ISMARA results: Atf4

Project

GSE49485: Hypoxia transcriptome sequencing of rat brain.

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Results for Atf4

Z-value: 0.38

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Transcription factors associated with Atf4

Gene Symbol	Gene ID	Gene Info
Atf4 NCBI RGD Ensembl	ENSRNOG00000017801	activating transcription factor 4

Activity-expression correlation:

Gene	Promoter	Pearson corr. coef.	P-value	Plot
Atf4	rn6_v1_chr7_+_121480723_121480723	0.74	1.5e-01	Click!

Activity profile of Atf4 motif

Sorted Z-values of Atf4 motif

Top targets:

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Promoter	Log-likelihood	Transcript	Gene	Gene Info
chr9_-_78969013 Show fit	0.15	ENSRNOT00000019772 ENSRNOT00000057585	Fn1 NCBI RGD Ensembl Show fit	fibronectin 1
chr6_-_125723944 Show fit	0.15	ENSRNOT00000007004	Fbln5 NCBI RGD Ensembl Show fit	fibulin 5
chr19_-_11057254 Show fit	0.14	ENSRNOT00000025559	Herpud1 NCBI RGD Ensembl Show fit	homocysteine inducible ER protein with ubiquitin like domain 1
chr5_-_137372993 Show fit	0.14	ENSRNOT00000092823	Tmem125 NCBI RGD Ensembl Show fit	transmembrane protein 125
chr19_+_14508616 Show fit	0.13	ENSRNOT00000019192	Hmox1 NCBI RGD Ensembl Show fit	heme oxygenase 1
chr5_+_136669674 Show fit	0.13	ENSRNOT00000048770	Slc6a9 NCBI RGD Ensembl Show fit	solute carrier family 6 member 9
chr6_-_125723732 Show fit	0.12	ENSRNOT00000084815	Fbln5 NCBI RGD Ensembl Show fit	fibulin 5
chr7_+_130296897 Show fit	0.10	ENSRNOT00000044854	Adm2 NCBI RGD Ensembl Show fit	adrenomedullin 2
chr15_-_33527031 Show fit	0.10	ENSRNOT00000019979	Homez NCBI RGD Ensembl Show fit	homeobox and leucine zipper encoding
chr1_-_101596822 Show fit	0.10	ENSRNOT00000028490	Fgf21 NCBI RGD Ensembl Show fit	fibroblast growth factor 21

Showing 1 to 10 of 74 entries

Network of associatons between targets according to the STRING database.

First level regulatory network of Atf4

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Gene Ontology Analysis

Gene overrepresentation in biological process category:

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Log-likelihood per target	Total log-likelihood	Term	Description
0.0	0.3	GO:0048251	elastic fiber assembly(GO:0048251)
0.1	0.2	GO:0007161	calcium-independent cell-matrix adhesion(GO:0007161) interaction with other organism via secreted substance involved in symbiotic interaction(GO:0052047) regulation of transforming growth factor-beta secretion(GO:2001201)
0.0	0.1	GO:0006788	heme oxidation(GO:0006788) regulation of transcription from RNA polymerase II promoter in response to iron(GO:0034395)
0.0	0.1	GO:1903071	positive regulation of ER-associated ubiquitin-dependent protein catabolic process(GO:1903071)
0.0	0.1	GO:0006419	alanyl-tRNA aminoacylation(GO:0006419)
0.0	0.1	GO:0021539	subthalamus development(GO:0021539)
0.0	0.1	GO:0018364	peptidyl-glutamine methylation(GO:0018364)
0.0	0.1	GO:1904640	response to methionine(GO:1904640)
0.0	0.1	GO:1904781	positive regulation of protein localization to centrosome(GO:1904781)
0.0	0.1	GO:0060012	synaptic transmission, glycinergic(GO:0060012)

Showing 1 to 10 of 15 entries

Gene overrepresentation in cellular component category:

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Log-likelihood per target	Total log-likelihood	Term	Description
0.1	0.3	GO:0071953	elastic fiber(GO:0071953)
0.0	0.2	GO:0005577	fibrinogen complex(GO:0005577)
0.0	0.1	GO:1990037	Lewy body core(GO:1990037)
0.0	0.1	GO:1990622	CHOP-C/EBP complex(GO:0036488) CHOP-ATF3 complex(GO:1990622)

Showing 1 to 4 of 4 entries

Gene overrepresentation in molecular function category:

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Total log-likelihood	Term	Description
0.2	GO:0045340	mercury ion binding(GO:0045340)
0.1	GO:0004392	heme oxygenase (decyclizing) activity(GO:0004392)
0.1	GO:0004813	alanine-tRNA ligase activity(GO:0004813)
0.1	GO:0003839	gamma-glutamylcyclotransferase activity(GO:0003839)
0.1	GO:0015187	glycine transmembrane transporter activity(GO:0015187)
0.0	GO:0004487	methylenetetrahydrofolate dehydrogenase (NAD+) activity(GO:0004487)

Showing 1 to 6 of 6 entries

Results for Atf4

Z-value: 0.38

Motif logo

Transcription factors associated with Atf4

Activity-expression correlation:

Activity profile of Atf4 motif

Sorted Z-values of Atf4 motif

Top targets:

Network of associatons between targets according to the STRING database.

First level regulatory network of Atf4

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Gene Ontology Analysis

Gene overrepresentation in biological process category:

Gene overrepresentation in cellular component category:

Gene overrepresentation in molecular function category: