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GSE49485: Hypoxia transcriptome sequencing of rat brain.

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Results for Ddit3

Z-value: 0.69

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Transcription factors associated with Ddit3

Gene Symbol Gene ID Gene Info
ENSRNOG00000006789 DNA-damage inducible transcript 3

Activity-expression correlation:

GenePromoterPearson corr. coef.P-valuePlot
Ddit3rn6_v1_chr7_+_70580198_70580252-0.494.0e-01Click!

Activity profile of Ddit3 motif

Sorted Z-values of Ddit3 motif

Promoter Log-likelihood Transcript Gene Gene Info
chr19_-_6031655 0.32 ENSRNOT00000092016

chr15_+_64939527 0.29 ENSRNOT00000045865

chr16_-_49820235 0.28 ENSRNOT00000029628
sorbin and SH3 domain containing 2
chr1_+_168668707 0.26 ENSRNOT00000015108

chrX_+_137934484 0.25 ENSRNOT00000049046
hypothetical protein LOC317588
chr2_-_112368557 0.25 ENSRNOT00000075017

chr17_+_48436720 0.25 ENSRNOT00000074309

chr1_-_4560789 0.25 ENSRNOT00000082415
androglobin
chr1_+_79790705 0.24 ENSRNOT00000018233
peptidoglycan recognition protein 1
chr7_-_99808612 0.23 ENSRNOT00000074953

chr1_+_254531659 0.23 ENSRNOT00000091377

chr19_+_24044103 0.19 ENSRNOT00000004621
ring finger protein 150
chr7_-_82687130 0.18 ENSRNOT00000006791
transmembrane protein 74
chr5_-_137104993 0.17 ENSRNOT00000027271
protein tyrosine phosphatase, receptor type, F
chr3_-_158328881 0.16 ENSRNOT00000044466
protein tyrosine phosphatase, receptor type, T
chr1_-_222350173 0.15 ENSRNOT00000030625
fibronectin leucine rich transmembrane protein 1
chr7_+_25919867 0.15 ENSRNOT00000009625
ENSRNOT00000090153
RIC8 guanine nucleotide exchange factor B
chr5_+_14415841 0.15 ENSRNOT00000010682
regulator of G-protein signaling 20
chr7_-_12393266 0.15 ENSRNOT00000021709
ephrin A2
chr9_-_30844199 0.15 ENSRNOT00000017169
collagen type XIX alpha 1 chain
chr5_+_27326762 0.15 ENSRNOT00000066191
RUNX1 translocation partner 1
chrX_+_39711201 0.14 ENSRNOT00000080512
ENSRNOT00000009802
connector enhancer of kinase suppressor of Ras 2
chr13_+_51795867 0.14 ENSRNOT00000006747
ubiquitin-conjugating enzyme E2T
chr4_+_120672152 0.14 ENSRNOT00000077231
monoglyceride lipase
chr3_+_15560712 0.14 ENSRNOT00000010218
prostaglandin-endoperoxide synthase 1
chr15_+_61069581 0.14 ENSRNOT00000084333
von Willebrand factor A domain containing 8
chr6_-_107325345 0.13 ENSRNOT00000049481
ENSRNOT00000042594
ENSRNOT00000013026
NUMB, endocytic adaptor protein
chr1_-_215033460 0.13 ENSRNOT00000044565
dual specificity phosphatase 8
chr7_+_64672722 0.13 ENSRNOT00000064448
ENSRNOT00000005539
glutamate receptor interacting protein 1
chr1_+_142679345 0.13 ENSRNOT00000034267
zinc finger and SCAN domain containing 2
chr6_-_1319541 0.13 ENSRNOT00000006527
striatin
chr9_-_8632017 0.13 ENSRNOT00000043269

chr10_-_2037891 0.12 ENSRNOT00000004563
ERCC excision repair 4, endonuclease catalytic subunit
chr14_+_104250617 0.12 ENSRNOT00000079874
sprouty-related, EVH1 domain containing 2
chr1_-_71173216 0.12 ENSRNOT00000020523
zinc finger protein 28
chr12_+_12624723 0.11 ENSRNOT00000092601
oncomodulin 2
chr2_-_138833933 0.11 ENSRNOT00000013343
protocadherin 18
chr9_-_52238564 0.11 ENSRNOT00000005073
collagen type V alpha 2 chain
chr5_-_164927869 0.11 ENSRNOT00000012080
dorsal inhibitory axon guidance protein
chr20_+_6054199 0.11 ENSRNOT00000092629
bromodomain and PHD finger containing, 3
chr1_-_255171691 0.11 ENSRNOT00000090224

chr4_+_174692331 0.11 ENSRNOT00000011770
pleckstrin homology domain containing A5
chr4_-_155740193 0.10 ENSRNOT00000043229
LRRGT00188
chr10_+_48903540 0.10 ENSRNOT00000004248
transient receptor potential cation channel, subfamily V, member 2
chr13_+_34400170 0.10 ENSRNOT00000061516
ENSRNOT00000061515
ENSRNOT00000061513
ENSRNOT00000084506
ENSRNOT00000086641
cytoplasmic linker associated protein 1
chr8_+_52729003 0.10 ENSRNOT00000081738
neurexophilin and PC-esterase domain family, member 4
chr2_-_38110567 0.10 ENSRNOT00000072212
importin 11
chr18_+_30487264 0.10 ENSRNOT00000040125
protocadherin beta 10
chr15_-_43542939 0.10 ENSRNOT00000012996
dihydropyrimidinase-like 2
chr10_+_49259194 0.09 ENSRNOT00000091100
ENSRNOT00000004390
F-box and WD repeat domain containing 10
chr8_+_82037977 0.09 ENSRNOT00000082288
myosin VA
chr10_+_40543288 0.09 ENSRNOT00000016755
solute carrier family 36 member 1
chr18_+_30895831 0.09 ENSRNOT00000026985
protocadherin gamma subfamily A, 10
chr3_-_38277440 0.09 ENSRNOT00000037857
signal transducing adaptor molecule 2
chr7_+_40217269 0.08 ENSRNOT00000082090
centrosomal protein 290
chr7_-_140502441 0.08 ENSRNOT00000089544
lysine methyltransferase 2D
chr15_-_71779033 0.08 ENSRNOT00000017765
protocadherin 20
chr11_+_38035611 0.08 ENSRNOT00000087603
ENSRNOT00000002695
MX dynamin like GTPase 2
chr10_+_975697 0.08 ENSRNOT00000089404

chr2_+_116970344 0.08 ENSRNOT00000039603
EGF-like and EMI domain containing 1
chr1_+_190462327 0.08 ENSRNOT00000030732
similar to ankyrin repeat domain 26
chr18_+_30387937 0.08 ENSRNOT00000027210
protocadherin beta 4
chr19_+_50848736 0.07 ENSRNOT00000077053
cadherin 13
chr12_-_2592838 0.07 ENSRNOT00000079918
ecotropic viral integration site 5-like
chr1_+_144831523 0.07 ENSRNOT00000039748
mex-3 RNA binding family member B
chr13_-_67688477 0.07 ENSRNOT00000068148
proteoglycan 4
chr7_-_122403667 0.07 ENSRNOT00000088814
megakaryoblastic leukemia (translocation) 1
chr3_-_143899370 0.07 ENSRNOT00000049635
androgen regulated protein
chrX_-_119162518 0.07 ENSRNOT00000073176
ubiquitin-conjugating enzyme E2 W
chr1_+_72882806 0.07 ENSRNOT00000024640
troponin I3, cardiac type
chr3_+_100786862 0.06 ENSRNOT00000080190
brain-derived neurotrophic factor
chr10_-_37215899 0.06 ENSRNOT00000006356
SEC24 homolog A, COPII coat complex component
chr8_+_82038967 0.06 ENSRNOT00000079535
myosin VA
chr20_+_48504264 0.06 ENSRNOT00000087740
cell division cycle 40
chr6_-_125812517 0.06 ENSRNOT00000007061
thyroid hormone receptor interactor 11
chr8_-_21831668 0.06 ENSRNOT00000027897
collagen type V alpha 3 chain
chr1_+_88586837 0.06 ENSRNOT00000080555
zinc finger protein 382
chr10_+_71536533 0.06 ENSRNOT00000088138
acetyl-CoA carboxylase alpha
chr9_-_9142339 0.06 ENSRNOT00000046852
similar to RIKEN cDNA 1700001E04
chr11_+_9642365 0.06 ENSRNOT00000087080
ENSRNOT00000042384
roundabout guidance receptor 1
chr3_-_93734282 0.06 ENSRNOT00000012428
cell cycle associated protein 1
chr18_+_53088994 0.06 ENSRNOT00000091921

chr2_-_221099738 0.06 ENSRNOT00000022947
sorting nexin 7
chr10_+_83081168 0.06 ENSRNOT00000035023
tachykinin 4 (hemokinin)
chr12_+_32103198 0.05 ENSRNOT00000085464
transmembrane protein 132D
chr7_-_124367630 0.05 ENSRNOT00000055978
tubulin tyrosine ligase like 1
chr4_-_28224858 0.05 ENSRNOT00000091075

