ISMARA results: Atoh1

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GSE49485: Hypoxia transcriptome sequencing of rat brain.

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Results for Atoh1_Bhlhe23

Z-value: 0.56

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Transcription factors associated with Atoh1_Bhlhe23

Gene Symbol	Gene ID	Gene Info
Atoh1 NCBI RGD Ensembl	ENSRNOG00000006383	atonal bHLH transcription factor 1
Bhlhe23 NCBI RGD Ensembl	ENSRNOG00000010312	basic helix-loop-helix family, member e23

Activity-expression correlation:

Gene	Promoter	Pearson corr. coef.	P-value	Plot
Atoh1	rn6_v1_chr4_+_95498003_95498003	0.88	5.1e-02	Click!
Bhlhe23	rn6_v1_chr3_-_176282211_176282211	0.69	1.9e-01	Click!

Activity profile of Atoh1_Bhlhe23 motif

Sorted Z-values of Atoh1_Bhlhe23 motif

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Promoter	Log-likelihood	Transcript	Gene	Gene Info
chr3_-_66417741 Show fit	0.75	ENSRNOT00000007662	Neurod1 NCBI RGD Ensembl Show fit	neuronal differentiation 1
chr10_-_63952726 Show fit	0.33	ENSRNOT00000090461	Doc2b NCBI RGD Ensembl Show fit	double C2 domain beta
chr8_+_69971778 Show fit	0.26	ENSRNOT00000058007 ENSRNOT00000037941 ENSRNOT00000050649	Megf11 NCBI RGD Ensembl Show fit	multiple EGF-like-domains 11
chr7_-_114848414 Show fit	0.26	ENSRNOT00000032620	Slc45a4 NCBI RGD Ensembl Show fit	solute carrier family 45, member 4
chr5_-_12563429 Show fit	0.23	ENSRNOT00000059625	St18 NCBI RGD Ensembl Show fit	suppression of tumorigenicity 18
chr8_-_63750531 Show fit	0.20	ENSRNOT00000009496	Neo1 NCBI RGD Ensembl Show fit	neogenin 1
chr4_-_31730386 Show fit	0.20	ENSRNOT00000013817	Slc25a13 NCBI RGD Ensembl Show fit	solute carrier family 25 member 13
chr7_-_117978787 Show fit	0.19	ENSRNOT00000074262	Zfp647 NCBI RGD Ensembl Show fit	zinc finger protein 647
chr3_-_66335869 Show fit	0.17	ENSRNOT00000079781 ENSRNOT00000043238 ENSRNOT00000073412 ENSRNOT00000057878 ENSRNOT00000079212	Cerkl NCBI RGD Ensembl Show fit	ceramide kinase-like
chr5_-_12526962 Show fit	0.17	ENSRNOT00000092104	St18 NCBI RGD Ensembl Show fit	suppression of tumorigenicity 18

Showing 1 to 10 of 90 entries

Network of associatons between targets according to the STRING database.

First level regulatory network of Atoh1_Bhlhe23

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Gene Ontology Analysis

Gene overrepresentation in biological process category:

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Log-likelihood per target	Total log-likelihood	Term	Description
0.2	0.8	GO:0060729	intestinal epithelial structure maintenance(GO:0060729)
0.1	0.3	GO:0015770	disaccharide transport(GO:0015766) sucrose transport(GO:0015770) oligosaccharide transport(GO:0015772)
0.0	0.3	GO:0031340	positive regulation of vesicle fusion(GO:0031340)
0.0	0.3	GO:0010842	retina layer formation(GO:0010842)
0.1	0.2	GO:1901581	post-embryonic appendage morphogenesis(GO:0035120) post-embryonic limb morphogenesis(GO:0035127) post-embryonic forelimb morphogenesis(GO:0035128) telomeric repeat-containing RNA transcription(GO:0097393) telomeric repeat-containing RNA transcription from RNA pol II promoter(GO:0097394) regulation of telomeric RNA transcription from RNA pol II promoter(GO:1901580) negative regulation of telomeric RNA transcription from RNA pol II promoter(GO:1901581) positive regulation of telomeric RNA transcription from RNA pol II promoter(GO:1901582)
0.1	0.2	GO:1904694	negative regulation of vascular smooth muscle contraction(GO:1904694)
0.0	0.2	GO:0043490	malate-aspartate shuttle(GO:0043490)
0.0	0.2	GO:0048022	negative regulation of melanin biosynthetic process(GO:0048022) negative regulation of secondary metabolite biosynthetic process(GO:1900377)
0.0	0.2	GO:2000766	negative regulation of cytoplasmic translation(GO:2000766)
0.0	0.2	GO:0048681	negative regulation of axon regeneration(GO:0048681)

Showing 1 to 10 of 17 entries

Gene overrepresentation in cellular component category:

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Log-likelihood per target	Total log-likelihood	Term	Description
0.1	0.2	GO:1990421	subtelomeric heterochromatin(GO:1990421) nuclear subtelomeric heterochromatin(GO:1990707)
0.0	0.1	GO:0071598	neuronal ribonucleoprotein granule(GO:0071598)

Showing 1 to 2 of 2 entries

Gene overrepresentation in molecular function category:

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Log-likelihood per target	Total log-likelihood	Term	Description
0.0	0.8	GO:0001102	RNA polymerase II activating transcription factor binding(GO:0001102)
0.1	0.3	GO:0015154	sucrose:proton symporter activity(GO:0008506) sucrose transmembrane transporter activity(GO:0008515) disaccharide transmembrane transporter activity(GO:0015154) oligosaccharide transmembrane transporter activity(GO:0015157)
0.0	0.2	GO:0015183	L-aspartate transmembrane transporter activity(GO:0015183)
0.0	0.2	GO:0001729	ceramide kinase activity(GO:0001729)
0.0	0.2	GO:0015616	DNA translocase activity(GO:0015616)
0.0	0.2	GO:0031697	beta-1 adrenergic receptor binding(GO:0031697)
0.0	0.2	GO:0039706	co-receptor binding(GO:0039706)
0.0	0.2	GO:0030215	semaphorin receptor binding(GO:0030215)
0.0	0.2	GO:0000900	translation repressor activity, nucleic acid binding(GO:0000900)
0.0	0.1	GO:0001069	regulatory region RNA binding(GO:0001069)

Showing 1 to 10 of 14 entries

Gene overrepresentation in curated gene sets: REACTOME pathways category:

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Log-likelihood per target	Total log-likelihood	Term	Description
0.0	0.7	REACTOME REGULATION OF GENE EXPRESSION IN BETA CELLS	Genes involved in Regulation of gene expression in beta cells

Showing 1 to 1 of 1 entries

Results for Atoh1_Bhlhe23

Z-value: 0.56

Motif logo

Transcription factors associated with Atoh1_Bhlhe23

Activity-expression correlation:

Activity profile of Atoh1_Bhlhe23 motif

Sorted Z-values of Atoh1_Bhlhe23 motif

Top targets:

Network of associatons between targets according to the STRING database.

First level regulatory network of Atoh1_Bhlhe23

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Gene Ontology Analysis

Gene overrepresentation in biological process category:

Gene overrepresentation in cellular component category:

Gene overrepresentation in molecular function category:

Gene overrepresentation in curated gene sets: REACTOME pathways category: