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GSE49485: Hypoxia transcriptome sequencing of rat brain.
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Results for Cux1
Z-value: 0.73
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Transcription factors associated with Cux1
Activity-expression correlation:
| Gene | Promoter | Pearson corr. coef. | P-value | Plot |
|---|---|---|---|---|
| Cux1 | rn6_v1_chr12_+_23151180_23151180 | -0.01 | 9.8e-01 | Click! |
| Promoter | Log-likelihood | Transcript | Gene | Gene Info |
|---|---|---|---|---|
| chr4_+_22859622 Show fit | 0.37 |
ENSRNOT00000073501
ENSRNOT00000068410 |
ADAM metallopeptidase domain 22 |
|
| chr19_-_39267928 Show fit | 0.34 |
ENSRNOT00000027686
|
transmembrane p24 trafficking protein 6 |
|
| chr2_-_157058194 Show fit | 0.33 |
ENSRNOT00000076409
|
|
|
| chr15_-_30147793 Show fit | 0.31 |
ENSRNOT00000060399
|
|
|
| chr15_+_36865548 Show fit | 0.30 |
ENSRNOT00000076460
|
poly (ADP-ribose) polymerase family, member 4 |
|
| chr5_+_142875773 Show fit | 0.27 |
ENSRNOT00000082120
ENSRNOT00000056496 |
EPH receptor A10 |
|
| chr11_-_60882379 Show fit | 0.27 |
ENSRNOT00000002799
|
CD200 receptor 1 |
|
| chr2_+_23289374 Show fit | 0.26 |
ENSRNOT00000090666
ENSRNOT00000032783 |
dimethylglycine dehydrogenase |
|
| chr11_-_62451149 Show fit | 0.26 |
ENSRNOT00000093686
ENSRNOT00000081443 |
zinc finger and BTB domain containing 20 |
|
| chr4_+_61814974 Show fit | 0.23 |
ENSRNOT00000074951
|
aldo-keto reductase family 1 member B10 |
Network of associatons between targets according to the STRING database.
First level regulatory network of Cux1
Gene Ontology Analysis
Gene overrepresentation in biological process category:
| Log-likelihood per target | Total log-likelihood | Term | Description |
|---|---|---|---|
| 0.0 | 0.4 | GO:0022011 | myelination in peripheral nervous system(GO:0022011) peripheral nervous system axon ensheathment(GO:0032292) |
| 0.1 | 0.3 | GO:0006579 | amino-acid betaine catabolic process(GO:0006579) |
| 0.0 | 0.3 | GO:0015860 | purine nucleoside transmembrane transport(GO:0015860) |
| 0.0 | 0.3 | GO:2000819 | regulation of nucleotide-excision repair(GO:2000819) |
| 0.0 | 0.3 | GO:0032728 | positive regulation of interferon-beta production(GO:0032728) |
| 0.1 | 0.2 | GO:0045959 | negative regulation of complement activation, classical pathway(GO:0045959) |
| 0.1 | 0.2 | GO:0006714 | sesquiterpenoid metabolic process(GO:0006714) polyprenol catabolic process(GO:0016095) |
| 0.1 | 0.2 | GO:0046338 | phosphatidylethanolamine catabolic process(GO:0046338) |
| 0.1 | 0.2 | GO:0036394 | amylase secretion(GO:0036394) |
| 0.1 | 0.2 | GO:0072642 | type I interferon secretion(GO:0072641) interferon-alpha secretion(GO:0072642) regulation of interferon-alpha secretion(GO:1902739) positive regulation of interferon-alpha secretion(GO:1902741) |
Gene overrepresentation in cellular component category:
| Log-likelihood per target | Total log-likelihood | Term | Description |
|---|---|---|---|
| 0.1 | 0.3 | GO:0031230 | intrinsic component of cell outer membrane(GO:0031230) integral component of cell outer membrane(GO:0045203) |
| 0.0 | 0.2 | GO:0042584 | chromaffin granule membrane(GO:0042584) |
| 0.0 | 0.2 | GO:0071821 | FANCM-MHF complex(GO:0071821) |
| 0.0 | 0.2 | GO:0032591 | dendritic spine membrane(GO:0032591) |
| 0.0 | 0.2 | GO:0044666 | MLL3/4 complex(GO:0044666) |
| 0.0 | 0.2 | GO:0044224 | juxtaparanode region of axon(GO:0044224) |
| 0.0 | 0.1 | GO:0000839 | Hrd1p ubiquitin ligase ERAD-L complex(GO:0000839) |
| 0.0 | 0.1 | GO:1990604 | IRE1-TRAF2-ASK1 complex(GO:1990604) |
| 0.0 | 0.1 | GO:0005760 | gamma DNA polymerase complex(GO:0005760) |
| 0.0 | 0.1 | GO:0008275 | gamma-tubulin small complex(GO:0008275) |
Gene overrepresentation in molecular function category:
| Log-likelihood per target | Total log-likelihood | Term | Description |
|---|---|---|---|
| 0.1 | 0.4 | GO:0005005 | transmembrane-ephrin receptor activity(GO:0005005) |
| 0.0 | 0.3 | GO:0005542 | folic acid binding(GO:0005542) |
| 0.0 | 0.3 | GO:0008137 | NADH dehydrogenase (ubiquinone) activity(GO:0008137) NADH dehydrogenase (quinone) activity(GO:0050136) |
| 0.1 | 0.2 | GO:0043533 | inositol 1,3,4,5 tetrakisphosphate binding(GO:0043533) |
| 0.1 | 0.2 | GO:0005415 | nucleoside:sodium symporter activity(GO:0005415) |
| 0.0 | 0.2 | GO:0071558 | histone demethylase activity (H3-K27 specific)(GO:0071558) |
| 0.0 | 0.2 | GO:0052650 | NADP-retinol dehydrogenase activity(GO:0052650) |
| 0.0 | 0.2 | GO:0005131 | growth hormone receptor binding(GO:0005131) |
| 0.0 | 0.2 | GO:0047499 | calcium-independent phospholipase A2 activity(GO:0047499) |
| 0.0 | 0.2 | GO:0017108 | 5'-flap endonuclease activity(GO:0017108) |
Gene overrepresentation in curated gene sets: canonical pathways category:
| Log-likelihood per target | Total log-likelihood | Term | Description |
|---|---|---|---|
| 0.0 | 0.2 | ST IL 13 PATHWAY | Interleukin 13 (IL-13) Pathway |
| 0.0 | 0.1 | PID GLYPICAN 1PATHWAY | Glypican 1 network |
| 0.0 | 0.1 | PID HNF3A PATHWAY | FOXA1 transcription factor network |
Gene overrepresentation in curated gene sets: REACTOME pathways category:
| Log-likelihood per target | Total log-likelihood | Term | Description |
|---|---|---|---|
| 0.0 | 0.3 | REACTOME HOMOLOGOUS RECOMBINATION REPAIR OF REPLICATION INDEPENDENT DOUBLE STRAND BREAKS | Genes involved in Homologous recombination repair of replication-independent double-strand breaks |
| 0.0 | 0.2 | REACTOME IL 6 SIGNALING | Genes involved in Interleukin-6 signaling |
| 0.0 | 0.2 | REACTOME REGULATION OF COMPLEMENT CASCADE | Genes involved in Regulation of Complement cascade |
| 0.0 | 0.1 | REACTOME PROSTANOID LIGAND RECEPTORS | Genes involved in Prostanoid ligand receptors |
| 0.0 | 0.1 | REACTOME IKK COMPLEX RECRUITMENT MEDIATED BY RIP1 | Genes involved in IKK complex recruitment mediated by RIP1 |