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GSE49485: Hypoxia transcriptome sequencing of rat brain.

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Results for E2f2_E2f5

Z-value: 0.29

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Transcription factors associated with E2f2_E2f5

Gene Symbol Gene ID Gene Info
ENSRNOG00000047741 E2F transcription factor 2
ENSRNOG00000010760 E2F transcription factor 5

Activity-expression correlation:

GenePromoterPearson corr. coef.P-valuePlot
E2f5rn6_v1_chr2_-_88366115_88366115-0.652.3e-01Click!
E2f2rn6_v1_chr5_+_154522119_1545221190.405.0e-01Click!

Activity profile of E2f2_E2f5 motif

Sorted Z-values of E2f2_E2f5 motif

Promoter Log-likelihood Transcript Gene Gene Info
chr1_-_42467586 0.14 ENSRNOT00000029416
F-box protein 5
chr8_+_117953444 0.11 ENSRNOT00000028141
cell division cycle 25A
chr12_+_943006 0.10 ENSRNOT00000001449
Klotho
chr17_+_44520537 0.08 ENSRNOT00000077985
histone cluster 1, H2ai-like2
chr3_-_124884570 0.08 ENSRNOT00000028887
proliferating cell nuclear antigen
chr6_+_144291974 0.07 ENSRNOT00000035255
non-SMC condensin II complex, subunit G2
chr3_+_125470551 0.07 ENSRNOT00000028898
minichromosome maintenance 8 homologous recombination repair factor
chr12_-_17186679 0.07 ENSRNOT00000001730
UNC homeobox
chr4_+_81244469 0.06 ENSRNOT00000044407
ENSRNOT00000015828
chromobox 3
chr10_+_72909550 0.06 ENSRNOT00000004540
protein phosphatase, Mg2+/Mn2+ dependent, 1D
chr12_+_19314251 0.06 ENSRNOT00000001827
adaptor-related protein complex 4, mu 1 subunit
chr3_-_150073721 0.06 ENSRNOT00000022428
E2F transcription factor 1
chr6_-_91518996 0.05 ENSRNOT00000005835
DNA polymerase epsilon 2, accessory subunit
chr12_-_19314016 0.05 ENSRNOT00000001825
minichromosome maintenance complex component 7
chr8_+_132032944 0.05 ENSRNOT00000089278
kinesin family member 15
chr12_-_52452040 0.05 ENSRNOT00000067453
DNA polymerase epsilon, catalytic subunit
chr4_-_183426439 0.05 ENSRNOT00000083310
family with sequence similarity 60, member A
chr10_-_108150511 0.05 ENSRNOT00000073337
chromobox 8
chr2_+_243105674 0.05 ENSRNOT00000013919
H2A histone family, member Z
chr8_+_12355767 0.05 ENSRNOT00000068445
family with sequence similarity 76, member B
chr4_-_120840111 0.05 ENSRNOT00000022231
minichromosome maintenance complex component 2
chr5_+_144581427 0.05 ENSRNOT00000015227
claspin
chr3_-_80052953 0.04 ENSRNOT00000018998
damage specific DNA binding protein 2
chr20_+_20576377 0.04 ENSRNOT00000000783
ENSRNOT00000086806
cyclin-dependent kinase 1
chr6_+_43884678 0.04 ENSRNOT00000091551
ribonucleotide reductase regulatory subunit M2
chr8_+_108958046 0.04 ENSRNOT00000079618
ENSRNOT00000066917
stromal antigen 1
chr9_-_26932201 0.04 ENSRNOT00000017081
minichromosome maintenance complex component 3
chr12_+_52452273 0.04 ENSRNOT00000056680
ENSRNOT00000088381
peroxisomal membrane protein 2
chr2_+_200187179 0.04 ENSRNOT00000093564
ENSRNOT00000025718
notch 2
chr7_+_97984862 0.04 ENSRNOT00000008508
ATPase family, AAA domain containing 2
chr19_+_14523554 0.04 ENSRNOT00000084271
ENSRNOT00000064731
minichromosome maintenance complex component 5
chr8_-_110813000 0.04 ENSRNOT00000010634
Eph receptor B1
chrX_+_157353577 0.04 ENSRNOT00000090596
HAUS augmin-like complex, subunit 7
chr1_-_33275540 0.03 ENSRNOT00000017019
iroquois homeobox 2
chr5_+_47853818 0.03 ENSRNOT00000009228
ENSRNOT00000079656
caspase 8 associated protein 2
chr3_-_125470413 0.03 ENSRNOT00000028893
tRNA methyltransferase 6
chr4_-_77347011 0.03 ENSRNOT00000008149
enhancer of zeste 2 polycomb repressive complex 2 subunit
chr17_+_9830332 0.03 ENSRNOT00000021946
RAB24, member RAS oncogene family
chr13_+_104284660 0.03 ENSRNOT00000005400
dual specificity phosphatase 10
chr10_-_13075864 0.03 ENSRNOT00000005220
progestin and adipoQ receptor family member 4
chr9_-_93377643 0.03 ENSRNOT00000024712
nucleolin
chr17_+_42302540 0.03 ENSRNOT00000025389
geminin, DNA replication inhibitor
chr6_+_126636662 0.03 ENSRNOT00000010739
ubiquitin protein ligase E3 component n-recognin 7 (putative)
chr17_-_88037034 0.03 ENSRNOT00000080193
ENSRNOT00000034907
phosphoribosyl transferase domain containing 1
chr4_-_157679962 0.03 ENSRNOT00000050443
glyceraldehyde-3-phosphate dehydrogenase
chr17_-_44520240 0.02 ENSRNOT00000086538
histone cluster 1 H2B family member h
chr8_-_68966108 0.02 ENSRNOT00000012155
SMAD family member 6
chr14_-_86706626 0.02 ENSRNOT00000082893
H2A histone family, member V
chr17_+_44763598 0.02 ENSRNOT00000079880
histone cluster 1, H3b
chr17_+_44528125 0.02 ENSRNOT00000084538
similar to Histone H2A type 1
chr10_+_13061170 0.02 ENSRNOT00000004936
protein kinase, membrane associated tyrosine/threonine 1
chr8_-_132032971 0.02 ENSRNOT00000005502
similar to RIKEN cDNA 1110059G10
chrX_+_157353730 0.02 ENSRNOT00000080691
HAUS augmin-like complex, subunit 7
chr9_+_9961021 0.02 ENSRNOT00000075767
tubulin, beta 4A class IVa
chr4_-_145487426 0.02 ENSRNOT00000013488
ER membrane protein complex subunit 3
chr15_+_2374582 0.02 ENSRNOT00000019644
zinc finger protein 503
chr20_+_46429222 0.02 ENSRNOT00000076818
forkhead box O3
chr10_+_14373679 0.02 ENSRNOT00000022063
intraflagellar transport 140
chr1_+_203509731 0.02 ENSRNOT00000028007
H6 family homeobox 3
chr14_-_79464770 0.02 ENSRNOT00000008932
GrpE-like 1, mitochondrial
chr1_-_89560719 0.02 ENSRNOT00000028653
sodium voltage-gated channel beta subunit 1
chr5_-_16706909 0.02 ENSRNOT00000011314
ribosomal protein S20
chr5_+_114940053 0.02 ENSRNOT00000012396
hook microtubule-tethering protein 1
chr2_-_4195810 0.02 ENSRNOT00000018457
SMC5-SMC6 complex localization factor 1
chr8_-_27852996 0.02 ENSRNOT00000037790
galactosidase, beta 1-like 2
chr10_-_14324170 0.02 ENSRNOT00000035513
ENSRNOT00000090587
hematological and neurological expressed 1-like
chr2_-_26699333 0.02 ENSRNOT00000024459
synaptic vesicle glycoprotein 2c
chr1_-_201110928 0.02 ENSRNOT00000027721
NSE4 homolog A, SMC5-SMC6 complex component
chr3_-_113091770 0.02 ENSRNOT00000068132
leucine carboxyl methyltransferase 2
chr7_-_94774569 0.02 ENSRNOT00000036399
DNA replication and sister chromatid cohesion 1
chr1_+_264507985 0.02 ENSRNOT00000085811
paired box 2
chr15_-_44627765 0.02 ENSRNOT00000058887
dedicator of cytokinesis 5
chr10_+_90622992 0.02 ENSRNOT00000032856
meiosis specific with coiled-coil domain
chr11_-_27080701 0.02 ENSRNOT00000002180
listerin E3 ubiquitin protein ligase 1
chr14_-_20816588 0.02 ENSRNOT00000033806
solute carrier family 4 member 4
chr1_+_174767960 0.02 ENSRNOT00000013362
WEE1 G2 checkpoint kinase
chr6_+_11644578 0.02 ENSRNOT00000021923
ENSRNOT00000093689
mutS homolog 6
chr3_-_117766120 0.02 ENSRNOT00000056022
fibrillin 1
chr13_+_110257571 0.02 ENSRNOT00000005715
integrator complex subunit 7
chr3_+_110918243 0.02 ENSRNOT00000056432
RAD51 recombinase
chr10_+_36098051 0.01 ENSRNOT00000083971
ADAM metallopeptidase with thrombospondin type 1 motif, 2
chr16_-_7103604 0.01 ENSRNOT00000033677
G protein nucleolar 3
chr5_+_154668179 0.01 ENSRNOT00000015971
heterogeneous nuclear ribonucleoprotein R
chr4_-_34282351 0.01 ENSRNOT00000011123
replication protein A3
chr4_+_170820594 0.01 ENSRNOT00000032568
similar to C030030A07Rik protein
chr2_-_181874223 0.01 ENSRNOT00000035846
RNA binding motif protein 46
chr17_+_11953552 0.01 ENSRNOT00000090782
receptor tyrosine kinase-like orphan receptor 2
chr6_+_108167716 0.01 ENSRNOT00000064426
lin-52 DREAM MuvB core complex component
chr1_+_167538744 0.01 ENSRNOT00000093070
ribonucleotide reductase catalytic subunit M1
chr2_+_128461224 0.01 ENSRNOT00000018872
jade family PHD finger 1
chr8_-_82351108 0.01 ENSRNOT00000013053
mitogen-activated protein kinase 6
chr17_+_17965881 0.01 ENSRNOT00000021751
DEK proto-oncogene
chr18_-_33414236 0.01 ENSRNOT00000020385
Yip1 domain family, member 5
chr17_+_77224112 0.01 ENSRNOT00000024178
minichromosome maintenance 10 replication initiation factor
chr9_+_17949764 0.01 ENSRNOT00000027264
cell division cycle 5-like
chr3_+_2158995 0.01 ENSRNOT00000010270
zinc finger, MYND-type containing 19
chr5_+_152721940 0.01 ENSRNOT00000039322
aurora kinase A and ninein interacting protein
chr8_-_65587658 0.01 ENSRNOT00000091982
leucine rich repeat containing 49
chr1_+_101884019 0.01 ENSRNOT00000028650
transmembrane protein 143
chr13_+_73196571 0.01 ENSRNOT00000004772
acyl-CoA binding domain containing 6
chr5_-_58455819 0.01 ENSRNOT00000078082
Fanconi anemia, complementation group G
chr15_+_3936786 0.01 ENSRNOT00000066163
calcium/calmodulin-dependent protein kinase II gamma
chr17_+_16333415 0.01 ENSRNOT00000060550
protein tyrosine phosphatase domain containing 1
chrX_-_154722220 0.01 ENSRNOT00000089743
ENSRNOT00000087893
fragile X mental retardation 1
chr1_+_142034423 0.01 ENSRNOT00000090006
tubulin tyrosine ligase-like family, member 13
chr6_+_126636491 0.01 ENSRNOT00000089601
ubiquitin protein ligase E3 component n-recognin 7 (putative)
chr8_-_97494834 0.01 ENSRNOT00000080421
mortality factor 4 like 1
chr13_+_48679774 0.01 ENSRNOT00000075674
nuclear casein kinase and cyclin-dependent kinase substrate 1
chr1_+_198214797 0.01 ENSRNOT00000068543
T-box 6
chr1_-_198706852 0.01 ENSRNOT00000024074
dCTP pyrophosphatase 1
chr3_+_146695344 0.01 ENSRNOT00000010955
GINS complex subunit 1
chr8_-_65587427 0.01 ENSRNOT00000016491
leucine rich repeat containing 49
chr19_-_37245217 0.01 ENSRNOT00000020927
hypothetical protein LOC688735
chr2_+_207108552 0.01 ENSRNOT00000027234
