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GSE49485: Hypoxia transcriptome sequencing of rat brain.

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Results for E2f4

Z-value: 0.29

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Transcription factors associated with E2f4

Gene Symbol Gene ID Gene Info
ENSRNOG00000015708 E2F transcription factor 4

Activity-expression correlation:

GenePromoterPearson corr. coef.P-valuePlot
E2f4rn6_v1_chr19_+_37252843_37252843-0.982.4e-03Click!

Activity profile of E2f4 motif

Sorted Z-values of E2f4 motif

Promoter Log-likelihood Transcript Gene Gene Info
chr7_-_28715224 0.22 ENSRNOT00000065899
PARP1 binding protein
chr15_-_61564695 0.14 ENSRNOT00000068216
regulator of cell cycle
chr9_-_82146874 0.11 ENSRNOT00000024190
FEV, ETS transcription factor
chr13_+_75059927 0.09 ENSRNOT00000080801
hypothetical protein LOC680254
chr2_-_187915596 0.09 ENSRNOT00000093008
late endosomal/lysosomal adaptor, MAPK and MTOR activator 2
chr2_+_187447501 0.08 ENSRNOT00000038589
IQ motif containing GTPase activating protein 3
chr20_+_4967194 0.08 ENSRNOT00000070846
LSM2 homolog, U6 small nuclear RNA and mRNA degradation associated
chr10_+_55626741 0.08 ENSRNOT00000008492
aurora kinase B
chr5_-_152198813 0.08 ENSRNOT00000082953
high mobility group nucleosomal binding domain 2
chr11_+_87435185 0.08 ENSRNOT00000002558
purinergic receptor P2X 6
chr5_-_57267002 0.08 ENSRNOT00000011455
Bcl2 associated athanogene 1
chr19_-_55967836 0.07 ENSRNOT00000051452
sulfotransferase family 5A, member 1
chr10_-_15098791 0.07 ENSRNOT00000026139
chromosome transmission fidelity factor 18
chr20_-_7930929 0.07 ENSRNOT00000000607
TEA domain transcription factor 3
chr5_+_103024376 0.07 ENSRNOT00000058536

