolic process(GO:2000295)
0.0 0.1 GO:0038163 thrombopoietin-mediated signaling pathway(GO:0038163)
0.0 0.4 GO:0007256 activation of JNKK activity(GO:0007256)
0.0 0.1 GO:0032916 positive regulation of transforming growth factor beta3 production(GO:0032916)
0.0 0.4 GO:0016926 protein desumoylation(GO:0016926)
0.0 0.1 GO:1902809 regulation of skeletal muscle fiber differentiation(GO:1902809)
0.0 0.2 GO:2000327 positive regulation of ligand-dependent nuclear receptor transcription coactivator activity(GO:2000327)
0.0 0.1 GO:0043316 cytotoxic T cell degranulation(GO:0043316)
0.0 0.1 GO:0097213 protein targeting to lysosome involved in chaperone-mediated autophagy(GO:0061740) regulation of lysosomal membrane permeability(GO:0097213) positive regulation of lysosomal membrane permeability(GO:0097214)
0.0 0.2 GO:0099633 protein localization to postsynaptic specialization membrane(GO:0099633) neurotransmitter receptor localization to postsynaptic specialization membrane(GO:0099645)
0.0 0.1 GO:0060061 Spemann organizer formation(GO:0060061) positive regulation of dermatome development(GO:0061184) canonical Wnt signaling pathway involved in midbrain dopaminergic neuron differentiation(GO:1904954)
0.0 0.1 GO:1900126 negative regulation of hyaluronan biosynthetic process(GO:1900126)
0.0 0.1 GO:0060821 inactivation of X chromosome by DNA methylation(GO:0060821)
0.0 0.2 GO:0000160 phosphorelay signal transduction system(GO:0000160)
0.0 0.1 GO:0016480 negative regulation of transcription from RNA polymerase III promoter(GO:0016480)
0.0 0.1 GO:0097167 circadian regulation of translation(GO:0097167)
0.0 0.2 GO:0021979 forebrain ventricular zone progenitor cell division(GO:0021869) hypothalamus cell differentiation(GO:0021979)
0.0 0.1 GO:1902525 regulation of protein monoubiquitination(GO:1902525)
0.0 0.1 GO:1902732 positive regulation of chondrocyte proliferation(GO:1902732)
0.0 0.1 GO:0071386 cellular response to corticosterone stimulus(GO:0071386)
0.0 0.1 GO:0046604 positive regulation of mitotic centrosome separation(GO:0046604)
0.0 0.1 GO:1990166 protein localization to site of double-strand break(GO:1990166)
0.0 0.1 GO:0070212 regulation of chromatin assembly(GO:0010847) protein poly-ADP-ribosylation(GO:0070212)
0.0 0.2 GO:0044154 histone H3-K14 acetylation(GO:0044154)
0.0 0.3 GO:0021860 pyramidal neuron development(GO:0021860)
0.0 0.1 GO:0098939 dendritic transport of mitochondrion(GO:0098939) anterograde dendritic transport of mitochondrion(GO:0098972)
0.0 0.1 GO:1903361 protein localization to basolateral plasma membrane(GO:1903361)
0.0 0.1 GO:2000622 regulation of nuclear-transcribed mRNA catabolic process, nonsense-mediated decay(GO:2000622) negative regulation of nuclear-transcribed mRNA catabolic process, nonsense-mediated decay(GO:2000623)
0.0 0.1 GO:1902109 negative regulation of mitochondrial membrane permeability involved in apoptotic process(GO:1902109)
0.0 0.1 GO:0042078 germ-line stem cell division(GO:0042078) male germ-line stem cell asymmetric division(GO:0048133) germline stem cell asymmetric division(GO:0098728)
0.0 0.0 GO:0042769 DNA damage response, detection of DNA damage(GO:0042769)
0.0 0.1 GO:0010701 positive regulation of norepinephrine secretion(GO:0010701)
0.0 0.1 GO:1903715 regulation of aerobic respiration(GO:1903715)
0.0 0.0 GO:1900673 olefin metabolic process(GO:1900673)
0.0 0.1 GO:0070317 negative regulation of G0 to G1 transition(GO:0070317)
0.0 0.0 GO:0046947 hydroxylysine metabolic process(GO:0046946) hydroxylysine biosynthetic process(GO:0046947)
0.0 0.0 GO:0090481 pyrimidine nucleotide-sugar transmembrane transport(GO:0090481)
0.0 0.0 GO:0090370 negative regulation of cholesterol efflux(GO:0090370)
0.0 0.2 GO:0097091 synaptic vesicle clustering(GO:0097091)
0.0 0.1 GO:0016191 synaptic vesicle uncoating(GO:0016191)
0.0 0.2 GO:1900273 positive regulation of long-term synaptic potentiation(GO:1900273)
0.0 0.1 GO:0070779 D-aspartate transport(GO:0070777) D-aspartate import(GO:0070779)
0.0 0.0 GO:0032304 negative regulation of icosanoid secretion(GO:0032304)
0.0 0.1 GO:1990416 cellular response to brain-derived neurotrophic factor stimulus(GO:1990416)
0.0 0.0 GO:2000861 estrogen secretion(GO:0035937) estradiol secretion(GO:0035938) regulation of estrogen secretion(GO:2000861) regulation of estradiol secretion(GO:2000864)
0.0 0.1 GO:0071420 cellular response to histamine(GO:0071420)
0.0 0.0 GO:0030576 Cajal body organization(GO:0030576)
0.0 0.2 GO:0010663 positive regulation of striated muscle cell apoptotic process(GO:0010663) positive regulation of cardiac muscle cell apoptotic process(GO:0010666)
0.0 0.1 GO:0071294 cellular response to zinc ion(GO:0071294)
0.0 0.1 GO:0010668 ectodermal cell differentiation(GO:0010668)

Gene overrepresentation in cellular component category:

Log-likelihood per target  Total log-likelihood Term Description
0.1 0.8 GO:1990454 L-type voltage-gated calcium channel complex(GO:1990454)
0.0 0.2 GO:0097427 microtubule bundle(GO:0097427)
0.0 0.1 GO:1990589 ATF4-CREB1 transcription factor complex(GO:1990589)
0.0 0.1 GO:1990836 lysosomal matrix(GO:1990836)
0.0 0.1 GO:0036488 CHOP-C/EBP complex(GO:0036488)
0.0 0.1 GO:0031092 platelet alpha granule membrane(GO:0031092)
0.0 0.2 GO:0008024 cyclin/CDK positive transcription elongation factor complex(GO:0008024)
0.0 0.2 GO:0012510 trans-Golgi network transport vesicle membrane(GO:0012510)
0.0 0.1 GO:0031315 extrinsic component of mitochondrial outer membrane(GO:0031315)
0.0 0.1 GO:0030015 CCR4-NOT core complex(GO:0030015)
0.0 0.0 GO:0032937 SREBP-SCAP-Insig complex(GO:0032937)
0.0 0.1 GO:0033256 I-kappaB/NF-kappaB complex(GO:0033256)
0.0 0.1 GO:0001740 Barr body(GO:0001740)
0.0 0.1 GO:0000812 Swr1 complex(GO:0000812)
0.0 0.2 GO:0001518 voltage-gated sodium channel complex(GO:0001518)
0.0 0.1 GO:0098839 postsynaptic density membrane(GO:0098839)
0.0 0.1 GO:0016602 CCAAT-binding factor complex(GO:0016602)
0.0 0.1 GO:0070032 synaptobrevin 2-SNAP-25-syntaxin-1a-complexin I complex(GO:0070032)
0.0 0.1 GO:0032591 dendritic spine membrane(GO:0032591)

Gene overrepresentation in molecular function category:

Log-likelihood per target  Total log-likelihood Term Description
0.1 0.4 GO:0086057 voltage-gated calcium channel activity involved in bundle of His cell action potential(GO:0086057)
0.1 0.3 GO:0031249 denatured protein binding(GO:0031249)
0.1 0.4 GO:0008093 cytoskeletal adaptor activity(GO:0008093)
0.1 0.4 GO:0086059 voltage-gated calcium channel activity involved SA node cell action potential(GO:0086059)
0.1 0.2 GO:0004359 glutaminase activity(GO:0004359)
0.1 0.2 GO:0034211 GTP-dependent protein kinase activity(GO:0034211)
0.0 0.2 GO:0086062 voltage-gated sodium channel activity involved in Purkinje myocyte action potential(GO:0086062)
0.0 0.1 GO:1990763 arrestin family protein binding(GO:1990763)
0.0 0.4 GO:0016929 SUMO-specific protease activity(GO:0016929)
0.0 0.1 GO:0070012 oligopeptidase activity(GO:0070012)
0.0 0.1 GO:0022852 glycine-gated chloride ion channel activity(GO:0022852)
0.0 0.2 GO:0055131 C3HC4-type RING finger domain binding(GO:0055131)
0.0 0.2 GO:0000155 phosphorelay sensor kinase activity(GO:0000155)
0.0 0.3 GO:0030306 ADP-ribosylation factor binding(GO:0030306)
0.0 0.2 GO:0035033 histone deacetylase regulator activity(GO:0035033)
0.0 0.1 GO:0097108 hedgehog family protein binding(GO:0097108)
0.0 0.3 GO:0051400 BH domain binding(GO:0051400)
0.0 0.2 GO:0050321 tau-protein kinase activity(GO:0050321)
0.0 0.1 GO:0032422 purine-rich negative regulatory element binding(GO:0032422)
0.0 0.1 GO:0034714 type III transforming growth factor beta receptor binding(GO:0034714)
0.0 0.2 GO:0016500 protein-hormone receptor activity(GO:0016500)
0.0 0.1 GO:0031697 beta-1 adrenergic receptor binding(GO:0031697)
0.0 0.2 GO:0015924 mannosyl-oligosaccharide mannosidase activity(GO:0015924)
0.0 0.2 GO:0070300 phosphatidic acid binding(GO:0070300)
0.0 0.1 GO:0008294 calcium- and calmodulin-responsive adenylate cyclase activity(GO:0008294)
0.0 0.1 GO:0031685 adenosine receptor binding(GO:0031685)
0.0 0.1 GO:0004859 phospholipase inhibitor activity(GO:0004859)
0.0 0.0 GO:0033823 procollagen-lysine 5-dioxygenase activity(GO:0008475) procollagen glucosyltransferase activity(GO:0033823)
0.0 0.1 GO:0046976 histone methyltransferase activity (H3-K27 specific)(GO:0046976)
0.0 0.1 GO:0016176 superoxide-generating NADPH oxidase activator activity(GO:0016176)
0.0 0.1 GO:0016004 phospholipase activator activity(GO:0016004)
0.0 0.1 GO:0030160 GKAP/Homer scaffold activity(GO:0030160)
0.0 0.1 GO:0005173 stem cell factor receptor binding(GO:0005173)
0.0 0.0 GO:0070644 vitamin D response element binding(GO:0070644)

Gene overrepresentation in curated gene sets: canonical pathways category:

Log-likelihood per target  Total log-likelihood Term Description
0.0 0.2 PID TCR JNK PATHWAY JNK signaling in the CD4+ TCR pathway

Gene overrepresentation in curated gene sets: REACTOME pathways category:

Log-likelihood per target  Total log-likelihood Term Description
0.0 0.2 REACTOME TRANSPORT OF ORGANIC ANIONS Genes involved in Transport of organic anions
0.0 0.2 REACTOME GLUTAMATE NEUROTRANSMITTER RELEASE CYCLE Genes involved in Glutamate Neurotransmitter Release Cycle
0.0 0.2 REACTOME DOPAMINE NEUROTRANSMITTER RELEASE CYCLE Genes involved in Dopamine Neurotransmitter Release Cycle
0.0 0.1 REACTOME CROSS PRESENTATION OF SOLUBLE EXOGENOUS ANTIGENS ENDOSOMES Genes involved in Cross-presentation of soluble exogenous antigens (endosomes)
0.0 0.2 REACTOME ACTIVATION OF THE AP1 FAMILY OF TRANSCRIPTION FACTORS Genes involved in Activation of the AP-1 family of transcription factors
0.0 0.1 REACTOME NEF MEDIATED DOWNREGULATION OF MHC CLASS I COMPLEX CELL SURFACE EXPRESSION Genes involved in Nef mediated downregulation of MHC class I complex cell surface expression
0.0 0.2 REACTOME PLATELET ADHESION TO EXPOSED COLLAGEN Genes involved in Platelet Adhesion to exposed collagen