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GSE49485: Hypoxia transcriptome sequencing of rat brain.

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Results for E2f3

Z-value: 0.36

Motif logo

Transcription factors associated with E2f3

Gene Symbol Gene ID Gene Info
ENSRNOG00000029273 E2F transcription factor 3

Activity-expression correlation:

GenePromoterPearson corr. coef.P-valuePlot
E2f3rn6_v1_chr17_+_36334589_363345890.375.4e-01Click!

Activity profile of E2f3 motif

Sorted Z-values of E2f3 motif

Promoter Log-likelihood Transcript Gene Gene Info
chr12_+_943006 0.25 ENSRNOT00000001449
Klotho
chr15_-_30147793 0.13 ENSRNOT00000060399

chr1_-_219422268 0.10 ENSRNOT00000025092
carnosine synthase 1
chr20_-_7654428 0.10 ENSRNOT00000045044
t-complex 11
chr2_+_30664639 0.09 ENSRNOT00000076372
ENSRNOT00000076294
ENSRNOT00000076434
ENSRNOT00000076484
TATA-box binding protein associated factor 9
chr20_-_14282873 0.09 ENSRNOT00000001759
adenosine A2a receptor
chr1_-_42467586 0.09 ENSRNOT00000029416
F-box protein 5
chr10_-_53037816 0.08 ENSRNOT00000057509
shisa family member 6
chr13_-_45068077 0.08 ENSRNOT00000004969
minichromosome maintenance complex component 6
chr4_-_152380023 0.08 ENSRNOT00000012397
ELKS/RAB6-interacting/CAST family member 1
chr6_+_33885495 0.08 ENSRNOT00000086633
syndecan 1
chr5_+_47853818 0.07 ENSRNOT00000009228
ENSRNOT00000079656
caspase 8 associated protein 2
chr2_+_198231291 0.07 ENSRNOT00000078288
ENSRNOT00000046739
OTU deubiquitinase 7B
chr2_+_4942775 0.06 ENSRNOT00000093548
ENSRNOT00000093741
family with sequence similarity 172, member A
chr1_-_270472866 0.06 ENSRNOT00000015979
sortilin-related VPS10 domain containing receptor 1
chr8_-_122402127 0.06 ENSRNOT00000074238
ENSRNOT00000076548
cartilage associated protein-like 1
chr11_+_73198522 0.06 ENSRNOT00000002356
xyloside xylosyltransferase 1
chr11_-_51202703 0.06 ENSRNOT00000002719
ENSRNOT00000077220
Cbl proto-oncogene B
chr8_+_69971778 0.06 ENSRNOT00000058007
ENSRNOT00000037941
ENSRNOT00000050649
multiple EGF-like-domains 11
chr18_-_47513030 0.05 ENSRNOT00000083881
ENSRNOT00000074226
lysyl oxidase
chr8_-_118378460 0.05 ENSRNOT00000047247
similar to ribosomal protein S23
chr3_+_138715570 0.05 ENSRNOT00000064723
Sec23 homolog B, coat complex II component
chr9_+_121802673 0.05 ENSRNOT00000086534
YES proto-oncogene 1, Src family tyrosine kinase
chr1_+_165724451 0.05 ENSRNOT00000025827
family with sequence similarity 168, member A
chr6_-_1622196 0.05 ENSRNOT00000007492
protein kinase D3
chr3_-_2938883 0.05 ENSRNOT00000084196
allergen Fel d 4-like
chr7_-_24667301 0.05 ENSRNOT00000009154
transmembrane protein 263
chr8_+_117953444 0.05 ENSRNOT00000028141
cell division cycle 25A
chr13_+_110257571 0.05 ENSRNOT00000005715
integrator complex subunit 7
chr4_-_78342863 0.05 ENSRNOT00000049038
GTPase, IMAP family member 6
chr7_-_124198200 0.05 ENSRNOT00000078947
ADP-ribosylation factor GTPase activating protein 3
chr5_-_169331163 0.05 ENSRNOT00000042301
espin
chr12_-_47793534 0.05 ENSRNOT00000001588
family with sequence similarity 222, member A
chr3_-_55951584 0.05 ENSRNOT00000036585
FAST kinase domains 1
chr19_+_52521809 0.05 ENSRNOT00000081019
kelch-like family member 36
chr18_+_30550877 0.05 ENSRNOT00000027164
protocadherin beta-7-like
chr9_-_46206605 0.04 ENSRNOT00000018640
TBC1 domain family, member 8
chr17_-_20364714 0.04 ENSRNOT00000070962
jumonji and AT-rich interaction domain containing 2
chr3_-_3660006 0.04 ENSRNOT00000045587
LIM homeobox 3
chr3_+_12262822 0.04 ENSRNOT00000022585
angiopoietin-like 2
chr3_+_146582752 0.04 ENSRNOT00000010157
glycogen phosphorylase B
chr8_+_22446661 0.04 ENSRNOT00000010030
queuine tRNA-ribosyltransferase catalytic subunit 1
chr4_+_157438605 0.04 ENSRNOT00000079988

chr7_+_130474279 0.04 ENSRNOT00000092388
SH3 and multiple ankyrin repeat domains 3
chr8_-_87245774 0.04 ENSRNOT00000085725
transmembrane protein 30A
chr18_-_38088457 0.04 ENSRNOT00000077814
janus kinase and microtubule interacting protein 2
chr8_+_7128656 0.04 ENSRNOT00000038313
progesterone receptor
chr10_-_70118194 0.04 ENSRNOT00000009944
chaperonin containing TCP1 subunit 6B
chr8_+_48422036 0.04 ENSRNOT00000036051
ubiquitin specific peptidase 2
chr2_-_157759819 0.04 ENSRNOT00000015763
ENSRNOT00000016016
cyclin-L1-like
chr11_-_68842320 0.04 ENSRNOT00000049180
adenylate cyclase 5
chrX_+_74200972 0.04 ENSRNOT00000076956
cysteine-rich hydrophobic domain 1
chr7_+_73588163 0.04 ENSRNOT00000015707
potassium voltage-gated channel, modifier subfamily S, member 2
chr2_-_198412350 0.04 ENSRNOT00000040210
histone H4-like
chr13_+_74154835 0.04 ENSRNOT00000059524
ABL proto-oncogene 2, non-receptor tyrosine kinase
chr1_+_126749508 0.04 ENSRNOT00000015845
proprotein convertase subtilisin/kexin type 6
chr11_-_27080701 0.04 ENSRNOT00000002180
listerin E3 ubiquitin protein ligase 1
chr1_-_1885981 0.04 ENSRNOT00000020810
glycoprotein integral membrane 1
chr5_+_138470069 0.04 ENSRNOT00000076343
ENSRNOT00000064073
zinc finger, MYND-type containing 12
chr6_-_15191660 0.04 ENSRNOT00000092654
neurexin 1
chr6_-_91518996 0.04 ENSRNOT00000005835
DNA polymerase epsilon 2, accessory subunit
chr15_+_34270648 0.03 ENSRNOT00000026333
ring finger protein 31
chr6_-_124735741 0.03 ENSRNOT00000064716
ENSRNOT00000091693
ribosomal protein S6 kinase A5
chr16_-_5795825 0.03 ENSRNOT00000048043
calcium voltage-gated channel auxiliary subunit alpha2delta 3
chr10_+_82292110 0.03 ENSRNOT00000004435
chondroadherin
chr1_+_222746023 0.03 ENSRNOT00000028787
atlastin GTPase 3
chr9_-_46309451 0.03 ENSRNOT00000018684
ring finger protein 149
chr9_+_10471742 0.03 ENSRNOT00000072276
scaffold attachment factor B2
chr7_+_117963740 0.03 ENSRNOT00000075405
COMM domain-containing protein 5
chr20_+_48504264 0.03 ENSRNOT00000087740
cell division cycle 40
chr2_+_128675814 0.03 ENSRNOT00000058366
similar to protein C33A12.3
chr6_+_119519714 0.03 ENSRNOT00000004955
fibronectin leucine rich transmembrane protein 2
chr13_+_44475970 0.03 ENSRNOT00000024602
ENSRNOT00000091645
cyclin T2
chr6_-_95890325 0.03 ENSRNOT00000050217
similar to 60S ribosomal protein L23a
chr8_-_48619592 0.03 ENSRNOT00000012534
ATP binding cassette subfamily G member 4
chr12_+_660011 0.03 ENSRNOT00000040830
PDS5 cohesin associated factor B
chr5_+_128923934 0.03 ENSRNOT00000064145
epidermal growth factor receptor pathway substrate 15
chr17_-_17947777 0.03 ENSRNOT00000036876
ring finger protein 144B
chr8_+_122197027 0.03 ENSRNOT00000013050
upstream binding protein 1 (LBP-1a)
chr15_-_24374753 0.03 ENSRNOT00000016274
autophagy related 14
chr3_+_100366168 0.03 ENSRNOT00000006689
kinesin family member 18A
chr12_-_14175945 0.03 ENSRNOT00000001469
adaptor-related protein complex 5, zeta 1 subunit
chr1_+_220746387 0.03 ENSRNOT00000027753
eukaryotic translation initiation factor 1A domain containing
chr3_-_148312791 0.03 ENSRNOT00000091419
Bcl2-like 1
chr2_-_196207560 0.03 ENSRNOT00000028589
proteasome 26S subunit, non-ATPase 4
chrX_+_74205842 0.03 ENSRNOT00000077003
cysteine-rich hydrophobic domain 1
chr4_-_152380184 0.03 ENSRNOT00000091473
ELKS/RAB6-interacting/CAST family member 1
chr16_+_36116258 0.03 ENSRNOT00000017652
Sin3A associated protein 30
chr1_-_219450451 0.03 ENSRNOT00000025317
RAD9 checkpoint clamp component A
chr15_-_40545824 0.03 ENSRNOT00000017204
nucleoporin 58
chr8_-_48736506 0.03 ENSRNOT00000016227
coiled-coil domain containing 84
chr14_+_17064353 0.03 ENSRNOT00000003052
scavenger receptor class B, member 2
chr6_-_135829953 0.03 ENSRNOT00000080623
ENSRNOT00000039059
CDC42 binding protein kinase beta
chr10_+_70118250 0.03 ENSRNOT00000009970
zinc finger protein 830
chr4_-_118578815 0.02 ENSRNOT00000080502
annexin A4
chr19_-_59384297 0.02 ENSRNOT00000077516
TAR RNA binding protein 1
chrX_-_105308554 0.02 ENSRNOT00000045556
TATA-box binding protein associated factor 7-like
chr3_-_124884570 0.02 ENSRNOT00000028887
proliferating cell nuclear antigen
chr20_-_6864387 0.02 ENSRNOT00000068527
peptidylprolyl isomerase like 1
chr1_-_213635546 0.02 ENSRNOT00000018861
sirtuin 3
chr3_+_14990652 0.02 ENSRNOT00000090735
DAB2 interacting protein
chr2_+_49682754 0.02 ENSRNOT00000079907
ENSRNOT00000085576
embigin
chr3_+_147422095 0.02 ENSRNOT00000006786
angiopoietin 4
chr11_+_31806618 0.02 ENSRNOT00000043410
ENSRNOT00000002769
Son DNA binding protein
chr3_+_151032952 0.02 ENSRNOT00000064013
acyl-CoA synthetase short-chain family member 2
chr10_-_2037891 0.02 ENSRNOT00000004563
ERCC excision repair 4, endonuclease catalytic subunit
chr15_-_37663584 0.02 ENSRNOT00000012093
crystallin, lambda 1
chr3_+_175493698 0.02 ENSRNOT00000087356
oxysterol binding protein-like 2
chr5_-_74366817 0.02 ENSRNOT00000076705
protein tyrosine phosphatase, non-receptor type 3
chr4_-_51844331 0.02 ENSRNOT00000003593
G protein-coupled receptor 37
chr15_+_2374582 0.02 ENSRNOT00000019644
zinc finger protein 503
chr3_-_133131192 0.02 ENSRNOT00000055630
taspase 1
chr5_-_138470096 0.02 ENSRNOT00000011392
phosphopantothenoylcysteine synthetase
chr18_+_24584900 0.02 ENSRNOT00000017075
WD repeat domain 33
chr2_-_128675408 0.02 ENSRNOT00000019256
sodium channel and clathrin linker 1
chr7_-_121302740 0.02 ENSRNOT00000067032
ribosomal protein L3
chr12_-_43940798 0.02 ENSRNOT00000001485
similar to hypothetical protein FLJ21415
chr3_+_146695344 0.02 ENSRNOT00000010955
GINS complex subunit 1
chr4_+_77212203 0.02 ENSRNOT00000085805
cullin 1
chr8_+_128577345 0.02 ENSRNOT00000082356
WD repeat domain 48
chr12_+_43940929 0.02 ENSRNOT00000001486
ring finger protein, transmembrane 2
chr1_+_260153645 0.02 ENSRNOT00000054717
zinc finger protein 518A
chr14_+_2613406 0.02 ENSRNOT00000000083
transmembrane p24 trafficking protein 5
chr3_-_10161989 0.02 ENSRNOT00000012312
exosome component 2
chr15_+_344685 0.02 ENSRNOT00000065542
ENSRNOT00000066928
potassium calcium-activated channel subfamily M alpha 1
chr10_+_975697 0.02 ENSRNOT00000089404

chr17_+_9837402 0.02 ENSRNOT00000076436
RAB24, member RAS oncogene family
chr20_-_34929965 0.02 ENSRNOT00000004499
minichromosome maintenance 9 homologous recombination repair factor
chr18_-_24693481 0.02 ENSRNOT00000021708
SFT2 domain containing 3
chr11_-_61748768 0.02 ENSRNOT00000078879
coiled-coil domain containing 191
chr13_+_56513286 0.02 ENSRNOT00000015596
zinc finger and BTB domain containing 41
chr5_+_155812105 0.02 ENSRNOT00000039341

chr12_+_13090172 0.02 ENSRNOT00000092558
ras-related C3 botulinum toxin substrate 1
chr8_-_36410612 0.02 ENSRNOT00000091308
FAD-dependent oxidoreductase domain containing 1
chr8_-_23084879 0.02 ENSRNOT00000018874
zinc finger protein 653
chr2_+_149214265 0.01 ENSRNOT00000084020
mediator complex subunit 12-like
chr1_+_72380711 0.01 ENSRNOT00000022236
FLT3-interacting zinc finger 1
chrX_+_27015884 0.01 ENSRNOT00000065814
male-specific lethal 3 homolog (Drosophila)
chr9_+_15166118 0.01 ENSRNOT00000020432
MyoD family inhibitor
chr3_-_175601127 0.01 ENSRNOT00000081226
laminin subunit alpha 5
chr19_+_55381565 0.01 ENSRNOT00000018923
chromatin licensing and DNA replication factor 1
chr5_+_157848206 0.01 ENSRNOT00000039663
ENSRNOT00000082138
ubiquitin protein ligase E3 component n-recognin 4
chrX_+_71540895 0.01 ENSRNOT00000004692
ENSRNOT00000082967
O-linked N-acetylglucosamine (GlcNAc) transferase
chr11_-_61748583 0.01 ENSRNOT00000093431
coiled-coil domain containing 191
chr1_+_174330695 0.01 ENSRNOT00000018497
A-kinase interacting protein 1
chr10_-_109979095 0.01 ENSRNOT00000073956
dihydrouridine synthase 1-like
chr11_+_61748883 0.01 ENSRNOT00000093552
queuine tRNA-ribosyltransferase accessory subunit 2
chr1_+_154377247 0.01 ENSRNOT00000092945
phosphatidylinositol binding clathrin assembly protein
chr18_+_3162543 0.01 ENSRNOT00000078615
RB binding protein 8, endonuclease
chr8_+_118525682 0.01 ENSRNOT00000028288
elongator acetyltransferase complex subunit 6
chr10_-_71837851 0.01 ENSRNOT00000000258
apoptosis antagonizing transcription factor
chr14_+_16491573 0.01 ENSRNOT00000002995
sosondowah ankyrin repeat domain family member B
chr5_-_62001196 0.01 ENSRNOT00000012602
tRNA methyltransferase O
chr5_-_152458023 0.01 ENSRNOT00000031225
connector enhancer of kinase suppressor of Ras 1
chr6_+_788548 0.01 ENSRNOT00000005983
cysteine rich transmembrane BMP regulator 1
chr8_+_36410683 0.01 ENSRNOT00000015177
SRP receptor alpha subunit
chr9_+_65279675 0.01 ENSRNOT00000019486
basic leucine zipper and W2 domains 1
chr8_-_21968415 0.01 ENSRNOT00000067325
ENSRNOT00000064932
DNA methyltransferase 1
chr8_+_128577080 0.01 ENSRNOT00000024172
WD repeat domain 48
chr8_+_111210811 0.01 ENSRNOT00000011347
angiomotin like 2
chr2_+_95008477 0.01 ENSRNOT00000015327
tumor protein D52
chrX_+_71324365 0.01 ENSRNOT00000004911
non-POU domain containing, octamer-binding
chr7_-_117041693 0.01 ENSRNOT00000073835
coiled-coil domain containing 166
chr18_+_3163214 0.01 ENSRNOT00000017291
RB binding protein 8, endonuclease
chr7_-_11353713 0.01 ENSRNOT00000061132
zinc finger RNA binding protein 2
chr10_-_71441389 0.01 ENSRNOT00000003699
transcriptional adaptor 2A
chr2_-_225389120 0.01 ENSRNOT00000016739
ATP binding cassette subfamily D member 3
chr8_+_22189600 0.01 ENSRNOT00000061100
phosphodiesterase 4A
chr7_-_2961873 0.01 ENSRNOT00000067441
ribosomal protein S15, pseudogene 2
chr7_-_31824064 0.01 ENSRNOT00000011494
ENSRNOT00000080824
solute carrier family 25 member 3
chr10_+_40553180 0.01 ENSRNOT00000087763
solute carrier family 36 member 1
chr8_+_118378059 0.01 ENSRNOT00000043247

chr11_+_87220618 0.01 ENSRNOT00000041975
goosecoid homeobox 2
chr10_-_67285617 0.01 ENSRNOT00000019044
UTP6 small subunit processome component
chr9_-_73871888 0.01 ENSRNOT00000017686
acyl-CoA dehydrogenase, long chain
chr6_+_110624856 0.01 ENSRNOT00000014017
vasohibin 1
chr2_-_30664163 0.01 ENSRNOT00000024801
RAD17 checkpoint clamp loader component
chr4_-_177331874 0.01 ENSRNOT00000065387
ENSRNOT00000091099
C2 calcium-dependent domain containing 5
chr10_+_80790168 0.01 ENSRNOT00000073315
ENSRNOT00000075163
carbonic anhydrase 10
chr12_+_51878153 0.01 ENSRNOT00000056798
HscB mitochondrial iron-sulfur cluster co-chaperone
chr13_+_96111800 0.01 ENSRNOT00000005967
desumoylating isopeptidase 2
chr15_-_34338956 0.01 ENSRNOT00000026914
magnesium-dependent phosphatase 1
chr4_-_129514390 0.01 ENSRNOT00000077530
EGF domain specific O-linked N-acetylglucosamine transferase
chr19_+_58505811 0.01 ENSRNOT00000031717
microtubule-associated protein 10
chr6_-_47811853 0.01 ENSRNOT00000010942
allantoicase
chr15_+_34297290 0.01 ENSRNOT00000081165
REC8 meiotic recombination protein
chrX_-_63203643 0.01 ENSRNOT00000065194
ENSRNOT00000076974
zinc finger protein X-linked
chr4_-_62438958 0.01 ENSRNOT00000014010
WD repeat domain 91
chr19_-_10596851 0.01 ENSRNOT00000021716
coenzyme Q9
chr7_+_141380322 0.01 ENSRNOT00000091207
COX14, cytochrome c oxidase assembly factor
chr19_-_39246545 0.01 ENSRNOT00000036634
peptide deformylase (mitochondrial)
chrX_-_35431164 0.01 ENSRNOT00000004968
sex comb on midleg-like 2 (Drosophila)
chr2_+_182006242 0.01 ENSRNOT00000064091
fibrinogen alpha chain
chr1_-_84008293 0.01 ENSRNOT00000002053
small nuclear ribonucleoprotein polypeptide A
chr19_-_55389256 0.01 ENSRNOT00000064180
adenine phosphoribosyl transferase
chr4_-_147893992 0.01 ENSRNOT00000032158
plexin D1
chr17_-_32953641 0.01 ENSRNOT00000023332
Werner helicase interacting protein 1
chr1_+_80920747 0.01 ENSRNOT00000026077
zinc finger protein 180
chr2_+_166403265 0.01 ENSRNOT00000012417
NMD3 ribosome export adaptor
chr4_-_71227872 0.00 ENSRNOT00000050392
TRPM8 channel-associated factor 2

Network of associatons between targets according to the STRING database.

First level regulatory network of E2f3

PNG image of the network

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Gene Ontology Analysis

Gene overrepresentation in biological process category:

Log-likelihood per target  Total log-likelihood Term Description
0.0 0.2 GO:0090080 positive regulation of MAPKKK cascade by fibroblast growth factor receptor signaling pathway(GO:0090080)
0.0 0.1 GO:0007056 spindle assembly involved in female meiosis(GO:0007056)
0.0 0.1 GO:0014057 positive regulation of acetylcholine secretion, neurotransmission(GO:0014057)
0.0 0.1 GO:0071947 protein deubiquitination involved in ubiquitin-dependent protein catabolic process(GO:0071947)
0.0 0.1 GO:1903553 positive regulation of extracellular exosome assembly(GO:1903553)
0.0 0.0 GO:0021526 medial motor column neuron differentiation(GO:0021526)
0.0 0.0 GO:1904700 granulosa cell apoptotic process(GO:1904700) regulation of granulosa cell apoptotic process(GO:1904708)
0.0 0.1 GO:0036337 Fas signaling pathway(GO:0036337)
0.0 0.1 GO:0000492 box C/D snoRNP assembly(GO:0000492)
0.0 0.1 GO:0097117 guanylate kinase-associated protein clustering(GO:0097117)
0.0 0.0 GO:0032902 nerve growth factor production(GO:0032902)
0.0 0.0 GO:1990164 histone H2A phosphorylation(GO:1990164)
0.0 0.1 GO:0006268 DNA unwinding involved in DNA replication(GO:0006268)
0.0 0.0 GO:0019086 late viral transcription(GO:0019086)

Gene overrepresentation in cellular component category:

Log-likelihood per target  Total log-likelihood Term Description
0.0 0.1 GO:0000125 PCAF complex(GO:0000125)

Gene overrepresentation in molecular function category:

Log-likelihood per target  Total log-likelihood Term Description
0.1 0.2 GO:0004566 beta-glucuronidase activity(GO:0004566)
0.0 0.1 GO:0031802 type 5 metabotropic glutamate receptor binding(GO:0031802)
0.0 0.0 GO:0008184 glycogen phosphorylase activity(GO:0008184)
0.0 0.1 GO:0001075 transcription factor activity, RNA polymerase II core promoter sequence-specific binding involved in preinitiation complex assembly(GO:0001075)
0.0 0.1 GO:0004720 protein-lysine 6-oxidase activity(GO:0004720)
0.0 0.0 GO:0034041 sterol-transporting ATPase activity(GO:0034041)

Gene overrepresentation in curated gene sets: REACTOME pathways category:

Log-likelihood per target  Total log-likelihood Term Description
0.0 0.2 REACTOME FGFR LIGAND BINDING AND ACTIVATION Genes involved in FGFR ligand binding and activation