chr1_+_31967978 0.07 ENSRNOT00000081471
ENSRNOT00000021532
thyroid hormone receptor interactor 13
chr16_+_41079444 0.07 ENSRNOT00000015623
nei-like DNA glycosylase 3
chr5_+_162351001 0.07 ENSRNOT00000065471
hypothetical protein LOC691162
chr12_+_943006 0.06 ENSRNOT00000001449
Klotho
chr8_-_12993651 0.06 ENSRNOT00000033932
lysine demethylase 4D
chr9_+_16139101 0.06 ENSRNOT00000070803
uncharacterized LOC100910668
chr6_+_10594122 0.06 ENSRNOT00000020534
CXXC repeat containing interactor of PDZ3 domain
chr13_+_110743098 0.06 ENSRNOT00000075086
retinal degeneration 3
chr9_+_9842585 0.05 ENSRNOT00000070806
Cd70 molecule
chr10_+_55627025 0.05 ENSRNOT00000091016
aurora kinase B
chr14_-_110883784 0.05 ENSRNOT00000086299
ENSRNOT00000068190
vaccinia related kinase 2
chr1_-_89488223 0.05 ENSRNOT00000028624
FXYD domain-containing ion transport regulator 1
chr11_-_36479868 0.05 ENSRNOT00000075762
non-histone chromosomal protein HMG-14-like
chr7_+_120901934 0.05 ENSRNOT00000019323
translocase of outer mitochondrial membrane 22
chr6_+_34155017 0.05 ENSRNOT00000073663
tetratricopeptide repeat domain 32
chr20_-_3439983 0.04 ENSRNOT00000080822
ENSRNOT00000001099
immediate early response 3
chr8_-_52814188 0.04 ENSRNOT00000087265
ENSRNOT00000047633
RNA exonuclease 2
chr6_-_7421456 0.04 ENSRNOT00000006725
zinc finger protein 36, C3H type-like 2
chr3_+_159421671 0.04 ENSRNOT00000010343
myeloblastosis oncogene-like 2
chr4_+_7258176 0.04 ENSRNOT00000061992
transmembrane and ubiquitin-like domain containing 1
chr10_+_39726507 0.04 ENSRNOT00000036822
meiotic kinetochore factor
chr8_+_48665652 0.04 ENSRNOT00000059715
H2A histone family, member X
chr20_-_6500523 0.04 ENSRNOT00000000629
copine 5
chr2_+_264704769 0.04 ENSRNOT00000012667
DEP domain containing 1
chr17_-_78735324 0.04 ENSRNOT00000036299
cerebral dopamine neurotrophic factor
chr14_+_86813082 0.04 ENSRNOT00000090360
CCM2 scaffolding protein
chr5_-_105212173 0.04 ENSRNOT00000010383
ribosomal protein S6
chr5_+_128450680 0.04 ENSRNOT00000010700
thioredoxin domain containing 12
chr20_-_5037022 0.04 ENSRNOT00000091022
ENSRNOT00000060762
mutS homolog 5
chr15_-_60512704 0.04 ENSRNOT00000049056
tumor necrosis factor superfamily member 11
chr8_+_79054237 0.04 ENSRNOT00000077613
meiosis-specific nuclear structural 1
chr13_-_55886679 0.03 ENSRNOT00000066601
similar to novel protein
chr1_+_48433079 0.03 ENSRNOT00000037369
solute carrier family 22 member 3
chr10_-_63499390 0.03 ENSRNOT00000032934
basic helix-loop-helix family, member a9
chr4_+_7257752 0.03 ENSRNOT00000088357
transmembrane and ubiquitin-like domain containing 1
chr6_-_55647665 0.03 ENSRNOT00000007414
basic leucine zipper and W2 domains 2
chrX_-_123731294 0.03 ENSRNOT00000092574
ENSRNOT00000032618
UPF3 regulator of nonsense transcripts homolog B (yeast)
chr15_-_70399924 0.03 ENSRNOT00000087940
diaphanous-related formin 3
chr10_-_86393141 0.03 ENSRNOT00000009485
migration and invasion enhancer 1
chr9_-_16807966 0.03 ENSRNOT00000073160
ribosomal protein S19
chr1_+_221448661 0.03 ENSRNOT00000072493
sororin-like
chr1_+_81750928 0.03 ENSRNOT00000027246
ribosomal protein S19
chr4_-_7281223 0.03 ENSRNOT00000019666
solute carrier family 4 member 2
chr5_+_57267312 0.03 ENSRNOT00000011907
charged multivesicular body protein 5
chrX_-_158655198 0.03 ENSRNOT00000045153
hypoxanthine-guanine phosphoribosyltransferase
chr10_+_4313100 0.03 ENSRNOT00000074487
eukaryotic peptide chain release factor GTP-binding subunit ERF3B-like
chr1_-_1116926 0.03 ENSRNOT00000062027
retinoic acid early transcript 1L
chr20_+_4966817 0.03 ENSRNOT00000081527
ENSRNOT00000081265
LSM2 homolog, U6 small nuclear RNA and mRNA degradation associated
chr9_+_81566074 0.03 ENSRNOT00000074131
ENSRNOT00000046229
ENSRNOT00000090383
paroxysmal nonkinesigenic dyskinesia
chr8_+_12994155 0.02 ENSRNOT00000011855
CWC15 spliceosome-associated protein
chr4_-_160803558 0.02 ENSRNOT00000049542
Sumo1/sentrin/SMT3 specific peptidase 18
chr6_+_129835919 0.02 ENSRNOT00000036035
vaccinia related kinase 1
chr3_+_91463660 0.02 ENSRNOT00000081984
ENSRNOT00000006628
COMM domain containing 9
chr9_+_64066579 0.02 ENSRNOT00000013511
similar to CG31122-PA
chr6_+_55648021 0.02 ENSRNOT00000064822
ENSRNOT00000091488
ankyrin repeat and MYND domain containing 2
chr7_-_140951071 0.02 ENSRNOT00000082521
family with sequence similarity 186, member B
chr10_-_45851984 0.02 ENSRNOT00000058308
zinc finger protein 496
chr1_-_221448570 0.02 ENSRNOT00000075165
zinc finger protein-like 1
chr20_+_27169267 0.02 ENSRNOT00000077525
heterogeneous nuclear ribonucleoprotein H3
chr2_+_244521699 0.02 ENSRNOT00000029382
sperm-tail PG-rich repeat containing 2
chrX_-_158228749 0.02 ENSRNOT00000065935
hypoxanthine phosphoribosyltransferase 1
chr14_-_33580566 0.02 ENSRNOT00000063942
phosphoribosylaminoimidazole carboxylase and phosphoribosylaminoimidazolesuccinocarboxamide synthase
chr4_-_145487426 0.02 ENSRNOT00000013488
ER membrane protein complex subunit 3
chr15_-_24199341 0.02 ENSRNOT00000015553
DLG associated protein 5
chr12_+_48101673 0.02 ENSRNOT00000065060
forkhead box N4
chr15_-_42638392 0.01 ENSRNOT00000022020
scavenger receptor class A, member 3
chr6_-_43862131 0.01 ENSRNOT00000089859
cystin 1
chr13_-_108178609 0.01 ENSRNOT00000004525
centromere protein F
chr8_+_44847157 0.01 ENSRNOT00000080288
CXADR-like membrane protein
chr8_-_65587658 0.01 ENSRNOT00000091982
leucine rich repeat containing 49
chr9_-_9934501 0.01 ENSRNOT00000074904

chr3_+_111597102 0.01 ENSRNOT00000081462
TYRO3 protein tyrosine kinase
chr9_-_81566096 0.01 ENSRNOT00000019497
angio-associated, migratory cell protein
chr16_+_19800463 0.01 ENSRNOT00000023065
ankyrin repeat and LEM domain containing 1
chr3_+_176217128 0.01 ENSRNOT00000013609
GID complex subunit 8
chr13_+_70852023 0.01 ENSRNOT00000003661
SHC binding and spindle associated 1 like
chr4_-_10329241 0.01 ENSRNOT00000017232
fibrinogen-like 2
chr10_+_4312863 0.01 ENSRNOT00000091610
eukaryotic peptide chain release factor GTP-binding subunit ERF3B-like
chr12_-_19314016 0.01 ENSRNOT00000001825
minichromosome maintenance complex component 7
chr1_-_198652674 0.01 ENSRNOT00000023706
TBC1 domain family, member 10b
chr8_-_132032971 0.01 ENSRNOT00000005502
similar to RIKEN cDNA 1110059G10
chr1_-_82546937 0.01 ENSRNOT00000028100
heterogeneous nuclear ribonucleoprotein U-like 1
chr11_-_74866451 0.01 ENSRNOT00000002330
interleukin 13 receptor subunit alpha 1
chr3_+_55960327 0.01 ENSRNOT00000086584
peptidylprolyl isomerase G
chr10_-_89454681 0.01 ENSRNOT00000028109
BRCA1, DNA repair associated
chr9_-_92963697 0.01 ENSRNOT00000023546
G protein-coupled receptor 55
chr1_-_184106200 0.01 ENSRNOT00000067609
cytochrome P450, family 2, subfamily r, polypeptide 1
chr8_+_70860671 0.01 ENSRNOT00000019258
programmed cell death 7
chrX_+_15171499 0.01 ENSRNOT00000008399
suppressor of variegation 3-9 homolog 1 (Drosophila)-like 1
chr5_-_151029233 0.01 ENSRNOT00000089155
protein phosphatase 1, regulatory subunit 8
chr5_+_152721940 0.01 ENSRNOT00000039322
aurora kinase A and ninein interacting protein
chrX_-_62903530 0.01 ENSRNOT00000076652
ENSRNOT00000017370
pyruvate dehydrogenase kinase 3
chr17_+_78735598 0.01 ENSRNOT00000020854
heat shock protein family A, member 14
chr1_-_198232344 0.01 ENSRNOT00000080988
aldolase, fructose-bisphosphate A
chr3_+_55960067 0.01 ENSRNOT00000010216
peptidylprolyl isomerase G
chr1_+_85470831 0.01 ENSRNOT00000057096
translocase of inner mitochondrial membrane 50
chr19_+_10024947 0.01 ENSRNOT00000061392
cilia and flagella associated protein 20
chr4_-_56897310 0.01 ENSRNOT00000043902
ENSRNOT00000090038
transportin 3
chr13_-_87847263 0.01 ENSRNOT00000003650
NUF2, NDC80 kinetochore complex component
chr10_+_10811937 0.01 ENSRNOT00000077347
ankyrin repeat and sterile alpha motif domain containing 3
chr8_-_49269411 0.01 ENSRNOT00000021321
ubiquitination factor E4A
chr9_+_93326283 0.01 ENSRNOT00000024578
UDP-GlcNAc:betaGal beta-1,3-N-acetylglucosaminyltransferase 7
chr1_-_157700064 0.01 ENSRNOT00000031974
DNA damage-induced apoptosis suppressor
chr3_+_1478525 0.01 ENSRNOT00000008161
pleckstrin and Sec7 domain containing 4
chr1_-_94494980 0.00 ENSRNOT00000020014
cyclin E1
chrX_+_15295473 0.00 ENSRNOT00000009295
histone deacetylase 6
chr8_-_65587427 0.00 ENSRNOT00000016491
leucine rich repeat containing 49
chr8_-_69807826 0.00 ENSRNOT00000014071
DIS3-like exosome 3'-5' exoribonuclease
chr1_-_31967915 0.00 ENSRNOT00000021000
bromodomain containing 9
chr5_+_154205402 0.00 ENSRNOT00000064925
serine and arginine rich splicing factor 10
chr2_-_208420163 0.00 ENSRNOT00000021920
ATP synthase subunit b, mitochondrial-like
chr5_+_76860515 0.00 ENSRNOT00000022866
similar to RIKEN cDNA E130308A19
chr14_+_82356916 0.00 ENSRNOT00000040229
stem-loop binding protein
chr10_+_4411766 0.00 ENSRNOT00000003213
eukaryotic peptide chain release factor GTP-binding subunit ERF3B-like
chr8_-_111850393 0.00 ENSRNOT00000044956
CDV3 homolog
chr6_+_10306405 0.00 ENSRNOT00000090420
ENSRNOT00000080507
endothelial PAS domain protein 1
chr3_+_149131785 0.00 ENSRNOT00000090321
DNA methyltransferase 3 beta
chr4_-_52350624 0.00 ENSRNOT00000060476
transmembrane protein 229A
chr7_+_28715300 0.00 ENSRNOT00000006760
ENSRNOT00000089161
nucleoporin 37
chr2_+_187915751 0.00 ENSRNOT00000026994
ubiquilin 4

Network of associatons between targets according to the STRING database.

First level regulatory network of E2f4

PNG image of the network

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Gene Ontology Analysis

Gene overrepresentation in biological process category:

Log-likelihood per target  Total log-likelihood Term Description
0.0 0.1 GO:0003330 regulation of extracellular matrix constituent secretion(GO:0003330) positive regulation of extracellular matrix constituent secretion(GO:0003331)
0.0 0.1 GO:0043988 histone H3-S28 phosphorylation(GO:0043988)
0.0 0.1 GO:2001034 positive regulation of double-strand break repair via nonhomologous end joining(GO:2001034)
0.0 0.2 GO:2000042 negative regulation of double-strand break repair via homologous recombination(GO:2000042)
0.0 0.0 GO:0006178 guanine salvage(GO:0006178) GMP catabolic process(GO:0046038) guanine biosynthetic process(GO:0046099)
0.0 0.1 GO:2000672 negative regulation of motor neuron apoptotic process(GO:2000672)
0.0 0.0 GO:0071847 TNFSF11-mediated signaling pathway(GO:0071847)
0.0 0.0 GO:1903797 positive regulation of inorganic anion transmembrane transport(GO:1903797)
0.0 0.1 GO:1902897 regulation of postsynaptic density protein 95 clustering(GO:1902897)
0.0 0.0 GO:0043987 histone H3-S10 phosphorylation(GO:0043987)
0.0 0.0 GO:0002184 cytoplasmic translational termination(GO:0002184)
0.0 0.1 GO:0007144 female meiosis I(GO:0007144)

Gene overrepresentation in cellular component category:

Log-likelihood per target  Total log-likelihood Term Description
0.0 0.1 GO:0032133 chromosome passenger complex(GO:0032133)
0.0 0.1 GO:1990726 Lsm1-7-Pat1 complex(GO:1990726)
0.0 0.1 GO:0071986 Ragulator complex(GO:0071986)
0.0 0.0 GO:0018444 translation release factor complex(GO:0018444)

Gene overrepresentation in molecular function category:

Log-likelihood per target  Total log-likelihood Term Description
0.0 0.1 GO:0004566 beta-glucuronidase activity(GO:0004566)
0.0 0.1 GO:0032027 myosin light chain binding(GO:0032027)
0.0 0.2 GO:0035174 histone serine kinase activity(GO:0035174)
0.0 0.1 GO:0000405 bubble DNA binding(GO:0000405)