chr15_+_39638510 0.05 ENSRNOT00000037800
RCC1 and BTB domain containing protein 1
chr19_+_30794571 0.05 ENSRNOT00000024390
ENSRNOT00000083219
GRB2-associated binding protein 1
chr10_-_104748003 0.05 ENSRNOT00000042372
ENSRNOT00000046754
acyl-CoA oxidase 1
chr15_-_4399589 0.05 ENSRNOT00000065858
ENSRNOT00000079812
family with sequence similarity 149, member B1
chr2_+_85377318 0.05 ENSRNOT00000016506
ENSRNOT00000085094
semaphorin 5A
chr14_-_18862407 0.05 ENSRNOT00000003823
C-X-C motif chemokine ligand 6
chr6_+_86852323 0.05 ENSRNOT00000059244
Fanconi anemia, complementation group M
chr5_+_106952082 0.05 ENSRNOT00000046931
similar to put. precursor MuIFN-alpha 5
chr2_-_196270826 0.05 ENSRNOT00000028609
phosphatidylinositol-4-phosphate 5-kinase, type 1, alpha
chr15_-_36798814 0.05 ENSRNOT00000065764
centromere protein J
chr1_-_214504569 0.04 ENSRNOT00000082221
chitinase domain containing 1
chr16_+_23668595 0.04 ENSRNOT00000067886
pleckstrin and Sec7 domain containing 3
chr1_-_214067657 0.04 ENSRNOT00000044390
chitinase domain-containing protein 1-like
chrX_+_156812064 0.04 ENSRNOT00000077142
host cell factor C1
chr11_-_87485833 0.04 ENSRNOT00000079948

chr2_-_34922721 0.04 ENSRNOT00000017832
CWC27 spliceosome-associated protein homolog
chr1_+_267618248 0.04 ENSRNOT00000017186
glutathione S-transferase omega 2
chr18_+_57654290 0.03 ENSRNOT00000025892
5-hydroxytryptamine receptor 4
chr11_+_80319177 0.03 ENSRNOT00000036777
receptor (chemosensory) transporter protein 2
chr8_-_21481735 0.03 ENSRNOT00000038069
zinc finger protein 426
chr8_+_22368745 0.03 ENSRNOT00000049973
solute carrier family 44 member 2
chr1_-_233145924 0.03 ENSRNOT00000018763
ENSRNOT00000082442
phosphoserine aminotransferase 1
chr2_-_122690617 0.03 ENSRNOT00000018942
methylcrotonoyl-CoA carboxylase 1
chr1_+_72356880 0.03 ENSRNOT00000021917
zinc finger protein 865
chr15_+_27739251 0.03 ENSRNOT00000011840
poly (ADP-ribose) polymerase 2
chr13_-_74520634 0.03 ENSRNOT00000077169
Ral GEF with PH domain and SH3 binding motif 2
chr10_+_86711240 0.03 ENSRNOT00000012812
male specific lethal 1 homolog
chr1_+_91152635 0.03 ENSRNOT00000073438
dermokine-like
chr1_+_101397828 0.03 ENSRNOT00000028189
potassium voltage-gated channel subfamily A member 7
chr15_-_28155291 0.02 ENSRNOT00000050820
ribonuclease A family member 2
chr14_-_37361798 0.02 ENSRNOT00000002980
cell wall biogenesis 43 C-terminal homolog
chr1_+_174655939 0.02 ENSRNOT00000014002
importin 7
chr5_+_172259520 0.02 ENSRNOT00000037211
tetratricopeptide repeat domain 34
chr2_-_149563905 0.02 ENSRNOT00000086186
immunoglobulin superfamily, member 10
chr6_-_23581052 0.02 ENSRNOT00000006190
protein phosphatase 1 catalytic subunit beta
chr1_+_169590308 0.02 ENSRNOT00000023147
olfactory receptor 155
chrX_-_159841072 0.02 ENSRNOT00000001158
Rac/Cdc42 guanine nucleotide exchange factor 6
chr12_+_13508933 0.02 ENSRNOT00000083976
ring finger protein 216
chr10_-_45514878 0.02 ENSRNOT00000036940
IBA57 homolog, iron-sulfur cluster assembly
chr1_-_171979933 0.02 ENSRNOT00000026744
cytochrome b5 reductase 2
chr1_-_264294630 0.02 ENSRNOT00000035758
SEC31 homolog B, COPII coat complex component
chr12_+_8032809 0.02 ENSRNOT00000082850
solute carrier family 7 member 1
chr2_-_22105710 0.02 ENSRNOT00000017705
zinc finger FYVE-type containing 16
chr10_-_107324355 0.02 ENSRNOT00000064450
ubiquitin specific peptidase 36
chr4_+_170820594 0.02 ENSRNOT00000032568
similar to C030030A07Rik protein
chr8_+_85259982 0.02 ENSRNOT00000010409
ELOVL fatty acid elongase 5
chr7_+_70335061 0.02 ENSRNOT00000072176
ENSRNOT00000084933
cytochrome P450, family 27, subfamily b, polypeptide 1
chr18_+_30808404 0.02 ENSRNOT00000060475
protocadherin gamma subfamily A, 1
chr7_+_12433933 0.02 ENSRNOT00000060690
CACN beta subunit associated regulatory protein
chr8_+_79638696 0.02 ENSRNOT00000085959
dyslexia susceptibility 1 candidate 1
chr6_-_26241337 0.01 ENSRNOT00000006525
solute carrier family 4 member 1 adaptor protein
chr7_+_80625010 0.01 ENSRNOT00000084940
oxidation resistance 1
chr10_-_70681672 0.01 ENSRNOT00000013836
matrix metallopeptidase 28
chr15_-_24374753 0.01 ENSRNOT00000016274
autophagy related 14
chr16_-_18645941 0.01 ENSRNOT00000079241
DPY30 domain containing 2
chrM_-_14061 0.01 ENSRNOT00000051268
mitochondrially encoded NADH dehydrogenase 6
chr2_+_18937458 0.01 ENSRNOT00000022377
transmembrane protein 167A
chr2_+_27003783 0.01 ENSRNOT00000061507
POC5 centriolar protein
chr3_-_45210474 0.01 ENSRNOT00000091777
coiled-coil domain containing 148
chr2_-_45480798 0.01 ENSRNOT00000066764
sorting nexin 18
chr20_+_48503973 0.01 ENSRNOT00000064081
cell division cycle 40
chr3_+_152294656 0.01 ENSRNOT00000027067
PHD finger protein 20
chr15_+_28439317 0.01 ENSRNOT00000060519
similar to ribosomal protein L31
chr10_-_88036040 0.01 ENSRNOT00000018851
keratin 13
chr2_-_149564113 0.01 ENSRNOT00000018628
immunoglobulin superfamily, member 10
chrX_+_31054394 0.01 ENSRNOT00000037439
similar to ribonucleic acid binding protein S1
chr18_-_30781292 0.01 ENSRNOT00000027125
TATA-box binding protein associated factor 7
chr1_-_171979757 0.01 ENSRNOT00000079844
cytochrome b5 reductase 2
chr9_-_17880706 0.01 ENSRNOT00000031549
alanyl-tRNA synthetase 2, mitochondrial
chr9_-_92775816 0.01 ENSRNOT00000029635
similar to Nuclear autoantigen Sp-100 (Speckled 100 kDa)
chr1_-_88723973 0.00 ENSRNOT00000082555
WD repeat domain 62-like 1
chr19_-_43528851 0.00 ENSRNOT00000036972
mixed lineage kinase domain like pseudokinase
chr4_+_98457810 0.00 ENSRNOT00000074175

chr19_+_57286985 0.00 ENSRNOT00000058074
component of oligomeric golgi complex 2
chr12_+_11240761 0.00 ENSRNOT00000001310
PDGFA associated protein 1
chr9_-_55256340 0.00 ENSRNOT00000028907
serum deprivation response
chr19_+_55206455 0.00 ENSRNOT00000039273
zinc finger CCCH-type containing 18

Network of associatons between targets according to the STRING database.

First level regulatory network of Ddit3

PNG image of the network

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Gene Ontology Analysis

Gene overrepresentation in biological process category:

Log-likelihood per target  Total log-likelihood Term Description
0.1 0.3 GO:0032197 transposition, RNA-mediated(GO:0032197)
0.0 0.1 GO:0021849 neuroblast division in subventricular zone(GO:0021849)
0.0 0.1 GO:0006296 nucleotide-excision repair, DNA incision, 5'-to lesion(GO:0006296)
0.0 0.2 GO:0032815 negative regulation of natural killer cell activation(GO:0032815)
0.0 0.2 GO:0051643 endoplasmic reticulum localization(GO:0051643)
0.0 0.1 GO:0035519 protein K29-linked ubiquitination(GO:0035519)
0.0 0.1 GO:2000124 regulation of endocannabinoid signaling pathway(GO:2000124)
0.0 0.1 GO:0048691 positive regulation of sprouting of injured axon(GO:0048687) positive regulation of axon extension involved in regeneration(GO:0048691)
0.0 0.2 GO:0051387 negative regulation of neurotrophin TRK receptor signaling pathway(GO:0051387)
0.0 0.1 GO:0019371 cyclooxygenase pathway(GO:0019371)
0.0 0.1 GO:1903225 negative regulation of endodermal cell differentiation(GO:1903225)
0.0 0.1 GO:0021836 chemorepulsion involved in postnatal olfactory bulb interneuron migration(GO:0021836)
0.0 0.1 GO:0033540 fatty acid beta-oxidation using acyl-CoA oxidase(GO:0033540)
0.0 0.1 GO:0045409 negative regulation of interleukin-6 biosynthetic process(GO:0045409)
0.0 0.1 GO:0001555 oocyte growth(GO:0001555)
0.0 0.0 GO:0070949 regulation of neutrophil mediated cytotoxicity(GO:0070948) regulation of neutrophil mediated killing of symbiont cell(GO:0070949)
0.0 0.1 GO:0044268 multicellular organismal protein metabolic process(GO:0044268) malonyl-CoA biosynthetic process(GO:2001295)
0.0 0.1 GO:0072697 protein localization to cell cortex(GO:0072697)
0.0 0.1 GO:0006610 ribosomal protein import into nucleus(GO:0006610)
0.0 0.1 GO:0015808 L-alanine transport(GO:0015808)
0.0 0.0 GO:0061511 centriole elongation(GO:0061511)
0.0 0.1 GO:0046878 positive regulation of saliva secretion(GO:0046878)
0.0 0.0 GO:0019046 viral latency(GO:0019042) release from viral latency(GO:0019046)

Gene overrepresentation in cellular component category:

Log-likelihood per target  Total log-likelihood Term Description
0.1 0.2 GO:0042642 actomyosin, myosin complex part(GO:0042642)
0.0 0.2 GO:0005588 collagen type V trimer(GO:0005588)
0.0 0.1 GO:0000110 nucleotide-excision repair factor 1 complex(GO:0000110)
0.0 0.1 GO:0031592 centrosomal corona(GO:0031592)
0.0 0.1 GO:1990584 cardiac Troponin complex(GO:1990584)
0.0 0.1 GO:0002079 inner acrosomal membrane(GO:0002079)
0.0 0.1 GO:0032584 growth cone membrane(GO:0032584)
0.0 0.1 GO:0070775 H3 histone acetyltransferase complex(GO:0070775) MOZ/MORF histone acetyltransferase complex(GO:0070776)

Gene overrepresentation in molecular function category:

Log-likelihood per target  Total log-likelihood Term Description
0.1 0.2 GO:0035373 chondroitin sulfate proteoglycan binding(GO:0035373)
0.0 0.2 GO:0042834 peptidoglycan binding(GO:0042834)
0.0 0.1 GO:1990599 3' overhang single-stranded DNA endodeoxyribonuclease activity(GO:1990599)
0.0 0.1 GO:0005302 L-tyrosine transmembrane transporter activity(GO:0005302)
0.0 0.3 GO:0045294 alpha-catenin binding(GO:0045294)
0.0 0.1 GO:0055100 adiponectin binding(GO:0055100)
0.0 0.1 GO:0005173 stem cell factor receptor binding(GO:0005173)
0.0 0.1 GO:0030172 troponin C binding(GO:0030172)
0.0 0.1 GO:0003989 acetyl-CoA carboxylase activity(GO:0003989)
0.0 0.1 GO:0070016 armadillo repeat domain binding(GO:0070016)
0.0 0.3 GO:0004198 calcium-dependent cysteine-type endopeptidase activity(GO:0004198)
0.0 0.1 GO:0043515 kinetochore binding(GO:0043515)
0.0 0.1 GO:0047372 acylglycerol lipase activity(GO:0047372)
0.0 0.1 GO:0003997 acyl-CoA oxidase activity(GO:0003997)

Gene overrepresentation in curated gene sets: REACTOME pathways category:

Log-likelihood per target  Total log-likelihood Term Description
0.0 0.2 REACTOME HORMONE SENSITIVE LIPASE HSL MEDIATED TRIACYLGLYCEROL HYDROLYSIS Genes involved in Hormone-sensitive lipase (HSL)-mediated triacylglycerol hydrolysis