ISMARA results: Ctcfl

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GSE49485: Hypoxia transcriptome sequencing of rat brain.

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Results for Ctcfl_Ctcf

Z-value: 1.09

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Transcription factors associated with Ctcfl_Ctcf

Gene Symbol	Gene ID	Gene Info
Ctcfl NCBI RGD Ensembl	ENSRNOG00000028661	CCCTC-binding factor like
Ctcf NCBI RGD Ensembl	ENSRNOG00000017674	CCCTC-binding factor

Activity-expression correlation:

Gene	Promoter	Pearson corr. coef.	P-value	Plot
Ctcfl	rn6_v1_chr3_-_171166454_171166454	0.29	6.3e-01	Click!
Ctcf	rn6_v1_chr19_+_37600148_37600148	0.12	8.5e-01	Click!

Activity profile of Ctcfl_Ctcf motif

Sorted Z-values of Ctcfl_Ctcf motif

Top targets:

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Promoter	Log-likelihood	Transcript	Gene	Gene Info
chr17_-_9695292 Show fit	1.62	ENSRNOT00000036162	Prr7 NCBI RGD Ensembl Show fit	proline rich 7 (synaptic)
chr10_-_15600858 Show fit	0.95	ENSRNOT00000035459	Hbq1b NCBI RGD Ensembl Show fit	hemoglobin, theta 1B
chr19_+_41482728 Show fit	0.77	ENSRNOT00000022943	Calb2 NCBI RGD Ensembl Show fit	calbindin 2
chr3_+_164424515 Show fit	0.60	ENSRNOT00000083876	Cebpb NCBI RGD Ensembl Show fit	CCAAT/enhancer binding protein beta
chr12_+_47551935 Show fit	0.59	ENSRNOT00000056932	RGD1560398 NCBI RGD Ensembl Show fit	RGD1560398
chr12_+_24651314 Show fit	0.58	ENSRNOT00000077016 ENSRNOT00000071569	Vps37d NCBI RGD Ensembl Show fit	VPS37D, ESCRT-I subunit
chr16_+_21282467 Show fit	0.47	ENSRNOT00000065345	Yjefn3 NCBI RGD Ensembl Show fit	YjeF N-terminal domain containing 3
chr6_+_137997335 Show fit	0.47	ENSRNOT00000006872	Tmem121 NCBI RGD Ensembl Show fit	transmembrane protein 121
chr10_-_90393317 Show fit	0.46	ENSRNOT00000028563	Fam171a2 NCBI RGD Ensembl Show fit	family with sequence similarity 171, member A2
chr19_-_26094756 Show fit	0.42	ENSRNOT00000067780	Junb NCBI RGD Ensembl Show fit	JunB proto-oncogene, AP-1 transcription factor subunit

Showing 1 to 10 of 200 entries

Network of associatons between targets according to the STRING database.

First level regulatory network of Ctcfl_Ctcf

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Gene Ontology Analysis

Gene overrepresentation in biological process category:

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Log-likelihood per target	Total log-likelihood	Term	Description
0.2	0.6	GO:0035711	granuloma formation(GO:0002432) T-helper 1 cell activation(GO:0035711)
0.1	0.4	GO:0002339	B cell selection(GO:0002339) post-embryonic camera-type eye morphogenesis(GO:0048597)
0.1	0.4	GO:0060136	embryonic process involved in female pregnancy(GO:0060136)
0.0	0.4	GO:0000185	activation of MAPKKK activity(GO:0000185)
0.1	0.3	GO:2000424	regulation of eosinophil chemotaxis(GO:2000422) positive regulation of eosinophil chemotaxis(GO:2000424)
0.1	0.3	GO:0001560	regulation of cell growth by extracellular stimulus(GO:0001560)
0.1	0.3	GO:0090290	positive regulation of osteoclast proliferation(GO:0090290)
0.1	0.3	GO:1904211	membrane protein proteolysis involved in retrograde protein transport, ER to cytosol(GO:1904211)
0.1	0.3	GO:0042322	negative regulation of circadian sleep/wake cycle, REM sleep(GO:0042322)
0.1	0.3	GO:0051562	negative regulation of mitochondrial calcium ion concentration(GO:0051562)

Showing 1 to 10 of 83 entries

Gene overrepresentation in cellular component category:

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Log-likelihood per target	Total log-likelihood	Term	Description
0.0	0.8	GO:0005921	gap junction(GO:0005921)
0.2	0.6	GO:0036488	CHOP-C/EBP complex(GO:0036488)
0.1	0.6	GO:0000813	ESCRT I complex(GO:0000813)
0.1	0.4	GO:0035976	AP1 complex(GO:0035976)
0.0	0.4	GO:0031307	integral component of mitochondrial outer membrane(GO:0031307)
0.1	0.3	GO:0097232	lamellar body membrane(GO:0097232) alveolar lamellar body membrane(GO:0097233)
0.0	0.3	GO:1990246	uniplex complex(GO:1990246)
0.0	0.3	GO:0071458	integral component of cytoplasmic side of endoplasmic reticulum membrane(GO:0071458) integral component of lumenal side of endoplasmic reticulum membrane(GO:0071556) lumenal side of endoplasmic reticulum membrane(GO:0098553)
0.1	0.2	GO:0005944	phosphatidylinositol 3-kinase complex, class IB(GO:0005944)
0.0	0.2	GO:0042825	TAP complex(GO:0042825)

Showing 1 to 10 of 35 entries

Gene overrepresentation in molecular function category:

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Log-likelihood per target	Total log-likelihood	Term	Description
0.0	0.4	GO:0051400	BH domain binding(GO:0051400)
0.0	0.4	GO:0016854	racemase and epimerase activity(GO:0016854)
0.0	0.4	GO:0035259	glucocorticoid receptor binding(GO:0035259)
0.1	0.3	GO:0035514	DNA demethylase activity(GO:0035514)
0.1	0.3	GO:0031705	bombesin receptor binding(GO:0031705)
0.0	0.3	GO:0097109	neuroligin family protein binding(GO:0097109)
0.0	0.3	GO:0042500	aspartic endopeptidase activity, intramembrane cleaving(GO:0042500)
0.0	0.3	GO:0035374	chondroitin sulfate binding(GO:0035374)
0.0	0.3	GO:0051378	serotonin binding(GO:0051378)
0.1	0.2	GO:0042296	ISG15 transferase activity(GO:0042296)

Showing 1 to 10 of 49 entries

Gene overrepresentation in curated gene sets: canonical pathways category:

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Total log-likelihood	Term	Description
0.6	PID IL3 PATHWAY	IL3-mediated signaling events
0.5	SA PROGRAMMED CELL DEATH	Programmed cell death, or apoptosis, eliminates damaged or unneeded cells.
0.5	PID IL27 PATHWAY	IL27-mediated signaling events
0.5	PID IL6 7 PATHWAY	IL6-mediated signaling events
0.4	PID P38 MKK3 6PATHWAY	p38 MAPK signaling pathway
0.3	PID NECTIN PATHWAY	Nectin adhesion pathway
0.2	PID PDGFRA PATHWAY	PDGFR-alpha signaling pathway
0.1	PID IL8 CXCR1 PATHWAY	IL8- and CXCR1-mediated signaling events

Showing 1 to 8 of 8 entries

Gene overrepresentation in curated gene sets: REACTOME pathways category:

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Log-likelihood per target	Total log-likelihood	Term	Description
0.1	0.6	REACTOME MEMBRANE BINDING AND TARGETTING OF GAG PROTEINS	Genes involved in Membrane binding and targetting of GAG proteins
0.0	0.5	REACTOME INTRINSIC PATHWAY FOR APOPTOSIS	Genes involved in Intrinsic Pathway for Apoptosis
0.0	0.4	REACTOME SMAD2 SMAD3 SMAD4 HETEROTRIMER REGULATES TRANSCRIPTION	Genes involved in SMAD2/SMAD3:SMAD4 heterotrimer regulates transcription
0.0	0.3	REACTOME ROLE OF DCC IN REGULATING APOPTOSIS	Genes involved in Role of DCC in regulating apoptosis
0.0	0.3	REACTOME SEROTONIN RECEPTORS	Genes involved in Serotonin receptors
0.0	0.3	REACTOME CRMPS IN SEMA3A SIGNALING	Genes involved in CRMPs in Sema3A signaling
0.0	0.3	REACTOME ABCA TRANSPORTERS IN LIPID HOMEOSTASIS	Genes involved in ABCA transporters in lipid homeostasis
0.0	0.3	REACTOME KINESINS	Genes involved in Kinesins
0.0	0.1	REACTOME PHOSPHORYLATION OF CD3 AND TCR ZETA CHAINS	Genes involved in Phosphorylation of CD3 and TCR zeta chains
0.0	0.1	REACTOME GAP JUNCTION DEGRADATION	Genes involved in Gap junction degradation

Showing 1 to 10 of 10 entries

Results for Ctcfl_Ctcf

Z-value: 1.09

Motif logo

Transcription factors associated with Ctcfl_Ctcf

Activity-expression correlation:

Activity profile of Ctcfl_Ctcf motif

Sorted Z-values of Ctcfl_Ctcf motif

Top targets:

Network of associatons between targets according to the STRING database.

First level regulatory network of Ctcfl_Ctcf

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Gene Ontology Analysis

Gene overrepresentation in biological process category:

Gene overrepresentation in cellular component category:

Gene overrepresentation in molecular function category:

Gene overrepresentation in curated gene sets: canonical pathways category:

Gene overrepresentation in curated gene sets: REACTOME pathways category: