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GSE49485: Hypoxia transcriptome sequencing of rat brain.

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Results for Atf6

Z-value: 0.47

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Transcription factors associated with Atf6

Gene Symbol Gene ID Gene Info
ENSRNOG00000024632 activating transcription factor 6

Activity-expression correlation:

GenePromoterPearson corr. coef.P-valuePlot
Atf6rn6_v1_chr13_-_89242443_892424430.118.6e-01Click!

Activity profile of Atf6 motif

Sorted Z-values of Atf6 motif

Promoter Log-likelihood Transcript Gene Gene Info
chr3_-_66417741 0.38 ENSRNOT00000007662
neuronal differentiation 1
chr12_-_41671437 0.35 ENSRNOT00000001883
LIM homeobox 5
chr1_-_209641123 0.19 ENSRNOT00000021702
early B-cell factor 3
chr1_+_274245184 0.15 ENSRNOT00000018889
dual specificity phosphatase 5
chr15_+_52241801 0.12 ENSRNOT00000082639
HR, lysine demethylase and nuclear receptor corepressor
chr11_+_80255790 0.12 ENSRNOT00000002522
B-cell CLL/lymphoma 6
chr10_+_84167331 0.11 ENSRNOT00000010965
homeo box B4
chr19_+_58823814 0.10 ENSRNOT00000027058
ENSRNOT00000088626
potassium two pore domain channel subfamily K member 1
chr11_-_34142753 0.08 ENSRNOT00000002297
claudin 14
chr4_-_147756294 0.08 ENSRNOT00000014537
methyl-CpG binding domain 4 DNA glycosylase
chr11_-_83867203 0.07 ENSRNOT00000002394
chordin
chr1_+_199941161 0.07 ENSRNOT00000027616
Bcl2-associated athanogene 3
chr9_+_10339075 0.07 ENSRNOT00000073402
vimentin-type intermediate filament associated coiled-coil protein
chr4_-_145390447 0.07 ENSRNOT00000091965
ENSRNOT00000012136
cell death-inducing DFFA-like effector c
chr7_-_11001933 0.07 ENSRNOT00000084006
transducin-like enhancer of split 2
chr5_+_164845925 0.06 ENSRNOT00000011384
methylenetetrahydrofolate reductase
chrX_-_63204530 0.06 ENSRNOT00000076175
zinc finger protein X-linked
chr10_+_58784660 0.06 ENSRNOT00000019925
uncharacterized LOC100912483
chr5_+_1417478 0.06 ENSRNOT00000008153
ENSRNOT00000085564
junctophilin 1
chr2_+_43266739 0.06 ENSRNOT00000087031
mesoderm induction early response 1, family member 3
chr1_+_78933372 0.06 ENSRNOT00000029810
coiled-coil domain containing 8
chr15_-_109394905 0.06 ENSRNOT00000019602
ENSRNOT00000078424
transmembrane and tetratricopeptide repeat containing 4
chr7_-_58286770 0.05 ENSRNOT00000005258
RAB21, member RAS oncogene family
chr4_+_56711049 0.05 ENSRNOT00000027237
filamin C
chr5_-_147584038 0.05 ENSRNOT00000010983
zinc finger and BTB domain containing 8a
chr10_+_90984227 0.05 ENSRNOT00000003890
ENSRNOT00000093707
coiled-coil domain containing 103
chr12_-_21832813 0.05 ENSRNOT00000075280
claudin 3
chr5_-_166726794 0.04 ENSRNOT00000022799
solute carrier family 25 member 33
chr1_+_47162394 0.04 ENSRNOT00000068457
transmembrane protein 181
chr3_-_79892429 0.04 ENSRNOT00000016191
solute carrier family 39 member 13
chr10_-_37209881 0.04 ENSRNOT00000090475
SEC24 homolog A, COPII coat complex component
chr20_+_33527932 0.04 ENSRNOT00000066492
nephrocan
chr4_-_157078130 0.04 ENSRNOT00000015570
calsyntenin 3
chr2_+_227455722 0.04 ENSRNOT00000064809
SEC24 homolog D, COPII coat complex component
chr4_-_152380023 0.04 ENSRNOT00000012397
ELKS/RAB6-interacting/CAST family member 1
chr10_-_96584896 0.04 ENSRNOT00000004699
ENSRNOT00000055073
protein kinase C, alpha
chr6_-_135412312 0.04 ENSRNOT00000010610
ankyrin repeat domain 9
chr7_-_2786856 0.04 ENSRNOT00000047530
ENSRNOT00000086939
coenzyme Q10A
chr10_+_84135116 0.04 ENSRNOT00000031035
homeo box B7
chrX_+_156999826 0.04 ENSRNOT00000081819
isocitrate dehydrogenase 3 (NAD), gamma
chr14_+_35683442 0.04 ENSRNOT00000003085
cysteine-rich hydrophobic domain 2
chr1_-_32643771 0.04 ENSRNOT00000016975
iroquois homeobox 4
chr16_+_59077574 0.04 ENSRNOT00000090477
DLC1 Rho GTPase activating protein
chr10_-_102269272 0.04 ENSRNOT00000048264
CDC42 effector protein 4
chr2_+_233615739 0.04 ENSRNOT00000051009
paired-like homeodomain 2
chr7_-_64341207 0.04 ENSRNOT00000006051
transmembrane protein 5
chr2_-_211352540 0.04 ENSRNOT00000023728
protein kish-B
chr6_-_80334522 0.04 ENSRNOT00000059316
F-box protein 33
chrX_+_105911925 0.04 ENSRNOT00000052422
armadillo repeat-containing X-linked protein 1
chrX_-_156999650 0.04 ENSRNOT00000083557
signal sequence receptor subunit 4
chr16_-_8685529 0.04 ENSRNOT00000092751
solute carrier family 18 member A3
chr1_+_221538104 0.04 ENSRNOT00000028527
basic leucine zipper ATF-like transcription factor 2
chr6_+_75429729 0.04 ENSRNOT00000043250
ribosomal protein S10-like 1
chr4_+_167754525 0.03 ENSRNOT00000007889
ets variant 6
chr5_+_76150840 0.03 ENSRNOT00000020702
DnaJ heat shock protein family (Hsp40) member C25
chr2_-_195935878 0.03 ENSRNOT00000028440
cingulin
chr4_-_152380184 0.03 ENSRNOT00000091473
ELKS/RAB6-interacting/CAST family member 1
chr18_-_56534415 0.03 ENSRNOT00000024374
solute carrier family 26 member 2
chr7_+_95309928 0.03 ENSRNOT00000005887
MDM2 binding protein
chr8_+_129158103 0.03 ENSRNOT00000025615
eukaryotic translation initiation factor 1B
chr10_-_40764185 0.03 ENSRNOT00000017486
secreted protein acidic and cysteine rich
chr14_+_11198896 0.03 ENSRNOT00000079767
heterogeneous nuclear ribonucleoprotein D-like
chr7_-_130408187 0.03 ENSRNOT00000015374
choline kinase beta
chr1_-_101086198 0.03 ENSRNOT00000027917
reticulocalbin 3
chr6_+_91476698 0.03 ENSRNOT00000005608
mannosyl (alpha-1,6-)-glycoprotein beta-1,2-N-acetylglucosaminyltransferase
chr4_+_113948514 0.03 ENSRNOT00000011521
mannosyl-oligosaccharide glucosidase
chr4_+_56711275 0.03 ENSRNOT00000088149
filamin C
chr11_+_87224421 0.03 ENSRNOT00000000308
DiGeorge syndrome critical region gene 14
chr9_-_115555261 0.03 ENSRNOT00000056366
protein tyrosine phosphatase, receptor type, M
chr1_+_167169442 0.03 ENSRNOT00000048172
short transient receptor potential channel 2-like
chr6_+_72124417 0.03 ENSRNOT00000040548
sec1 family domain containing 1
chr5_+_169452493 0.03 ENSRNOT00000014444
G protein-coupled receptor 153
chr9_-_113331319 0.03 ENSRNOT00000020681
VAMP associated protein A
chrX_-_4945944 0.03 ENSRNOT00000077238
lysine demethylase 6A
chr14_-_37108341 0.03 ENSRNOT00000002899
spermatogenesis associated 18
chr1_+_198383201 0.03 ENSRNOT00000037405
seizure related 6 homolog like 2
chr11_-_70961358 0.03 ENSRNOT00000002427
leishmanolysin like peptidase
chr12_-_14175945 0.03 ENSRNOT00000001469
adaptor-related protein complex 5, zeta 1 subunit
chr14_-_86387606 0.02 ENSRNOT00000089384
ENSRNOT00000006642
DEAD-box helicase 56
chr8_-_53146953 0.02 ENSRNOT00000045356
zinc finger and BTB domain containing 16
chr8_-_83421612 0.02 ENSRNOT00000015824
hypocretin receptor 2
chr5_+_62109328 0.02 ENSRNOT00000012260
N-acetylneuraminate synthase
chr17_+_85356042 0.02 ENSRNOT00000022201
COMM domain containing 3
chr1_-_101085884 0.02 ENSRNOT00000085352
reticulocalbin 3
chr7_-_70969905 0.02 ENSRNOT00000057745
Ngfi-A binding protein 2
chr2_+_124149872 0.02 ENSRNOT00000023584
spermatogenesis associated 5
chr12_-_24556976 0.02 ENSRNOT00000041798
BCL tumor suppressor 7B
chr6_-_88232252 0.02 ENSRNOT00000047597
ribosomal protein L10-like
chr1_-_81144024 0.02 ENSRNOT00000088431
zinc finger protein 94
chr7_-_24667301 0.02 ENSRNOT00000009154
transmembrane protein 263
chr17_+_26925828 0.02 ENSRNOT00000018310
thioredoxin domain containing 5
chr13_+_35554964 0.02 ENSRNOT00000072632
transmembrane protein 185B
chr12_-_19314016 0.02 ENSRNOT00000001825
minichromosome maintenance complex component 7
chr5_-_138222534 0.02 ENSRNOT00000009691
zinc finger protein 691
chr5_-_62001196 0.02 ENSRNOT00000012602
tRNA methyltransferase O
chr14_-_114484127 0.02 ENSRNOT00000056706
echinoderm microtubule associated protein like 6
chr10_+_43768708 0.02 ENSRNOT00000086218
SH3 binding domain protein 5 like
chr1_+_264768105 0.02 ENSRNOT00000086766
ENSRNOT00000048843
leucine zipper tumor suppressor 2
chr14_+_1462358 0.02 ENSRNOT00000077243
colony stimulating factor 2 receptor alpha subunit
chr10_+_40247436 0.02 ENSRNOT00000079830
glutathione peroxidase 3
chr8_-_49075892 0.02 ENSRNOT00000082687
archain 1
chr16_+_23668595 0.02 ENSRNOT00000067886
pleckstrin and Sec7 domain containing 3
chr11_-_34598102 0.02 ENSRNOT00000068743
phosphatidylinositol glycan anchor biosynthesis, class P
chr4_+_157554794 0.02 ENSRNOT00000024116
inhibitor of growth family, member 4
chr12_-_52676608 0.02 ENSRNOT00000072507
phosphatidylinositol-specific phospholipase C, X domain containing 1
chr3_-_161212188 0.02 ENSRNOT00000065751
WAP four-disulfide core domain 3
chr1_-_229639187 0.02 ENSRNOT00000016804
zinc finger protein 91
chr13_+_80125391 0.02 ENSRNOT00000044190
microRNA 199a-2
chr13_+_90467265 0.02 ENSRNOT00000008518
coatomer protein complex subunit alpha
chr7_+_12144162 0.02 ENSRNOT00000077122
transcription factor 3
chr12_+_24473981 0.02 ENSRNOT00000001973
frizzled class receptor 9
chr10_+_7279920 0.02 ENSRNOT00000003749
transmembrane protein 114
chr16_+_81493355 0.02 ENSRNOT00000023736
ENSRNOT00000090674
cell division cycle 16
chr10_+_20591432 0.02 ENSRNOT00000059780
pantothenate kinase 3
chr5_+_143500441 0.02 ENSRNOT00000045513
glutamate ionotropic receptor kainate type subunit 3
chr2_+_225854629 0.02 ENSRNOT00000036931
deoxynucleotidyltransferase, terminal, interacting protein 2
chr17_-_1672021 0.02 ENSRNOT00000036287
zinc finger protein 367
chr1_+_220009397 0.02 ENSRNOT00000084410
RNA binding motif protein 4B
chr8_+_48422036 0.01 ENSRNOT00000036051
ubiquitin specific peptidase 2
chr8_-_103554399 0.01 ENSRNOT00000079965
ENSRNOT00000089833
short transient receptor potential channel 1-like
chr8_-_67232298 0.01 ENSRNOT00000049441
sperm equatorial segment protein 1
chr15_+_61826711 0.01 ENSRNOT00000068269
E74-like factor 1
chr14_+_44413636 0.01 ENSRNOT00000003552
small integral membrane protein 14
chr19_-_56731372 0.01 ENSRNOT00000024182
nucleoporin 133
chr1_+_226947105 0.01 ENSRNOT00000028373
pre-mRNA processing factor 19
chr5_-_39650894 0.01 ENSRNOT00000010421
ENSRNOT00000089522
Ufm1-specific ligase 1
chr6_-_109205004 0.01 ENSRNOT00000010512
transmembrane p24 trafficking protein 10
chr7_+_141249044 0.01 ENSRNOT00000084911
aquaporin 5
chr6_+_143901280 0.01 ENSRNOT00000091884
ENSRNOT00000005648
zinc finger protein 386 (Kruppel-like)
chr3_+_113415774 0.01 ENSRNOT00000056151
small EDRK-rich factor 2
chr14_+_11199404 0.01 ENSRNOT00000003106
heterogeneous nuclear ribonucleoprotein D-like
chr2_+_209840404 0.01 ENSRNOT00000050149
potassium voltage-gated channel subfamily A member 2
chr5_+_150725654 0.01 ENSRNOT00000089852
ENSRNOT00000017740
DnaJ heat shock protein family (Hsp40) member C8
chr7_+_11295892 0.01 ENSRNOT00000089004
tight junction protein 3
chr20_-_48881119 0.01 ENSRNOT00000018892
glutaminyl-tRNA synthase (glutamine-hydrolyzing)-like 1
chr4_-_157486844 0.01 ENSRNOT00000038281
ENSRNOT00000022874
COP9 signalosome subunit 7A
chr11_-_34598275 0.01 ENSRNOT00000077233
phosphatidylinositol glycan anchor biosynthesis, class P
chrX_+_73390903 0.01 ENSRNOT00000077002
zinc finger protein 449
chr12_+_16340922 0.01 ENSRNOT00000001696
sorting nexin 8
chr5_+_90800082 0.01 ENSRNOT00000093696
ENSRNOT00000093206
lysine demethylase 4C
chr5_-_147784311 0.01 ENSRNOT00000074172
family with sequence similarity 167, member B
chr10_-_74298599 0.01 ENSRNOT00000007379
yippee-like 2
chr2_+_104854572 0.01 ENSRNOT00000064828
ENSRNOT00000090912
helicase-like transcription factor
chr1_-_183729569 0.01 ENSRNOT00000083293
coatomer protein complex, subunit beta 1
chr12_-_43940798 0.01 ENSRNOT00000001485
similar to hypothetical protein FLJ21415
chr4_-_55713620 0.01 ENSRNOT00000010246
GRIP and coiled-coil domain containing 1
chr8_+_117117430 0.01 ENSRNOT00000073247
glutathione peroxidase 1
chr1_-_174588529 0.01 ENSRNOT00000017485
DENN domain containing 5A
chr16_+_2338333 0.01 ENSRNOT00000017692
ADP-ribosylation factor 4
chr1_+_162768156 0.01 ENSRNOT00000049321
p21 (RAC1) activated kinase 1
chr16_+_61758917 0.01 ENSRNOT00000084858
leptin receptor overlapping transcript-like 1
chr10_+_88356615 0.01 ENSRNOT00000022687
kelch-like family member 10
chr9_-_61810417 0.01 ENSRNOT00000020910
raftlin family member 2
chr19_-_39257451 0.01 ENSRNOT00000066312
component of oligomeric golgi complex 8
chr10_+_76343847 0.01 ENSRNOT00000055674
tripartite motif-containing 25
chr11_+_87678295 0.01 ENSRNOT00000091675
kelch-like family member 22
chr10_-_90983928 0.01 ENSRNOT00000055176
elongation factor Tu GTP binding domain containing 2
chr1_+_221420271 0.01 ENSRNOT00000028481
similar to Finkel-Biskis-Reilly murine sarcoma virusubiquitously expressed
chr1_-_32429917 0.01 ENSRNOT00000024111
lysophosphatidylcholine acyltransferase 1
chrX_-_19369746 0.01 ENSRNOT00000075249
ras-related GTP-binding protein B
chr1_+_173532803 0.01 ENSRNOT00000021017
eukaryotic translation initiation factor 3, subunit F
chr4_+_176565694 0.01 ENSRNOT00000016794
pyridine nucleotide-disulphide oxidoreductase domain 1
chr18_+_58325319 0.01 ENSRNOT00000065802
ENSRNOT00000077726
NSF attachment protein gamma
chr10_+_70134729 0.01 ENSRNOT00000076739
DNA ligase 3
chr3_-_46457201 0.01 ENSRNOT00000010683
lymphocyte antigen 75
chrX_-_19134869 0.01 ENSRNOT00000004235
Ras-related GTP binding B
chr1_-_87174530 0.01 ENSRNOT00000089578
potassium two pore domain channel subfamily K member 6
chr10_+_74436534 0.01 ENSRNOT00000008298
tripartite motif-containing 37
chr5_+_21632926 0.01 ENSRNOT00000008522
RAB2A, member RAS oncogene family
chr12_+_23463157 0.01 ENSRNOT00000044841
cut-like homeobox 1
chr20_+_2501252 0.01 ENSRNOT00000079307
ENSRNOT00000084559
tripartite motif-containing 39
chr3_+_95232166 0.01 ENSRNOT00000017952
hypothetical protein LOC691083
chr1_-_218810118 0.01 ENSRNOT00000065950
ENSRNOT00000020886
protein phosphatase 6, regulatory subunit 3
chr1_-_263718745 0.01 ENSRNOT00000074810
dynamin binding protein
chr7_+_114724610 0.01 ENSRNOT00000014541
DENN domain containing 3
chrX_-_1856258 0.01 ENSRNOT00000079980
similar to RuvB-like protein 1
chr15_+_61826937 0.01 ENSRNOT00000084005
ENSRNOT00000079417
E74-like factor 1
chr8_-_25904564 0.01 ENSRNOT00000082744
ENSRNOT00000064783
T-box 20
chr1_-_205842428 0.01 ENSRNOT00000024655
DEAH-box helicase 32 (putative)
chr6_+_52459946 0.00 ENSRNOT00000073277
ENSRNOT00000013474
ataxin 7-like 1
chr10_+_15241590 0.00 ENSRNOT00000037372
ENSRNOT00000037381
methyltransferase like 26
chr2_+_144591755 0.00 ENSRNOT00000044424
spermatogenesis and oogenesis specific basic helix-loop-helix 2
chr1_+_77994203 0.00 ENSRNOT00000002044
NSF attachment protein alpha
chr1_+_224939497 0.00 ENSRNOT00000025664
syntaxin 5
chr1_-_175895510 0.00 ENSRNOT00000064535
eukaryotic translation initiation factor 4, gamma 2
chr6_-_86713370 0.00 ENSRNOT00000005821
kelch-like family member 28
chr1_-_100865894 0.00 ENSRNOT00000027580
prostate tumor overexpressed 1
chr6_-_94818349 0.00 ENSRNOT00000005933
G protein-coupled receptor 135
chr11_+_77239098 0.00 ENSRNOT00000058701
geminin coiled-coil domain containing
chr1_+_282188110 0.00 ENSRNOT00000013845
family with sequence similarity 45, member A
chr2_+_207108552 0.00 ENSRNOT00000027234
solute carrier family 16 member 1
chr20_-_11737050 0.00 ENSRNOT00000001637
small ubiquitin-like modifier 3
chr4_+_56625561 0.00 ENSRNOT00000008356
ENSRNOT00000090808
ENSRNOT00000008972
calumenin
chr10_+_74436208 0.00 ENSRNOT00000090921
ENSRNOT00000091163
tripartite motif-containing 37
chr3_+_161212156 0.00 ENSRNOT00000020280
ENSRNOT00000083553
deoxynucleotidyltransferase, terminal, interacting protein 1
chr4_-_62663200 0.00 ENSRNOT00000040969
CCR4-NOT transcription complex, subunit 4
chr12_-_48663143 0.00 ENSRNOT00000082809
FIC domain containing
chr10_-_84789832 0.00 ENSRNOT00000071719
CDK5 regulatory subunit associated protein 3
chr7_-_140506925 0.00 ENSRNOT00000083354
lysine methyltransferase 2D
chr20_+_2004052 0.00 ENSRNOT00000001008
myelin oligodendrocyte glycoprotein

Network of associatons between targets according to the STRING database.

First level regulatory network of Atf6

PNG image of the network

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Gene Ontology Analysis

Gene overrepresentation in biological process category:

Log-likelihood per target  Total log-likelihood Term Description
0.1 0.4 GO:0060729 intestinal epithelial structure maintenance(GO:0060729)
0.1 0.4 GO:0021937 cerebellar Purkinje cell-granule cell precursor cell signaling involved in regulation of granule cell precursor cell proliferation(GO:0021937)
0.0 0.1 GO:0032763 regulation of mast cell cytokine production(GO:0032763) regulation of memory T cell differentiation(GO:0043380) negative regulation of isotype switching to IgE isotypes(GO:0048294)
0.0 0.1 GO:0048539 bone marrow development(GO:0048539)
0.0 0.1 GO:0060075 regulation of resting membrane potential(GO:0060075)
0.0 0.0 GO:0060577 pulmonary vein morphogenesis(GO:0060577)
0.0 0.0 GO:0035408 histone H3-T6 phosphorylation(GO:0035408)
0.0 0.1 GO:0070827 chromatin maintenance(GO:0070827)
0.0 0.0 GO:0007089 traversing start control point of mitotic cell cycle(GO:0007089)

Gene overrepresentation in cellular component category:

Log-likelihood per target  Total log-likelihood Term Description
0.0 0.1 GO:0014701 junctional sarcoplasmic reticulum membrane(GO:0014701)
0.0 0.1 GO:0010009 cytoplasmic side of endosome membrane(GO:0010009)
0.0 0.1 GO:0045098 type III intermediate filament(GO:0045098)
0.0 0.0 GO:0005962 mitochondrial isocitrate dehydrogenase complex (NAD+)(GO:0005962) isocitrate dehydrogenase complex (NAD+)(GO:0045242)

Gene overrepresentation in molecular function category:

Log-likelihood per target  Total log-likelihood Term Description
0.0 0.1 GO:0008263 pyrimidine-specific mismatch base pair DNA N-glycosylase activity(GO:0008263)
0.0 0.1 GO:0022841 potassium ion leak channel activity(GO:0022841)
0.0 0.0 GO:0004698 calcium-dependent protein kinase C activity(GO:0004698) histone kinase activity (H3-T6 specific)(GO:0035403)
0.0 0.0 GO:1901375 acetylcholine transmembrane transporter activity(GO:0005277) acetate ester transmembrane transporter activity(GO:1901375)
0.0 0.1 GO:0001161 intronic transcription regulatory region sequence-specific DNA binding(GO:0001161)

Gene overrepresentation in curated gene sets: REACTOME pathways category:

Log-likelihood per target  Total log-likelihood Term Description
0.0 0.4 REACTOME REGULATION OF GENE EXPRESSION IN BETA CELLS Genes involved in Regulation of gene expression in beta cells