solute carrier family 16 member 1
chr17_-_1672021 0.01 ENSRNOT00000036287
zinc finger protein 367
chr8_+_127789048 0.01 ENSRNOT00000052275
deleted in lung and esophageal cancer 1
chr17_+_44738643 0.01 ENSRNOT00000087643
histone H2A type 1-like
chr15_-_88622413 0.01 ENSRNOT00000092174
POU class 4 homeobox 1
chr3_-_59688692 0.01 ENSRNOT00000078752
Sp3 transcription factor
chr7_+_11784341 0.01 ENSRNOT00000026155
pleckstrin homology domain containing J1
chr10_-_6870011 0.01 ENSRNOT00000003439
similar to CG4768-PA
chr20_+_5114013 0.01 ENSRNOT00000076738
G patch domain and ankyrin repeats 1
chr20_+_6049286 0.01 ENSRNOT00000042143
ENSRNOT00000092566
bromodomain and PHD finger containing, 3
chr3_-_164964702 0.01 ENSRNOT00000014595
activity-dependent neuroprotector homeobox
chr1_+_221448661 0.01 ENSRNOT00000072493
sororin-like
chr19_+_25262076 0.01 ENSRNOT00000030658
hypothetical LOC304654
chr17_+_43734461 0.01 ENSRNOT00000072564
histone cluster 1, H1d
chr5_-_173659675 0.01 ENSRNOT00000027547
kelch-like family member 17
chr16_-_38063821 0.01 ENSRNOT00000077452
ENSRNOT00000089533
glycine receptor, alpha 3
chr1_-_21854763 0.01 ENSRNOT00000089196
ENSRNOT00000020528
connective tissue growth factor
chr9_+_93545396 0.01 ENSRNOT00000025093
hypothetical protein LOC100359583
chr1_+_228337767 0.01 ENSRNOT00000066247
PAT1 homolog 1, processing body mRNA decay factor
chrX_+_54734385 0.01 ENSRNOT00000005023
nuclear receptor subfamily 0, group B, member 1
chr5_-_128186532 0.01 ENSRNOT00000012635
pre-mRNA processing factor 38A
chrX_+_40363646 0.01 ENSRNOT00000010135
spermine synthase
chr10_+_67427066 0.01 ENSRNOT00000035642
ATPase family, AAA domain containing 5
chr19_-_9843673 0.01 ENSRNOT00000015795
GINS complex subunit 3
chr17_-_44748188 0.01 ENSRNOT00000081970
histone H2A type 1-E
chr16_+_7103998 0.01 ENSRNOT00000016581
polybromo 1
chr13_-_80703615 0.01 ENSRNOT00000004599
flavin containing monooxygenase 4
chr15_+_28377996 0.01 ENSRNOT00000078475
Rho guanine nucleotide exchange factor 40
chr2_+_190007216 0.01 ENSRNOT00000015612
S100 calcium binding protein A6
chr17_+_8299131 0.01 ENSRNOT00000083687
predicted gene 45623
chr16_-_37908173 0.01 ENSRNOT00000075026
glycine receptor, alpha 3
chr10_-_46206135 0.01 ENSRNOT00000091471
COP9 signalosome subunit 3
chr15_-_83442008 0.01 ENSRNOT00000039400
mitotic spindle organizing protein 1
chr1_+_273563441 0.01 ENSRNOT00000048691
similar to 60S ribosomal protein L8
chr2_-_84608712 0.01 ENSRNOT00000028561
membrane associated ring-CH-type finger 6
chr6_-_126636484 0.01 ENSRNOT00000088000
ENSRNOT00000063786
GON7, KEOPS complex subunit homolog
chr1_+_48033768 0.01 ENSRNOT00000020064
mitochondrial ribosomal protein L18
chr16_+_80729400 0.01 ENSRNOT00000036383
testis development related protein
chr7_-_49741540 0.00 ENSRNOT00000006523
myogenic factor 6
chr16_+_80729959 0.00 ENSRNOT00000082049
testis development related protein
chr10_-_62699723 0.00 ENSRNOT00000086706
coronin 6
chr6_-_103935122 0.00 ENSRNOT00000058354
hypothetical protein LOC500684
chr1_-_31262466 0.00 ENSRNOT00000029531
mitochondrial ribosomal protein L36
chr7_+_27438351 0.00 ENSRNOT00000077976

chr4_+_62299044 0.00 ENSRNOT00000032077
ATP/GTP binding protein-like 3
chr11_-_89510871 0.00 ENSRNOT00000035247
protein kinase, DNA activated, catalytic polypeptide
chr10_-_36716601 0.00 ENSRNOT00000038838
similar to hypothetical protein 4930503F14
chr7_-_136853154 0.00 ENSRNOT00000087376
neural EGFL like 2
chr14_-_44375804 0.00 ENSRNOT00000042825
ribosomal protein P2-like
chr6_-_2886465 0.00 ENSRNOT00000038448
serine and arginine rich splicing factor 7
chr1_+_167538263 0.00 ENSRNOT00000074058
ribonucleotide reductase catalytic subunit M1
chr19_-_52206310 0.00 ENSRNOT00000087886
membrane-bound transcription factor peptidase, site 1
chr10_+_11206226 0.00 ENSRNOT00000006979
transcription factor AP-4
chr1_-_250727079 0.00 ENSRNOT00000079942
ENSRNOT00000087588
sphingomyelin synthase 1
chr15_+_4356261 0.00 ENSRNOT00000009009
DnaJ heat shock protein family (Hsp40) member C9
chr15_+_83442144 0.00 ENSRNOT00000039344
bora, aurora kinase A activator
chrX_+_113510621 0.00 ENSRNOT00000025912
nuclear transport factor 2-like export factor 2
chr3_+_111597102 0.00 ENSRNOT00000081462
TYRO3 protein tyrosine kinase
chrX_-_128268285 0.00 ENSRNOT00000009755
ENSRNOT00000081880
THO complex 2
chr15_+_45422010 0.00 ENSRNOT00000012231
ribonuclease H2, subunit B
chr1_-_80630038 0.00 ENSRNOT00000025281
translocase of outer mitochondrial membrane 40
chr10_-_59743315 0.00 ENSRNOT00000093646
ER membrane protein complex subunit 6
chr10_+_105796680 0.00 ENSRNOT00000000264
major facilitator superfamily domain containing 11
chr1_-_218810118 0.00 ENSRNOT00000065950
ENSRNOT00000020886
protein phosphatase 6, regulatory subunit 3
chr9_+_81672758 0.00 ENSRNOT00000020646
CTD small phosphatase 1
chr10_+_4313100 0.00 ENSRNOT00000074487
eukaryotic peptide chain release factor GTP-binding subunit ERF3B-like
chr10_-_74119009 0.00 ENSRNOT00000085712
ENSRNOT00000006926
DEAH-box helicase 40
chr14_-_35149608 0.00 ENSRNOT00000003050
ENSRNOT00000090654
KIT proto-oncogene receptor tyrosine kinase
chr6_+_132805794 0.00 ENSRNOT00000006281
WD repeat domain 25
chr7_+_122636171 0.00 ENSRNOT00000068666
X-prolyl aminopeptidase 3
chr13_-_101697684 0.00 ENSRNOT00000078834
BRO1 domain and CAAX motif containing
chr1_-_82546937 0.00 ENSRNOT00000028100
heterogeneous nuclear ribonucleoprotein U-like 1
chr12_+_660011 0.00 ENSRNOT00000040830
PDS5 cohesin associated factor B
chr13_-_45068077 0.00 ENSRNOT00000004969
minichromosome maintenance complex component 6
chr3_-_176431423 0.00 ENSRNOT00000037271
YTH N(6)-methyladenosine RNA binding protein 1
chr9_-_10293980 0.00 ENSRNOT00000072703
dihydrouridine synthase 3-like
chr11_+_89511191 0.00 ENSRNOT00000002510
minichromosome maintenance complex component 4
chr8_+_71514281 0.00 ENSRNOT00000022256
NS5A (hepatitis C virus) transactivated protein 9
chr15_+_61731735 0.00 ENSRNOT00000015517
kelch repeat and BTB domain containing 6
chr1_+_264670841 0.00 ENSRNOT00000034814
ENSRNOT00000082412
SMC5-SMC6 complex localization factor 2

Network of associatons between targets according to the STRING database.

First level regulatory network of E2f2_E2f5

PNG image of the network

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Gene Ontology Analysis

Gene overrepresentation in biological process category:

Log-likelihood per target  Total log-likelihood Term Description
0.0 0.1 GO:0007056 spindle assembly involved in female meiosis(GO:0007056)
0.0 0.1 GO:0006287 base-excision repair, gap-filling(GO:0006287)
0.0 0.1 GO:0006268 DNA unwinding involved in DNA replication(GO:0006268)
0.0 0.0 GO:0035622 intrahepatic bile duct development(GO:0035622)
0.0 0.1 GO:0090080 positive regulation of MAPKKK cascade by fibroblast growth factor receptor signaling pathway(GO:0090080)
0.0 0.1 GO:0071930 negative regulation of transcription involved in G1/S transition of mitotic cell cycle(GO:0071930)
0.0 0.1 GO:0042276 error-prone translesion synthesis(GO:0042276)

Gene overrepresentation in cellular component category:

Log-likelihood per target  Total log-likelihood Term Description
0.0 0.1 GO:0070557 PCNA-p21 complex(GO:0070557)
0.0 0.2 GO:0042555 MCM complex(GO:0042555)
0.0 0.1 GO:0008622 epsilon DNA polymerase complex(GO:0008622)
0.0 0.1 GO:0035985 senescence-associated heterochromatin focus(GO:0035985)
0.0 0.1 GO:0005971 ribonucleoside-diphosphate reductase complex(GO:0005971)
0.0 0.0 GO:0097125 cyclin B1-CDK1 complex(GO:0097125)
0.0 0.0 GO:0031515 tRNA (m1A) methyltransferase complex(GO:0031515)

Gene overrepresentation in molecular function category:

Log-likelihood per target  Total log-likelihood Term Description
0.0 0.1 GO:0004566 beta-glucuronidase activity(GO:0004566)
0.0 0.1 GO:0030337 DNA polymerase processivity factor activity(GO:0030337)
0.0 0.1 GO:0016728 ribonucleoside-diphosphate reductase activity, thioredoxin disulfide as acceptor(GO:0004748) oxidoreductase activity, acting on CH or CH2 groups, disulfide as acceptor(GO:0016728) ribonucleoside-diphosphate reductase activity(GO:0061731)

Gene overrepresentation in curated gene sets: canonical pathways category:

Log-likelihood per target  Total log-likelihood Term Description
0.0 0.2 SA G2 AND M PHASES Cdc25 activates the cdc2/cyclin B complex to induce the G2/M transition.

Gene overrepresentation in curated gene sets: REACTOME pathways category:

Log-likelihood per target  Total log-likelihood Term Description
0.0 0.3 REACTOME UNWINDING OF DNA Genes involved in Unwinding of DNA
0.0 0.4 REACTOME G1 S SPECIFIC TRANSCRIPTION Genes involved in G1/S-Specific Transcription